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Entry version 184 (07 Apr 2021)
Sequence version 1 (21 Jun 2004)
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Protein

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Gene

PPP1CA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).5 Publications
(Microbial infection) Necessary for alphaviruses replication.1 Publication

Caution

Was originally thought to be part of the MLL5-L complex, at least composed of KMT2E, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT (PubMed:19377461). However, the corresponding article has been retracted (PubMed:24336203).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64Manganese 1By similarity1
Metal bindingi66Manganese 1By similarity1
Metal bindingi92Manganese1
Metal bindingi92Manganese 1By similarity1
Metal bindingi92Manganese 2By similarity1
Metal bindingi124Manganese1
Metal bindingi124Manganese 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Proton donorBy similarity1
Metal bindingi173Manganese1
Metal bindingi173Manganese 2By similarity1
Metal bindingi248Manganese1
Metal bindingi248Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCarbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Host-virus interaction
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.1.3.16, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P62136

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-163560, Triglyceride catabolism
R-HSA-180024, DARPP-32 events
R-HSA-2173788, Downregulation of TGF-beta receptor signaling
R-HSA-400253, Circadian Clock

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P62136

SIGNOR Signaling Network Open Resource

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SIGNORi
P62136

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P62136, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (EC:3.1.3.161 Publication)
Short name:
PP-1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1CA
Synonyms:PPP1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9281, PPP1CA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176875, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P62136

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000172531.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
5499

Open Targets

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OpenTargetsi
ENSG00000172531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33609

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P62136, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2164

Drug and drug target database

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DrugBanki
DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PPP1CA

Domain mapping of disease mutations (DMDM)

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DMDMi
49065811

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000587742 – 330Serine/threonine-protein phosphatase PP1-alpha catalytic subunitAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei305N6-acetyllysineBy similarity1
Modified residuei306PhosphotyrosineBy similarity1
Modified residuei320PhosphothreonineCombined sources1 Publication1
Modified residuei325PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62136

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62136

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P62136

MaxQB - The MaxQuant DataBase

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MaxQBi
P62136

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62136

PeptideAtlas

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PeptideAtlasi
P62136

PRoteomics IDEntifications database

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PRIDEi
P62136

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
1632
57365 [P62136-1]
57366 [P62136-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62136-1 [P62136-1]

2D gel databases

USC-OGP 2-DE database

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OGPi
P08129

PTM databases

DEPOD human dephosphorylation database

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DEPODi
PPP1CA

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62136

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62136

SwissPalm database of S-palmitoylation events

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SwissPalmi
P62136

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000172531, Expressed in endometrium epithelium and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62136, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62136, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000172531, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen.

Interacts with PPP1R39 (By similarity).

Interacts with BTBD10 (By similarity).

Interacts with KCTD20 (By similarity).

Interacts with PPP1R9A and PPP1R9B.

Part of a complex containing PPP1R15B, PP1 and NCK1/2.

Interacts with PHACTR4; which acts as an activator of PP1 activity (By similarity).

Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1.

Interacts with PPP1R7.

Interacts with YLPM1.

Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5.

Interacts with NOM1 and PPP1R8.

Interacts with PPP1R16B.

Interacts with RPSA only in the presence of PPP1R16B.

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC.

Interacts with PPP1R10/PNUTS and PPP1R8.

Interacts with WDR82 in the presence of PPP1R10/PNUTS.

Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site.

Interacts with isoform 1 and isoform 4 of NEK2.

Interacts with FER; this promotes phosphorylation at Thr-320.

Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction.

Interacts with FOXP3 (PubMed:23396208).

Interacts with CENPA (PubMed:25556658).

Interacts with ATG16L1 (PubMed:26083323).

Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).

By similarity19 Publications

(Microbial infection) Interacts with HHV-1 ICP34.5.

