YWHAE

Functionⁱ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).By similarity1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
calcium channel regulator activity
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10788521
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 17085597
- 20936779
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11953308
MHC class II protein complex binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 20458337
phosphoprotein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
phosphoserine residue binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
potassium channel regulator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11953308
protein domain specific binding Source: InterPro
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11953308
Rab guanyl-nucleotide exchange factor activity Source: Reactome
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
scaffold protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10409742
ubiquitin protein ligase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 19725078

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to heat
Source: UniProtKB
Inferred from direct assayⁱ
- 12917326
ciliary basal body-plasma membrane docking Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
hippo signaling Source: Reactome
intracellular signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7644510
MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 12917326
membrane organization Source: Reactome
membrane repolarization during cardiac muscle cell action potential
Source: BHF-UCL
Inferred by curatorⁱ
- 11953308
negative regulation of calcium ion export across plasma membrane
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012
negative regulation of calcium ion transmembrane transporter activity
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
negative regulation of peptidyl-serine dephosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 11953308
positive regulation of protein export from nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 12917326
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
protein localization to nucleus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29769719
regulation of cellular response to heat Source: Reactome
regulation of cytosolic calcium ion concentration
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012
regulation of G2/M transition of mitotic cell cycle Source: Reactome
regulation of heart rate by cardiac conduction
Source: BHF-UCL
Inferred by curatorⁱ
- 11953308
regulation of heart rate by hormone
Source: BHF-UCL
Non-traceable author statementⁱ
- 11953308
regulation of membrane repolarization
Source: BHF-UCL
Inferred from direct assayⁱ
- 11953308
regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
regulation of potassium ion transmembrane transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11953308
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction

Biological process

Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-2028269 Signaling by Hippo R-HSA-205025 NADE modulates death signalling R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371511 HSF1 activation R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8854518 AURKA Activation by TPX2 R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkⁱ	P62258
SIGNORⁱ	P62258

Protein family/group databases

MoonDBⁱ	P62258 Predicted

MoonDBⁱ

P62258 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 14-3-3 protein epsilon Short name: 14-3-3E
Gene namesⁱ	Name:YWHAE
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108953.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12851 YWHAE
MIMⁱ	605066 gene
neXtProtⁱ	NX_P62258

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7531
MalaCards human disease database More...MalaCardsⁱ	YWHAE
Open Targets More...OpenTargetsⁱ	ENSG00000108953
Orphanetⁱ	217385 17p13.3 microduplication syndrome 457246 Clear cell sarcoma of kidney 261257 Distal 17p13.3 microdeletion syndrome 213711 Endometrial stromal sarcoma 531 Miller-Dieker syndrome
PharmGKBⁱ	PA37440

Chemistry databases

ChEMBLⁱ	CHEMBL3329082
Drug and drug target database More...DrugBankⁱ	DB01780 Fusicoccin

Polymorphism and mutation databases

BioMutaⁱ	YWHAE
DMDMⁱ	51702210

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058618	1 – 255	14-3-3 protein epsilonAdd BLAST		255

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication	1
Modified residueⁱ	50	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	50	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	65	PhosphoserineBy similarity	1
Modified residueⁱ	69	N6-acetyllysineCombined sources	1
Modified residueⁱ	118	N6-acetyllysineCombined sources	1
Modified residueⁱ	123	N6-acetyllysineCombined sources	1
Modified residueⁱ	131	PhosphotyrosineBy similarity	1
Modified residueⁱ	137	PhosphothreonineBy similarity	1
Modified residueⁱ	210	PhosphoserineCombined sources	1
Modified residueⁱ	232	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P62258
PaxDbⁱ	P62258
PeptideAtlas More...PeptideAtlasⁱ	P62258
PRIDEⁱ	P62258
TopDownProteomicsⁱ	P62258-1 [P62258-1]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P42655
UCD-2DPAGEⁱ	P62258

