UniProtKB - P62277 (RS13_HUMAN)
Protein
40S ribosomal protein S13
Gene
RPS13
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- mRNA 5'-UTR binding Source: CAFA
- mRNA binding Source: UniProtKB
- RNA binding Source: UniProtKB
- small ribosomal subunit rRNA binding Source: GO_Central
- structural constituent of ribosome Source: FlyBase
GO - Biological processi
- negative regulation of RNA splicing Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P62277 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P62277 |
Protein family/group databases
MoonProti | P62277 |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S13Alternative name(s): Small ribosomal subunit protein uS151 Publication |
Gene namesi | Name:RPS13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10386, RPS13 |
MIMi | 180476, gene |
neXtProti | NX_P62277 |
VEuPathDBi | HostDB:ENSG00000110700.6 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic small ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleolus Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- postsynaptic density Source: SynGO
- ribosome Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6207 |
OpenTargetsi | ENSG00000110700 |
PharmGKBi | PA34785 |
Miscellaneous databases
Pharosi | P62277, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Genetic variation databases
BioMutai | RPS13 |
DMDMi | 50403608 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000115661 | 2 – 151 | 40S ribosomal protein S13Add BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 27 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 30 | PhosphoserineCombined sources | 1 | |
Modified residuei | 34 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 38 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 43 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P62277 |
jPOSTi | P62277 |
MassIVEi | P62277 |
MaxQBi | P62277 |
PaxDbi | P62277 |
PeptideAtlasi | P62277 |
PRIDEi | P62277 |
ProteomicsDBi | 57384 |
TopDownProteomicsi | P62277 |
PTM databases
iPTMneti | P62277 |
PhosphoSitePlusi | P62277 |
SwissPalmi | P62277 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110700, Expressed in cortical plate and 120 other tissues |
ExpressionAtlasi | P62277, baseline and differential |
Genevisiblei | P62277, HS |
Organism-specific databases
HPAi | ENSG00000110700, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP62277
With | #Exp. | IntAct |
---|---|---|
LRRK2 [Q5S007] | 3 | EBI-351850,EBI-5323863 |
MAP3K14 [Q99558] | 3 | EBI-351850,EBI-358011 |
PDCD4 [Q53EL6] | 2 | EBI-351850,EBI-935824 |
Protein-protein interaction databases
BioGRIDi | 112121, 327 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P62277 |
IntActi | P62277, 85 interactors |
MINTi | P62277 |
STRINGi | 9606.ENSP00000435777 |
Miscellaneous databases
RNActi | P62277, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P62277 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uS15 family.Curated
Phylogenomic databases
eggNOGi | KOG0400, Eukaryota |
GeneTreei | ENSGT00390000017491 |
HOGENOMi | CLU_090139_1_0_1 |
InParanoidi | P62277 |
OMAi | WHLVKKA |
OrthoDBi | 1387147at2759 |
PhylomeDBi | P62277 |
TreeFami | TF300190 |
Family and domain databases
CDDi | cd00353, Ribosomal_S15p_S13e, 1 hit |
HAMAPi | MF_01343_A, Ribosomal_S15_A, 1 hit |
InterProi | View protein in InterPro IPR012606, Ribosomal_S13/S15_N IPR000589, Ribosomal_S15 IPR023029, Ribosomal_S15P IPR009068, S15_NS1_RNA-bd |
PANTHERi | PTHR11885, PTHR11885, 1 hit |
Pfami | View protein in Pfam PF08069, Ribosomal_S13_N, 1 hit PF00312, Ribosomal_S15, 1 hit |
SMARTi | View protein in SMART SM01386, Ribosomal_S13_N, 1 hit SM01387, Ribosomal_S15, 1 hit |
SUPFAMi | SSF47060, SSF47060, 1 hit |
PROSITEi | View protein in PROSITE PS00362, RIBOSOMAL_S15, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P62277-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI
60 70 80 90 100
GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK
110 120 130 140 150
HLERNRKDKD AKFRLILIES RIHRLARYYK TKRVLPPNWK YESSTASALV
A
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KMX5 | J3KMX5_HUMAN | 40S ribosomal protein S13 | RPS13 | 148 | Annotation score: | ||
E9PS50 | E9PS50_HUMAN | 40S ribosomal protein S13 | RPS13 | 116 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 82 | P → S in AAC15854 (Ref. 8) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01124 mRNA Translation: AAA60283.1 X79239 mRNA Translation: CAA55821.1 D88010 Genomic DNA Translation: BAA13528.1 AK312060 mRNA Translation: BAG34996.1 CH471064 Genomic DNA Translation: EAW68448.1 BC000475 mRNA Translation: AAH00475.1 BC006772 mRNA Translation: AAH06772.1 BC029732 mRNA Translation: AAH29732.1 BC066322 mRNA Translation: AAH66322.1 BC100032 mRNA Translation: AAI00033.1 L05090 mRNA Translation: AAC15854.1 |
CCDSi | CCDS7823.1 |
PIRi | S34109 |
RefSeqi | NP_001008.1, NM_001017.2 |
Genome annotation databases
Ensembli | ENST00000525634; ENSP00000435777; ENSG00000110700 |
GeneIDi | 6207 |
KEGGi | hsa:6207 |
UCSCi | uc001mmp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01124 mRNA Translation: AAA60283.1 X79239 mRNA Translation: CAA55821.1 D88010 Genomic DNA Translation: BAA13528.1 AK312060 mRNA Translation: BAG34996.1 CH471064 Genomic DNA Translation: EAW68448.1 BC000475 mRNA Translation: AAH00475.1 BC006772 mRNA Translation: AAH06772.1 BC029732 mRNA Translation: AAH29732.1 BC066322 mRNA Translation: AAH66322.1 BC100032 mRNA Translation: AAI00033.1 L05090 mRNA Translation: AAC15854.1 |
CCDSi | CCDS7823.1 |
PIRi | S34109 |
RefSeqi | NP_001008.1, NM_001017.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | SN | 1-151 | [»] | |
4V6X | electron microscopy | 5.00 | AN | 1-151 | [»] | |
5A2Q | electron microscopy | 3.90 | N | 1-151 | [»] | |
5AJ0 | electron microscopy | 3.50 | BN | 1-151 | [»] | |
5FLX | electron microscopy | 3.90 | N | 1-151 | [»] | |
5LKS | electron microscopy | 3.60 | SN | 1-151 | [»] | |
5OA3 | electron microscopy | 4.30 | N | 1-151 | [»] | |
5T2C | electron microscopy | 3.60 | AN | 1-151 | [»] | |
5VYC | X-ray | 6.00 | N1/N2/N3/N4/N5/N6 | 1-151 | [»] | |
6EK0 | electron microscopy | 2.90 | SN | 1-151 | [»] | |
6FEC | electron microscopy | 6.30 | Z | 2-151 | [»] | |
6G18 | electron microscopy | 3.60 | N | 1-151 | [»] | |
6G4S | electron microscopy | 4.00 | N | 1-151 | [»] | |
6G4W | electron microscopy | 4.50 | N | 1-151 | [»] | |
6G51 | electron microscopy | 4.10 | N | 1-151 | [»] | |
6G53 | electron microscopy | 4.50 | N | 1-151 | [»] | |
6G5H | electron microscopy | 3.60 | N | 1-151 | [»] | |
6G5I | electron microscopy | 3.50 | N | 1-151 | [»] | |
6IP5 | electron microscopy | 3.90 | 3K | 1-151 | [»] | |
6IP6 | electron microscopy | 4.50 | 3K | 1-151 | [»] | |
6IP8 | electron microscopy | 3.90 | 3K | 1-151 | [»] | |
6OLE | electron microscopy | 3.10 | SN | 2-151 | [»] | |
6OLF | electron microscopy | 3.90 | SN | 2-151 | [»] | |
6OLG | electron microscopy | 3.40 | BN | 2-150 | [»] | |
6OLI | electron microscopy | 3.50 | SN | 2-151 | [»] | |
6OLZ | electron microscopy | 3.90 | BN | 2-150 | [»] | |
6OM0 | electron microscopy | 3.10 | SN | 2-151 | [»] | |
6OM7 | electron microscopy | 3.70 | SN | 2-151 | [»] | |
6QZP | electron microscopy | 2.90 | SN | 2-151 | [»] | |
6XA1 | electron microscopy | 2.80 | SN | 2-151 | [»] | |
6Y0G | electron microscopy | 3.20 | SN | 1-151 | [»] | |
6Y2L | electron microscopy | 3.00 | SN | 1-151 | [»] | |
6Y57 | electron microscopy | 3.50 | SN | 1-151 | [»] | |
6YBD | electron microscopy | 3.30 | I | 1-151 | [»] | |
6YBW | electron microscopy | 3.10 | I | 1-151 | [»] | |
6Z6L | electron microscopy | 3.00 | SN | 1-151 | [»] | |
6Z6M | electron microscopy | 3.10 | SN | 1-151 | [»] | |
6Z6N | electron microscopy | 2.90 | SN | 1-151 | [»] | |
6ZLW | electron microscopy | 2.60 | N | 1-151 | [»] | |
6ZM7 | electron microscopy | 2.70 | SN | 1-151 | [»] | |
