RPS23

Functionⁱ

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692).4 Publications

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
structural constituent of ribosome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28257692

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic translation
Source: UniProtKB
Inferred from direct assayⁱ
- 25957688
maintenance of translational fidelity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28257692
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
SRP-dependent cotranslational protein targeting to membrane Source: Reactome
stress granule assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28257692
translation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28257692
translational initiation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649 Translation initiation complex formation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 40S ribosomal protein S23 Alternative name(s): Small ribosomal subunit protein uS121 Publication
Gene namesⁱ	Name:RPS23
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186468.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10410 RPS23
MIMⁱ	603683 gene
neXtProtⁱ	NX_P62266

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Brachycephaly, trichomegaly, and developmental delay (BTDD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant developmental disorder characterized by brachycephaly, ciliary trichomegaly, dysmorphic features of the face and hands, hearing loss, and developmental delay with short stature. Intellectual disability and autism spectrum disorder may be present in some patients.

Keywords - Diseaseⁱ

Deafness, Disease mutation, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6228
MalaCards human disease database More...MalaCardsⁱ	RPS23
MIMⁱ	617412 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000186468
PharmGKBⁱ	PA34813

Polymorphism and mutation databases

BioMutaⁱ	RPS23
DMDMⁱ	50403755

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000146457	2 – 143	40S ribosomal protein S23Add BLAST		142

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	37	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	54	N6-succinyllysineBy similarity	1
Modified residueⁱ	62	3-hydroxyproline3 Publications	1
Modified residueⁱ	135	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Hydroxylation at Pro-62 affects translation termination efficiency.3 Publications

Keywords - PTMⁱ

Acetylation, Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P62266
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62266
PaxDbⁱ	P62266
PeptideAtlas More...PeptideAtlasⁱ	P62266
PRIDEⁱ	P62266
ProteomicsDBⁱ	57380
TopDownProteomicsⁱ	P62266

PTM databases

iPTMnetⁱ	P62266
PhosphoSitePlusⁱ	P62266
SwissPalmⁱ	P62266

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186468
CleanExⁱ	HS_RPS23
ExpressionAtlasⁱ	P62266 baseline and differential
Genevisibleⁱ	P62266 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054853

HPAⁱ

HPA054853

Interactionⁱ

Subunit structureⁱ

Component of the 40S small ribosomal subunit.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DCC	P43146	2	EBI-353072,EBI-1222919
LRRK2	Q5S007	2	EBI-353072,EBI-5323863

Show more details

Protein-protein interaction databases

BioGridⁱ	112142, 155 interactors
CORUMⁱ	P62266
IntActⁱ	P62266, 34 interactors
Molecular INTeraction database More...MINTⁱ	P62266
STRINGⁱ	9606.ENSP00000296674

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4CXG	electron microscopy	8.70	X	1-143	[»]
	4CXH	electron microscopy	8.90	X	1-143	[»]
	4UG0	electron microscopy	-	SX	1-143	[»]
	4V6X	electron microscopy	5.00	AX	1-143	[»]
	5A2Q	electron microscopy	3.90	X	1-143	[»]
	5AJ0	electron microscopy	3.50	BX	1-143	[»]
	5FLX	electron microscopy	3.90	X	1-143	[»]
	5LKS	electron microscopy	3.60	SX	1-143	[»]
	5OA3	electron microscopy	4.30	X	1-143	[»]
	5T2C	electron microscopy	3.60	AD	1-143	[»]
	5VYC	X-ray	6.00	X1/X2/X3/X4/X5/X6	1-143	[»]
	6EK0	electron microscopy	2.90	SX	1-143	[»]
	6FEC	electron microscopy	6.30	Q	1-142	[»]
ProteinModelPortalⁱ	P62266
SMRⁱ	P62266
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uS12 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1749 Eukaryota COG0048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074784
HOGENOMⁱ	HOG000040064
HOVERGENⁱ	HBG054200
InParanoidⁱ	P62266
KEGG Orthology (KO) More...KOⁱ	K02973
OMAⁱ	KFRWSQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R2G
PhylomeDBⁱ	P62266
TreeFamⁱ	TF300871

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03367 Ribosomal_S23, 1 hit
InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR006032 Ribosomal_S12/S23 IPR005680 Ribosomal_S23_euk/arc
PANTHERⁱ	PTHR11652 PTHR11652, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00164 Ribosom_S12_S23, 1 hit
PIRSFⁱ	PIRSF002133 Ribosomal_S12/S23, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00982 uS12_E_A, 1 hit
PROSITEⁱ	View protein in PROSITE PS00055 RIBOSOMAL_S12, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P62266-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI 
        60         70         80         90        100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV 
       110        120        130        140 
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS

Length:143

Mass (Da):15,808

Last modified:January 23, 2007 - v3

Checksum:ⁱ8417A48B8CF0A8E5

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_079133	67	R → K in BTDD; decreases hydroxylation of the protein; decreases the accuracy of translation; decreases levels of incorporation of the mutant protein into ribosomes and polysomes; patient cells become highly sensitive to oxidative stress. 1 Publication		1
Natural variantⁱVAR_079134	120	F → I in BTDD; decreases hydroxylation of the protein; decreases the accuracy of translation; decreases levels of incorporation of the mutant protein into polysomes; patient cells become highly sensitive to oxidative stress. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D14530 mRNA Translation: BAA03400.1 CR456996 mRNA Translation: CAG33277.1 BC070221 mRNA Translation: AAH70221.1 AB007158 Genomic DNA Translation: BAA25822.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47241.1
PIRⁱ	S42105
NCBI Reference Sequences More...RefSeqⁱ	NP_001016.1, NM_001025.4
UniGeneⁱ	Hs.527193