PTM databases

iPTMnetⁱ	P62258
PhosphoSitePlusⁱ	P62258
SwissPalmⁱ	P62258

Miscellaneous databases

PMAP-CutDBⁱ	P62258

PMAP-CutDBⁱ

P62258

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108953 Expressed in 237 organ(s), highest expression level in female gonad
CleanExⁱ	HS_YWHAE
ExpressionAtlasⁱ	P62258 baseline and differential
Genevisibleⁱ	P62258 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016200 CAB021109 CAB047350 HPA008445

HPAⁱ

CAB016200
CAB021109
CAB047350
HPA008445

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:17085597). Heterodimerizes with YWHAZ (PubMed:16376338). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (PubMed:15696159). Interacts with ARHGEF28 (By similarity). Interacts with BEX3 (By similarity). Weakly interacts with CDKN1B (PubMed:12042314). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with DENND1A (PubMed:26055712). Interacts with GAB2 (PubMed:19172738). Interacts with phosphorylated GRB10 (PubMed:15722337). Interacts with KSR1 (PubMed:10409742). Interacts with NDEL1 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with TIAM2. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts with ZFP36 (via phosphorylated form) (By similarity). Interacts with SLITRK1 (PubMed:19640509). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner (PubMed:12917326). Interacts with RIPOR2 isoform 2 (PubMed:25588844). Interacts with KLHL22; required for the nuclear localization of KLHL22 upon amino acid starvation (PubMed:29769719).By similarity16 Publications

(Microbial infection) Interacts with HCV core protein.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	57	Interaction with phosphoserine on interacting protein		1
Siteⁱ	130	Interaction with phosphoserine on interacting protein		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-356498,EBI-356498
	O92972	5	EBI-356498,EBI-9213553	From Hepatitis C virus genotype 1b (strain HC-J4).
ACD	Q96AP0	2	EBI-356498,EBI-717666
APAF1	O14727	2	EBI-356498,EBI-446492
ARAF	P10398	3	EBI-356498,EBI-365961
CBX4	O00257-3	2	EBI-356498,EBI-4392727
CBY1	Q9Y3M2	3	EBI-356498,EBI-947308
CDK14	O94921	3	EBI-356498,EBI-1043945
DLD	P09622	5	EBI-356498,EBI-353366
DLST	P36957	4	EBI-356498,EBI-351007
FBXO4	Q9UKT5	5	EBI-356498,EBI-960409
HDAC4	P56524	4	EBI-356498,EBI-308629
KANK1	Q14678-2	3	EBI-356498,EBI-6173812
LRRK2	Q5S007	6	EBI-356498,EBI-5323863
MAP3K3	Q99759	3	EBI-356498,EBI-307281
MDM4	O15151	3	EBI-356498,EBI-398437
MLF1	P58340	3	EBI-356498,EBI-721328
Prdx6	O35244	2	EBI-356498,EBI-915490	From Rattus norvegicus.
RAF1	P04049	3	EBI-356498,EBI-365996
Rnd3	P61588	2	EBI-356498,EBI-6930266	From Mus musculus.
STAC	Q99469	2	EBI-356498,EBI-2652799
VDAC1	P21796	5	EBI-356498,EBI-354158
WWTR1	Q9GZV5	3	EBI-356498,EBI-747743
YAP1	P46937	5	EBI-356498,EBI-1044059
YWHAB	P31946	4	EBI-356498,EBI-359815
YWHAG	P61981	5	EBI-356498,EBI-359832
YWHAQ	P27348	4	EBI-356498,EBI-359854
YWHAZ	P63104	6	EBI-356498,EBI-347088

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10788521
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 17085597
- 20936779
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11953308
phosphoprotein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
phosphoserine residue binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
protein domain specific binding Source: InterPro
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11953308
Rab guanyl-nucleotide exchange factor activity Source: Reactome
scaffold protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10409742
ubiquitin protein ligase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 19725078

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113363, 437 interactors
CORUMⁱ	P62258
Database of interacting proteins More...DIPⁱ	DIP-36676N
ELMⁱ	P62258
IntActⁱ	P62258, 187 interactors
Molecular INTeraction database More...MINTⁱ	P62258
STRINGⁱ	9606.ENSP00000264335

