RRAS2

Functionⁱ

GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes (PubMed:31130282).

Involved in the regulation of MAPK signaling pathway (PubMed:31130282, PubMed:31130285).

Regulation of craniofacial development (PubMed:31130282, PubMed:31130285).

2 Publications

Catalytic activityⁱ

GTP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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See the description of this molecule in ChEBI.
=
GDP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
phosphate
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.18
  "Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome."
  Capri Y., Flex E., Krumbach O.H.F., Carpentieri G., Cecchetti S., Lissewski C., Rezaei Adariani S., Schanze D., Brinkmann J., Piard J., Pantaleoni F., Lepri F.R., Goh E.S., Chong K., Stieglitz E., Meyer J., Kuechler A., Bramswig N.C.
  Zenker M.
  Am. J. Hum. Genet. 104:1223-1232(2019) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, INTERACTION WITH RASSF5, INVOLVEMENT IN NS12, VARIANTS NS12 VAL-23; GLY-GLY-GLY-24 INS; GLY-VAL-GLY-26 INS; THR-70 AND LEU-72, CHARACTERIZATION OF VARIANTS NS12 VAL-23; GLY-GLY-GLY-24 INS; GLY-VAL-GLY-26 INS; THR-70 AND LEU-72.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.18
  "Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome."
  Capri Y., Flex E., Krumbach O.H.F., Carpentieri G., Cecchetti S., Lissewski C., Rezaei Adariani S., Schanze D., Brinkmann J., Piard J., Pantaleoni F., Lepri F.R., Goh E.S., Chong K., Stieglitz E., Meyer J., Kuechler A., Bramswig N.C.
  Zenker M.
  Am. J. Hum. Genet. 104:1223-1232(2019) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, INTERACTION WITH RASSF5, INVOLVEMENT IN NS12, VARIANTS NS12 VAL-23; GLY-GLY-GLY-24 INS; GLY-VAL-GLY-26 INS; THR-70 AND LEU-72, CHARACTERIZATION OF VARIANTS NS12 VAL-23; GLY-GLY-GLY-24 INS; GLY-VAL-GLY-26 INS; THR-70 AND LEU-72.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
GTP
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H₂O
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GDP
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H⁺
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phosphate
zoom

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	21 – 29	GTPCombined sources1 Publication	9
Nucleotide bindingⁱ	68 – 72	GTPBy similarity	5
Nucleotide bindingⁱ	127 – 130	GTPCombined sources1 Publication	4
Nucleotide bindingⁱ	157 – 159	GTPCombined sources1 Publication	3

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	P62070
Reactomeⁱ	R-HSA-9696273, RND1 GTPase cycle
SignaLinkⁱ	P62070
SIGNORⁱ	P62070

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein R-Ras2 (EC:3.6.5.-1 Publication) Alternative name(s): Ras-like protein TC21 Teratocarcinoma oncogene
Gene namesⁱ	Name:RRAS2Imported Synonyms:TC21
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17271, RRAS2
MIMⁱ	600098, gene
neXtProtⁱ	NX_P62070
VEuPathDBⁱ	HostDB:ENSG00000133818

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ovarian cancer (OC)1 Publication

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Disease descriptionThe term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Related information in OMIM

Noonan syndrome 12 (NS12)2 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS12 inheritance is autosomal dominant. There is considerable variability in severity.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_083149	23	G → V in NS12; increased MAPK signaling. 1 PublicationCorresponds to variant dbSNP:rs1591495779EnsemblClinVar.	1
Natural variantⁱVAR_083150	24	G → GGGG in NS12; increased MAPK signaling. 1 Publication	1
Natural variantⁱVAR_083151	26	G → GGVG in NS12; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 2 Publications	1
Natural variantⁱVAR_083152	70	A → T in NS12; decreased GAP-stimulated GTPase activity leading to an accumulation of RRAS2 in its GTP-bound active state; increased MAPK signaling; loss of interaction with RASSF5. 1 PublicationCorresponds to variant dbSNP:rs782457908EnsemblClinVar.	1
Natural variantⁱVAR_083153	72	Q → H in NS12; associated in cis with C-75; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish; results in craniofacial patterning defects in zebrafish when associated with C-75. 1 Publication	1
Natural variantⁱVAR_006848	72	Q → L in NS12; also found as somatic mutation in ovarian cancer; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 3 PublicationsCorresponds to variant dbSNP:rs113954997EnsemblClinVar.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	192 – 197	KEKDKK → RERDRR: Strongly decreased lysine fatty-acylation. 1 Publication		6
Mutagenesisⁱ	199	C → S: Does not affect lysine fatty-acylation. 1 Publication		1

