UniProtKB - P62195 (PRS8_HUMAN)
26S proteasome regulatory subunit 8
PSMC5
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 190 – 197 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- TBP-class protein binding Source: GO_Central
- thyrotropin-releasing hormone receptor binding Source: UniProtKB
- transcription factor binding Source: GO_Central
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- modulation of chemical synaptic transmission Source: GO_Central
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- negative regulation of programmed cell death Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: Ensembl
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- positive regulation of inclusion body assembly Source: Ensembl
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: GO_Central
- positive regulation of transcription, DNA-templated Source: UniProtKB
- post-translational protein modification Source: Reactome
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P62195 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit 8Alternative name(s): 26S proteasome AAA-ATPase subunit RPT6 Proteasome 26S subunit ATPase 5 Proteasome subunit p45 Thyroid hormone receptor-interacting protein 1 Short name: TRIP1 p45/SUG |
Gene namesi | Name:PSMC5 Synonyms:SUG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9552, PSMC5 |
MIMi | 601681, gene |
neXtProti | NX_P62195 |
VEuPathDBi | HostDB:ENSG00000087191.12 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic proteasome complex Source: GO_Central
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear proteasome complex Source: GO_Central
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: UniProtKB
- inclusion body Source: Ensembl
- membrane Source: UniProtKB
- postsynapse Source: GO_Central
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: UniProtKB
- proteasome regulatory particle, base subcomplex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5705 |
NIAGADSi | ENSG00000087191 |
OpenTargetsi | ENSG00000087191 |
PharmGKBi | PA33897 |
Miscellaneous databases
Pharosi | P62195, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Genetic variation databases
BioMutai | PSMC5 |
DMDMi | 49065819 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000084721 | 2 – 406 | 26S proteasome regulatory subunit 8Add BLAST | 405 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | ||
Modified residuei | 120 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 222 | N6-acetyllysineCombined sources | 1 | ||
Isoform 2 (identifier: P62195-2) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P62195 |
jPOSTi | P62195 |
MassIVEi | P62195 |
MaxQBi | P62195 |
PaxDbi | P62195 |
PeptideAtlasi | P62195 |
PRIDEi | P62195 |
ProteomicsDBi | 1859 57371 [P62195-1] |
PTM databases
GlyGeni | P62195, 1 site |
iPTMneti | P62195 |
MetOSitei | P62195 |
PhosphoSitePlusi | P62195 |
SwissPalmi | P62195 |
Expressioni
Gene expression databases
Bgeei | ENSG00000087191, Expressed in testis and 244 other tissues |
ExpressionAtlasi | P62195, baseline and differential |
Genevisiblei | P62195, HS |
Organism-specific databases
HPAi | ENSG00000087191, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27428775, PubMed:27342858).
Component of a complex with USP49 and RUVBL1 (PubMed:23824326).
Interacts with PRPF19.
Interacts with TRIM5 (PubMed:22078707).
Interacts with NDC80 (PubMed:9295362, PubMed:10409732).
Interacts with PAAF1 (PubMed:15831487).
Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity).
Interacts with ERCC6 (PubMed:26030138).
By similarity8 PublicationsBinary interactionsi
Hide detailsP62195
GO - Molecular functioni
- TBP-class protein binding Source: GO_Central
- thyrotropin-releasing hormone receptor binding Source: UniProtKB
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111678, 323 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P62195 |
DIPi | DIP-36645N |
IntActi | P62195, 149 interactors |
MINTi | P62195 |
STRINGi | 9606.ENSP00000310572 |
Miscellaneous databases
RNActi | P62195, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P62195 |
SMRi | P62195 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62195 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 186 – 406 | May mediate interaction with PRPF9By similarityAdd BLAST | 221 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0728, Eukaryota |
