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Protein

40S ribosomal protein S7

Gene

Rps7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for rRNA maturation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S7
Gene namesi
Name:Rps7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1333818 Rps7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741911 – 19440S ribosomal protein S7Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei74N6-acetyllysine; alternateBy similarity1
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylated by NEK6.By similarity
Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62082
PaxDbiP62082
PeptideAtlasiP62082
PRIDEiP62082
TopDownProteomicsiP62082

PTM databases

iPTMnetiP62082
PhosphoSitePlusiP62082
SwissPalmiP62082

Expressioni

Gene expression databases

BgeeiENSMUSG00000061477
CleanExiMM_RPS7
ExpressionAtlasiP62082 baseline and differential
GenevisibleiP62082 MM

Interactioni

Subunit structurei

Binds IPO9 with high affinity. Interacts with NEK6. Interacts with DESI2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203016, 6 interactors
IntActiP62082, 8 interactors
MINTiP62082
STRINGi10090.ENSMUSP00000073880

Structurei

3D structure databases

ProteinModelPortaliP62082
SMRiP62082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 120Arg/Lys-rich (basic)Add BLAST23

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3320 Eukaryota
ENOG410ZYKB LUCA
GeneTreeiENSGT00390000014122
HOGENOMiHOG000197237
HOVERGENiHBG001698
InParanoidiP62082
KOiK02993
OMAiGFHRVQQ
OrthoDBiEOG091G0L94
PhylomeDBiP62082
TreeFamiTF343364

Family and domain databases

InterProiView protein in InterPro
IPR000554 Ribosomal_S7e
PANTHERiPTHR11278 PTHR11278, 1 hit
PfamiView protein in Pfam
PF01251 Ribosomal_S7e, 1 hit
PROSITEiView protein in PROSITE
PS00948 RIBOSOMAL_S7E, 1 hit

Sequencei

Sequence statusi: Complete.

P62082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE
60 70 80 90 100
IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI
110 120 130 140 150
LPKPTRKSRT KNKQKRPRSR TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG
160 170 180 190
SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL TGKDVNFEFP EFQL
Length:194
Mass (Da):22,127
Last modified:June 21, 2004 - v1
Checksum:iE21089929CC061E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043285 Genomic DNA Translation: AAB97861.1
BC002014 mRNA Translation: AAH02014.1
CCDSiCCDS25851.1
RefSeqiNP_035430.1, NM_011300.3
UniGeneiMm.279839
Mm.371579

Genome annotation databases

EnsembliENSMUST00000074267; ENSMUSP00000073880; ENSMUSG00000061477
ENSMUST00000221871; ENSMUSP00000152456; ENSMUSG00000061477
GeneIDi20115
KEGGimmu:20115
UCSCiuc007nfs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRS7_MOUSE
AccessioniPrimary (citable) accession number: P62082
Secondary accession number(s): P23821, P24818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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