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 17	Combined sources	14
Helixⁱ	20 – 31	Combined sources	12
Helixⁱ	39 – 73	Combined sources	35
Helixⁱ	76 – 106	Combined sources	31
Helixⁱ	108 – 111	Combined sources	4
Helixⁱ	115 – 135	Combined sources	21
Helixⁱ	138 – 162	Combined sources	25
Helixⁱ	168 – 183	Combined sources	16
Helixⁱ	188 – 204	Combined sources	17
Helixⁱ	205 – 208	Combined sources	4
Turnⁱ	211 – 213	Combined sources	3
Helixⁱ	214 – 231	Combined sources	18

Show more details

3D structure databases

ProteinModelPortalⁱ	P62258
SMRⁱ	P62258
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P62258

EvolutionaryTraceⁱ

P62258

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119116
HOVERGENⁱ	HBG050423
InParanoidⁱ	P62258
KEGG Orthology (KO) More...KOⁱ	K06630
OMAⁱ	MKEHEKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VKY
PhylomeDBⁱ	P62258
TreeFamⁱ	TF102003

Family and domain databases

Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P62258-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK 
        60         70         80         90        100
NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI 
       110        120        130        140        150
LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV 
       160        170        180        190        200
AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD 
       210        220        230        240        250
DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV 

EDENQ

Length:255

Mass (Da):29,174

Last modified:July 5, 2004 - v1

Checksum:ⁱ07817CCBD1F75B26

GO

Isoform SV (identifier: P62258-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-22: Missing.

« Hide

        10         20         30         40         50
MVESMKKVAG MDVELTVEER NLLSVAYKNV IGARRASWRI ISSIEQKEEN 
        60         70         80         90        100
KGGEDKLKMI REYRQMVETE LKLICCDILD VLDKHLIPAA NTGESKVFYY 
       110        120        130        140        150
KMKGDYHRYL AEFATGNDRK EAAENSLVAY KAASDIAMTE LPPTHPIRLG 
       160        170        180        190        200
LALNFSVFYY EILNSPDRAC RLAKAAFDDA IAELDTLSEE SYKDSTLIMQ 
       210        220        230 
LLRDNLTLWT SDMQGDGEEQ NKEALQDVED ENQ

Note: Unable to dimerize with YWHAZ.

Show »

Length:233

Mass (Da):26,504

Checksum:ⁱ20302F1E0AB73C8A

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4DJF2	B4DJF2_HUMAN	cDNA FLJ51975, moderately similar t... cDNA FLJ51975, moderately similar to 14-3-3 protein epsilon (14-3-3E)	YWHAE	94	Annotation score:
K7EIT4	K7EIT4_HUMAN	14-3-3 protein epsilon 14-3-3 protein epsilon	YWHAE	109	Annotation score:
K7EM20	K7EM20_HUMAN	14-3-3 protein epsilon 14-3-3 protein epsilon	YWHAE	115	Annotation score:
I3L3T1	I3L3T1_HUMAN	14-3-3 protein epsilon 14-3-3 protein epsilon	YWHAE	107	Annotation score:
I3L0W5	I3L0W5_HUMAN	14-3-3 protein epsilon 14-3-3 protein epsilon	YWHAE	38	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	106 – 107	KH → NY AA sequence (PubMed:2026444).Curated	2
Sequence conflictⁱ	143	E → F AA sequence (PubMed:2026444).Curated	1
Sequence conflictⁱ	148	S → T AA sequence (PubMed:2026444).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040621	1 – 22	Missing in isoform SV. 2 PublicationsAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20972 mRNA Translation: AAC50175.1 U54778 mRNA Translation: AAC50710.1 U43399 mRNA Translation: AAC50625.1 U43430 mRNA Translation: AAD00026.1 U28936 mRNA Translation: AAA75301.1 AB017103 Genomic DNA Translation: BAA32538.1 AY883089 mRNA Translation: AAX68683.1 AK128785 mRNA Translation: BAG54733.1 AK295260 mRNA Translation: BAG58249.1 AK316185 mRNA Translation: BAH14556.1 BT007161 mRNA Translation: AAP35825.1 CH471108 Genomic DNA Translation: EAW90628.1 CH471108 Genomic DNA Translation: EAW90629.1 BC000179 mRNA Translation: AAH00179.1 BC001440 mRNA Translation: AAH01440.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11001.1 [P62258-1]
PIRⁱ	A61235 I38947
NCBI Reference Sequences More...RefSeqⁱ	NP_006752.1, NM_006761.4 [P62258-1]
UniGeneⁱ	Hs.513851

