UBE2H

Functionⁱ

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).4 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation5 Publications

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N₆-monoubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation3 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	87	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ubiquitin conjugating enzyme activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20061386

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
protein K11-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 20061386
protein K48-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 20061386
protein ubiquitination Source: Reactome
ubiquitin-dependent protein catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.3.2.B6 2681
Reactomeⁱ	R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	P62256
UniPathwayⁱ	UPA00143

Protein family/group databases

MoonDBⁱ	P62256 Predicted

MoonDBⁱ

P62256 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-conjugating enzyme E2 H (EC:2.3.2.235 Publications) Alternative name(s): (E3-independent) E2 ubiquitin-conjugating enzyme H (EC:2.3.2.242 Publications) E2 ubiquitin-conjugating enzyme H UbcH2 Ubiquitin carrier protein H Ubiquitin-conjugating enzyme E2-20K Ubiquitin-protein ligase H
Gene namesⁱ	Name:UBE2H
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186591.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12484 UBE2H
MIMⁱ	601082 gene
neXtProtⁱ	NX_P62256

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7328
Open Targets More...OpenTargetsⁱ	ENSG00000186591
PharmGKBⁱ	PA37133

Polymorphism and mutation databases

BioMutaⁱ	UBE2H
DMDMⁱ	51338683

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082486	1 – 183	Ubiquitin-conjugating enzyme E2 HAdd BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	60	N6-acetyllysineBy similarity		1

Post-translational modificationⁱ

Autoubiquitinated in vitro in the presence of NEDD4L.1 Publication

Keywords - PTMⁱ

Acetylation, Ubl conjugation

Proteomic databases

EPDⁱ	P62256
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62256
PaxDbⁱ	P62256
PeptideAtlas More...PeptideAtlasⁱ	P62256
PRIDEⁱ	P62256
ProteomicsDBⁱ	57376

PTM databases

iPTMnetⁱ	P62256
PhosphoSitePlusⁱ	P62256

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186591 Expressed in 233 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_UBE2H
ExpressionAtlasⁱ	P62256 baseline and differential
Genevisibleⁱ	P62256 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003302

HPAⁱ

HPA003302

Interactionⁱ

Subunit structureⁱ

Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MAGEA2B	P43356	2	EBI-2129909,EBI-5650739
MAGEC2	Q9UBF1	3	EBI-2129909,EBI-5651487

Protein-protein interaction databases

BioGridⁱ	113176, 90 interactors
IntActⁱ	P62256, 50 interactors
STRINGⁱ	9606.ENSP00000347836

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 20	Combined sources	15
Beta strandⁱ	21 – 23	Combined sources	3
Beta strandⁱ	25 – 30	Combined sources	6
Beta strandⁱ	33 – 39	Combined sources	7
Turnⁱ	45 – 48	Combined sources	4
Beta strandⁱ	50 – 56	Combined sources	7
Turnⁱ	59 – 63	Combined sources	5
Beta strandⁱ	67 – 72	Combined sources	6
Turnⁱ	81 – 83	Combined sources	3
Helixⁱ	88 – 94	Combined sources	7
Helixⁱ	103 – 106	Combined sources	4
Helixⁱ	108 – 114	Combined sources	7
Helixⁱ	124 – 132	Combined sources	9
Helixⁱ	134 – 148	Combined sources	15
Helixⁱ	151 – 154	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P62256
SMRⁱ	P62256
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P62256

EvolutionaryTraceⁱ

P62256

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0416 Eukaryota ENOG410XRC5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004852
HOGENOMⁱ	HOG000233452
HOVERGENⁱ	HBG063308
InParanoidⁱ	P62256
KEGG Orthology (KO) More...KOⁱ	K10576
OMAⁱ	NLVNDNM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RI1
PhylomeDBⁱ	P62256
TreeFamⁱ	TF101121

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P62256-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV 
        60         70         80         90        100
WKVRVDLPDK YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD 
       110        120        130        140        150
LTNIFESFLP QLLAYPNPID PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT 
       160        170        180 
EEALKEQEEG TGDSSSESSM SDFSEDEAQD MEL

Length:183

Mass (Da):20,655

Last modified:July 5, 2004 - v1

Checksum:ⁱ3DD5D365945F708C

GO

Isoform 2 (identifier: P62256-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
69-99: Missing.