Keywords - Diseaseⁱ

Disease variant, Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22800
GeneReviewsⁱ	RRAS2
MalaCards human disease database More...MalaCardsⁱ	RRAS2
MIMⁱ	167000, phenotype 618624, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000133818
Orphanetⁱ	648, Noonan syndrome
PharmGKBⁱ	PA34862

Miscellaneous databases

Pharosⁱ	P62070, Tbio

Pharosⁱ

P62070, Tbio

Genetic variation databases

BioMutaⁱ	RRAS2
DMDMⁱ	49065833

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000082652	2 – 201	Ras-related protein R-Ras2Add BLAST	200
PropeptideⁱPRO_0000281302	202 – 204	Removed in mature formBy similarity	3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	186	PhosphoserineCombined sources	1
Lipidationⁱ	192	N6-palmitoyl lysine1 Publication	1
Lipidationⁱ	194	N6-palmitoyl lysine1 Publication	1
Lipidationⁱ	196	N6-palmitoyl lysine1 Publication	1
Lipidationⁱ	197	N6-palmitoyl lysine1 Publication	1
Lipidationⁱ	199	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	201	Cysteine methyl ester1 Publication	1
Lipidationⁱ	201	S-farnesyl cysteine1 Publication	1

Post-translational modificationⁱ

May be post-translationally modified by both palmitoylation and polyisoprenylation.1 Publication

Fatty-acylation at Lys-192, Lys-194; lys-196 and Lys-197 is required for localization to the plasma membrane and activity (PubMed:28406396). Defatty-acylated by SIRT6, affecting its localization to the plasma membrane (PubMed:28406396).1 Publication

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	P62070
jPOSTⁱ	P62070
MassIVEⁱ	P62070
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62070
PaxDbⁱ	P62070
PeptideAtlas More...PeptideAtlasⁱ	P62070
PRIDEⁱ	P62070
ProteomicsDBⁱ	57360 [P62070-1] 57361 [P62070-2] 6730 6771

PTM databases

iPTMnetⁱ	P62070
MetOSiteⁱ	P62070
PhosphoSitePlusⁱ	P62070
SwissPalmⁱ	P62070

Expressionⁱ

Tissue specificityⁱ

Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000133818, Expressed in secondary oocyte and 239 other tissues
ExpressionAtlasⁱ	P62070, baseline and differential
Genevisibleⁱ	P62070, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000133818, Low tissue specificity

HPAⁱ

ENSG00000133818, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts with RASSF5.

1 Publication

Binary interactionsⁱ

Hide details

P62070

With	#Exp.	IntAct
ARAF [P10398]	3	EBI-491037,EBI-365961
HDAC7 - isoform 6 [Q8WUI4-6]	3	EBI-491037,EBI-12094670
RAP1GDS1 - isoform 5 [P52306-5]	3	EBI-491037,EBI-12832744
RGL3 [Q3MIN7]	3	EBI-491037,EBI-2856274
RIN1 [Q13671]	4	EBI-491037,EBI-366017

Protein-protein interaction databases

BioGRIDⁱ	116480, 90 interactors
IntActⁱ	P62070, 47 interactors
Molecular INTeraction database More...MINTⁱ	P62070
STRINGⁱ	9606.ENSP00000256196

