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Entry version 165 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

40S ribosomal protein S15a

Gene

RPS15A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the ribosome (PubMed:23636399). Required for proper erythropoiesis (PubMed:27909223).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S15a
Alternative name(s):
Small ribosomal subunit protein uS81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS15A
ORF Names:OK/SW-cl.82
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10389 RPS15A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603674 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62244

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 20 (DBA20)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. DBA20 inheritance is autosomal dominant.
Related information in OMIM

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
6210

MalaCards human disease database

More...
MalaCardsi
RPS15A
MIMi618313 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134419

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
124 Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34788

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P62244

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS15A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403624

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001266022 – 13040S ribosomal protein S15aAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei88N6-succinyllysineBy similarity1

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62244

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62244

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P62244

MaxQB - The MaxQuant DataBase

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MaxQBi
P62244

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62244

PeptideAtlas

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PeptideAtlasi
P62244

PRoteomics IDEntifications database

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PRIDEi
P62244

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57373

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62244

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P62244

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62244

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62244

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62244

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P62244

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134419 Expressed in 181 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62244 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62244 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 40S ribosomal subunit.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112124, 226 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P62244

Protein interaction database and analysis system

More...
IntActi
P62244, 38 interactors

Molecular INTeraction database

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MINTi
P62244

STRING: functional protein association networks

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STRINGi
9606.ENSP00000318646

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62244

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1754 Eukaryota
COG0096 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000204097

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62244

KEGG Orthology (KO)

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KOi
K02957

Identification of Orthologs from Complete Genome Data

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OMAi
LPAKNFG

Database of Orthologous Groups

More...
OrthoDBi
1417658at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62244

TreeFam database of animal gene trees

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TreeFami
TF300067

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_01302_A Ribosomal_S8_A, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000630 Ribosomal_S8
IPR035987 Ribosomal_S8_sf

The PANTHER Classification System

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PANTHERi
PTHR11758 PTHR11758, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00410 Ribosomal_S8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56047 SSF56047, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00053 RIBOSOMAL_S8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P62244-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF
60 70 80 90 100
EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG
110 120 130
FIVLTTSAGI MDHEEARRKH TGGKILGFFF
Length:130
Mass (Da):14,840
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4AC1E8864E3A184
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3P7I3L3P7_HUMAN
40S ribosomal protein S15a
RPS15A
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT37H3BT37_HUMAN
40S ribosomal protein S15a
RPS15A
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV27H3BV27_HUMAN
40S ribosomal protein S15a
RPS15A
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L246I3L246_HUMAN
40S ribosomal protein S15a
RPS15A
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L303I3L303_HUMAN
40S ribosomal protein S15a
RPS15A
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVC7H3BVC7_HUMAN
40S ribosomal protein S15a
RPS15A
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA44568 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3R → C AA sequence (PubMed:8706699).Curated1
Sequence conflicti40V → L in CAA59127 (Ref. 2) Curated1
Sequence conflicti79F → S in AAH01697 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X62691 mRNA Translation: CAA44568.1 Frameshift.
X84407 mRNA Translation: CAA59127.1
AY208299 mRNA Translation: AAO48936.1
AB062400 mRNA Translation: BAB93487.1
BC001697 mRNA Translation: AAH01697.1
BC030569 mRNA Translation: AAH30569.1
BC046113 mRNA Translation: AAH46113.1
BC105273 mRNA Translation: AAI05274.1
BC105292 mRNA Translation: AAI05293.1
AB007154 Genomic DNA Translation: BAA28592.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10571.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S52339

NCBI Reference Sequences

More...
RefSeqi
NP_001010.2, NM_001019.4
NP_001025180.1, NM_001030009.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322989; ENSP00000318646; ENSG00000134419
ENST00000563390; ENSP00000457000; ENSG00000134419
ENST00000565420; ENSP00000458115; ENSG00000134419
ENST00000572008; ENSP00000458528; ENSG00000134419

