UniProtKB - P62070 (RRAS2_HUMAN)
Ras-related protein R-Ras2
RRAS2
Functioni
GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes (PubMed:31130282).
Involved in the regulation of MAPK signaling pathway (PubMed:31130282, PubMed:31130285).
Regulation of craniofacial development (PubMed:31130282, PubMed:31130285).
2 PublicationsCatalytic activityi
- This reaction proceeds in the forward1 Publication direction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 21 – 29 | GTPCombined sources1 Publication | 9 | |
Nucleotide bindingi | 68 – 72 | GTPBy similarity | 5 | |
Nucleotide bindingi | 127 – 130 | GTPCombined sources1 Publication | 4 | |
Nucleotide bindingi | 157 – 159 | GTPCombined sources1 Publication | 3 |
GO - Molecular functioni
- GDP binding Source: GO_Central
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
GO - Biological processi
- osteoblast differentiation Source: UniProtKB
- positive regulation of cell migration Source: Ensembl
- Ras protein signal transduction Source: GO_Central
- regulation of neuron death Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P62070 |
Reactomei | R-HSA-9696273, RND1 GTPase cycle |
SignaLinki | P62070 |
SIGNORi | P62070 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein R-Ras2 (EC:3.6.5.-1 Publication)Alternative name(s): Ras-like protein TC21 Teratocarcinoma oncogene |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17271, RRAS2 |
MIMi | 600098, gene |
neXtProti | NX_P62070 |
VEuPathDBi | HostDB:ENSG00000133818 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication
Plasma membrane
- Cell membrane 2 Publications; Lipid-anchor 2 Publications; Cytoplasmic side
Endoplasmic reticulum
- endoplasmic reticulum Source: ProtInc
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Ovarian cancer (OC)1 Publication
Noonan syndrome 12 (NS12)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083149 | 23 | G → V in NS12; increased MAPK signaling. 1 PublicationCorresponds to variant dbSNP:rs1591495779EnsemblClinVar. | 1 | |
Natural variantiVAR_083150 | 24 | G → GGGG in NS12; increased MAPK signaling. 1 Publication | 1 | |
Natural variantiVAR_083151 | 26 | G → GGVG in NS12; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 2 Publications | 1 | |
Natural variantiVAR_083152 | 70 | A → T in NS12; decreased GAP-stimulated GTPase activity leading to an accumulation of RRAS2 in its GTP-bound active state; increased MAPK signaling; loss of interaction with RASSF5. 1 PublicationCorresponds to variant dbSNP:rs782457908EnsemblClinVar. | 1 | |
Natural variantiVAR_083153 | 72 | Q → H in NS12; associated in cis with C-75; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish; results in craniofacial patterning defects in zebrafish when associated with C-75. 1 Publication | 1 | |
Natural variantiVAR_006848 | 72 | Q → L in NS12; also found as somatic mutation in ovarian cancer; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 3 PublicationsCorresponds to variant dbSNP:rs113954997EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 192 – 197 | KEKDKK → RERDRR: Strongly decreased lysine fatty-acylation. 1 Publication | 6 | |
Mutagenesisi | 199 | C → S: Does not affect lysine fatty-acylation. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 22800 |
GeneReviewsi | RRAS2 |
MalaCardsi | RRAS2 |
MIMi | 167000, phenotype 618624, phenotype |
OpenTargetsi | ENSG00000133818 |
Orphaneti | 648, Noonan syndrome |
PharmGKBi | PA34862 |
Miscellaneous databases
Pharosi | P62070, Tbio |
Genetic variation databases
BioMutai | RRAS2 |
DMDMi | 49065833 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000082652 | 2 – 201 | Ras-related protein R-Ras2Add BLAST | 200 | |
PropeptideiPRO_0000281302 | 202 – 204 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 186 | PhosphoserineCombined sources | 1 | |
Lipidationi | 192 | N6-palmitoyl lysine1 Publication | 1 | |
Lipidationi | 194 | N6-palmitoyl lysine1 Publication | 1 | |
Lipidationi | 196 | N6-palmitoyl lysine1 Publication | 1 | |
Lipidationi | 197 | N6-palmitoyl lysine1 Publication | 1 | |
Lipidationi | 199 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 201 | Cysteine methyl ester1 Publication | 1 | |
Lipidationi | 201 | S-farnesyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, PrenylationProteomic databases
EPDi | P62070 |
jPOSTi | P62070 |
MassIVEi | P62070 |
MaxQBi | P62070 |
PaxDbi | P62070 |
PeptideAtlasi | P62070 |
PRIDEi | P62070 |
ProteomicsDBi | 57360 [P62070-1] 57361 [P62070-2] 6730 6771 |
PTM databases
iPTMneti | P62070 |
MetOSitei | P62070 |
PhosphoSitePlusi | P62070 |
SwissPalmi | P62070 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000133818, Expressed in secondary oocyte and 239 other tissues |
ExpressionAtlasi | P62070, baseline and differential |
Genevisiblei | P62070, HS |
Organism-specific databases
HPAi | ENSG00000133818, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RASSF5.