Miscellaneous databases

RNActⁱ	P62070, protein

RNActⁱ

P62070, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	14 – 21	Combined sources	8
Helixⁱ	27 – 36	Combined sources	10
Beta strandⁱ	49 – 57	Combined sources	9
Beta strandⁱ	60 – 68	Combined sources	9
Helixⁱ	77 – 85	Combined sources	9
Beta strandⁱ	87 – 94	Combined sources	8
Helixⁱ	98 – 102	Combined sources	5
Helixⁱ	104 – 115	Combined sources	12
Beta strandⁱ	121 – 127	Combined sources	7
Helixⁱ	139 – 148	Combined sources	10
Beta strandⁱ	152 – 155	Combined sources	4
Turnⁱ	158 – 161	Combined sources	4
Helixⁱ	164 – 178	Combined sources	15

Show more details

3D structure databases

AlphaFoldDBⁱ	P62070
SMRⁱ	P62070
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P62070

EvolutionaryTraceⁱ

P62070

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	43 – 51	Effector region		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155328
InParanoidⁱ	P62070
OMAⁱ	KNKRGCH
Database of Orthologous Groups More...OrthoDBⁱ	1259506at2759
PhylomeDBⁱ	P62070
TreeFamⁱ	TF312796

Family and domain databases

Gene3Dⁱ	3.40.50.300, 1 hit
InterProⁱ	View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070, PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071, Ras, 1 hit
SMARTⁱ	View protein in SMART SM00174, RHO, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231, small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421, RAS, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P62070-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS 
        60         70         80         90        100
YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS 
       110        120        130        140        150
FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK 
       160        170        180        190        200
VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH 

CVIF

Length:204

Mass (Da):23,400

Last modified:June 21, 2004 - v1

Checksum:ⁱBA7D4759DC49446F

GO

Isoform 2 (identifier: P62070-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-77: Missing.

« Hide

        10         20         30         40         50
MREQYMRTGE GFLLVFSVTD RGSFEEIYKF QRQILRVKDR DEFPMILIGN 
        60         70         80         90        100
KADLDHQRQV TQEEGQQLAR QLKVTYMEAS AKIRMNVDQA FHELVRVIRK 
       110        120 
FQEQECPPSP EPTRKEKDKK GCHCVIF

Show »

Length:127

Mass (Da):15,094

Checksum:ⁱ58F3090C7A5F9B60

GO

Isoform 3 (identifier: P62070-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-36: MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQ → M

« Hide

        10         20         30         40         50
MSYFVTDYDP TIEDSYTKQC VIDDRAARLD ILDTAGQEEF GAMREQYMRT 
        60         70         80         90        100
GEGFLLVFSV TDRGSFEEIY KFQRQILRVK DRDEFPMILI GNKADLDHQR 
       110        120        130        140        150
QVTQEEGQQL ARQLKVTYME ASAKIRMNVD QAFHELVRVI RKFQEQECPP 
       160 
SPEPTRKEKD KKGCHCVIF

Show »

Length:169

Mass (Da):19,841

Checksum:ⁱA9C28F683B9E5A63

GO

Isoform 4 (identifier: P62070-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
36-36: Q → QFFLFLQ

« Hide

        10         20         30         40         50
MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQFFLF LQSYFVTDYD 
        60         70         80         90        100
PTIEDSYTKQ CVIDDRAARL DILDTAGQEE FGAMREQYMR TGEGFLLVFS 
       110        120        130        140        150
VTDRGSFEEI YKFQRQILRV KDRDEFPMIL IGNKADLDHQ RQVTQEEGQQ 
       160        170        180        190        200
LARQLKVTYM EASAKIRMNV DQAFHELVRV IRKFQEQECP PSPEPTRKEK 
       210
DKKGCHCVIF

Show »

Length:210

Mass (Da):24,196

Checksum:ⁱ881713C4D54A663E

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PK85	E9PK85_HUMAN	Ras-related protein R-Ras2 Ras-related protein R-Ras2	RRAS2	166	Annotation score:
E9PQ87	E9PQ87_HUMAN	Ras-related protein R-Ras2 Ras-related protein R-Ras2	RRAS2	69	Annotation score:
E9PQK5	E9PQK5_HUMAN	Ras-related protein R-Ras2 Ras-related protein R-Ras2	RRAS2	47	Annotation score:
E9PQC5	E9PQC5_HUMAN	Ras-related protein R-Ras2 Ras-related protein R-Ras2	RRAS2	52	Annotation score:

