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Protein

Calmodulin

Gene

Cam

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+ (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca2+ influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104).By similarity1 Publication

Miscellaneous

This protein has four functional calcium-binding sites.
Two alternative gene models exist that generate identical translations.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • myosin heavy chain binding Source: FlyBase
  • myosin V binding Source: FlyBase
  • myosin VI head/neck binding Source: FlyBase

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:Cam
ORF Names:CG8472
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000253 Cam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001982782 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei95N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

Trimethylation of Lys-116 observed in other calmodulins is absent here, but does occur at Lys-95 specifically in the compound eye.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116Not N6-methylated1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP62152
PRIDEiP62152

Expressioni

Gene expression databases

BgeeiFBgn0000253 Expressed in 66 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiP62152 baseline and differential
GenevisibleiP62152 DM

Interactioni

Subunit structurei

Interacts with Crag (PubMed:18331716). Interacts with stac (PubMed:9813038).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62106, 57 interactors
DIPiDIP-42091N
ELMiP62152
IntActiP62152, 62 interactors
MINTiP62152
STRINGi7227.FBpp0293502

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00344
ProteinModelPortaliP62152
SMRiP62152
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62152

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
InParanoidiP62152
KOiK02183
OMAiESELTDM
OrthoDBiEOG091G0V73
PhylomeDBiP62152

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P62152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVTMMTSK
Length:149
Mass (Da):16,811
Last modified:January 23, 2007 - v2
Checksum:i6B44A8917FC7027B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LF57A0A0B4LF57_DROME
Calmodulin, isoform C
Cam CG8472, Dmel_CG8472
149Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00133 mRNA Translation: CAA68327.1
X05948 Genomic DNA Translation: CAA29380.1
X05949 Genomic DNA Translation: CAA29381.1
X05950 Genomic DNA Translation: CAB51566.1
X05951 Genomic DNA Translation: CAA29383.1
AE013599 Genomic DNA Translation: AAF58542.1
AE013599 Genomic DNA Translation: AAF58543.1
AY118890 mRNA Translation: AAM50750.1
BT003282 mRNA Translation: AAO25039.1
PIRiS01173 MCFF
RefSeqiNP_001246276.1, NM_001259347.2
NP_001246277.1, NM_001259348.3
NP_001286337.1, NM_001299408.1
NP_523710.1, NM_078986.3
NP_725120.1, NM_165870.2
UniGeneiDm.577

Genome annotation databases

EnsemblMetazoaiFBtr0088001; FBpp0087109; FBgn0000253
FBtr0088002; FBpp0087110; FBgn0000253
FBtr0304963; FBpp0293502; FBgn0000253
FBtr0304964; FBpp0293503; FBgn0000253
FBtr0345018; FBpp0311269; FBgn0000253
GeneIDi36329
KEGGidme:Dmel_CG8472
UCSCiCG8472-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCALM_DROME
AccessioniPrimary (citable) accession number: P62152
Secondary accession number(s): P07181, Q9V3T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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