Genome annotation databases

Ensemblⁱ	ENST00000264335; ENSP00000264335; ENSG00000108953 [P62258-1] ENST00000571732; ENSP00000461762; ENSG00000108953 [P62258-2] ENST00000616643; ENSP00000481059; ENSG00000274474 [P62258-2] ENST00000627231; ENSP00000487356; ENSG00000274474 [P62258-1]
GeneIDⁱ	7531
KEGGⁱ	hsa:7531
UCSC genome browser More...UCSCⁱ	uc002fsk.4 human [P62258-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62258	14-3-3 protein epsilon		BOVIN		255	UniRef100_P62258
14-3-3 protein epsilon		CHICK		255
14-3-3 protein epsilon		MOUSE		255
14-3-3 protein epsilon		RAT		255
14-3-3 protein epsilon		SHEEP		255
+46
P62258-2	14-3-3 protein epsilon		MYODS		361	UniRef100_P62258-2
14-3-3 protein epsilon		PTEAL		223
14-3-3 protein epsilon		CHICK		223
14-3-3 protein epsilon (Fragment)		EURHL		219
14-3-3 protein epsilon (Fragment)		PHALP		219
+22

Protein	Similar proteins		Species	Score	Length	Source
P62258	14-3-3 protein epsilon		BOVIN		255	UniRef90_P62258
14-3-3 protein epsilon		CHICK		255
14-3-3 protein epsilon		MOUSE		255
14-3-3 protein epsilon		RAT		255
14-3-3 protein epsilon		SHEEP		255
+78
P62258-2	14-3-3 protein epsilon		MYODS		361	UniRef90_P62258-2
14-3-3 protein epsilon		PTEAL		223
14-3-3 protein epsilon		CHICK		223
14-3-3 protein epsilon (Fragment)		EURHL		219
14-3-3 protein epsilon (Fragment)		PHALP		219
+22

Protein	Similar proteins		Species	Score	Length	Source
P62258	14-3-3 protein epsilon		BOVIN		255	UniRef50_P62258
14-3-3 protein epsilon		CHICK		255
14-3-3 protein epsilon		MOUSE		255
14-3-3 protein epsilon		RAT		255
14-3-3 protein epsilon		SHEEP		255
+296
P62258-2	14-3-3 protein epsilon		MYODS		361	UniRef50_P62258-2
14-3-3 protein epsilon		PTEAL		223
14-3-3 protein epsilon		CHICK		223
14-3-3 protein epsilon (Fragment)		EURHL		219
14-3-3 protein epsilon (Fragment)		PHALP		219
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20972 mRNA Translation: AAC50175.1 U54778 mRNA Translation: AAC50710.1 U43399 mRNA Translation: AAC50625.1 U43430 mRNA Translation: AAD00026.1 U28936 mRNA Translation: AAA75301.1 AB017103 Genomic DNA Translation: BAA32538.1 AY883089 mRNA Translation: AAX68683.1 AK128785 mRNA Translation: BAG54733.1 AK295260 mRNA Translation: BAG58249.1 AK316185 mRNA Translation: BAH14556.1 BT007161 mRNA Translation: AAP35825.1 CH471108 Genomic DNA Translation: EAW90628.1 CH471108 Genomic DNA Translation: EAW90629.1 BC000179 mRNA Translation: AAH00179.1 BC001440 mRNA Translation: AAH01440.1
CCDSⁱ	CCDS11001.1 [P62258-1]
PIRⁱ	A61235 I38947
RefSeqⁱ	NP_006752.1, NM_006761.4 [P62258-1]
UniGeneⁱ	Hs.513851