1 PublicationBinary interactionsi
P62070
Protein-protein interaction databases
BioGRIDi | 116480, 90 interactors |
IntActi | P62070, 47 interactors |
MINTi | P62070 |
STRINGi | 9606.ENSP00000256196 |
Miscellaneous databases
RNActi | P62070, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P62070 |
SMRi | P62070 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62070 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 43 – 51 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000155328 |
InParanoidi | P62070 |
OMAi | KNKRGCH |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P62070 |
TreeFami | TF312796 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS
60 70 80 90 100
YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS
110 120 130 140 150
FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK
160 170 180 190 200
VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH
CVIF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PK85 | E9PK85_HUMAN | Ras-related protein R-Ras2 | RRAS2 | 166 | Annotation score: | ||
E9PQ87 | E9PQ87_HUMAN | Ras-related protein R-Ras2 | RRAS2 | 69 | Annotation score: | ||
E9PQK5 | E9PQK5_HUMAN | Ras-related protein R-Ras2 | RRAS2 | 47 | Annotation score: | ||
E9PQC5 | E9PQC5_HUMAN | Ras-related protein R-Ras2 | RRAS2 | 52 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083149 | 23 | G → V in NS12; increased MAPK signaling. 1 PublicationCorresponds to variant dbSNP:rs1591495779EnsemblClinVar. | 1 | |
Natural variantiVAR_083150 | 24 | G → GGGG in NS12; increased MAPK signaling. 1 Publication | 1 | |
Natural variantiVAR_083151 | 26 | G → GGVG in NS12; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 2 Publications | 1 | |
Natural variantiVAR_083152 | 70 | A → T in NS12; decreased GAP-stimulated GTPase activity leading to an accumulation of RRAS2 in its GTP-bound active state; increased MAPK signaling; loss of interaction with RASSF5. 1 PublicationCorresponds to variant dbSNP:rs782457908EnsemblClinVar. | 1 | |
Natural variantiVAR_083153 | 72 | Q → H in NS12; associated in cis with C-75; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish; results in craniofacial patterning defects in zebrafish when associated with C-75. 1 Publication | 1 | |
Natural variantiVAR_006848 | 72 | Q → L in NS12; also found as somatic mutation in ovarian cancer; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 3 PublicationsCorresponds to variant dbSNP:rs113954997EnsemblClinVar. | 1 | |
Natural variantiVAR_083154 | 75 | F → C Likely benign variant; associated in cis with H-72 in a patient with Noonan syndrome; has no effect on MAPK signaling; has no effect on craniofacial patterning when expressed in zebrafish; results in craniofacial patterning defects in zebrafish when associated with H-72. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043066 | 1 – 77 | Missing in isoform 2. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_044485 | 1 – 36 | MAAAG…IQFIQ → M in isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_055842 | 36 | Q → QFFLFLQ in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31468 mRNA Translation: AAA36545.1 Frameshift. AF493924 mRNA Translation: AAM12638.1 Frameshift. AK299606 mRNA Translation: BAH13078.1 AK300103 mRNA Translation: BAH13210.1 AK302033 mRNA Translation: BAH13612.1 AK313976 mRNA Translation: BAG36690.1 AC011084 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68487.1 BC013106 mRNA Translation: AAH13106.1 |
