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Protein

40S ribosomal protein S11

Gene

RPS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S11
Alternative name(s):
Small ribosomal subunit protein uS171 Publication
Gene namesi
Name:RPS11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142534.6
HGNCiHGNC:10384 RPS11
MIMi180471 gene
neXtProtiNX_P62280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi60C → S: Abolishes S-acylation. 1 Publication1

Organism-specific databases

DisGeNETi6205
OpenTargetsiENSG00000142534
PharmGKBiPA34782

Polymorphism and mutation databases

BioMutaiRPS11
DMDMi50403609

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001285092 – 15840S ribosomal protein S11Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei22CitrullineBy similarity1
Modified residuei38N6-acetyllysineCombined sources1
Modified residuei45N6-acetyllysineCombined sources1
Modified residuei58N6-acetyllysineBy similarity1
Lipidationi60S-palmitoyl cysteine1 Publication1
Modified residuei67PhosphoserineCombined sources1
Modified residuei69Omega-N-methylarginineBy similarity1
Modified residuei110PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

EPDiP62280
MaxQBiP62280
PaxDbiP62280
PeptideAtlasiP62280
PRIDEiP62280
ProteomicsDBi57385
TopDownProteomicsiP62280

2D gel databases

SWISS-2DPAGEiP62280

PTM databases

iPTMnetiP62280
PhosphoSitePlusiP62280
SwissPalmiP62280

Miscellaneous databases

PMAP-CutDBiP62280

Expressioni

Gene expression databases

BgeeiENSG00000142534
CleanExiHS_RPS11
ExpressionAtlasiP62280 baseline and differential
GenevisibleiP62280 HS

Organism-specific databases

HPAiHPA049719

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0073EBI-1047710,EBI-5323863

Protein-protein interaction databases

BioGridi112119, 183 interactors
CORUMiP62280
IntActiP62280, 76 interactors
MINTiP62280
STRINGi9606.ENSP00000270625

Structurei

3D structure databases

ProteinModelPortaliP62280
SMRiP62280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1728 Eukaryota
COG0186 LUCA
GeneTreeiENSGT00390000002732
HOGENOMiHOG000231341
HOVERGENiHBG004670
InParanoidiP62280
KOiK02949
OMAiKKYERYE
OrthoDBiEOG091G0QVV
PhylomeDBiP62280
TreeFamiTF300126

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR032440 Ribosomal_S11_N
IPR000266 Ribosomal_S17/S11
IPR028333 Ribosomal_S17_arc-typ
IPR019979 Ribosomal_S17_CS
PANTHERiPTHR10744 PTHR10744, 1 hit
PfamiView protein in Pfam
PF00366 Ribosomal_S17, 1 hit
PF16205 Ribosomal_S17_N, 1 hit
PRINTSiPR00973 RIBOSOMALS17
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001295 Ribosomal_S17, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR03630 uS17_arch, 1 hit
PROSITEiView protein in PROSITE
PS00056 RIBOSOMAL_S17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIQTERAY QKQPTIFQNK KRVLLGETGK EKLPRYYKNI GLGFKTPKEA
60 70 80 90 100
IEGTYIDKKC PFTGNVSIRG RILSGVVTKM KMQRTIVIRR DYLHYIRKYN
110 120 130 140 150
RFEKRHKNMS VHLSPCFRDV QIGDIVTVGE CRPLSKTVRF NVLKVTKAAG

TKKQFQKF
Length:158
Mass (Da):18,431
Last modified:January 23, 2007 - v3
Checksum:i9FB75DC1D99614B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06617 mRNA Translation: CAA29834.1
AB028893 Genomic DNA Translation: BAA88215.1
AK311809 mRNA Translation: BAG34752.1
CH471177 Genomic DNA Translation: EAW52497.1
BC007283 mRNA Translation: AAH07283.1
BC007603 mRNA Translation: AAH07603.1
BC007945 mRNA Translation: AAH07945.1
BC010028 mRNA Translation: AAH10028.1
BC016378 mRNA Translation: AAH16378.1
BC070224 mRNA Translation: AAH70224.1
BC100025 mRNA Translation: AAI00026.1
AB007152 Genomic DNA Translation: BAA25818.1
CCDSiCCDS12769.1
PIRiS02133 R3HU11
RefSeqiNP_001006.1, NM_001015.4
UniGeneiHs.433529

Genome annotation databases

EnsembliENST00000270625; ENSP00000270625; ENSG00000142534
GeneIDi6205
KEGGihsa:6205
UCSCiuc002pob.3 human

Similar proteinsi

Entry informationi

Entry nameiRS11_HUMAN
AccessioniPrimary (citable) accession number: P62280
Secondary accession number(s): B2R4F5
, P04643, Q498Y6, Q6IRY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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