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UniProtKB - P62266 (RS23_HUMAN)

Entry version 161 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

40S ribosomal protein S23

Gene

RPS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P62266

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649, Translation initiation complex formation
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S23
Alternative name(s):
Small ribosomal subunit protein uS121 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000186468.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:10410, RPS23

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603683, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P62266

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Brachycephaly, trichomegaly, and developmental delay (BTDD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant developmental disorder characterized by brachycephaly, ciliary trichomegaly, dysmorphic features of the face and hands, hearing loss, and developmental delay with short stature. Intellectual disability and autism spectrum disorder may be present in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07913367R → K in BTDD; decreases hydroxylation of the protein; decreases the accuracy of translation; decreases levels of incorporation of the mutant protein into ribosomes and polysomes; patient cells become highly sensitive to oxidative stress. 1 PublicationCorresponds to variant dbSNP:rs1060505034EnsemblClinVar.1
Natural variantiVAR_079134120F → I in BTDD; decreases hydroxylation of the protein; decreases the accuracy of translation; decreases levels of incorporation of the mutant protein into polysomes; patient cells become highly sensitive to oxidative stress. 1 PublicationCorresponds to variant dbSNP:rs1060505035EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		6228

MalaCards human disease database

More...MalaCardsi		RPS23
MIMi617412, phenotype

Open Targets

More...OpenTargetsi		ENSG00000186468

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34813

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P62266, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPS23

Domain mapping of disease mutations (DMDM)

More...DMDMi		50403755

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001464572 – 14340S ribosomal protein S23Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei54N6-succinyllysineBy similarity1
Modified residuei623-hydroxyproline3 Publications1
Modified residuei135N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.3 Publications

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P62266

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P62266

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P62266

MaxQB - The MaxQuant DataBase

More...MaxQBi		P62266

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62266

PeptideAtlas

More...PeptideAtlasi		P62266

PRoteomics IDEntifications database

More...PRIDEi		P62266

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57380

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P62266

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62266

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62266

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P62266

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186468, Expressed in female gonad and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P62266, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62266, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186468, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 40S small ribosomal subunit.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112142, 207 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5223, 40S cytosolic small ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P62266

Protein interaction database and analysis system

More...IntActi		P62266, 47 interactors

Molecular INTeraction database

More...MINTi		P62266

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296674

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62266, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62266

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uS12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1749, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_115574_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62266

Identification of Orthologs from Complete Genome Data

More...OMAi		KFRWSQR

Database of Orthologous Groups

More...OrthoDBi		1402984at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P62266

TreeFam database of animal gene trees

More...TreeFami		TF300871

Family and domain databases

Conserved Domains Database

More...CDDi		cd03367, Ribosomal_S23, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012340, NA-bd_OB-fold
IPR006032, Ribosomal_S12/S23
IPR005680, Ribosomal_S23_euk/arc

The PANTHER Classification System

More...PANTHERi		PTHR11652, PTHR11652, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00164, Ribosom_S12_S23, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002133, Ribosomal_S12/S23, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00982, uS12_E_A, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00055, RIBOSOMAL_S12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P62266-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI 
        60         70         80         90        100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV 
       110        120        130        140 
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8417A48B8CF0A8E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD47D6RD47_HUMAN
40S ribosomal protein S23
RPS23
134Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIX0D6RIX0_HUMAN
40S ribosomal protein S23
RPS23
85Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9I7D6R9I7_HUMAN
40S ribosomal protein S23
RPS23
123Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDJ2D6RDJ2_HUMAN
40S ribosomal protein S23
RPS23
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07913367R → K in BTDD; decreases hydroxylation of the protein; decreases the accuracy of translation; decreases levels of incorporation of the mutant protein into ribosomes and polysomes; patient cells become highly sensitive to oxidative stress. 1 PublicationCorresponds to variant dbSNP:rs1060505034EnsemblClinVar.1
Natural variantiVAR_079134120F → I in BTDD; decreases hydroxylation of the protein; decreases the accuracy of translation; decreases levels of incorporation of the mutant protein into polysomes; patient cells become highly sensitive to oxidative stress. 1 PublicationCorresponds to variant dbSNP:rs1060505035EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D14530 mRNA Translation: BAA03400.1
CR456996 mRNA Translation: CAG33277.1
BC070221 mRNA Translation: AAH70221.1
AB007158 Genomic DNA Translation: BAA25822.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47241.1

Protein sequence database of the Protein Information Resource

More...PIRi		S42105

NCBI Reference Sequences

More...RefSeqi		NP_001016.1, NM_001025.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296674; ENSP00000296674; ENSG00000186468
ENST00000651545; ENSP00000498621; ENSG00000186468

