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Protein

Abnormal spindle-like microcephaly-associated protein homolog

Gene

ASPM

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Abnormal spindle-like microcephaly-associated protein homolog
Gene namesi
Name:ASPM
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913351 – 3479Abnormal spindle-like microcephaly-associated protein homologAdd BLAST3479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei280PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei1103PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP62292

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000338

Structurei

3D structure databases

ProteinModelPortaliP62292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini920 – 1056Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST137
Domaini1110 – 1261Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST152
Domaini1347 – 1378IQ 1PROSITE-ProRule annotationAdd BLAST32
Domaini1393 – 1422IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini1582 – 1613IQ 3PROSITE-ProRule annotationAdd BLAST32
Domaini1605 – 1634IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1632 – 1661IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1655 – 1684IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1728 – 1757IQ 7PROSITE-ProRule annotationAdd BLAST30
Domaini1751 – 1782IQ 8PROSITE-ProRule annotationAdd BLAST32
Domaini1801 – 1830IQ 9PROSITE-ProRule annotationAdd BLAST30
Domaini1824 – 1853IQ 10PROSITE-ProRule annotationAdd BLAST30
Domaini1874 – 1903IQ 11PROSITE-ProRule annotationAdd BLAST30
Domaini1897 – 1928IQ 12PROSITE-ProRule annotationAdd BLAST32
Domaini1947 – 1978IQ 13PROSITE-ProRule annotationAdd BLAST32
Domaini1970 – 2001IQ 14PROSITE-ProRule annotationAdd BLAST32
Domaini2020 – 2049IQ 15PROSITE-ProRule annotationAdd BLAST30
Domaini2043 – 2074IQ 16PROSITE-ProRule annotationAdd BLAST32
Domaini2093 – 2124IQ 17PROSITE-ProRule annotationAdd BLAST32
Domaini2116 – 2147IQ 18PROSITE-ProRule annotationAdd BLAST32
Domaini2239 – 2270IQ 19PROSITE-ProRule annotationAdd BLAST32
Domaini2262 – 2293IQ 20PROSITE-ProRule annotationAdd BLAST32
Domaini2311 – 2342IQ 21PROSITE-ProRule annotationAdd BLAST32
Domaini2334 – 2365IQ 22PROSITE-ProRule annotationAdd BLAST32
Domaini2384 – 2415IQ 23PROSITE-ProRule annotationAdd BLAST32
Domaini2407 – 2438IQ 24PROSITE-ProRule annotationAdd BLAST32
Domaini2533 – 2564IQ 25PROSITE-ProRule annotationAdd BLAST32
Domaini2627 – 2656IQ 26PROSITE-ProRule annotationAdd BLAST30
Domaini2668 – 2699IQ 27PROSITE-ProRule annotationAdd BLAST32
Domaini2691 – 2722IQ 28PROSITE-ProRule annotationAdd BLAST32
Domaini2741 – 2770IQ 29PROSITE-ProRule annotationAdd BLAST30
Domaini2817 – 2848IQ 30PROSITE-ProRule annotationAdd BLAST32
Domaini2862 – 2893IQ 31PROSITE-ProRule annotationAdd BLAST32
Domaini2912 – 2941IQ 32PROSITE-ProRule annotationAdd BLAST30
Domaini2935 – 2966IQ 33PROSITE-ProRule annotationAdd BLAST32
Domaini2957 – 2988IQ 34PROSITE-ProRule annotationAdd BLAST32
Domaini3032 – 3063IQ 35PROSITE-ProRule annotationAdd BLAST32
Domaini3082 – 3113IQ 36PROSITE-ProRule annotationAdd BLAST32
Domaini3206 – 3237IQ 37PROSITE-ProRule annotationAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1057 – 1078Sequence analysisAdd BLAST22

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0165 Eukaryota
ENOG410XSAR LUCA
HOGENOMiHOG000034105
HOVERGENiHBG050595
InParanoidiP62292
KOiK16743

Family and domain databases

Gene3Di1.10.418.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR031549 ASH
IPR029955 ASPM
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR013783 Ig-like_fold
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PANTHERiPTHR44613 PTHR44613, 3 hits
PfamiView protein in Pfam
PF15780 ASH, 1 hit
PF00307 CH, 1 hit
PF00612 IQ, 40 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 66 hits
SUPFAMiSSF47576 SSF47576, 3 hits
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 17 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
PS50096 IQ, 37 hits

Sequencei

Sequence statusi: Complete.