Sequence cautionⁱ

The sequence AAA36545 differs from that shown. Reason: Frameshift.Curated

The sequence AAM12638 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_083149	23	G → V in NS12; increased MAPK signaling. 1 PublicationCorresponds to variant dbSNP:rs1591495779EnsemblClinVar.	1
Natural variantⁱVAR_083150	24	G → GGGG in NS12; increased MAPK signaling. 1 Publication	1
Natural variantⁱVAR_083151	26	G → GGVG in NS12; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 2 Publications	1
Natural variantⁱVAR_083152	70	A → T in NS12; decreased GAP-stimulated GTPase activity leading to an accumulation of RRAS2 in its GTP-bound active state; increased MAPK signaling; loss of interaction with RASSF5. 1 PublicationCorresponds to variant dbSNP:rs782457908EnsemblClinVar.	1
Natural variantⁱVAR_083153	72	Q → H in NS12; associated in cis with C-75; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish; results in craniofacial patterning defects in zebrafish when associated with C-75. 1 Publication	1
Natural variantⁱVAR_006848	72	Q → L in NS12; also found as somatic mutation in ovarian cancer; increased MAPK signaling; results in craniofacial patterning defects when expressed in zebrafish. 3 PublicationsCorresponds to variant dbSNP:rs113954997EnsemblClinVar.	1
Natural variantⁱVAR_083154	75	F → C Likely benign variant; associated in cis with H-72 in a patient with Noonan syndrome; has no effect on MAPK signaling; has no effect on craniofacial patterning when expressed in zebrafish; results in craniofacial patterning defects in zebrafish when associated with H-72. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043066	1 – 77	Missing in isoform 2. 1 PublicationAdd BLAST	77
Alternative sequenceⁱVSP_044485	1 – 36	MAAAG…IQFIQ → M in isoform 3. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_055842	36	Q → QFFLFLQ in isoform 4. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M31468 mRNA Translation: AAA36545.1 Frameshift. AF493924 mRNA Translation: AAM12638.1 Frameshift. AK299606 mRNA Translation: BAH13078.1 AK300103 mRNA Translation: BAH13210.1 AK302033 mRNA Translation: BAH13612.1 AK313976 mRNA Translation: BAG36690.1 AC011084 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68487.1 BC013106 mRNA Translation: AAH13106.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44544.1 [P62070-2] CCDS53603.1 [P62070-3] CCDS7814.1 [P62070-1]
PIRⁱ	B34788, TVHUC2
NCBI Reference Sequences More...RefSeqⁱ	NP_001096139.1, NM_001102669.2 [P62070-2] NP_001170785.1, NM_001177314.1 [P62070-3] NP_001170786.1, NM_001177315.1 [P62070-2] NP_036382.2, NM_012250.5 [P62070-1]