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6210

UCSC genome browser

More...
UCSCi
uc002dfh.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62691 mRNA Translation: CAA44568.1 Frameshift.
X84407 mRNA Translation: CAA59127.1
AY208299 mRNA Translation: AAO48936.1
AB062400 mRNA Translation: BAB93487.1
BC001697 mRNA Translation: AAH01697.1
BC030569 mRNA Translation: AAH30569.1
BC046113 mRNA Translation: AAH46113.1
BC105273 mRNA Translation: AAI05274.1
BC105292 mRNA Translation: AAI05293.1
AB007154 Genomic DNA Translation: BAA28592.1
CCDSiCCDS10571.1
PIRiS52339
RefSeqiNP_001010.2, NM_001019.4
NP_001025180.1, NM_001030009.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SW1-130[»]
4V6Xelectron microscopy5.00AW1-130[»]
5A2Qelectron microscopy3.90W1-130[»]
5AJ0electron microscopy3.50BW1-130[»]
5FLXelectron microscopy3.90W1-130[»]
5LKSelectron microscopy3.60SW1-130[»]
5OA3electron microscopy4.30W1-130[»]
5T2Celectron microscopy3.60AP1-130[»]
5VYCX-ray6.00W1/W2/W3/W4/W5/W61-130[»]
6EK0electron microscopy2.90SW1-130[»]
6FECelectron microscopy6.30a2-130[»]
6G18electron microscopy3.60W1-130[»]
6G4Selectron microscopy4.00W1-130[»]
6G4Welectron microscopy4.50W1-130[»]
6G51electron microscopy4.10W1-130[»]
6G53electron microscopy4.50W1-130[»]
6G5Helectron microscopy3.60W1-130[»]
6G5Ielectron microscopy3.50W1-130[»]
6IP5electron microscopy3.903M1-130[»]
6IP6electron microscopy4.503M1-130[»]
6IP8electron microscopy3.903M1-130[»]
6OLEelectron microscopy3.10SW2-130[»]
6OLFelectron microscopy3.90SW2-130[»]
6OLGelectron microscopy3.40BW2-130[»]
6OLIelectron microscopy3.50SW2-130[»]
6OLZelectron microscopy3.90BW2-130[»]
6OM0electron microscopy3.10SW2-130[»]
6OM7electron microscopy3.70SW2-130[»]
6QZPelectron microscopy2.90SW2-130[»]
SMRiP62244
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112124, 226 interactors
CORUMiP62244
IntActiP62244, 38 interactors
MINTiP62244
STRINGi9606.ENSP00000318646

PTM databases

iPTMnetiP62244
PhosphoSitePlusiP62244
SwissPalmiP62244

Polymorphism and mutation databases

BioMutaiRPS15A
DMDMi50403624

2D gel databases

SWISS-2DPAGEiP62244

Proteomic databases

EPDiP62244
jPOSTiP62244
MassIVEiP62244
MaxQBiP62244
PaxDbiP62244
PeptideAtlasiP62244
PRIDEiP62244
ProteomicsDBi57373
TopDownProteomicsiP62244

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6210

Genome annotation databases

EnsembliENST00000322989; ENSP00000318646; ENSG00000134419
ENST00000563390; ENSP00000457000; ENSG00000134419
ENST00000565420; ENSP00000458115; ENSG00000134419
ENST00000572008; ENSP00000458528; ENSG00000134419
GeneIDi6210
KEGGihsa:6210
UCSCiuc002dfh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6210
DisGeNETi6210

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS15A
HGNCiHGNC:10389 RPS15A
HPAiHPA047103
MalaCardsiRPS15A
MIMi603674 gene
618313 phenotype
neXtProtiNX_P62244
OpenTargetsiENSG00000134419
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34788

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1754 Eukaryota
COG0096 LUCA
GeneTreeiENSGT00950000183198
HOGENOMiHOG000204097
InParanoidiP62244
KOiK02957
OMAiLPAKNFG
OrthoDBi1417658at2759
PhylomeDBiP62244
TreeFamiTF300067

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS15A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS15A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6210
PharosiP62244
PMAP-CutDBiP62244

Protein Ontology

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PROi
PR:P62244

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134419 Expressed in 181 organ(s), highest expression level in ectocervix
ExpressionAtlasiP62244 baseline and differential
GenevisibleiP62244 HS

Family and domain databases

HAMAPiMF_01302_A Ribosomal_S8_A, 1 hit
InterProiView protein in InterPro
IPR000630 Ribosomal_S8
IPR035987 Ribosomal_S8_sf
PANTHERiPTHR11758 PTHR11758, 1 hit
PfamiView protein in Pfam
PF00410 Ribosomal_S8, 1 hit
SUPFAMiSSF56047 SSF56047, 1 hit
PROSITEiView protein in PROSITE
PS00053 RIBOSOMAL_S8, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS15A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62244
Secondary accession number(s): P39027
, P39031, Q3MHD9, Q8C023, Q9BV24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
UniProt is an ELIXIR core data resource
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