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Protein

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Gene

PPP1CA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).5 Publications

Caution

Was originally thought to be part of the MLL5-L complex, at least composed of KMT2E, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT (PubMed:19377461). However, the corresponding article has been retracted (PubMed:24336203).2 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Mn2+1 PublicationNote: Binds 2 manganese ions per subunit.1 Publication

Activity regulationi

The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Manganese 1By similarity1
Metal bindingi66Manganese 1By similarity1
Metal bindingi92Manganese1
Metal bindingi92Manganese 1By similarity1
Metal bindingi92Manganese 2By similarity1
Metal bindingi124Manganese1
Metal bindingi124Manganese 2By similarity1
Active sitei125Proton donorBy similarity1
Metal bindingi173Manganese1
Metal bindingi173Manganese 2By similarity1
Metal bindingi248Manganese1
Metal bindingi248Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCarbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-180024 DARPP-32 events
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-400253 Circadian Clock
SignaLinkiP62136
SIGNORiP62136

Protein family/group databases

MoonDBiP62136 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (EC:3.1.3.161 Publication)
Short name:
PP-1A
Gene namesi
Name:PPP1CA
Synonyms:PPP1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172531.14
HGNCiHGNC:9281 PPP1CA
MIMi176875 gene
neXtProtiNX_P62136

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5499
OpenTargetsiENSG00000172531
PharmGKBiPA33609

Chemistry databases

ChEMBLiCHEMBL2164

Polymorphism and mutation databases

BioMutaiPPP1CA
DMDMi49065811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000587742 – 330Serine/threonine-protein phosphatase PP1-alpha catalytic subunitAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei305N6-acetyllysineBy similarity1
Modified residuei306PhosphotyrosineBy similarity1
Modified residuei320PhosphothreonineCombined sources1 Publication1
Modified residuei325PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62136
MaxQBiP62136
PaxDbiP62136
PeptideAtlasiP62136
PRIDEiP62136
ProteomicsDBi57365
57366 [P62136-2]
TopDownProteomicsiP62136-1 [P62136-1]

2D gel databases

OGPiP08129

PTM databases

DEPODiP62136
iPTMnetiP62136
PhosphoSitePlusiP62136
SwissPalmiP62136

Expressioni

Inductioni

Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.1 Publication

Gene expression databases

BgeeiENSG00000172531 Expressed in 226 organ(s), highest expression level in endometrium epithelium
CleanExiHS_PPP1CA
ExpressionAtlasiP62136 baseline and differential
GenevisibleiP62136 HS

Organism-specific databases

HPAiCAB004545
HPA046833

Interactioni

Subunit structurei

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PHACTR4; which acts as an activator of PP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site. Interacts with isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320. Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with FOXP3 (PubMed:23396208). Interacts with CENPA (PubMed:25556658). Interacts with ATG16L1 (PubMed:26083323). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).By similarity19 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1P317494EBI-357253,EBI-296087
APAF1O147272EBI-357253,EBI-446492
AXIN1O151694EBI-357253,EBI-710484
BRCA1P383982EBI-357253,EBI-349905
CD2BP2O954002EBI-357253,EBI-768015
CDC5LQ994592EBI-357253,EBI-374880
CDH1P128302EBI-357253,EBI-727477
CEP192Q8TEP82EBI-357253,EBI-2339778
CHCHD3Q9NX632EBI-357253,EBI-743375
ClockO087852EBI-357253,EBI-79859From Mus musculus.
CNSTQ6PJW83EBI-357253,EBI-750390
CSRNP1Q96S656EBI-357253,EBI-4311573
CSRNP2Q9H1758EBI-357253,EBI-5235958
DLG3Q927962EBI-357253,EBI-80440
ELLP551992EBI-357253,EBI-1245868
FOXP3Q9BZS12EBI-357253,EBI-983719
KNL1Q8NG312EBI-357253,EBI-1001161
LRRK2Q5S0076EBI-357253,EBI-5323863
MPHOSPH10O005662EBI-357253,EBI-5235884
ORF23Q76TK52EBI-357253,EBI-14033469From Human herpesvirus 8.
PPP1R10Q96QC03EBI-357253,EBI-1210346
PPP1R13BQ96KQ49EBI-357253,EBI-1105153
PPP1R13LQ8WUF57EBI-357253,EBI-5550163
PPP1R15AO758075EBI-357253,EBI-714746
PPP1R15BQ5SWA15EBI-357253,EBI-2815482
PPP1R18Q6NYC84EBI-357253,EBI-2557469
PPP1R2P4123610EBI-357253,EBI-1056517
PPP1R26Q5T8A72EBI-357253,EBI-308500
PPP1R27Q86WC66EBI-357253,EBI-5235602
PPP1R2BQ6NXS15EBI-357253,EBI-10251630
PPP1R32Q7Z5V63EBI-357253,EBI-4311771
PPP1R37O758644EBI-357253,EBI-5235692
PPP1R3BQ86XI63EBI-357253,EBI-3918864
PPP1R3CQ9UQK14EBI-357253,EBI-2506727
PPP1R7Q154356EBI-357253,EBI-1024281
PPP1R8Q129727EBI-357253,EBI-716633
PPP1R8Q12972-16EBI-357253,EBI-16012257
PPP1R8Q12972-24EBI-357253,EBI-12252736
Ppp1r9aO358673EBI-357253,EBI-7092421From Rattus norvegicus.
PPP1R9BQ96SB35EBI-357253,EBI-351275
Ppp1r9bO352748EBI-357253,EBI-80022From Rattus norvegicus.
PTENP604842EBI-357253,EBI-696162
RB1P064002EBI-357253,EBI-491274
RIF1Q5UIP04EBI-357253,EBI-711331
RL1P363134EBI-357253,EBI-6149234From Human herpesvirus 1 (strain 17).
RRP1BQ146843EBI-357253,EBI-372051
SFI1A8K8P32EBI-357253,EBI-743371
SGO2Q562F64EBI-357253,EBI-989213
SH2D4AQ9H7882EBI-357253,EBI-747035
SH3RF2Q8TEC53EBI-357253,EBI-2130111
SKP1P632083EBI-357253,EBI-307486
SPRED1Q7Z6994EBI-357253,EBI-5235340
SYTL2Q9HCH52EBI-357253,EBI-2690103
TMEM132DQ14C872EBI-357253,EBI-5235567
TP53BP2Q136259EBI-357253,EBI-77642
TPRNQ4KMQ13EBI-357253,EBI-3942777
TRPC4APQ8TEL62EBI-357253,EBI-2559060
TSC2P498152EBI-357253,EBI-396587
VCPP550722EBI-357253,EBI-355164
WBP11Q9Y2W23EBI-357253,EBI-714455
WNK1Q9H4A32EBI-357253,EBI-457907
YBX3P169893EBI-357253,EBI-358193
YLPM1P497503EBI-357253,EBI-712871
ZFYVE1Q9HBF42EBI-357253,EBI-4401611
ZFYVE9O954053EBI-357253,EBI-296817

