Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein R-Ras2

Gene

Rras2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4
Nucleotide bindingi157 – 159GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • cellular process Source: MGI
  • positive regulation of cell migration Source: MGI
  • Ras protein signal transduction Source: MGI
  • regulation of neuron death Source: MGI

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras2
Gene namesi
Name:Rras2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914172 Rras2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000826532 – 201Ras-related protein R-Ras2Add BLAST200
PropeptideiPRO_0000281303202 – 204Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei186PhosphoserineCombined sources1
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei201Cysteine methyl esterBy similarity1
Lipidationi201S-farnesyl cysteineBy similarity1

Post-translational modificationi

May be post-translationally modified by both palmitoylation and polyisoprenylation.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiP62071
MaxQBiP62071
PaxDbiP62071
PeptideAtlasiP62071
PRIDEiP62071

PTM databases

iPTMnetiP62071
PhosphoSitePlusiP62071
SwissPalmiP62071

Expressioni

Gene expression databases

BgeeiENSMUSG00000055723 Expressed in 264 organ(s), highest expression level in primary oocyte
CleanExiMM_RRAS2
ExpressionAtlasiP62071 baseline and differential
GenevisibleiP62071 MM

Interactioni

Protein-protein interaction databases

BioGridi211811, 7 interactors
IntActiP62071, 1 interactor
MINTiP62071
STRINGi10090.ENSMUSP00000069752

Structurei

3D structure databases

ProteinModelPortaliP62071
SMRiP62071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 51Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP62071
KOiK07830
OMAiQCVIDDI
OrthoDBiEOG091G0UAU
PhylomeDBiP62071
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62071-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS
60 70 80 90 100
YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS
110 120 130 140 150
FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK
160 170 180 190 200
VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH

CVIF
Length:204
Mass (Da):23,400
Last modified:June 21, 2004 - v1
Checksum:iBA7D4759DC49446F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRT5A0A1B0GRT5_MOUSE
Ras-related protein R-Ras2
Rras2
139Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → D in BAC37432 (PubMed:16141072).Curated1
Sequence conflicti96T → R in BAB27607 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011419 mRNA Translation: BAB27607.1
AK078870 mRNA Translation: BAC37432.1
AK172037 mRNA Translation: BAE42790.1
BC003871 mRNA Translation: AAH03871.1
CCDSiCCDS21758.1
RefSeqiNP_080122.2, NM_025846.2
UniGeneiMm.276572

Genome annotation databases

EnsembliENSMUST00000069449; ENSMUSP00000069752; ENSMUSG00000055723
GeneIDi66922
KEGGimmu:66922
UCSCiuc009jhw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011419 mRNA Translation: BAB27607.1
AK078870 mRNA Translation: BAC37432.1
AK172037 mRNA Translation: BAE42790.1
BC003871 mRNA Translation: AAH03871.1
CCDSiCCDS21758.1
RefSeqiNP_080122.2, NM_025846.2
UniGeneiMm.276572

3D structure databases

ProteinModelPortaliP62071
SMRiP62071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211811, 7 interactors
IntActiP62071, 1 interactor
MINTiP62071
STRINGi10090.ENSMUSP00000069752

PTM databases

iPTMnetiP62071
PhosphoSitePlusiP62071
SwissPalmiP62071

Proteomic databases

EPDiP62071
MaxQBiP62071
PaxDbiP62071
PeptideAtlasiP62071
PRIDEiP62071

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069449; ENSMUSP00000069752; ENSMUSG00000055723
GeneIDi66922
KEGGimmu:66922
UCSCiuc009jhw.2 mouse

Organism-specific databases

CTDi22800
MGIiMGI:1914172 Rras2

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP62071
KOiK07830
OMAiQCVIDDI
OrthoDBiEOG091G0UAU
PhylomeDBiP62071
TreeFamiTF312796

Miscellaneous databases

ChiTaRSiRras2 mouse
PROiPR:P62071
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055723 Expressed in 264 organ(s), highest expression level in primary oocyte
CleanExiMM_RRAS2
ExpressionAtlasiP62071 baseline and differential
GenevisibleiP62071 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRAS2_MOUSE
AccessioniPrimary (citable) accession number: P62071
Secondary accession number(s): P17082
, Q3TA79, Q8C5D1, Q9D0H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again