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6228

UCSC genome browser

More...UCSCi		uc003khu.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14530 mRNA Translation: BAA03400.1
CR456996 mRNA Translation: CAG33277.1
BC070221 mRNA Translation: AAH70221.1
AB007158 Genomic DNA Translation: BAA25822.1
CCDSiCCDS47241.1
PIRiS42105
RefSeqiNP_001016.1, NM_001025.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CXGelectron microscopy8.70X1-143[»]
4CXHelectron microscopy8.90X1-143[»]
4UG0electron microscopy-SX1-143[»]
4V6Xelectron microscopy5.00AX1-143[»]
5A2Qelectron microscopy3.90X1-143[»]
5AJ0electron microscopy3.50BX1-143[»]
5FLXelectron microscopy3.90X1-143[»]
5LKSelectron microscopy3.60SX1-143[»]
5OA3electron microscopy4.30X1-143[»]
5T2Celectron microscopy3.60AD1-143[»]
5VYCX-ray6.00X1/X2/X3/X4/X5/X61-143[»]
6EK0electron microscopy2.90SX1-143[»]
6FECelectron microscopy6.30Q1-142[»]
6G18electron microscopy3.60X1-143[»]
6G4Selectron microscopy4.00X1-143[»]
6G4Welectron microscopy4.50X1-143[»]
6G51electron microscopy4.10X1-143[»]
6G53electron microscopy4.50X1-143[»]
6G5Helectron microscopy3.60X1-143[»]
6G5Ielectron microscopy3.50X1-143[»]
6IP5electron microscopy3.903B1-143[»]
6IP6electron microscopy4.503B1-143[»]
6IP8electron microscopy3.903B1-143[»]
6OLEelectron microscopy3.10SX2-142[»]
6OLFelectron microscopy3.90SX2-142[»]
6OLGelectron microscopy3.40BX2-140[»]
6OLIelectron microscopy3.50SX2-142[»]
6OLZelectron microscopy3.90BX2-140[»]
6OM0electron microscopy3.10SX2-142[»]
6OM7electron microscopy3.70SX2-142[»]
6QZPelectron microscopy2.90SX2-142[»]
6Y0Gelectron microscopy3.20SX1-143[»]
6Y2Lelectron microscopy3.00SX1-143[»]
6Y57electron microscopy3.50SX1-143[»]
6Z6Lelectron microscopy3.00SX1-143[»]
6Z6Melectron microscopy3.10SX1-143[»]
6Z6Nelectron microscopy2.90SX1-143[»]
6ZLWelectron microscopy2.60X1-143[»]
6ZM7electron microscopy2.70SX1-143[»]
6ZMEelectron microscopy3.00SX1-143[»]
6ZMIelectron microscopy2.60SX1-143[»]
6ZMOelectron microscopy3.10SX1-143[»]
6ZMTelectron microscopy3.00X1-143[»]
6ZN5electron microscopy3.20X2-142[»]
6ZOJelectron microscopy2.80X1-143[»]
6ZOKelectron microscopy2.80X1-143[»]
6ZONelectron microscopy3.00j1-143[»]
6ZP4electron microscopy2.90j1-143[»]
6ZVHelectron microscopy2.90X2-142[»]
SMRiP62266
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112142, 207 interactors
ComplexPortaliCPX-5223, 40S cytosolic small ribosomal subunit
CORUMiP62266
IntActiP62266, 47 interactors
MINTiP62266
STRINGi9606.ENSP00000296674

PTM databases

iPTMnetiP62266
PhosphoSitePlusiP62266
SwissPalmiP62266

Polymorphism and mutation databases

BioMutaiRPS23
DMDMi50403755

Proteomic databases

EPDiP62266
jPOSTiP62266
MassIVEiP62266
MaxQBiP62266
PaxDbiP62266
PeptideAtlasiP62266
PRIDEiP62266
ProteomicsDBi57380
TopDownProteomicsiP62266

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24716, 130 antibodies

Genome annotation databases

EnsembliENST00000296674; ENSP00000296674; ENSG00000186468
ENST00000651545; ENSP00000498621; ENSG00000186468
GeneIDi6228
KEGGihsa:6228
UCSCiuc003khu.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6228
DisGeNETi6228
EuPathDBiHostDB:ENSG00000186468.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPS23
HGNCiHGNC:10410, RPS23
HPAiENSG00000186468, Low tissue specificity
MalaCardsiRPS23
MIMi603683, gene
617412, phenotype
neXtProtiNX_P62266
OpenTargetsiENSG00000186468
PharmGKBiPA34813

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1749, Eukaryota
GeneTreeiENSGT00550000074784
HOGENOMiCLU_115574_0_1_1
InParanoidiP62266
OMAiKFRWSQR
OrthoDBi1402984at2759
PhylomeDBiP62266
TreeFamiTF300871

Enzyme and pathway databases

PathwayCommonsiP62266
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649, Translation initiation complex formation
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6228, 748 hits in 827 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPS23, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPS23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6228
PharosiP62266, Tbio

Protein Ontology

More...PROi		PR:P62266
RNActiP62266, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186468, Expressed in female gonad and 201 other tissues
ExpressionAtlasiP62266, baseline and differential
GenevisibleiP62266, HS

Family and domain databases

CDDicd03367, Ribosomal_S23, 1 hit
InterProiView protein in InterPro
IPR012340, NA-bd_OB-fold
IPR006032, Ribosomal_S12/S23
IPR005680, Ribosomal_S23_euk/arc
PANTHERiPTHR11652, PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164, Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133, Ribosomal_S12/S23, 1 hit
SUPFAMiSSF50249, SSF50249, 1 hit
TIGRFAMsiTIGR00982, uS12_E_A, 1 hit
PROSITEiView protein in PROSITE
PS00055, RIBOSOMAL_S12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS23_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62266
Secondary accession number(s): P39028, Q6IB08
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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