P62292-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANRRVGRGC WEVSPTERRP PAALRGPATE EEASSPPVLF LSHFCRSPFL
60 70 80 90 100
CFGDVLLGDS RTLPLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP
110 120 130 140 150
KEKIVISVNW TPFKEGRVRE IMTFLVNDVL KHQAILLGNA EKQKKKKRSL
160 170 180 190 200
WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS VSQKVDRVRS PLQACENLAM
210 220 230 240 250
NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS VRRSTTYSSL
260 270 280 290 300
HASENRELLN VDSANVSKVS FNEKAVTETS FNSINVNDQS GENSKLILTP
310 320 330 340 350
NYSSTLNITQ SQINFLSPDS FVNNSHGANN ELELVTCLSS DMFMTDNSKP
360 370 380 390 400
VHLQSTTAHE IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN
410 420 430 440 450
MAYMCTSQQT YKVPLSNENS QVPQSPQDWS KSEVSPCIPE YQGSKSPKAI
460 470 480 490 500
FEELVEMKSN YYSFIKQNNP KFSAVQDISS HSHDKQPKRR PILSATVTKR
510 520 530 540 550
KPTCTRENQT EINKPKAKRC LNSAVGEHEK VIHNQKEKED FHSYLPVIDP
560 570 580 590 600
VLSKSKSYKN QIMPSLTTAS VARKRKSDGS MEDANVRVAV TEHTEEREIK
610 620 630 640 650
RIHFSPSEPK TSAVKKTKNV ITPISKCISN REKLNLKKKT DLLIFKTPIS
660 670 680 690 700
KTSKRTKPII AVAQSNLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE
710 720 730 740 750
QGFTWWLNFI LTPDDFTVKT NISEVNAATL LLGVENQHKI SVPRAPTKEE
760 770 780 790 800
MSLRAYTARC RLNRLRRAAC RLFTSEKMVK AIKKLEIEIE ARRLIVRKDR
810 820 830 840 850
HLWKDVGERQ KVLNWLLSYN PLWLRIGLET IYGELISLED NSDVTGLAMF
860 870 880 890 900
ILNRLLWNPD IAAEYRHPTV PHLYRDGHEG ALSKFTLKKL LLLICFLDYA
910 920 930 940 950
KISKLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP
960 970 980 990 1000
VNHVQTPFDE FDFAITNLAV DLQCGVRLVR TMELLTQNWN LSKKLRIPAI
1010 1020 1030 1040 1050
SRLQKMHNVD IVLQVLKSRG IELSDEHGNT ILSKDIVDRH REKTLRLLWK
1060 1070 1080 1090 1100
IAFAFQVDIS LNLDQLKEEI AFLKHTKSIK KTISLLSCHS DALINKKKGK
1110 1120 1130 1140 1150
RDSGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD GRVLCYLIHH
1160 1170 1180 1190 1200
YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
1210 1220 1230 1240 1250
NTSELYKELL ENEKKNFQLI RSAVRDLGGI PAMINHSDMS NTIPDEKVVI
1260 1270 1280 1290 1300
TYLSFLCARL LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ ERDKAARIIQ
1310 1320 1330 1340 1350
SAVINFLAKQ RLRKRVNAAL IIQKYWRRVL AQRKLLILKK EKLEKVQNKA
1360 1370 1380 1390 1400
ASLIQGYWRR YSTRKRFLKL KYYSIILQSR IRMIIAVTSY KRYLWATVTI
1410 1420 1430 1440 1450
QRHWRAYLRR KQDQQRYEML KSSSLIIQSM FRKWKRRKMQ SQVKATVILQ
1460 1470 1480 1490 1500
