Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S13

Gene

RPS13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: CAFA
  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonProtiP62277

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S13
Alternative name(s):
Small ribosomal subunit protein uS151 Publication
Gene namesi
Name:RPS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110700.6
HGNCiHGNC:10386 RPS13
MIMi180476 gene
neXtProtiNX_P62277

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6207
OpenTargetsiENSG00000110700
PharmGKBiPA34785

Polymorphism and mutation databases

BioMutaiRPS13
DMDMi50403608

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001156612 – 15140S ribosomal protein S13Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-acetyllysine; alternateCombined sources1
Modified residuei27N6-succinyllysine; alternateBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei34N6-succinyllysineBy similarity1
Modified residuei38PhosphotyrosineCombined sources1
Cross-linki43Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62277
MaxQBiP62277
PaxDbiP62277
PeptideAtlasiP62277
PRIDEiP62277
ProteomicsDBi57384
TopDownProteomicsiP62277

PTM databases

iPTMnetiP62277
PhosphoSitePlusiP62277
SwissPalmiP62277

Expressioni

Gene expression databases

BgeeiENSG00000110700
CleanExiHS_RPS13
ExpressionAtlasiP62277 baseline and differential
GenevisibleiP62277 HS

Organism-specific databases

HPAiHPA005985

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PDCD4Q53EL62EBI-351850,EBI-935824

Protein-protein interaction databases

BioGridi112121, 235 interactors
CORUMiP62277
IntActiP62277, 50 interactors
MINTiP62277
STRINGi9606.ENSP00000435777

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SN1-151[»]
4V6Xelectron microscopy5.00AN1-151[»]
5A2Qelectron microscopy3.90N1-151[»]
5AJ0electron microscopy3.50BN1-151[»]
5FLXelectron microscopy3.90N1-151[»]
5LKSelectron microscopy3.60SN1-151[»]
5OA3electron microscopy4.30N1-151[»]
5T2Celectron microscopy3.60AN1-151[»]
5VYCX-ray6.00N1/N2/N3/N4/N5/N61-151[»]
6EK0electron microscopy2.90SN1-151[»]
6FECelectron microscopy6.30Z2-151[»]
ProteinModelPortaliP62277
SMRiP62277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0400 Eukaryota
COG0184 LUCA
GeneTreeiENSGT00390000017491
HOGENOMiHOG000180723
HOVERGENiHBG000938
InParanoidiP62277
KOiK02953
OMAiWHLVKKA
OrthoDBiEOG091G0X8F
PhylomeDBiP62277
TreeFamiTF300190

Family and domain databases

CDDicd00353 Ribosomal_S15p_S13e, 1 hit
HAMAPiMF_01343_A Ribosomal_S15_A, 1 hit
InterProiView protein in InterPro
IPR012606 Ribosomal_S13/S15_N
IPR000589 Ribosomal_S15
IPR023029 Ribosomal_S15P
IPR009068 S15_NS1_RNA-bd
PANTHERiPTHR11885 PTHR11885, 1 hit
PfamiView protein in Pfam
PF08069 Ribosomal_S13_N, 1 hit
PF00312 Ribosomal_S15, 1 hit
SMARTiView protein in SMART
SM01386 Ribosomal_S13_N, 1 hit
SM01387 Ribosomal_S15, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
PROSITEiView protein in PROSITE
PS00362 RIBOSOMAL_S15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI
60 70 80 90 100
GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK
110 120 130 140 150
HLERNRKDKD AKFRLILIES RIHRLARYYK TKRVLPPNWK YESSTASALV

A
Length:151
Mass (Da):17,222
Last modified:January 23, 2007 - v2
Checksum:i23F94D38F87B8D53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82P → S in AAC15854 (Ref. 8) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01124 mRNA Translation: AAA60283.1
X79239 mRNA Translation: CAA55821.1
D88010 Genomic DNA Translation: BAA13528.1
AK312060 mRNA Translation: BAG34996.1
CH471064 Genomic DNA Translation: EAW68448.1
BC000475 mRNA Translation: AAH00475.1
BC006772 mRNA Translation: AAH06772.1
BC029732 mRNA Translation: AAH29732.1
BC066322 mRNA Translation: AAH66322.1
BC100032 mRNA Translation: AAI00033.1
L05090 mRNA Translation: AAC15854.1
CCDSiCCDS7823.1
PIRiS34109
RefSeqiNP_001008.1, NM_001017.2
UniGeneiHs.446588

Genome annotation databases

EnsembliENST00000525634; ENSP00000435777; ENSG00000110700
GeneIDi6207
KEGGihsa:6207
UCSCiuc001mmp.4 human

Similar proteinsi

Entry informationi

Entry nameiRS13_HUMAN
AccessioniPrimary (citable) accession number: P62277
Secondary accession number(s): B2R549
, P19116, Q02546, Q29200, Q498Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health