GeneTreei | ENSGT01000000214468 |
HOGENOMi | CLU_000688_2_0_1 |
InParanoidi | P62195 |
OMAi | MALDTFF |
OrthoDBi | 571919at2759 |
PhylomeDBi | P62195 |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALDGPEQME LEEGKAGSGL RQYYLSKIEE LQLIVNDKSQ NLRRLQAQRN
60 70 80 90 100
ELNAKVRLLR EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD
110 120 130 140 150
KNIDINDVTP NCRVALRNDS YTLHKILPNK VDPLVSLMMV EKVPDSTYEM
160 170 180 190 200
IGGLDKQIKE IKEVIELPVK HPELFEALGI AQPKGVLLYG PPGTGKTLLA
210 220 230 240 250
RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE HAPSIIFMDE
260 270 280 290 300
IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI
310 320 330 340 350
LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL
360 370 380 390 400
MPGASGAEVK GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS
IKKLWK
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QLH6 | J3QLH6_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 215 | Annotation score: | ||
J3QQM1 | J3QQM1_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 263 | Annotation score: | ||
J3QSA9 | J3QSA9_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 257 | Annotation score: | ||
J3KRP2 | J3KRP2_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 241 | Annotation score: | ||
J3QRW1 | J3QRW1_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 143 | Annotation score: | ||
J3QRR3 | J3QRR3_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 127 | Annotation score: | ||
J3QSE0 | J3QSE0_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 169 | Annotation score: | ||
J3KTQ9 | J3KTQ9_HUMAN | 26S proteasome regulatory subunit 8 | PSMC5 | 52 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | E → R in BAA07919 (PubMed:7729537).Curated | 1 | |
Sequence conflicti | 127 – 128 | LP → ML in AAB88187 (PubMed:9110174).Curated | 2 | |
Sequence conflicti | 266 | D → S in AAC41735 (PubMed:7776974).Curated | 1 | |
Sequence conflicti | 272 | T → Q in AAC41735 (PubMed:7776974).Curated | 1 | |
Sequence conflicti | 300 | I → M in AAC41735 (PubMed:7776974).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035901 | 60 | R → Q in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_048119 | 258 | R → W. Corresponds to variant dbSNP:rs11543211Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045441 | 1 – 8 | Missing in isoform 2. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D44467 mRNA Translation: BAA07919.1 L38810 mRNA Translation: AAC41735.1 AK290758 mRNA Translation: BAF83447.1 AK291878 mRNA Translation: BAF84567.1 AC015651 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94270.1 CH471109 Genomic DNA Translation: EAW94271.1 CH471109 Genomic DNA Translation: EAW94272.1 BC001932 mRNA Translation: AAH01932.1 BC002367 mRNA Translation: AAH02367.3 AF035309 mRNA Translation: AAB88187.1 |
CCDSi | CCDS11645.1 [P62195-1] CCDS56043.1 [P62195-2] |
PIRi | S60343 S65536 |
RefSeqi | NP_001186092.1, NM_001199163.1 [P62195-2] NP_002796.4, NM_002805.5 [P62195-1] |
Genome annotation databases
Ensembli | ENST00000310144; ENSP00000310572; ENSG00000087191 [P62195-1] ENST00000375812; ENSP00000364970; ENSG00000087191 [P62195-2] ENST00000580864; ENSP00000462495; ENSG00000087191 [P62195-2] ENST00000581882; ENSP00000463938; ENSG00000087191 [P62195-2] |
GeneIDi | 5705 |
KEGGi | hsa:5705 |
UCSCi | uc002jcb.4, human [P62195-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D44467 mRNA Translation: BAA07919.1 L38810 mRNA Translation: AAC41735.1 AK290758 mRNA Translation: BAF83447.1 AK291878 mRNA Translation: BAF84567.1 AC015651 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94270.1 CH471109 Genomic DNA Translation: EAW94271.1 CH471109 Genomic DNA Translation: EAW94272.1 BC001932 mRNA Translation: AAH01932.1 BC002367 mRNA Translation: AAH02367.3 AF035309 mRNA Translation: AAB88187.1 |
CCDSi | CCDS11645.1 [P62195-1] CCDS56043.1 [P62195-2] |
PIRi | S60343 S65536 |
RefSeqi | NP_001186092.1, NM_001199163.1 [P62195-2] NP_002796.4, NM_002805.5 [P62195-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KRK | NMR | - | A | 320-395 | [»] | |
3KW6 | X-ray | 2.10 | A | 318-395 | [»] | |
5GJQ | electron microscopy | 4.50 | J | 1-406 | [»] | |
5GJR | electron microscopy | 3.50 | J/x | 1-406 | [»] | |
5L4G | electron microscopy | 4.02 | J | 1-406 | [»] | |
5LN3 | electron microscopy | 6.80 | J | 1-406 | [»] | |
