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Entry version 171 (07 Apr 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Calmodulin

Gene

Cam

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+ (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca2+ influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420).By similarity3 Publications

Miscellaneous

This protein has four functional calcium-binding sites.
Two alternative gene models exist that generate identical translations.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-111932, CaMK IV-mediated phosphorylation of CREB
R-DME-111933, Calmodulin induced events
R-DME-111957, Cam-PDE 1 activation
R-DME-114608, Platelet degranulation
R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-163615, PKA activation
R-DME-1855204, Synthesis of IP3 and IP4 in the cytosol
R-DME-2025928, Calcineurin activates NFAT
R-DME-203615, eNOS activation
R-DME-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-4086398, Ca2+ pathway
R-DME-442729, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-DME-451308, Activation of Ca-permeable Kainate Receptor
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5578775, Ion homeostasis
R-DME-5607763, CLEC7A (Dectin-1) induces NFAT activation
R-DME-6798695, Neutrophil degranulation
R-DME-70221, Glycogen breakdown (glycogenolysis)
R-DME-8876725, Protein methylation
R-DME-9009391, Extra-nuclear estrogen signaling
R-DME-936837, Ion transport by P-type ATPases
R-DME-9619229, Activation of RAC1 downstream of NMDARs
R-DME-9648002, RAS processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cam
ORF Names:CG8472
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000253, Cam

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in the perineurial glia increases ethanol sedation resistance and decreases ethanol tolerance.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001982782 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei95N6,N6,N6-trimethyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Trimethylation of Lys-116 observed in other calmodulins is absent here, but does occur at Lys-95 specifically in the compound eye.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei116Not N6-methylated1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62152

PRoteomics IDEntifications database

More...
PRIDEi
P62152

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000253, Expressed in cleaving embryo and 73 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P62152, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P62152, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Crag (PubMed:18331716).

Interacts with stac (PubMed:9813038).

Interacts with Akap200; the interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62106, 64 interactors

Database of interacting proteins

More...
DIPi
DIP-42091N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P62152

Protein interaction database and analysis system

More...
IntActi
P62152, 62 interactors

Molecular INTeraction database

More...
MINTi
P62152

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293502

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62152

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P62152

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0027, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162930

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_061288_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62152

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPHESSN

Database of Orthologous Groups

More...
OrthoDBi
1386217at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62152

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 2 hits

Database of protein disorder

More...
DisProti
DP00344

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50080

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039030, Calmodulin
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23050:SF401, PTHR23050:SF401, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499, EF-hand_7, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVTMMTSK
Length:149
Mass (Da):16,811
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B44A8917FC7027B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LF57A0A0B4LF57_DROME
Calmodulin
Cam 3909, anon-EST:Posey59, Cal, Cal49A, CalA
149Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00133 mRNA Translation: CAA68327.1
X05948 Genomic DNA Translation: CAA29380.1
X05949 Genomic DNA Translation: CAA29381.1
X05950 Genomic DNA Translation: CAB51566.1
X05951 Genomic DNA Translation: CAA29383.1
AE013599 Genomic DNA Translation: AAF58542.1
AE013599 Genomic DNA Translation: AAF58543.1
AY118890 mRNA Translation: AAM50750.1
BT003282 mRNA Translation: AAO25039.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S01173, MCFF

NCBI Reference Sequences

More...
RefSeqi
NP_001246276.1, NM_001259347.2
NP_001246277.1, NM_001259348.3
NP_001286337.1, NM_001299408.1
NP_523710.1, NM_078986.3
NP_725120.1, NM_165870.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0088001; FBpp0087109; FBgn0000253
FBtr0088002; FBpp0087110; FBgn0000253
FBtr0304963; FBpp0293502; FBgn0000253
FBtr0304964; FBpp0293503; FBgn0000253
FBtr0345018; FBpp0311269; FBgn0000253