« Hide

        10         20         30         40         50
MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV 
        60         70         80         90        100
WKVRVDLPDK YPFKSPSIDL TNIFESFLPQ LLAYPNPIDP LNGDAAAMYL 
       110        120        130        140        150
HRPEEYKQKI KEYIQKYATE EALKEQEEGT GDSSSESSMS DFSEDEAQDM 

EL

Note: No experimental confirmation available.

Show »

Length:152

Mass (Da):17,174

Checksum:ⁱC24F6341C98931F0

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J8Q9	C9J8Q9_HUMAN	Ubiquitin-conjugating enzyme E2 H Ubiquitin-conjugating enzyme E2 H	UBE2H	149	Annotation score:
C9JZY6	C9JZY6_HUMAN	Ubiquitin-conjugating enzyme E2 H Ubiquitin-conjugating enzyme E2 H	UBE2H	123	Annotation score:
C9JZG9	C9JZG9_HUMAN	Ubiquitin-conjugating enzyme E2 H Ubiquitin-conjugating enzyme E2 H	UBE2H	103	Annotation score:
H7C4M9	H7C4M9_HUMAN	Ubiquitin-conjugating enzyme E2 H Ubiquitin-conjugating enzyme E2 H	UBE2H	62	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	165	S → P in AAP57630 (Ref. 2) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044580	69 – 99	Missing in isoform 2. 1 PublicationAdd BLAST		31

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z29328 mRNA Translation: CAA82525.1 Z29330 mRNA Translation: CAA82527.1 Z29331 mRNA Translation: CAA82528.1 AY302138 mRNA Translation: AAP57630.1 BT006756 mRNA Translation: AAP35402.1 AC073320 Genomic DNA No translation available. AC084865 Genomic DNA No translation available. CH236950 Genomic DNA Translation: EAL24099.1 CH471070 Genomic DNA Translation: EAW83736.1 BC006277 mRNA Translation: AAH06277.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47710.1 [P62256-2] CCDS5814.1 [P62256-1]
PIRⁱ	A53516
NCBI Reference Sequences More...RefSeqⁱ	NP_001189427.1, NM_001202498.1 NP_003335.1, NM_003344.3 [P62256-1] NP_874356.1, NM_182697.2 [P62256-2]
UniGeneⁱ	Hs.643548

Genome annotation databases

Ensemblⁱ	ENST00000355621; ENSP00000347836; ENSG00000186591 [P62256-1] ENST00000473814; ENSP00000419097; ENSG00000186591 [P62256-2]
GeneIDⁱ	7328
KEGGⁱ	hsa:7328
UCSC genome browser More...UCSCⁱ	uc003vpf.3 human [P62256-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P62256	Ubiquitin-conjugating enzyme E2 H		BOVIN		183	UniRef100_P62256
Ubiquitin-conjugating enzyme E2 H		MOUSE		183
Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)		HUMAN		183
Ubiquitin-conjugating enzyme E2 H isoform 1		CALJA		183
UBE2H isoform 1		PANTR		183
+49
P62256-2	Ubiquitin-conjugating enzyme E2 H		MOUSE		152	UniRef100_E9Q3U1
Ubiquitin-conjugating enzyme E2 H isoform 2		CALJA		152
UBE2H isoform 2		PANTR		152
Ubiquitin conjugating enzyme E2 H		SAIBB		152
Uncharacterized protein		PROCO		152
+23

Protein	Similar proteins		Species	Score	Length	Source
P62256	Ubiquitin-conjugating enzyme E2 H		BOVIN		183	UniRef90_P62256
Ubiquitin-conjugating enzyme E2 H		MOUSE		183
Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)		HUMAN		183
Ubiquitin-conjugating enzyme E2 H isoform 1		CALJA		183
UBE2H isoform 1		PANTR		183
+130
P62256-2	Ubiquitin-conjugating enzyme E2 H		MOUSE		152	UniRef90_E9Q3U1
Ubiquitin-conjugating enzyme E2 H isoform 2		CALJA		152
UBE2H isoform 2		PANTR		152
Ubiquitin conjugating enzyme E2 H		SAIBB		152
Uncharacterized protein		PROCO		152
+25