5M32 | electron microscopy | 3.80 | h | 38-392 | [»] | |
5T0C | electron microscopy | 3.80 | AC/BC | 1-406 | [»] | |
5T0G | electron microscopy | 4.40 | C | 9-406 | [»] | |
5T0H | electron microscopy | 6.80 | C | 9-406 | [»] | |
5T0I | electron microscopy | 8.00 | C | 9-406 | [»] | |
5T0J | electron microscopy | 8.00 | C | 9-406 | [»] | |
5VFP | electron microscopy | 4.20 | C | 11-402 | [»] | |
5VFQ | electron microscopy | 4.20 | C | 11-402 | [»] | |
5VFR | electron microscopy | 4.90 | C | 11-402 | [»] | |
5VFS | electron microscopy | 3.60 | C | 9-397 | [»] | |
5VFT | electron microscopy | 7.00 | C | 11-394 | [»] | |
5VFU | electron microscopy | 5.80 | C | 11-394 | [»] | |
5VGZ | electron microscopy | 3.70 | C | 11-128 | [»] | |
5VHF | electron microscopy | 5.70 | C | 11-395 | [»] | |
5VHH | electron microscopy | 6.10 | C | 11-395 | [»] | |
5VHI | electron microscopy | 6.80 | C | 11-395 | [»] | |
5VHJ | electron microscopy | 8.50 | C | 130-395 | [»] | |
5VHM | electron microscopy | 8.30 | C | 130-395 | [»] | |
5VHN | electron microscopy | 7.30 | C | 130-395 | [»] | |
5VHO | electron microscopy | 8.30 | C | 130-395 | [»] | |
5VHP | electron microscopy | 7.90 | C | 130-395 | [»] | |
5VHQ | electron microscopy | 8.90 | C | 130-395 | [»] | |
5VHR | electron microscopy | 7.70 | C | 130-395 | [»] | |
5VHS | electron microscopy | 8.80 | C | 11-395 | [»] | |
6MSB | electron microscopy | 3.00 | C | 9-406 | [»] | |
6MSD | electron microscopy | 3.20 | C | 9-406 | [»] | |
6MSG | electron microscopy | 3.50 | C | 9-406 | [»] | |
6MSH | electron microscopy | 3.60 | C | 9-406 | [»] | |
6MSJ | electron microscopy | 3.30 | C | 9-406 | [»] | |
6MSK | electron microscopy | 3.20 | C | 9-406 | [»] | |
6WJD | electron microscopy | 4.80 | C | 9-406 | [»] | |
6WJN | electron microscopy | 5.70 | C | 11-402 | [»] | |
BMRBi | P62195 | |||||
SMRi | P62195 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111678, 323 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P62195 |
DIPi | DIP-36645N |
IntActi | P62195, 149 interactors |
MINTi | P62195 |
STRINGi | 9606.ENSP00000310572 |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
PTM databases
GlyGeni | P62195, 1 site |
iPTMneti | P62195 |
MetOSitei | P62195 |
PhosphoSitePlusi | P62195 |
SwissPalmi | P62195 |
Genetic variation databases
BioMutai | PSMC5 |
DMDMi | 49065819 |
Proteomic databases
EPDi | P62195 |
jPOSTi | P62195 |
MassIVEi | P62195 |
MaxQBi | P62195 |
PaxDbi | P62195 |
PeptideAtlasi | P62195 |
PRIDEi | P62195 |
ProteomicsDBi | 1859 57371 [P62195-1] |
Protocols and materials databases
Antibodypediai | 18742, 298 antibodies |
DNASUi | 5705 |
Genome annotation databases
Ensembli | ENST00000310144; ENSP00000310572; ENSG00000087191 [P62195-1] ENST00000375812; ENSP00000364970; ENSG00000087191 [P62195-2] ENST00000580864; ENSP00000462495; ENSG00000087191 [P62195-2] ENST00000581882; ENSP00000463938; ENSG00000087191 [P62195-2] |
GeneIDi | 5705 |
KEGGi | hsa:5705 |
UCSCi | uc002jcb.4, human [P62195-1] |
Organism-specific databases
CTDi | 5705 |
DisGeNETi | 5705 |
GeneCardsi | PSMC5 |
HGNCi | HGNC:9552, PSMC5 |
HPAi | ENSG00000087191, Low tissue specificity |
MIMi | 601681, gene |
neXtProti | NX_P62195 |
NIAGADSi | ENSG00000087191 |
OpenTargetsi | ENSG00000087191 |
PharmGKBi | PA33897 |
VEuPathDBi | HostDB:ENSG00000087191.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0728, Eukaryota |
GeneTreei | ENSGT01000000214468 |
HOGENOMi | CLU_000688_2_0_1 |
InParanoidi | P62195 |
OMAi | MALDTFF |
OrthoDBi | 571919at2759 |
PhylomeDBi | P62195 |
Enzyme and pathway databases
PathwayCommonsi | P62195 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 5705, 581 hits in 879 CRISPR screens |
ChiTaRSi | PSMC5, human |
EvolutionaryTracei | P62195 |
GeneWikii | PSMC5 |
GenomeRNAii | 5705 |
Pharosi | P62195, Tbio |
PROi | PR:P62195 |
RNActi | P62195, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087191, Expressed in testis and 244 other tissues |
ExpressionAtlasi | P62195, baseline and differential |
Genevisiblei | P62195, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRS8_HUMAN | |
Accessioni | P62195Primary (citable) accession number: P62195 Secondary accession number(s): A8K3Z3 P52916 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | June 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families