Genome annotation databases

Ensemblⁱ	ENST00000256196.9; ENSP00000256196.4; ENSG00000133818.14 ENST00000414023.6; ENSP00000403282.2; ENSG00000133818.14 [P62070-2] ENST00000526063.5; ENSP00000434104.1; ENSG00000133818.14 [P62070-2] ENST00000529237.5; ENSP00000433230.1; ENSG00000133818.14 [P62070-2] ENST00000532814.5; ENSP00000431954.1; ENSG00000133818.14 [P62070-2] ENST00000534746.5; ENSP00000437083.1; ENSG00000133818.14 [P62070-2] ENST00000537760.5; ENSP00000437547.1; ENSG00000133818.14 [P62070-3]
GeneIDⁱ	22800
KEGGⁱ	hsa:22800
MANE-Selectⁱ	ENST00000256196.9; ENSP00000256196.4; NM_012250.6; NP_036382.2
UCSC genome browser More...UCSCⁱ	uc001mlf.5, human [P62070-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P62070	Ras-related protein R-Ras2		MOUSE		204	UniRef100_P62070
RAS related 2		HORSE		382
Ras-related protein R-Ras2 (Fragment)		NEOVI		106
Ras-related protein R-Ras2 isoform a (Fragment)		MACMU		194
Uncharacterized protein		PIG		204
+54
P62070-2	Uncharacterized protein		CALJA		434	UniRef100_A0A8I3WFC1
Uncharacterized protein (Fragment)		MOUSE		92
Putative ras-related protein r-ras2 (Fragment)		DESRO		169
Ras-related protein R-Ras2 (Fragment)		HUMAN		69
RRAS2 isoform 10 (Fragment)		PONAB		69
+37
P62070-3	RAS related 2		CANLF		169	UniRef100_A0A8C0Z2L9
RAS related 2		MOLMO		169
Uncharacterized protein		PONAB		169
RRAS2 isoform 2		PANTR		169
RAS related 2		PANPA		169
+8
P62070-4	RAS related 2		RHIRO		176	UniRef100_A0A2K6RLK0
RAS related 2		CEBIM		176
RAS related 2		MANLE		176
Uncharacterized protein		RHIBE		176

Protein	Similar proteins		Species	Score	Length	Source
P62070	Ras-related protein R-Ras2		MOUSE		204	UniRef90_P62070
RAS related 2		HORSE		382
Ras-related protein R-Ras2 (Fragment)		NEOVI		106
Ras-related protein R-Ras2 isoform a (Fragment)		MACMU		194
Uncharacterized protein		PIG		204
+56
P62070-2	Uncharacterized protein		CALJA		434	UniRef90_A0A8I3WFC1
Uncharacterized protein (Fragment)		MOUSE		92
Putative ras-related protein r-ras2 (Fragment)		DESRO		169
Ras-related protein R-Ras2 (Fragment)		HUMAN		69
RRAS2 isoform 10 (Fragment)		PONAB		69
+37
P62070-3	RAS related 2		CANLF		169	UniRef90_A0A8C0Z2L9
RAS related 2		MOLMO		169
Uncharacterized protein		PONAB		169
RRAS2 isoform 2		PANTR		169
RAS related 2		PANPA		169
+8
P62070-4	RAS related 2		RHIRO		176	UniRef90_A0A2K6RLK0
RAS related 2		CEBIM		176
RAS related 2		MANLE		176
Uncharacterized protein		RHIBE		176
+1

Protein	Similar proteins		Species	Score	Length	Source
P62070	Ras-related protein R-Ras2		MOUSE		204	UniRef50_P62070
RAS related 2		HORSE		382
Ras-related protein R-Ras2 (Fragment)		NEOVI		106
Ras-related protein R-Ras2 isoform a (Fragment)		MACMU		194
Uncharacterized protein		PIG		204
+175
P62070-2	Uncharacterized protein		CALJA		434	UniRef50_A0A8I3WFC1
Uncharacterized protein (Fragment)		MOUSE		92
Putative ras-related protein r-ras2 (Fragment)		DESRO		169
Ras-related protein R-Ras2 (Fragment)		HUMAN		69
RRAS2 isoform 10 (Fragment)		PONAB		69
+37
P62070-3	Ras-like protein 2		DROME		192	UniRef50_P04388
Uncharacterized protein		DROYA		192
Ras64B		DROSI		192
Uncharacterized protein		DROER		192
ras-like protein 2		DROMA		192
+811

