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Entry version 164 (18 Sep 2019)
Sequence version 3 (23 Jan 2007)
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Protein

40S ribosomal protein S18

Gene

RPS18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S18
Alternative name(s):
Ke-3
Short name:
Ke3
Small ribosomal subunit protein uS131 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS18
Synonyms:D6S218E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10401 RPS18

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180473 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62269

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6222

Open Targets

More...
OpenTargetsi
ENSG00000231500

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34801

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638 Artenimol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403625

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001322122 – 15240S ribosomal protein S18Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei94N6-acetyllysine; alternateCombined sources1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei106N6-acetyllysine; alternateCombined sources1
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P62269

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62269

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P62269

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P62269

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62269

PeptideAtlas

More...
PeptideAtlasi
P62269

PRoteomics IDEntifications database

More...
PRIDEi
P62269

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57381

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P62269

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62269

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000231500 Expressed in 86 organ(s), highest expression level in right ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P62269 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P62269 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050159
HPA055007

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0073EBI-352451,EBI-5323863

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112136, 209 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P62269

Database of interacting proteins

More...
DIPi
DIP-32892N

Protein interaction database and analysis system

More...
IntActi
P62269, 64 interactors

Molecular INTeraction database

More...
MINTi
P62269

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62269

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3311 Eukaryota
COG0099 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012691

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000039877

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62269

KEGG Orthology (KO)

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KOi
K02964

Identification of Orthologs from Complete Genome Data

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OMAi
HKRGQKV

Database of Orthologous Groups

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OrthoDBi
1343043at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62269

TreeFam database of animal gene trees

More...
TreeFami
TF317649

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.910.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01315 Ribosomal_S13_S18, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027437 30s_Rbsml_prot_S13_C
IPR001892 Ribosomal_S13
IPR010979 Ribosomal_S13-like_H2TH
IPR018269 Ribosomal_S13_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00416 Ribosomal_S13, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002134 Ribosomal_S13, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46946 SSF46946, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00646 RIBOSOMAL_S13_1, 1 hit
PS50159 RIBOSOMAL_S13_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P62269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI
60 70 80 90 100
DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA
110 120 130 140 150
NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK

KK
Length:152
Mass (Da):17,719
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DAF0662C3F37F22
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3JS69J3JS69_HUMAN
40S ribosomal protein S18
RPS18 hCG_1640167, hCG_1777176
82Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5GGW2Q5GGW2_HUMAN
40S ribosomal protein S18
RPS18
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQH2A0A0G2JQH2_HUMAN
40S ribosomal protein S18
RPS18
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55R → S AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69150 mRNA Translation: CAB56794.1
AL031228 Genomic DNA Translation: CAA20231.1
AL662827 Genomic DNA No translation available.
AL713971 Genomic DNA No translation available.
AL645940 Genomic DNA No translation available.
AL662820 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03695.1
BC101786 mRNA Translation: AAI01787.1
BC101788 mRNA Translation: AAI01789.1
BC106063 mRNA Translation: AAI06064.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4771.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S30393

NCBI Reference Sequences

More...
RefSeqi
NP_072045.1, NM_022551.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000211372; ENSP00000211372; ENSG00000096150
ENST00000434122; ENSP00000403175; ENSG00000226225
ENST00000439602; ENSP00000393241; ENSG00000231500
ENST00000454021; ENSP00000416110; ENSG00000235650
ENST00000457341; ENSP00000412583; ENSG00000223367