6ZME | electron microscopy | 3.00 | SN | 1-151 | [»] | |
6ZMI | electron microscopy | 2.60 | SN | 1-151 | [»] | |
6ZMO | electron microscopy | 3.10 | SN | 1-151 | [»] | |
6ZMT | electron microscopy | 3.00 | N | 1-151 | [»] | |
6ZMW | electron microscopy | 3.70 | I | 1-151 | [»] | |
6ZN5 | electron microscopy | 3.20 | N | 2-150 | [»] | |
6ZOJ | electron microscopy | 2.80 | N | 1-151 | [»] | |
6ZOK | electron microscopy | 2.80 | N | 1-151 | [»] | |
6ZON | electron microscopy | 3.00 | m | 1-151 | [»] | |
6ZP4 | electron microscopy | 2.90 | m | 1-151 | [»] | |
6ZVH | electron microscopy | 2.90 | N | 2-151 | [»] | |
6ZVJ | electron microscopy | 3.80 | m | 2-150 | [»] | |
6ZXD | electron microscopy | 3.20 | N | 1-151 | [»] | |
6ZXE | electron microscopy | 3.00 | N | 1-151 | [»] | |
6ZXF | electron microscopy | 3.70 | N | 1-151 | [»] | |
6ZXG | electron microscopy | 2.60 | N | 1-151 | [»] | |
6ZXH | electron microscopy | 2.70 | N | 1-151 | [»] | |
7A09 | electron microscopy | 3.50 | m | 1-151 | [»] | |
7K5I | electron microscopy | 2.90 | N | 1-151 | [»] | |
SMRi | P62277 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112121, 327 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P62277 |
IntActi | P62277, 85 interactors |
MINTi | P62277 |
STRINGi | 9606.ENSP00000435777 |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Protein family/group databases
MoonProti | P62277 |
PTM databases
iPTMneti | P62277 |
PhosphoSitePlusi | P62277 |
SwissPalmi | P62277 |
Genetic variation databases
BioMutai | RPS13 |
DMDMi | 50403608 |
Proteomic databases
EPDi | P62277 |
jPOSTi | P62277 |
MassIVEi | P62277 |
MaxQBi | P62277 |
PaxDbi | P62277 |
PeptideAtlasi | P62277 |
PRIDEi | P62277 |
ProteomicsDBi | 57384 |
TopDownProteomicsi | P62277 |
Protocols and materials databases
Antibodypediai | 42458, 226 antibodies |
DNASUi | 6207 |
Genome annotation databases
Ensembli | ENST00000525634; ENSP00000435777; ENSG00000110700 |
GeneIDi | 6207 |
KEGGi | hsa:6207 |
UCSCi | uc001mmp.4, human |
Organism-specific databases
CTDi | 6207 |
DisGeNETi | 6207 |
GeneCardsi | RPS13 |
HGNCi | HGNC:10386, RPS13 |
HPAi | ENSG00000110700, Low tissue specificity |
MIMi | 180476, gene |
neXtProti | NX_P62277 |
OpenTargetsi | ENSG00000110700 |
PharmGKBi | PA34785 |
VEuPathDBi | HostDB:ENSG00000110700.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0400, Eukaryota |
GeneTreei | ENSGT00390000017491 |
HOGENOMi | CLU_090139_1_0_1 |
InParanoidi | P62277 |
OMAi | WHLVKKA |
OrthoDBi | 1387147at2759 |
PhylomeDBi | P62277 |
TreeFami | TF300190 |
Enzyme and pathway databases
PathwayCommonsi | P62277 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P62277 |
Miscellaneous databases
BioGRID-ORCSi | 6207, 786 hits in 965 CRISPR screens |
ChiTaRSi | RPS13, human |
GeneWikii | RPS13 |
GenomeRNAii | 6207 |
Pharosi | P62277, Tbio |
PROi | PR:P62277 |
RNActi | P62277, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110700, Expressed in cortical plate and 120 other tissues |
ExpressionAtlasi | P62277, baseline and differential |
Genevisiblei | P62277, HS |
Family and domain databases
CDDi | cd00353, Ribosomal_S15p_S13e, 1 hit |
HAMAPi | MF_01343_A, Ribosomal_S15_A, 1 hit |
InterProi | View protein in InterPro IPR012606, Ribosomal_S13/S15_N IPR000589, Ribosomal_S15 IPR023029, Ribosomal_S15P IPR009068, S15_NS1_RNA-bd |
PANTHERi | PTHR11885, PTHR11885, 1 hit |
Pfami | View protein in Pfam PF08069, Ribosomal_S13_N, 1 hit PF00312, Ribosomal_S15, 1 hit |
SMARTi | View protein in SMART SM01386, Ribosomal_S13_N, 1 hit SM01387, Ribosomal_S15, 1 hit |
SUPFAMi | SSF47060, SSF47060, 1 hit |
PROSITEi | View protein in PROSITE PS00362, RIBOSOMAL_S15, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS13_HUMAN | |
Accessioni | P62277Primary (citable) accession number: P62277 Secondary accession number(s): B2R549 Q498Y0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families