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2BR9	X-ray	1.75	A	1-233	[»]
	3UAL	X-ray	1.80	A	1-232	[»]
	3UBW	X-ray	1.90	A	1-234	[»]
	6EIH	X-ray	2.70	A	3-232	[»]
ProteinModelPortalⁱ	P62258
SMRⁱ	P62258
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113363, 437 interactors
CORUMⁱ	P62258
DIPⁱ	DIP-36676N
ELMⁱ	P62258
IntActⁱ	P62258, 187 interactors
MINTⁱ	P62258
STRINGⁱ	9606.ENSP00000264335

Chemistry databases

ChEMBLⁱ	CHEMBL3329082
DrugBankⁱ	DB01780 Fusicoccin

Protein family/group databases

MoonDBⁱ	P62258 Predicted

MoonDBⁱ

P62258 Predicted

PTM databases

iPTMnetⁱ	P62258
PhosphoSitePlusⁱ	P62258
SwissPalmⁱ	P62258

Polymorphism and mutation databases

BioMutaⁱ	YWHAE
DMDMⁱ	51702210

2D gel databases

OGPⁱ	P42655
UCD-2DPAGEⁱ	P62258

Proteomic databases

EPDⁱ	P62258
PaxDbⁱ	P62258
PeptideAtlasⁱ	P62258
PRIDEⁱ	P62258
TopDownProteomicsⁱ	P62258-1 [P62258-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7531
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264335; ENSP00000264335; ENSG00000108953 [P62258-1] ENST00000571732; ENSP00000461762; ENSG00000108953 [P62258-2] ENST00000616643; ENSP00000481059; ENSG00000274474 [P62258-2] ENST00000627231; ENSP00000487356; ENSG00000274474 [P62258-1]
GeneIDⁱ	7531
KEGGⁱ	hsa:7531
UCSCⁱ	uc002fsk.4 human [P62258-1]

Organism-specific databases

CTDⁱ	7531
DisGeNETⁱ	7531
EuPathDBⁱ	HostDB:ENSG00000108953.16
GeneCardsⁱ	YWHAE
H-InvDBⁱ	HIX0013751 HIX0030006
HGNCⁱ	HGNC:12851 YWHAE
HPAⁱ	CAB016200 CAB021109 CAB047350 HPA008445
MalaCardsⁱ	YWHAE
MIMⁱ	605066 gene
neXtProtⁱ	NX_P62258
OpenTargetsⁱ	ENSG00000108953
Orphanetⁱ	217385 17p13.3 microduplication syndrome 457246 Clear cell sarcoma of kidney 261257 Distal 17p13.3 microdeletion syndrome 213711 Endometrial stromal sarcoma 531 Miller-Dieker syndrome
PharmGKBⁱ	PA37440
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
GeneTreeⁱ	ENSGT00760000119116
HOVERGENⁱ	HBG050423
InParanoidⁱ	P62258
KOⁱ	K06630
OMAⁱ	MKEHEKG
OrthoDBⁱ	EOG091G0VKY
PhylomeDBⁱ	P62258
TreeFamⁱ	TF102003

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-2028269 Signaling by Hippo R-HSA-205025 NADE modulates death signalling R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371511 HSF1 activation R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8854518 AURKA Activation by TPX2 R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkⁱ	P62258
SIGNORⁱ	P62258

Miscellaneous databases

ChiTaRSⁱ	YWHAE human
EvolutionaryTraceⁱ	P62258
GeneWikiⁱ	YWHAE
GenomeRNAiⁱ	7531
PMAP-CutDBⁱ	P62258
Protein Ontology More...PROⁱ	PR:P62258
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108953 Expressed in 237 organ(s), highest expression level in female gonad
CleanExⁱ	HS_YWHAE
ExpressionAtlasⁱ	P62258 baseline and differential
Genevisibleⁱ	P62258 HS

Family and domain databases

Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1433E_HUMAN
Accessionⁱ	P62258Primary (citable) accession number: P62258 Secondary accession number(s): B3KY71 Q7M4R4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P62258 (1433E_HUMAN)

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14-3-3 protein epsilon

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

Alternative sequence

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Keywords - Coding sequence diversityi

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Sequence databases

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Chemistry databases

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PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