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Protein

40S ribosomal protein S18

Gene

RPS18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S18
Alternative name(s):
Ke-3
Short name:
Ke3
Small ribosomal subunit protein uS131 Publication
Gene namesi
Name:RPS18
Synonyms:D6S218E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000231500.6
HGNCiHGNC:10401 RPS18
MIMi180473 gene
neXtProtiNX_P62269

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6222
OpenTargetsiENSG00000231500
PharmGKBiPA34801

Polymorphism and mutation databases

BioMutaiRPS18
DMDMi50403625

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001322122 – 15240S ribosomal protein S18Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei94N6-acetyllysine; alternateCombined sources1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei106N6-acetyllysine; alternateCombined sources1
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62269
MaxQBiP62269
PaxDbiP62269
PeptideAtlasiP62269
PRIDEiP62269
ProteomicsDBi57381
TopDownProteomicsiP62269

PTM databases

iPTMnetiP62269
PhosphoSitePlusiP62269
SwissPalmiP62269

Expressioni

Gene expression databases

BgeeiENSG00000231500
CleanExiHS_RPS18
ExpressionAtlasiP62269 baseline and differential
GenevisibleiP62269 HS

Organism-specific databases

HPAiHPA050159
HPA055007

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112136, 168 interactors
CORUMiP62269
DIPiDIP-32892N
IntActiP62269, 57 interactors
MINTiP62269
STRINGi9606.ENSP00000393241

Structurei

3D structure databases

ProteinModelPortaliP62269
SMRiP62269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3311 Eukaryota
COG0099 LUCA
GeneTreeiENSGT00390000012691
HOGENOMiHOG000039877
HOVERGENiHBG000200
InParanoidiP62269
KOiK02964
OMAiHKRGQKV
OrthoDBiEOG09370VOB
PhylomeDBiP62269
TreeFamiTF317649

Family and domain databases

Gene3Di4.10.910.10, 1 hit
HAMAPiMF_01315 Ribosomal_S13_S18, 1 hit
InterProiView protein in InterPro
IPR027437 30s_Rbsml_prot_S13_C
IPR001892 Ribosomal_S13
IPR010979 Ribosomal_S13-like_H2TH
IPR018269 Ribosomal_S13_CS
PfamiView protein in Pfam
PF00416 Ribosomal_S13, 1 hit
PIRSFiPIRSF002134 Ribosomal_S13, 1 hit
SUPFAMiSSF46946 SSF46946, 1 hit
PROSITEiView protein in PROSITE
PS00646 RIBOSOMAL_S13_1, 1 hit
PS50159 RIBOSOMAL_S13_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI
60 70 80 90 100
DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA
110 120 130 140 150
NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK

KK
Length:152
Mass (Da):17,719
Last modified:January 23, 2007 - v3
Checksum:i4DAF0662C3F37F22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55R → S AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69150 mRNA Translation: CAB56794.1
AL031228 Genomic DNA Translation: CAA20231.1
AL662827 Genomic DNA No translation available.
AL713971 Genomic DNA No translation available.
AL645940 Genomic DNA No translation available.
AL662820 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03695.1
BC101786 mRNA Translation: AAI01787.1
BC101788 mRNA Translation: AAI01789.1
BC106063 mRNA Translation: AAI06064.1
CCDSiCCDS4771.1
PIRiS30393
RefSeqiNP_072045.1, NM_022551.2
UniGeneiHs.448854
Hs.627414

Genome annotation databases

EnsembliENST00000211372; ENSP00000211372; ENSG00000096150
ENST00000434122; ENSP00000403175; ENSG00000226225
ENST00000439602; ENSP00000393241; ENSG00000231500
ENST00000454021; ENSP00000416110; ENSG00000235650
ENST00000457341; ENSP00000412583; ENSG00000223367
GeneIDi6222
KEGGihsa:6222
UCSCiuc003odp.2 human

Similar proteinsi

Entry informationi

Entry nameiRS18_HUMAN
AccessioniPrimary (citable) accession number: P62269
Secondary accession number(s): P25232, Q5SUJ3, Q6IPF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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