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111493, 338 interactors
CORUMiP62136
DIPiDIP-221N
DIP-38195N
ELMiP62136
IntActiP62136, 377 interactors
MINTiP62136
STRINGi9606.ENSP00000326031

Chemistry databases

BindingDBiP62136

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62136
SMRiP62136
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62136

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN85 Eukaryota
ENOG410XPVF LUCA
GeneTreeiENSGT00530000062911
HOGENOMiHOG000172697
HOVERGENiHBG000216
InParanoidiP62136
KOiK06269
OMAiYLVMESR
OrthoDBiEOG091G0EKF
PhylomeDBiP62136
TreeFamiTF354243

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR037979 PPP1CA/PPP1CB
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PANTHERiPTHR11668:SF377 PTHR11668:SF377, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL
210 220 230 240 250
LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD
310 320 330
KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK
Length:330
Mass (Da):37,512
Last modified:June 21, 2004 - v1
Checksum:i60C37E1AD9831DAC
GO
Isoform 2 (identifier: P62136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-18: E → EGSRVLTPHCAP

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):38,631
Checksum:iCE50F8B9DC84AB6F
GO
Isoform 3 (identifier: P62136-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-62: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:286
Mass (Da):32,595
Checksum:iE0560E7C422C353C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMD7E9PMD7_HUMAN
Serine/threonine-protein phosphatas...
PPP1CA
253Annotation score:
F5H1L6F5H1L6_HUMAN
Serine/threonine-protein phosphatas...
PPP1CA
169Annotation score:
F5H037F5H037_HUMAN
Serine/threonine-protein phosphatas...
PPP1CA
179Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04337718E → EGSRVLTPHCAP in isoform 2. 1 Publication1
Alternative sequenceiVSP_04675419 – 62Missing in isoform 3. CuratedAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70848 mRNA Translation: CAA50197.1
S57501 mRNA Translation: AAB26015.1
M63960 mRNA Translation: AAA36508.1
AK313586 mRNA Translation: BAG36355.1
BT006629 mRNA Translation: AAP35275.1
AP003419 Genomic DNA No translation available.
BC001888 mRNA Translation: AAH01888.1
BC004482 mRNA Translation: AAH04482.1
BC008010 mRNA Translation: AAH08010.1
J04759 mRNA Translation: AAA36475.1
CCDSiCCDS31618.1 [P62136-2]
CCDS8160.1 [P62136-1]
CCDS8161.1 [P62136-3]
RefSeqiNP_001008709.1, NM_001008709.1 [P62136-2]
NP_002699.1, NM_002708.3 [P62136-1]
NP_996756.1, NM_206873.1 [P62136-3]
UniGeneiHs.183994