1 Publication

(Microbial infection) Interacts with Venezuelan equine encephalitis virus (VEEV) capsid protein; this interaction dephosphorylates the capsid protein, which increases its ability to bind to the viral genome.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P62136
With#Exp.IntAct
AATK [Q6ZMQ8]3EBI-357253,EBI-2008380
AKT1 [P31749]4EBI-357253,EBI-296087
APAF1 [O14727]2EBI-357253,EBI-446492
APP [P05067]3EBI-357253,EBI-77613
AXIN1 [O15169]4EBI-357253,EBI-710484
BRCA1 [P38398]2EBI-357253,EBI-349905
CD2BP2 [O95400]2EBI-357253,EBI-768015
CDC5L [Q99459]2EBI-357253,EBI-374880
CDH1 [P12830]2EBI-357253,EBI-727477
CEP192 [Q8TEP8]2EBI-357253,EBI-2339778
CHCHD3 [Q9NX63]2EBI-357253,EBI-743375
CNST [Q6PJW8]4EBI-357253,EBI-750390
CSRNP1 [Q96S65]8EBI-357253,EBI-4311573
CSRNP2 [Q9H175]10EBI-357253,EBI-5235958
DLG3 [Q92796]2EBI-357253,EBI-80440
ELL [P55199]2EBI-357253,EBI-1245868
FOXP3 [Q9BZS1]2EBI-357253,EBI-983719
HTT [P42858]10EBI-357253,EBI-466029
KIF18A [Q8NI77]3EBI-357253,EBI-355426
KNL1 [Q8NG31]2EBI-357253,EBI-1001161
LRRK2 [Q5S007]6EBI-357253,EBI-5323863
MPHOSPH10 [O00566]2EBI-357253,EBI-5235884
PPP1R10 [Q96QC0]4EBI-357253,EBI-1210346
PPP1R13B [Q96KQ4]11EBI-357253,EBI-1105153
PPP1R13L [Q8WUF5]8EBI-357253,EBI-5550163
PPP1R15A [O75807]5EBI-357253,EBI-714746
PPP1R15B [Q5SWA1]5EBI-357253,EBI-2815482
PPP1R16B [Q96T49]4EBI-357253,EBI-10293968
PPP1R18 [Q6NYC8]5EBI-357253,EBI-2557469
PPP1R2 [P41236]11EBI-357253,EBI-1056517
PPP1R26 [Q5T8A7]2EBI-357253,EBI-308500
PPP1R27 [Q86WC6]5EBI-357253,EBI-5235602
PPP1R2B [Q6NXS1]3EBI-357253,EBI-10251630
PPP1R2C [O14990]3EBI-357253,EBI-12404293
PPP1R32 [Q7Z5V6]3EBI-357253,EBI-4311771
PPP1R37 [O75864]5EBI-357253,EBI-5235692
PPP1R3B [Q86XI6]4EBI-357253,EBI-3918864
PPP1R3C [Q9UQK1]5EBI-357253,EBI-2506727
PPP1R3D [O95685]3EBI-357253,EBI-1045661
PPP1R7 [Q15435]7EBI-357253,EBI-1024281
PPP1R8 [Q12972]7EBI-357253,EBI-716633
PPP1R8 - isoform Alpha [Q12972-1]6EBI-357253,EBI-16012257
PPP1R8 - isoform Beta [Q12972-2]7EBI-357253,EBI-12252736
PPP1R9B [Q96SB3]6EBI-357253,EBI-351275
PTEN [P60484]2EBI-357253,EBI-696162
RB1 [P06400]2EBI-357253,EBI-491274
RIF1 [Q5UIP0]4EBI-357253,EBI-711331
RRP1B [Q14684]3EBI-357253,EBI-372051
S100B [P04271]3EBI-357253,EBI-458391
SFI1 [A8K8P3]2EBI-357253,EBI-743371
SGO2 [Q562F6]4EBI-357253,EBI-989213
SH2D4A [Q9H788]3EBI-357253,EBI-747035
SH3RF2 [Q8TEC5]3EBI-357253,EBI-2130111
SKP1 [P63208]3EBI-357253,EBI-307486
SPRED1 [Q7Z699]4EBI-357253,EBI-5235340
SYK - isoform Short [P43405-2]3EBI-357253,EBI-25892332
SYTL2 [Q9HCH5]2EBI-357253,EBI-2690103
TMEM132D [Q14C87]2EBI-357253,EBI-5235567
TOR1AIP1 [Q5JTV8]2EBI-357253,EBI-2559665
TP53BP2 [Q05BL1]3EBI-357253,EBI-11952721
TP53BP2 [Q13625]9EBI-357253,EBI-77642
TPRN [Q4KMQ1]3EBI-357253,EBI-3942777
TPRN - isoform 2 [Q4KMQ1-2]6EBI-357253,EBI-11978969
TRPC4AP [Q8TEL6]2EBI-357253,EBI-2559060
TSC2 [P49815]2EBI-357253,EBI-396587
VCP [P55072]2EBI-357253,EBI-355164
WBP11 [Q9Y2W2]4EBI-357253,EBI-714455
WNK1 [Q9H4A3]2EBI-357253,EBI-457907
YBX3 [P16989]3EBI-357253,EBI-358193
YLPM1 [P49750]3EBI-357253,EBI-712871
ZFYVE1 [Q9HBF4]2EBI-357253,EBI-4401611
ZFYVE9 [O95405]3EBI-357253,EBI-296817
Clock [O08785] from Mus musculus.2EBI-357253,EBI-79859
ICP34.5 [P36313] from Human herpesvirus 1 (strain 17).4EBI-357253,EBI-6149234
ORF23 [Q76TK5] from Human herpesvirus 8.2EBI-357253,EBI-14033469
Ppp1r9a [O35867] from Rattus norvegicus.3EBI-357253,EBI-7092421
Ppp1r9b [O35274] from Rattus norvegicus.8EBI-357253,EBI-80022