Genome annotation databases

Ensemblⁱ	ENST00000296674; ENSP00000296674; ENSG00000186468
GeneIDⁱ	6228
KEGGⁱ	hsa:6228
UCSC genome browser More...UCSCⁱ	uc003khu.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P62266	40S ribosomal protein S23		BOVIN		143
40S ribosomal protein S23		CHILA		143
40S ribosomal protein S23		MOUSE		143
40S ribosomal protein S23		RAT		143
Ribosomal protein S23, isoform CRA_a		HUMAN		143
+48

Protein	Similar proteins		Species	Score	Length
P62266	40S ribosomal protein S23		BOVIN		143
40S ribosomal protein S23		CHILA		143
40S ribosomal protein S23		MOUSE		143
40S ribosomal protein S23		RAT		143
Ribosomal protein S23, isoform CRA_a		HUMAN		143
+69

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D14530 mRNA Translation: BAA03400.1 CR456996 mRNA Translation: CAG33277.1 BC070221 mRNA Translation: AAH70221.1 AB007158 Genomic DNA Translation: BAA25822.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47241.1
PIRⁱ	S42105
NCBI Reference Sequences More...RefSeqⁱ	NP_001016.1, NM_001025.4
UniGeneⁱ	Hs.527193

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4CXG	electron microscopy	8.70	X	1-143	[»]
	4CXH	electron microscopy	8.90	X	1-143	[»]
	4UG0	electron microscopy	-	SX	1-143	[»]
	4V6X	electron microscopy	5.00	AX	1-143	[»]
	5A2Q	electron microscopy	3.90	X	1-143	[»]
	5AJ0	electron microscopy	3.50	BX	1-143	[»]
	5FLX	electron microscopy	3.90	X	1-143	[»]
	5LKS	electron microscopy	3.60	SX	1-143	[»]
	5OA3	electron microscopy	4.30	X	1-143	[»]
	5T2C	electron microscopy	3.60	AD	1-143	[»]
	5VYC	X-ray	6.00	X1/X2/X3/X4/X5/X6	1-143	[»]
	6EK0	electron microscopy	2.90	SX	1-143	[»]
	6FEC	electron microscopy	6.30	Q	1-142	[»]
ProteinModelPortalⁱ	P62266
SMRⁱ	P62266
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112142, 155 interactors
CORUMⁱ	P62266
IntActⁱ	P62266, 34 interactors
Molecular INTeraction database More...MINTⁱ	P62266
STRINGⁱ	9606.ENSP00000296674

PTM databases

iPTMnetⁱ	P62266
PhosphoSitePlusⁱ	P62266
SwissPalmⁱ	P62266

Polymorphism and mutation databases

BioMutaⁱ	RPS23
DMDMⁱ	50403755

Proteomic databases

EPDⁱ	P62266
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62266
PaxDbⁱ	P62266
PeptideAtlas More...PeptideAtlasⁱ	P62266
PRIDEⁱ	P62266
ProteomicsDBⁱ	57380
TopDownProteomicsⁱ	P62266

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296674; ENSP00000296674; ENSG00000186468
GeneIDⁱ	6228
KEGGⁱ	hsa:6228
UCSC genome browser More...UCSCⁱ	uc003khu.4 human

Organism-specific databases

CTDⁱ	6228
DisGeNET More...DisGeNETⁱ	6228
EuPathDBⁱ	HostDB:ENSG00000186468.12
GeneCardsⁱ	RPS23
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10410 RPS23
Human Protein Atlas More...HPAⁱ	HPA054853
MalaCards human disease database More...MalaCardsⁱ	RPS23
MIMⁱ	603683 gene 617412 phenotype
neXtProtⁱ	NX_P62266
Open Targets More...OpenTargetsⁱ	ENSG00000186468
PharmGKBⁱ	PA34813
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1749 Eukaryota COG0048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074784
HOGENOMⁱ	HOG000040064
HOVERGENⁱ	HBG054200
InParanoidⁱ	P62266
KEGG Orthology (KO) More...KOⁱ	K02973
OMAⁱ	KFRWSQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R2G
PhylomeDBⁱ	P62266
TreeFamⁱ	TF300871

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649 Translation initiation complex formation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	RPS23 human
GeneWikiⁱ	RPS23
GenomeRNAiⁱ	6228
Protein Ontology More...PROⁱ	PR:P62266
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186468
CleanExⁱ	HS_RPS23
ExpressionAtlasⁱ	P62266 baseline and differential
Genevisibleⁱ	P62266 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03367 Ribosomal_S23, 1 hit
InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR006032 Ribosomal_S12/S23 IPR005680 Ribosomal_S23_euk/arc
PANTHERⁱ	PTHR11652 PTHR11652, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00164 Ribosom_S12_S23, 1 hit
PIRSFⁱ	PIRSF002133 Ribosomal_S12/S23, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00982 uS12_E_A, 1 hit
PROSITEⁱ	View protein in PROSITE PS00055 RIBOSOMAL_S12, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RS23_HUMAN
Accessionⁱ	P62266Primary (citable) accession number: P62266 Secondary accession number(s): P39028, Q6IB08
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Ribosomal proteins
Ribosomal proteins families and list of entries
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P62266 (RS23_HUMAN)

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40S ribosomal protein S23

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Cytosol

Other locations

Cytosol

Endoplasmic reticulum

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