Genome annotation databases

EnsembliENST00000312989; ENSP00000326031; ENSG00000172531 [P62136-2]
ENST00000358239; ENSP00000350974; ENSG00000172531 [P62136-3]
ENST00000376745; ENSP00000365936; ENSG00000172531 [P62136-1]
GeneIDi5499
KEGGihsa:5499
UCSCiuc001oku.2 human [P62136-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The things we forget - Issue 32 of March 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70848 mRNA Translation: CAA50197.1
S57501 mRNA Translation: AAB26015.1
M63960 mRNA Translation: AAA36508.1
AK313586 mRNA Translation: BAG36355.1
BT006629 mRNA Translation: AAP35275.1
AP003419 Genomic DNA No translation available.
BC001888 mRNA Translation: AAH01888.1
BC004482 mRNA Translation: AAH04482.1
BC008010 mRNA Translation: AAH08010.1
J04759 mRNA Translation: AAA36475.1
CCDSiCCDS31618.1 [P62136-2]
CCDS8160.1 [P62136-1]
CCDS8161.1 [P62136-3]
RefSeqiNP_001008709.1, NM_001008709.1 [P62136-2]
NP_002699.1, NM_002708.3 [P62136-1]
NP_996756.1, NM_206873.1 [P62136-3]
UniGeneiHs.183994

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E7AX-ray1.63A/B7-300[»]
3E7BX-ray1.70A/B7-300[»]
3EGGX-ray1.85A/B7-330[»]
3EGHX-ray2.00A/B7-330[»]
3HVQX-ray2.20A/B7-330[»]
3N5UX-ray3.20A/B1-300[»]
3V4YX-ray2.10A/C/E/G7-307[»]
4G9JX-ray3.10A/B1-330[»]
4MOVX-ray1.45A/B7-300[»]
4MOYX-ray2.20A7-300[»]
4MP0X-ray2.10A/C7-300[»]
4XPNX-ray2.29A/C7-300[»]
5IOHX-ray2.57A/C7-300[»]
6ALZX-ray2.21A/B7-300[»]
ProteinModelPortaliP62136
SMRiP62136
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111493, 338 interactors
CORUMiP62136
DIPiDIP-221N
DIP-38195N
ELMiP62136
IntActiP62136, 377 interactors
MINTiP62136
STRINGi9606.ENSP00000326031

Chemistry databases

BindingDBiP62136
ChEMBLiCHEMBL2164

Protein family/group databases

MoonDBiP62136 Predicted

PTM databases

DEPODiP62136
iPTMnetiP62136
PhosphoSitePlusiP62136
SwissPalmiP62136

Polymorphism and mutation databases

BioMutaiPPP1CA
DMDMi49065811

2D gel databases

OGPiP08129

Proteomic databases

EPDiP62136
MaxQBiP62136
PaxDbiP62136
PeptideAtlasiP62136
PRIDEiP62136
ProteomicsDBi57365
57366 [P62136-2]
TopDownProteomicsiP62136-1 [P62136-1]

Protocols and materials databases

DNASUi5499
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312989; ENSP00000326031; ENSG00000172531 [P62136-2]
ENST00000358239; ENSP00000350974; ENSG00000172531 [P62136-3]
ENST00000376745; ENSP00000365936; ENSG00000172531 [P62136-1]
GeneIDi5499
KEGGihsa:5499
UCSCiuc001oku.2 human [P62136-1]

Organism-specific databases

CTDi5499
DisGeNETi5499
EuPathDBiHostDB:ENSG00000172531.14
GeneCardsiPPP1CA
HGNCiHGNC:9281 PPP1CA
HPAiCAB004545
HPA046833
MIMi176875 gene
neXtProtiNX_P62136
OpenTargetsiENSG00000172531
PharmGKBiPA33609
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN85 Eukaryota
ENOG410XPVF LUCA
GeneTreeiENSGT00530000062911
HOGENOMiHOG000172697
HOVERGENiHBG000216
InParanoidiP62136
KOiK06269
OMAiYLVMESR
OrthoDBiEOG091G0EKF
PhylomeDBiP62136
TreeFamiTF354243

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-180024 DARPP-32 events
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-400253 Circadian Clock
SignaLinkiP62136
SIGNORiP62136

Miscellaneous databases

ChiTaRSiPPP1CA human
EvolutionaryTraceiP62136
GeneWikiiPPP1CA
GenomeRNAii5499
PROiPR:P62136
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172531 Expressed in 226 organ(s), highest expression level in endometrium epithelium
CleanExiHS_PPP1CA
ExpressionAtlasiP62136 baseline and differential
GenevisibleiP62136 HS

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR037979 PPP1CA/PPP1CB
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PANTHERiPTHR11668:SF377 PTHR11668:SF377, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPP1A_HUMAN
AccessioniPrimary (citable) accession number: P62136
Secondary accession number(s): A6NNR3
, B2R908, P08129, P20653, P22802, Q07161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 21, 2004
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
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