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Entry version 154 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

40S ribosomal protein S8

Gene

RPS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S8
Alternative name(s):
Small ribosomal subunit protein eS81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS8
ORF Names:OK/SW-cl.83
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142937.11

Human Gene Nomenclature Database

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HGNCi
HGNC:10441 RPS8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600357 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6202

Open Targets

More...
OpenTargetsi
ENSG00000142937

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34856

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403622

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001222402 – 20840S ribosomal protein S8Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37N6-acetyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei160PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P62241

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62241

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62241

PeptideAtlas

More...
PeptideAtlasi
P62241

PRoteomics IDEntifications database

More...
PRIDEi
P62241

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57372

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P62241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62241

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62241

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P62241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142937 Expressed in 89 organ(s), highest expression level in right ovary

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62241 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62241 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029266

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112116, 322 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P62241

Protein interaction database and analysis system

More...
IntActi
P62241, 55 interactors

Molecular INTeraction database

More...
MINTi
P62241

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379888

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SI1-208[»]
4V6Xelectron microscopy5.00AI1-208[»]
5A2Qelectron microscopy3.90I1-208[»]
5AJ0electron microscopy3.50BI1-208[»]
5FLXelectron microscopy3.90I1-208[»]
5LKSelectron microscopy3.60SI1-208[»]
5OA3electron microscopy4.30I1-208[»]
5T2Celectron microscopy3.60Au1-208[»]
5VYCX-ray6.00I1/I2/I3/I4/I5/I61-208[»]
6EK0electron microscopy2.90SI1-208[»]
6FECelectron microscopy6.30o2-207[»]
6G18electron microscopy3.60I1-208[»]
6G4Selectron microscopy4.00I1-208[»]
6G4Welectron microscopy4.50I1-208[»]
6G51electron microscopy4.10I1-208[»]
6G53electron microscopy4.50I1-208[»]
6G5Helectron microscopy3.60I1-208[»]
6G5Ielectron microscopy3.50I1-208[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P62241

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62241

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3283 Eukaryota
COG2007 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000211544

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG030738

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62241

KEGG Orthology (KO)

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KOi
K02995

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWGSEHV

Database of Orthologous Groups

More...
OrthoDBi
1278610at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62241

TreeFam database of animal gene trees

More...
TreeFami
TF300041

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001047 Ribosomal_S8e
IPR022309 Ribosomal_S8e/biogenesis_NSA2
IPR018283 Ribosomal_S8e_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10394 PTHR10394, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01201 Ribosomal_S8e, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00307 eS8, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01193 RIBOSOMAL_S8E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG
60 70 80 90 100
GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC
110 120 130 140 150
IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD
160 170 180 190 200
ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR

KIKARKGK
Length:208
Mass (Da):24,205
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i407FDF59171F7422
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JR95Q5JR95_HUMAN
40S ribosomal protein S8
RPS8
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051861110R → G. Corresponds to variant dbSNP:rs11537870Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67247 Genomic DNA Translation: CAA47670.1
AB062401 mRNA Translation: BAB93488.1
BC070875 mRNA Translation: AAH70875.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS513.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S25022

NCBI Reference Sequences

More...
RefSeqi
NP_001003.1, NM_001012.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.512675

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396651; ENSP00000379888; ENSG00000142937

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6202

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67247 Genomic DNA Translation: CAA47670.1
AB062401 mRNA Translation: BAB93488.1
BC070875 mRNA Translation: AAH70875.1
CCDSiCCDS513.1
PIRiS25022
RefSeqiNP_001003.1, NM_001012.1
UniGeneiHs.512675

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SI1-208[»]
4V6Xelectron microscopy5.00AI1-208[»]
5A2Qelectron microscopy3.90I1-208[»]
5AJ0electron microscopy3.50BI1-208[»]
5FLXelectron microscopy3.90I1-208[»]
5LKSelectron microscopy3.60SI1-208[»]
5OA3electron microscopy4.30I1-208[»]
5T2Celectron microscopy3.60Au1-208[»]
5VYCX-ray6.00I1/I2/I3/I4/I5/I61-208[»]
6EK0electron microscopy2.90SI1-208[»]
6FECelectron microscopy6.30o2-207[»]
6G18electron microscopy3.60I1-208[»]
6G4Selectron microscopy4.00I1-208[»]
6G4Welectron microscopy4.50I1-208[»]
6G51electron microscopy4.10I1-208[»]
6G53electron microscopy4.50I1-208[»]
6G5Helectron microscopy3.60I1-208[»]
6G5Ielectron microscopy3.50I1-208[»]
ProteinModelPortaliP62241
SMRiP62241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112116, 322 interactors
CORUMiP62241
IntActiP62241, 55 interactors
MINTiP62241
STRINGi9606.ENSP00000379888

PTM databases

iPTMnetiP62241
PhosphoSitePlusiP62241
SwissPalmiP62241

Polymorphism and mutation databases

BioMutaiRPS8
DMDMi50403622

Proteomic databases

EPDiP62241
jPOSTiP62241
PaxDbiP62241
PeptideAtlasiP62241
PRIDEiP62241
ProteomicsDBi57372
TopDownProteomicsiP62241

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6202
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396651; ENSP00000379888; ENSG00000142937
GeneIDi6202
KEGGihsa:6202

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6202
DisGeNETi6202
EuPathDBiHostDB:ENSG00000142937.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPS8
HGNCiHGNC:10441 RPS8
HPAiHPA029266
MIMi600357 gene
neXtProtiNX_P62241
OpenTargetsiENSG00000142937
PharmGKBiPA34856

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3283 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000012433
HOGENOMiHOG000211544
HOVERGENiHBG030738
InParanoidiP62241
KOiK02995
OMAiAWGSEHV
OrthoDBi1278610at2759
PhylomeDBiP62241
TreeFamiTF300041

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6202
PMAP-CutDBiP62241

Protein Ontology

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PROi
PR:P62241

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000142937 Expressed in 89 organ(s), highest expression level in right ovary
ExpressionAtlasiP62241 baseline and differential
GenevisibleiP62241 HS

Family and domain databases

InterProiView protein in InterPro
IPR001047 Ribosomal_S8e
IPR022309 Ribosomal_S8e/biogenesis_NSA2
IPR018283 Ribosomal_S8e_CS
PANTHERiPTHR10394 PTHR10394, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit
TIGRFAMsiTIGR00307 eS8, 1 hit
PROSITEiView protein in PROSITE
PS01193 RIBOSOMAL_S8E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62241
Secondary accession number(s): P09058, Q6IRL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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