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111493, 484 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62136

Database of interacting proteins

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DIPi
DIP-221N
DIP-38195N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P62136

Protein interaction database and analysis system

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IntActi
P62136, 407 interactors

Molecular INTeraction database

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MINTi
P62136

STRING: functional protein association networks

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STRINGi
9606.ENSP00000326031

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P62136

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P62136, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...
SASBDBi
P62136

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62136

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P62136

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0374, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004962_8_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62136

Identification of Orthologs from Complete Genome Data

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OMAi
YLVMESR

Database for complete collections of gene phylogenies

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PhylomeDBi
P62136

TreeFam database of animal gene trees

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TreeFami
TF354243

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.60.21.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00311

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
IPR037979, PPP1CA
IPR006186, Ser/Thr-sp_prot-phosphatase
IPR031675, STPPase_N

The PANTHER Classification System

More...
PANTHERi
PTHR11668:SF377, PTHR11668:SF377, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00149, Metallophos, 1 hit
PF16891, STPPase_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00114, STPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00156, PP2Ac, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00125, SER_THR_PHOSPHATASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL
210 220 230 240 250
LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD
310 320 330
KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK
Length:330
Mass (Da):37,512
Last modified:June 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60C37E1AD9831DAC
GO
Isoform 2 (identifier: P62136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-18: E → EGSRVLTPHCAP

Show »
Length:341
Mass (Da):38,631
Checksum:iCE50F8B9DC84AB6F
GO
Isoform 3 (identifier: P62136-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-62: Missing.

Show »
Length:286
Mass (Da):32,595
Checksum:iE0560E7C422C353C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMD7E9PMD7_HUMAN
Serine/threonine-protein phosphatas...
PPP1CA
295Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4F7A0A7I2V4F7_HUMAN
Serine/threonine-protein phosphatas...
PPP1CA
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04337718E → EGSRVLTPHCAP in isoform 2. 1 Publication1
Alternative sequenceiVSP_04675419 – 62Missing in isoform 3. CuratedAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X70848 mRNA Translation: CAA50197.1
S57501 mRNA Translation: AAB26015.1
M63960 mRNA Translation: AAA36508.1
AK313586 mRNA Translation: BAG36355.1
BT006629 mRNA Translation: AAP35275.1
AP003419 Genomic DNA No translation available.
BC001888 mRNA Translation: AAH01888.1
BC004482 mRNA Translation: AAH04482.1
BC008010 mRNA Translation: AAH08010.1
J04759 mRNA Translation: AAA36475.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31618.1 [P62136-2]
CCDS8160.1 [P62136-1]
CCDS8161.1 [P62136-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001008709.1, NM_001008709.1 [P62136-2]
NP_002699.1, NM_002708.3 [P62136-1]
NP_996756.1, NM_206873.1 [P62136-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312989; ENSP00000326031; ENSG00000172531 [P62136-2]
ENST00000358239; ENSP00000350974; ENSG00000172531 [P62136-3]
ENST00000376745; ENSP00000365936; ENSG00000172531 [P62136-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5499

UCSC genome browser

More...
UCSCi
uc001oku.2, human [P62136-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The things we forget - Issue 32 of March 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70848 mRNA Translation: CAA50197.1
S57501 mRNA Translation: AAB26015.1
M63960 mRNA Translation: AAA36508.1
AK313586 mRNA Translation: BAG36355.1
BT006629 mRNA Translation: AAP35275.1
AP003419 Genomic DNA No translation available.
BC001888 mRNA Translation: AAH01888.1
BC004482 mRNA Translation: AAH04482.1
BC008010 mRNA Translation: AAH08010.1
J04759 mRNA Translation: AAA36475.1
CCDSiCCDS31618.1 [P62136-2]
CCDS8160.1 [P62136-1]
CCDS8161.1 [P62136-3]
RefSeqiNP_001008709.1, NM_001008709.1 [P62136-2]
NP_002699.1, NM_002708.3 [P62136-1]
NP_996756.1, NM_206873.1 [P62136-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E7AX-ray1.63A/B7-300[»]
3E7BX-ray1.70A/B7-300[»]
3EGGX-ray1.85A/B7-330[»]
3EGHX-ray2.00A/B7-330[»]
3HVQX-ray2.20A/B7-330[»]
3N5UX-ray3.20A/B1-300[»]
3V4YX-ray2.10A/C/E/G7-307[»]
4G9JX-ray3.10A/B1-330[»]
4MOVX-ray1.45A/B7-300[»]
4MOYX-ray2.20A7-300[»]
4MP0X-ray2.10A/C7-300[»]
4XPNX-ray2.29A/C7-300[»]
5IOHX-ray2.57A/C7-300[»]
6ALZX-ray2.21A/B7-300[»]
6CZOX-ray2.95A/C7-300[»]
6DCXX-ray3.41A/B1-330[»]
6DNOX-ray1.45A7-300[»]
6G0IX-ray2.00A1-330[»]
6G0JX-ray2.10A1-330[»]
6GHMX-ray2.15A/B7-330[»]
6OBNX-ray2.70A/B1-300[»]
6OBPX-ray2.70A1-300[»]
6OBQX-ray1.84A/B7-300[»]
6OBRX-ray1.50A/B7-300[»]
6OBSX-ray1.80A/B7-300[»]
6OBUX-ray1.95A/B7-300[»]
6ZEEX-ray1.90A/B/I/K/P/Q7-300[»]
6ZEFX-ray1.94A/B7-300[»]
6ZEGX-ray1.09A/B7-304[»]
6ZEHX-ray1.30A/B7-304[»]
6ZEIX-ray1.39A/B7-304[»]
6ZEJX-ray1.78A/D/F/I/L/O7-304[»]
6ZK6X-ray1.90A1-330[»]
SASBDBiP62136
SMRiP62136
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111493, 484 interactors
CORUMiP62136
DIPiDIP-221N
DIP-38195N
ELMiP62136
IntActiP62136, 407 interactors
MINTiP62136
STRINGi9606.ENSP00000326031

