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Protein

Ubiquitin-conjugating enzyme E2 G1

Gene

Ube2g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 G1 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme G1
E217K
UBC7
Ubiquitin carrier protein G1
Ubiquitin-protein ligase G1
Cleaved into the following chain:
Gene namesi
Name:Ube2g1
Synonyms:Ube2g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914378 Ube2g1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004245161 – 170Ubiquitin-conjugating enzyme E2 G1Add BLAST170
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00000824812 – 170Ubiquitin-conjugating enzyme E2 G1, N-terminally processedAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Ubiquitin-conjugating enzyme E2 G1, N-terminally processedBy similarity1

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiP62254
PaxDbiP62254
PeptideAtlasiP62254
PRIDEiP62254

2D gel databases

REPRODUCTION-2DPAGEiIPI00310850
P62254

PTM databases

iPTMnetiP62254
PhosphoSitePlusiP62254

Expressioni

Gene expression databases

BgeeiENSMUSG00000020794 Expressed in 301 organ(s), highest expression level in primary oocyte
ExpressionAtlasiP62254 baseline and differential
GenevisibleiP62254 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211962, 3 interactors
IntActiP62254, 1 interactor
MINTiP62254
STRINGi10090.ENSMUSP00000021148

Structurei

3D structure databases

ProteinModelPortaliP62254
SMRiP62254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiP62254
KOiK10575
OMAiFITPMWH
OrthoDBiEOG091G0O9F
PhylomeDBiP62254
TreeFamiTF101118

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTELQSALLL RRQLAELNKN PVEGFSAGLI DDNDLYRWEV LIIGPPDTLY
60 70 80 90 100
EGGVFKAHLT FPKDYPLRPP KMKFITEIWH PNVDKNGDVC ISILHEPGED
110 120 130 140 150
KYGYEKPEER WLPIHTVETI MISVISMLAD PNGDSPANVD AAKEWREDRN
160 170
GEFKRKVARC VRKSQETAFE
Length:170
Mass (Da):19,509
Last modified:January 23, 2007 - v3
Checksum:i36B61766D995B332
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RES1D6RES1_MOUSE
Ubiquitin-conjugating enzyme E2 G1
Ube2g1
99Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013902 mRNA Translation: BAB29048.1
BC096474 mRNA Translation: AAH96474.1
CCDSiCCDS36217.1
RefSeqiNP_080261.2, NM_025985.4
UniGeneiMm.458052

Genome annotation databases

EnsembliENSMUST00000021148; ENSMUSP00000021148; ENSMUSG00000020794
GeneIDi67128
KEGGimmu:67128
UCSCiuc007jzc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013902 mRNA Translation: BAB29048.1
BC096474 mRNA Translation: AAH96474.1
CCDSiCCDS36217.1
RefSeqiNP_080261.2, NM_025985.4
UniGeneiMm.458052

3D structure databases

ProteinModelPortaliP62254
SMRiP62254
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211962, 3 interactors
IntActiP62254, 1 interactor
MINTiP62254
STRINGi10090.ENSMUSP00000021148

PTM databases

iPTMnetiP62254
PhosphoSitePlusiP62254

2D gel databases

REPRODUCTION-2DPAGEiIPI00310850
P62254

Proteomic databases

EPDiP62254
PaxDbiP62254
PeptideAtlasiP62254
PRIDEiP62254

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021148; ENSMUSP00000021148; ENSMUSG00000020794
GeneIDi67128
KEGGimmu:67128
UCSCiuc007jzc.1 mouse

Organism-specific databases

CTDi7326
MGIiMGI:1914378 Ube2g1

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiP62254
KOiK10575
OMAiFITPMWH
OrthoDBiEOG091G0O9F
PhylomeDBiP62254
TreeFamiTF101118

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiUbe2g1 mouse
PROiPR:P62254
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020794 Expressed in 301 organ(s), highest expression level in primary oocyte
ExpressionAtlasiP62254 baseline and differential
GenevisibleiP62254 MM

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2G1_MOUSE
AccessioniPrimary (citable) accession number: P62254
Secondary accession number(s): Q4VAA6, Q99462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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