CCDSi | CCDS44544.1 [P62070-2] CCDS53603.1 [P62070-3] CCDS7814.1 [P62070-1] |
PIRi | B34788, TVHUC2 |
RefSeqi | NP_001096139.1, NM_001102669.2 [P62070-2] NP_001170785.1, NM_001177314.1 [P62070-3] NP_001170786.1, NM_001177315.1 [P62070-2] NP_036382.2, NM_012250.5 [P62070-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31468 mRNA Translation: AAA36545.1 Frameshift. AF493924 mRNA Translation: AAM12638.1 Frameshift. AK299606 mRNA Translation: BAH13078.1 AK300103 mRNA Translation: BAH13210.1 AK302033 mRNA Translation: BAH13612.1 AK313976 mRNA Translation: BAG36690.1 AC011084 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68487.1 BC013106 mRNA Translation: AAH13106.1 |
CCDSi | CCDS44544.1 [P62070-2] CCDS53603.1 [P62070-3] CCDS7814.1 [P62070-1] |
PIRi | B34788, TVHUC2 |
RefSeqi | NP_001096139.1, NM_001102669.2 [P62070-2] NP_001170785.1, NM_001177314.1 [P62070-3] NP_001170786.1, NM_001177315.1 [P62070-2] NP_036382.2, NM_012250.5 [P62070-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ERY | X-ray | 1.70 | A/B | 12-181 | [»] | |
AlphaFoldDBi | P62070 | |||||
SMRi | P62070 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116480, 90 interactors |
IntActi | P62070, 47 interactors |
MINTi | P62070 |
STRINGi | 9606.ENSP00000256196 |
PTM databases
iPTMneti | P62070 |
MetOSitei | P62070 |
PhosphoSitePlusi | P62070 |
SwissPalmi | P62070 |
Genetic variation databases
BioMutai | RRAS2 |
DMDMi | 49065833 |
Proteomic databases
EPDi | P62070 |
jPOSTi | P62070 |
MassIVEi | P62070 |
MaxQBi | P62070 |
PaxDbi | P62070 |
PeptideAtlasi | P62070 |
PRIDEi | P62070 |
ProteomicsDBi | 57360 [P62070-1] 57361 [P62070-2] 6730 6771 |
Protocols and materials databases
Antibodypediai | 4173, 270 antibodies from 36 providers |
DNASUi | 22800 |
Genome annotation databases
Organism-specific databases
CTDi | 22800 |
DisGeNETi | 22800 |
GeneCardsi | RRAS2 |
GeneReviewsi | RRAS2 |
HGNCi | HGNC:17271, RRAS2 |
HPAi | ENSG00000133818, Low tissue specificity |
MalaCardsi | RRAS2 |
MIMi | 167000, phenotype 600098, gene 618624, phenotype |
neXtProti | NX_P62070 |
OpenTargetsi | ENSG00000133818 |
Orphaneti | 648, Noonan syndrome |
PharmGKBi | PA34862 |
VEuPathDBi | HostDB:ENSG00000133818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000155328 |
InParanoidi | P62070 |
OMAi | KNKRGCH |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P62070 |
TreeFami | TF312796 |
Enzyme and pathway databases
PathwayCommonsi | P62070 |
Reactomei | R-HSA-9696273, RND1 GTPase cycle |
SignaLinki | P62070 |
SIGNORi | P62070 |
Miscellaneous databases
BioGRID-ORCSi | 22800, 16 hits in 1041 CRISPR screens |
ChiTaRSi | RRAS2, human |
EvolutionaryTracei | P62070 |
GeneWikii | RRAS2 |
GenomeRNAii | 22800 |
Pharosi | P62070, Tbio |
PROi | PR:P62070 |
RNActi | P62070, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133818, Expressed in secondary oocyte and 239 other tissues |
ExpressionAtlasi | P62070, baseline and differential |
Genevisiblei | P62070, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RRAS2_HUMAN | |
Accessioni | P62070Primary (citable) accession number: P62070 Secondary accession number(s): B2R9Z3 P17082 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | June 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families