Chemistry databases

BindingDBiP62136
ChEMBLiCHEMBL2164
DrugBankiDB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid

Protein family/group databases

MoonDBiP62136, Predicted

PTM databases

DEPODiPPP1CA
iPTMnetiP62136
PhosphoSitePlusiP62136
SwissPalmiP62136

Genetic variation databases

BioMutaiPPP1CA
DMDMi49065811

2D gel databases

OGPiP08129

Proteomic databases

EPDiP62136
jPOSTiP62136
MassIVEiP62136
MaxQBiP62136
PaxDbiP62136
PeptideAtlasiP62136
PRIDEiP62136
ProteomicsDBi1632
57365 [P62136-1]
57366 [P62136-2]
TopDownProteomicsiP62136-1 [P62136-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3872, 599 antibodies

The DNASU plasmid repository

More...
DNASUi
5499

Genome annotation databases

EnsembliENST00000312989; ENSP00000326031; ENSG00000172531 [P62136-2]
ENST00000358239; ENSP00000350974; ENSG00000172531 [P62136-3]
ENST00000376745; ENSP00000365936; ENSG00000172531 [P62136-1]
GeneIDi5499
KEGGihsa:5499
UCSCiuc001oku.2, human [P62136-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5499
DisGeNETi5499

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP1CA
HGNCiHGNC:9281, PPP1CA
HPAiENSG00000172531, Tissue enhanced (blood)
MIMi176875, gene
neXtProtiNX_P62136
OpenTargetsiENSG00000172531
PharmGKBiPA33609
VEuPathDBiHostDB:ENSG00000172531.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0374, Eukaryota
GeneTreeiENSGT00940000153472
HOGENOMiCLU_004962_8_1_1
InParanoidiP62136
OMAiYLVMESR
PhylomeDBiP62136
TreeFamiTF354243

Enzyme and pathway databases

BRENDAi3.1.3.16, 2681
PathwayCommonsiP62136
ReactomeiR-HSA-163560, Triglyceride catabolism
R-HSA-180024, DARPP-32 events
R-HSA-2173788, Downregulation of TGF-beta receptor signaling
R-HSA-400253, Circadian Clock
SignaLinkiP62136
SIGNORiP62136

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5499, 425 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP1CA, human
EvolutionaryTraceiP62136

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP1CA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5499
PharosiP62136, Tchem

Protein Ontology

More...
PROi
PR:P62136
RNActiP62136, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172531, Expressed in endometrium epithelium and 239 other tissues
ExpressionAtlasiP62136, baseline and differential
GenevisibleiP62136, HS

Family and domain databases

Gene3Di3.60.21.10, 1 hit
IDEALiIID00311
InterProiView protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
IPR037979, PPP1CA
IPR006186, Ser/Thr-sp_prot-phosphatase
IPR031675, STPPase_N
PANTHERiPTHR11668:SF377, PTHR11668:SF377, 1 hit
PfamiView protein in Pfam
PF00149, Metallophos, 1 hit
PF16891, STPPase_N, 1 hit
PRINTSiPR00114, STPHPHTASE
SMARTiView protein in SMART
SM00156, PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125, SER_THR_PHOSPHATASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62136
Secondary accession number(s): A6NNR3
, B2R908, P08129, P20653, P22802, Q07161
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 21, 2004
Last modified: April 7, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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