RAFREWHLRK RAKEENSAIV IQSWYRMHKE LRKYIYIRSC VIVIQKRFRC
1510 1520 1530 1540 1550
FQAQKLYKRK KESILTIQKY YKAYLKGKIE RTNYLQKRAA AIQLQAAFRR
1560 1570 1580 1590 1600
LKAHNLCRQI RAACVIQSYW RMRQDRVRFL NLKKTIIKLQ AHIRKHQQLQ
1610 1620 1630 1640 1650
KYKKMKKAAV IIQTHFRAYI FTRKVLASYQ KTRSAVIVLQ SAYRGMQARK
1660 1670 1680 1690 1700
VYIHILTSVI KIQSYYRAYV SKKEFLSLKN TTIKLQSIVK MKQTRKQYLH
1710 1720 1730 1740 1750
LRAAALFIQQ CYRSKKITTQ KREEYMQMRE SCIKLQAFVR GYLVRKQMRL
1760 1770 1780 1790 1800
QRKAVISLQS YFRMRKARQY YLKMCKAIMV IQNYYHAYKA QVNQRKNFLR
1810 1820 1830 1840 1850
VKKAATCLQA AYRGYKVRQL IKQQSIAALK IQSAFRGYNK RVKYQSVLQS
1860 1870 1880 1890 1900
IIKIQRWYRA YKTLHDTRTH FLKTKAAVVS LQSAYRGWKV RKQIRREHQA
1910 1920 1930 1940 1950
ALKIQSAFRM AKAQKQFRLF KTAALVIQQN FRAWTAGRKQ RMEYIELRHA
1960 1970 1980 1990 2000
VLILQSMWKG KTLRRQLQRQ HKCAIIIQSY YRMHVQQKKW KIMKKAALLI
2010 2020 2030 2040 2050
QKYYKAYSIG REQHHLYLKT KAAVVTLQSA YRGMKVRKRI KDCNKAAVTI
2060 2070 2080 2090 2100
QSKYRAYKTK KKYATYRASA IIIQRWYRGI KITHRQHQEY LNLKKTAIKI
2110 2120 2130 2140 2150
QSVYRGIRVR RHIQHMHRAA TFIKAMFKMH QSRISYHTMR KAAIVIQVRF
2160 2170 2180 2190 2200
RAYYQGKMHR EKYLTILKAV KILQASFRGV RVRWTLRKMQ IAATLIQSNY
2210 2220 2230 2240 2250
RRYKQQTYFN KLKKITKTIQ QRYRAVKERN IQFKRYNKLR HSVIYIQAIF
2260 2270 2280 2290 2300
RGKKARRHLK MMHVAATLIQ RRFRTLMMRR RFLSLKKTAV WIQRKYRAHL
2310 2320 2330 2340 2350
CTKHHLQFLQ VQNAVIKIQS SYRRWMIRKK MREMHRAATF IQATFRMHRV
2360 2370 2380 2390 2400
HMRYQALKQA SVVIQQQYRA NRAAKLQRQH YLRQRRSAVI LQAAFRGVKT
2410 2420 2430 2440 2450
RRHLKSMHSS ATLIQSRFRS LLVRRRFISL KKATIFVQRK YRATICAKHK
2460 2470 2480 2490 2500
LHQFLQLRKA AITIQSSYCT IRRLMVKKKL QEMQRAAVLI QATFRMHRTC
2510 2520 2530 2540 2550
VTFQTWKQAS ILIQQHYRTY RAAKLQKENY IRQWHSAVVI QTAYKGMKAR
2560 2570 2580 2590 2600
QHLREKHKAA IIIQSTYRMY RQYCFYQKLQ WATKIIQEKY RANKKKQKAL
2610 2620 2630 2640 2650
QHNELKKETC VQASFQDMNI QKQIQEQHQA AIIIQKHCKA FKIRKHYLHL
2660 2670 2680 2690 2700
RATVVSIQRR YRKLTAVRTQ AVICIQSYYR GFKVRRDIQN MHRAATLIQS
2710 2720 2730 2740 2750
FYRMHRAKVD YQTKKTAIVV IQNYYRLYVR VKTERKSFLP VQKSVRTIQA
2760 2770 2780 2790 2800
AFRGMKVRQK LKIVSEEKMA AIVNQSALCC YRSKTQYEAV QSEGVMIQEW
2810 2820 2830 2840 2850
YKASDLACSQ EAECHSQSRA AVTIQNAFRR MVTRKLETQK CAALRIQFFL
2860 2870 2880 2890 2900
QMAVYRRRFV QQKRAAITLQ HYFRTWQTRK QFLLYRKAAV VLQNHYRAFL
2910 2920 2930 2940 2950
SAKHQRQVYL QIRSSVIIIQ ARSKGFIQKR KFQEIKNSTI KIQAMWRRYR
2960 2970 2980 2990 3000
AKKYLCKVKA ACKIQAWYRC WRAHKEYLAI LKAVKIIQGC FYTKLERTWF
