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Protein

40S ribosomal protein S16

Gene

RPS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S16
Alternative name(s):
Small ribosomal subunit protein uS91 Publication
Gene namesi
Name:RPS16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105193.8
HGNCiHGNC:10396 RPS16
MIMi603675 gene
neXtProtiNX_P62249

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6217
OpenTargetsiENSG00000105193
PharmGKBiPA34796

Polymorphism and mutation databases

BioMutaiRPS16
DMDMi50403607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001114792 – 14640S ribosomal protein S16Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1
Modified residuei60N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62249
MaxQBiP62249
PaxDbiP62249
PeptideAtlasiP62249
PRIDEiP62249
ProteomicsDBi57374
TopDownProteomicsiP62249

PTM databases

iPTMnetiP62249
PhosphoSitePlusiP62249
SwissPalmiP62249

Expressioni

Gene expression databases

BgeeiENSG00000105193
CleanExiHS_RPS16
ExpressionAtlasiP62249 baseline and differential
GenevisibleiP62249 HS

Organism-specific databases

HPAiHPA064222

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-352480,EBI-5323863

Protein-protein interaction databases

BioGridi112131, 283 interactors
CORUMiP62249
DIPiDIP-33200N
IntActiP62249, 46 interactors
MINTiP62249
STRINGi9606.ENSP00000251453

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SQ1-146[»]
4V6Xelectron microscopy5.00AQ1-146[»]
5A2Qelectron microscopy3.90Q1-146[»]
5AJ0electron microscopy3.50BQ1-146[»]
5FLXelectron microscopy3.90Q1-146[»]
5LKSelectron microscopy3.60SQ1-146[»]
5OA3electron microscopy4.30Q1-146[»]
5T2Celectron microscopy3.60Ay1-146[»]
5VYCX-ray6.00Q1/Q2/Q3/Q4/Q5/Q61-146[»]
6EK0electron microscopy2.90SQ1-146[»]
6FECelectron microscopy6.30H6-146[»]
ProteinModelPortaliP62249
SMRiP62249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1753 Eukaryota
COG0103 LUCA
GeneTreeiENSGT00390000013067
HOGENOMiHOG000019803
HOVERGENiHBG055171
InParanoidiP62249
KOiK02960
OMAiFMGQAEA
PhylomeDBiP62249
TreeFamiTF300088

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR000754 Ribosomal_S9
IPR020574 Ribosomal_S9_CS
PANTHERiPTHR21569 PTHR21569, 1 hit
PfamiView protein in Pfam
PF00380 Ribosomal_S9, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS00360 RIBOSOMAL_S9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKVNGRPLE MIEPRTLQYK
60 70 80 90 100
LLEPVLLLGK ERFAGVDIRV RVKGGGHVAQ IYAIRQSISK ALVAYYQKYV
110 120 130 140
DEASKKEIKD ILIQYDRTLL VADPRRCESK KFGGPGARAR YQKSYR
Length:146
Mass (Da):16,445
Last modified:January 23, 2007 - v2
Checksum:i519BCFB91BB68A15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60854 mRNA Translation: AAA60583.1
AB061841 Genomic DNA Translation: BAB79479.1
AK315498 mRNA Translation: BAG37882.1
CH471126 Genomic DNA Translation: EAW56894.1
BC004324 mRNA Translation: AAH04324.1
BC007977 mRNA Translation: AAH07977.1
CCDSiCCDS12535.1
PIRiA39760 R3HU16
RefSeqiNP_001011.1, NM_001020.5
UniGeneiHs.397609

Genome annotation databases

EnsembliENST00000251453; ENSP00000251453; ENSG00000105193
GeneIDi6217
KEGGihsa:6217
UCSCiuc002olk.4 human

Similar proteinsi

Entry informationi

Entry nameiRS16_HUMAN
AccessioniPrimary (citable) accession number: P62249
Secondary accession number(s): B2RDD5, P17008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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