Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S18

Gene

Rps18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S18
Alternative name(s):
Ke-3
Short name:
Ke3
Gene namesi
Name:Rps18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98146 Rps18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001322132 – 15240S ribosomal protein S18Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei94N6-acetyllysine; alternateBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei106N6-acetyllysine; alternateBy similarity1
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62270
PaxDbiP62270
PRIDEiP62270

PTM databases

iPTMnetiP62270
PhosphoSitePlusiP62270

Expressioni

Gene expression databases

BgeeiENSMUSG00000008668
CleanExiMM_RPS18
ExpressionAtlasiP62270 baseline and differential
GenevisibleiP62270 MM

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203006, 4 interactors
IntActiP62270, 5 interactors
MINTiP62270
STRINGi10090.ENSMUSP00000008812

Structurei

3D structure databases

ProteinModelPortaliP62270
SMRiP62270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3311 Eukaryota
COG0099 LUCA
GeneTreeiENSGT00390000012691
HOGENOMiHOG000039877
HOVERGENiHBG000200
InParanoidiP62270
KOiK02964
OMAiHKRGQKV
OrthoDBiEOG091G0W4F
PhylomeDBiP62270
TreeFamiTF317649

Family and domain databases

Gene3Di4.10.910.10, 1 hit
HAMAPiMF_01315 Ribosomal_S13_S18, 1 hit
InterProiView protein in InterPro
IPR027437 30s_Rbsml_prot_S13_C
IPR001892 Ribosomal_S13
IPR010979 Ribosomal_S13-like_H2TH
IPR018269 Ribosomal_S13_CS
PfamiView protein in Pfam
PF00416 Ribosomal_S13, 1 hit
PIRSFiPIRSF002134 Ribosomal_S13, 1 hit
SUPFAMiSSF46946 SSF46946, 1 hit
PROSITEiView protein in PROSITE
PS00646 RIBOSOMAL_S13_1, 1 hit
PS50159 RIBOSOMAL_S13_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI
60 70 80 90 100
DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA
110 120 130 140 150
NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK

KK
Length:152
Mass (Da):17,719
Last modified:January 23, 2007 - v3
Checksum:i4DAF0662C3F37F22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104D → H in AAA16796 (PubMed:1543907).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76763 mRNA Translation: AAA16795.1
M76762 Unassigned DNA Translation: AAA16796.1
AF100956 Genomic DNA Translation: AAC69898.1
AF110520 Genomic DNA Translation: AAC97978.1
AK050626 mRNA Translation: BAC34350.1
BC081459 mRNA Translation: AAH81459.1
BC081458 mRNA Translation: AAH81458.1
CCDSiCCDS37573.1
PIRiI76666
RefSeqiNP_035426.1, NM_011296.2
UniGeneiMm.298745
Mm.324762
Mm.440079

Genome annotation databases

EnsembliENSMUST00000008812; ENSMUSP00000008812; ENSMUSG00000008668
GeneIDi20084
KEGGimmu:20084
UCSCiuc008cak.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRS18_MOUSE
AccessioniPrimary (citable) accession number: P62270
Secondary accession number(s): P25232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health