3010 3020 3030 3040 3050
LNVRASAIII QRKWRAILSA KIAHEHFLMI KRHRAACLIQ AHYRGYKERQ
3060 3070 3080 3090 3100
VFLRQKSAAL IIQKYIRARE AGKRERIKYI EFKKSTVILQ ALVRGWLVRK
3110 3120 3130 3140 3150
RILEQKTKIR LLHFTAAAYY HLNALRIQRA YKLYLAVKNA NKQVNSVICI
3160 3170 3180 3190 3200
QRWFRARLQQ KKFIQKYSIK KIEHEGQECL SQQNRAASVI QKAVRHFVLR
3210 3220 3230 3240 3250
KKQEKFTSGI IKIQALWRGY SWRKKNDCTK IKAIRLSLQV VNREIREENK
3260 3270 3280 3290 3300
LYKRTALALH YLLTYKHLSA ILEALKHLEV VTRLSPLCCE NMAQSGAISK
3310 3320 3330 3340 3350
IFVLIRSCNR SVPCMEVIRY AVQVLLNVSK YEKTTSAVYD VENCIDTLLE
3360 3370 3380 3390 3400
LLQIYREKPG NKVADKGGSI FTKTCCLLAV LLKTTNRASD VRSRSKVVDR
3410 3420 3430 3440 3450
IYSLYKLTAH KHKMNTERIL HKQKKNSSIS IPFIPETPVR TRIVSRLKPD
3460 3470
WVLRRDNMEE ITNPLQAIQM VMDTLGIPY
Length:3,479
Mass (Da):410,106
Last modified:July 5, 2004 - v1
Checksum:i589BA40F2D79BCC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497013 Genomic DNA Translation: AAS48529.1
RefSeqiNP_001098005.1, NM_001104535.1
UniGeneiMmu.17304

Genome annotation databases

GeneIDi711153
KEGGimcc:711153

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497013 Genomic DNA Translation: AAS48529.1
RefSeqiNP_001098005.1, NM_001104535.1
UniGeneiMmu.17304

3D structure databases

ProteinModelPortaliP62292
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000338

Proteomic databases

PRIDEiP62292

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi711153
KEGGimcc:711153

Organism-specific databases

CTDi259266

Phylogenomic databases

eggNOGiKOG0165 Eukaryota
ENOG410XSAR LUCA
HOGENOMiHOG000034105
HOVERGENiHBG050595
InParanoidiP62292
KOiK16743

Family and domain databases

Gene3Di1.10.418.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR031549 ASH
IPR029955 ASPM
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR013783 Ig-like_fold
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PANTHERiPTHR44613 PTHR44613, 3 hits
PfamiView protein in Pfam
PF15780 ASH, 1 hit
PF00307 CH, 1 hit
PF00612 IQ, 40 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 66 hits
SUPFAMiSSF47576 SSF47576, 3 hits
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 17 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
PS50096 IQ, 37 hits
ProtoNetiSearch...

Entry informationi

Entry nameiASPM_MACMU
AccessioniPrimary (citable) accession number: P62292
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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