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M31468 mRNA Translation: AAA36545.1 Frameshift. AF493924 mRNA Translation: AAM12638.1 Frameshift. AK299606 mRNA Translation: BAH13078.1 AK300103 mRNA Translation: BAH13210.1 AK302033 mRNA Translation: BAH13612.1 AK313976 mRNA Translation: BAG36690.1 AC011084 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68487.1 BC013106 mRNA Translation: AAH13106.1
CCDSⁱ	CCDS44544.1 [P62070-2] CCDS53603.1 [P62070-3] CCDS7814.1 [P62070-1]
PIRⁱ	B34788, TVHUC2
RefSeqⁱ	NP_001096139.1, NM_001102669.2 [P62070-2] NP_001170785.1, NM_001177314.1 [P62070-3] NP_001170786.1, NM_001177315.1 [P62070-2] NP_036382.2, NM_012250.5 [P62070-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ERY	X-ray	1.70	A/B	12-181	[»]
AlphaFoldDBⁱ	P62070
SMRⁱ	P62070
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	116480, 90 interactors
IntActⁱ	P62070, 47 interactors
MINTⁱ	P62070
STRINGⁱ	9606.ENSP00000256196

PTM databases

iPTMnetⁱ	P62070
MetOSiteⁱ	P62070
PhosphoSitePlusⁱ	P62070
SwissPalmⁱ	P62070

Genetic variation databases

BioMutaⁱ	RRAS2
DMDMⁱ	49065833

Proteomic databases

EPDⁱ	P62070
jPOSTⁱ	P62070
MassIVEⁱ	P62070
MaxQBⁱ	P62070
PaxDbⁱ	P62070
PeptideAtlasⁱ	P62070
PRIDEⁱ	P62070
ProteomicsDBⁱ	57360 [P62070-1] 57361 [P62070-2] 6730 6771

Protocols and materials databases

Antibodypediaⁱ	4173, 270 antibodies from 36 providers
The DNASU plasmid repository More...DNASUⁱ	22800

Genome annotation databases

Organism-specific databases

CTDⁱ	22800
DisGeNETⁱ	22800
GeneCardsⁱ	RRAS2
GeneReviewsⁱ	RRAS2
HGNCⁱ	HGNC:17271, RRAS2
HPAⁱ	ENSG00000133818, Low tissue specificity
MalaCardsⁱ	RRAS2
MIMⁱ	167000, phenotype 600098, gene 618624, phenotype
neXtProtⁱ	NX_P62070
OpenTargetsⁱ	ENSG00000133818
Orphanetⁱ	648, Noonan syndrome
PharmGKBⁱ	PA34862
VEuPathDBⁱ	HostDB:ENSG00000133818
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395, Eukaryota
GeneTreeⁱ	ENSGT00940000155328
InParanoidⁱ	P62070
OMAⁱ	KNKRGCH
OrthoDBⁱ	1259506at2759
PhylomeDBⁱ	P62070
TreeFamⁱ	TF312796

Enzyme and pathway databases

PathwayCommonsⁱ	P62070
Reactomeⁱ	R-HSA-9696273, RND1 GTPase cycle
SignaLinkⁱ	P62070
SIGNORⁱ	P62070

Miscellaneous databases

BioGRID-ORCSⁱ	22800, 16 hits in 1041 CRISPR screens
ChiTaRSⁱ	RRAS2, human
EvolutionaryTraceⁱ	P62070
GeneWikiⁱ	RRAS2
GenomeRNAiⁱ	22800
Pharosⁱ	P62070, Tbio
Protein Ontology More...PROⁱ	PR:P62070
RNActⁱ	P62070, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133818, Expressed in secondary oocyte and 239 other tissues
ExpressionAtlasⁱ	P62070, baseline and differential
Genevisibleⁱ	P62070, HS

Family and domain databases

Gene3Dⁱ	3.40.50.300, 1 hit
InterProⁱ	View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070, PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071, Ras, 1 hit
SMARTⁱ	View protein in SMART SM00174, RHO, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231, small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421, RAS, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRAS2_HUMAN
Accessionⁱ	P62070Primary (citable) accession number: P62070 Secondary accession number(s): B2R9Z3 , B7Z5Z2, B7Z6C4, B7Z7H6, P17082
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
	Last sequence update:	June 21, 2004
	Last modified:	May 25, 2022
	This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P62070 (RRAS2_HUMAN)

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Ras-related protein R-Ras2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Golgi apparatus

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P62070

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