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8472

UCSC genome browser

More...
UCSCi
CG8472-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00133 mRNA Translation: CAA68327.1
X05948 Genomic DNA Translation: CAA29380.1
X05949 Genomic DNA Translation: CAA29381.1
X05950 Genomic DNA Translation: CAB51566.1
X05951 Genomic DNA Translation: CAA29383.1
AE013599 Genomic DNA Translation: AAF58542.1
AE013599 Genomic DNA Translation: AAF58543.1
AY118890 mRNA Translation: AAM50750.1
BT003282 mRNA Translation: AAO25039.1
PIRiS01173, MCFF
RefSeqiNP_001246276.1, NM_001259347.2
NP_001246277.1, NM_001259348.3
NP_001286337.1, NM_001299408.1
NP_523710.1, NM_078986.3
NP_725120.1, NM_165870.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MXEX-ray1.70A/B2-149[»]
2BBMNMR-A2-149[»]
2BBNNMR-A2-149[»]
2BKHX-ray2.40B2-148[»]
2VASX-ray2.40B1-149[»]
2X51X-ray2.20B1-149[»]
3GN4X-ray2.70B/D/F/H1-149[»]
3L9IX-ray2.20C1-149[»]
4ANJX-ray2.60B1-149[»]
4CLNX-ray2.20A2-149[»]
4DBPX-ray2.20C1-149[»]
4DBQX-ray2.60B1-149[»]
4PJJX-ray2.40B1-149[»]
SMRiP62152
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi62106, 64 interactors
DIPiDIP-42091N
ELMiP62152
IntActiP62152, 62 interactors
MINTiP62152
STRINGi7227.FBpp0293502

Proteomic databases

PaxDbiP62152
PRIDEiP62152

Genome annotation databases

EnsemblMetazoaiFBtr0088001; FBpp0087109; FBgn0000253
FBtr0088002; FBpp0087110; FBgn0000253
FBtr0304963; FBpp0293502; FBgn0000253
FBtr0304964; FBpp0293503; FBgn0000253
FBtr0345018; FBpp0311269; FBgn0000253
GeneIDi36329
KEGGidme:Dmel_CG8472
UCSCiCG8472-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36329
FlyBaseiFBgn0000253, Cam

Phylogenomic databases

eggNOGiKOG0027, Eukaryota
GeneTreeiENSGT00940000162930
HOGENOMiCLU_061288_2_0_1
InParanoidiP62152
OMAiSPHESSN
OrthoDBi1386217at2759
PhylomeDBiP62152

Enzyme and pathway databases

ReactomeiR-DME-111932, CaMK IV-mediated phosphorylation of CREB
R-DME-111933, Calmodulin induced events
R-DME-111957, Cam-PDE 1 activation
R-DME-114608, Platelet degranulation
R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-163615, PKA activation
R-DME-1855204, Synthesis of IP3 and IP4 in the cytosol
R-DME-2025928, Calcineurin activates NFAT
R-DME-203615, eNOS activation
R-DME-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-4086398, Ca2+ pathway
R-DME-442729, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-DME-451308, Activation of Ca-permeable Kainate Receptor
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5578775, Ion homeostasis
R-DME-5607763, CLEC7A (Dectin-1) induces NFAT activation
R-DME-6798695, Neutrophil degranulation
R-DME-70221, Glycogen breakdown (glycogenolysis)
R-DME-8876725, Protein methylation
R-DME-9009391, Extra-nuclear estrogen signaling
R-DME-936837, Ion transport by P-type ATPases
R-DME-9619229, Activation of RAC1 downstream of NMDARs
R-DME-9648002, RAS processing

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
36329, 2 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cam, fly
EvolutionaryTraceiP62152

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36329

Protein Ontology

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PROi
PR:P62152

Gene expression databases

BgeeiFBgn0000253, Expressed in cleaving embryo and 73 other tissues
ExpressionAtlasiP62152, baseline and differential
GenevisibleiP62152, DM

Family and domain databases

CDDicd00051, EFh, 2 hits
DisProtiDP00344
IDEALiIID50080
InterProiView protein in InterPro
IPR039030, Calmodulin
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PANTHERiPTHR23050:SF401, PTHR23050:SF401, 1 hit
PfamiView protein in Pfam
PF13499, EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054, EFh, 4 hits
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCALM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62152
Secondary accession number(s): P07181, Q9V3T4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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