Database of genes from NCBI RefSeq genomes

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GeneIDi
6222

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6222

UCSC genome browser

More...
UCSCi
uc003odp.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69150 mRNA Translation: CAB56794.1
AL031228 Genomic DNA Translation: CAA20231.1
AL662827 Genomic DNA No translation available.
AL713971 Genomic DNA No translation available.
AL645940 Genomic DNA No translation available.
AL662820 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03695.1
BC101786 mRNA Translation: AAI01787.1
BC101788 mRNA Translation: AAI01789.1
BC106063 mRNA Translation: AAI06064.1
CCDSiCCDS4771.1
PIRiS30393
RefSeqiNP_072045.1, NM_022551.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SS1-152[»]
4V6Xelectron microscopy5.00AS1-152[»]
5A2Qelectron microscopy3.90S1-152[»]
5AJ0electron microscopy3.50BS1-152[»]
5FLXelectron microscopy3.90S1-152[»]
5LKSelectron microscopy3.60SS1-152[»]
5OA3electron microscopy4.30S1-152[»]
5T2Celectron microscopy3.60A01-152[»]
5VYCX-ray6.00S1/S2/S3/S4/S5/S61-152[»]
6EK0electron microscopy2.90SS1-152[»]
6FECelectron microscopy6.30L6-142[»]
6G18electron microscopy3.60S1-152[»]
6G4Selectron microscopy4.00S1-152[»]
6G4Welectron microscopy4.50S1-152[»]
6G51electron microscopy4.10S1-152[»]
6G53electron microscopy4.50S1-152[»]
6G5Helectron microscopy3.60S1-152[»]
6G5Ielectron microscopy3.50S1-152[»]
6IP5electron microscopy3.902z1-152[»]
6IP6electron microscopy4.502z1-152[»]
6IP8electron microscopy3.902z1-152[»]
6OLEelectron microscopy3.10SS1-145[»]
6OLFelectron microscopy3.90SS1-145[»]
6OLGelectron microscopy3.40BS4-142[»]
6OLIelectron microscopy3.50SS1-145[»]
6OLZelectron microscopy3.90BS4-142[»]
6OM0electron microscopy3.10SS1-145[»]
6OM7electron microscopy3.70SS1-145[»]
6QZPelectron microscopy2.90SS1-145[»]
SMRiP62269
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112136, 209 interactors
CORUMiP62269
DIPiDIP-32892N
IntActiP62269, 64 interactors
MINTiP62269
STRINGi9606.ENSP00000393241

Chemistry databases

DrugBankiDB11638 Artenimol

PTM databases

iPTMnetiP62269
PhosphoSitePlusiP62269
SwissPalmiP62269

Polymorphism and mutation databases

BioMutaiRPS18
DMDMi50403625

Proteomic databases

EPDiP62269
jPOSTiP62269
MassIVEiP62269
MaxQBiP62269
PaxDbiP62269
PeptideAtlasiP62269
PRIDEiP62269
ProteomicsDBi57381
TopDownProteomicsiP62269

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000211372; ENSP00000211372; ENSG00000096150
ENST00000434122; ENSP00000403175; ENSG00000226225
ENST00000439602; ENSP00000393241; ENSG00000231500
ENST00000454021; ENSP00000416110; ENSG00000235650
ENST00000457341; ENSP00000412583; ENSG00000223367
GeneIDi6222
KEGGihsa:6222
UCSCiuc003odp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6222
DisGeNETi6222

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS18
HGNCiHGNC:10401 RPS18
HPAiHPA050159
HPA055007
MIMi180473 gene
neXtProtiNX_P62269
OpenTargetsiENSG00000231500
PharmGKBiPA34801

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3311 Eukaryota
COG0099 LUCA
GeneTreeiENSGT00390000012691
HOGENOMiHOG000039877
InParanoidiP62269
KOiK02964
OMAiHKRGQKV
OrthoDBi1343043at2759
PhylomeDBiP62269
TreeFamiTF317649

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS18 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6222

Pharos

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Pharosi
P62269

Protein Ontology

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PROi
PR:P62269

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000231500 Expressed in 86 organ(s), highest expression level in right ovary
ExpressionAtlasiP62269 baseline and differential
GenevisibleiP62269 HS

Family and domain databases

Gene3Di4.10.910.10, 1 hit
HAMAPiMF_01315 Ribosomal_S13_S18, 1 hit
InterProiView protein in InterPro
IPR027437 30s_Rbsml_prot_S13_C
IPR001892 Ribosomal_S13
IPR010979 Ribosomal_S13-like_H2TH
IPR018269 Ribosomal_S13_CS
PfamiView protein in Pfam
PF00416 Ribosomal_S13, 1 hit
PIRSFiPIRSF002134 Ribosomal_S13, 1 hit
SUPFAMiSSF46946 SSF46946, 1 hit
PROSITEiView protein in PROSITE
PS00646 RIBOSOMAL_S13_1, 1 hit
PS50159 RIBOSOMAL_S13_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62269
Secondary accession number(s): P25232, Q5SUJ3, Q6IPF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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