Protein	Similar proteins		Species	Score	Length	Source
P62256	Ubiquitin-conjugating enzyme E2 H		BOVIN		183	UniRef50_P62256
Ubiquitin-conjugating enzyme E2 H		MOUSE		183
Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)		HUMAN		183
Ubiquitin-conjugating enzyme E2 H isoform 1		CALJA		183
UBE2H isoform 1		PANTR		183
+178
P62256-2	Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)		ASTMX		140	UniRef50_W5LIZ0
Ubiquitin-conjugating enzyme E2 H		MOUSE		152
Ubiquitin-conjugating enzyme E2 H isoform 2		CALJA		152
UBE2H isoform 2		PANTR		152
Ubiquitin conjugating enzyme E2 H		SAIBB		152
+48

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z29328 mRNA Translation: CAA82525.1 Z29330 mRNA Translation: CAA82527.1 Z29331 mRNA Translation: CAA82528.1 AY302138 mRNA Translation: AAP57630.1 BT006756 mRNA Translation: AAP35402.1 AC073320 Genomic DNA No translation available. AC084865 Genomic DNA No translation available. CH236950 Genomic DNA Translation: EAL24099.1 CH471070 Genomic DNA Translation: EAW83736.1 BC006277 mRNA Translation: AAH06277.1
CCDSⁱ	CCDS47710.1 [P62256-2] CCDS5814.1 [P62256-1]
PIRⁱ	A53516
RefSeqⁱ	NP_001189427.1, NM_001202498.1 NP_003335.1, NM_003344.3 [P62256-1] NP_874356.1, NM_182697.2 [P62256-2]
UniGeneⁱ	Hs.643548

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2Z5D	X-ray	2.10	A/B	1-160	[»]
ProteinModelPortalⁱ	P62256
SMRⁱ	P62256
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113176, 90 interactors
IntActⁱ	P62256, 50 interactors
STRINGⁱ	9606.ENSP00000347836

Protein family/group databases

MoonDBⁱ	P62256 Predicted

MoonDBⁱ

P62256 Predicted

PTM databases

iPTMnetⁱ	P62256
PhosphoSitePlusⁱ	P62256

Polymorphism and mutation databases

BioMutaⁱ	UBE2H
DMDMⁱ	51338683

Proteomic databases

EPDⁱ	P62256
MaxQBⁱ	P62256
PaxDbⁱ	P62256
PeptideAtlasⁱ	P62256
PRIDEⁱ	P62256
ProteomicsDBⁱ	57376

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7328
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000355621; ENSP00000347836; ENSG00000186591 [P62256-1] ENST00000473814; ENSP00000419097; ENSG00000186591 [P62256-2]
GeneIDⁱ	7328
KEGGⁱ	hsa:7328
UCSCⁱ	uc003vpf.3 human [P62256-1]

Organism-specific databases

CTDⁱ	7328
DisGeNETⁱ	7328
EuPathDBⁱ	HostDB:ENSG00000186591.11
GeneCardsⁱ	UBE2H
H-InvDBⁱ	HIX0123428
HGNCⁱ	HGNC:12484 UBE2H
HPAⁱ	HPA003302
MIMⁱ	601082 gene
neXtProtⁱ	NX_P62256
OpenTargetsⁱ	ENSG00000186591
PharmGKBⁱ	PA37133
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0416 Eukaryota ENOG410XRC5 LUCA
GeneTreeⁱ	ENSGT00390000004852
HOGENOMⁱ	HOG000233452
HOVERGENⁱ	HBG063308
InParanoidⁱ	P62256
KOⁱ	K10576
OMAⁱ	NLVNDNM
OrthoDBⁱ	EOG091G0RI1
PhylomeDBⁱ	P62256
TreeFamⁱ	TF101121

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BRENDAⁱ	2.3.2.B6 2681
Reactomeⁱ	R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	P62256

Miscellaneous databases

ChiTaRSⁱ	UBE2H human
EvolutionaryTraceⁱ	P62256
GeneWikiⁱ	UBE2H
GenomeRNAiⁱ	7328
Protein Ontology More...PROⁱ	PR:P62256
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186591 Expressed in 233 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_UBE2H
ExpressionAtlasⁱ	P62256 baseline and differential
Genevisibleⁱ	P62256 HS

Family and domain databases

CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBE2H_HUMAN
Accessionⁱ	P62256Primary (citable) accession number: P62256 Secondary accession number(s): A4D1L6 , C9JY93, P37286, Q7Z6F4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62256 (UBE2H_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Ubiquitin-conjugating enzyme E2 H

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