UniProtKB - P61999 (TF2B_PYRWO)
Protein
Transcription initiation factor IIB
Gene
tfb
Organism
Pyrococcus woesei
Status
Functioni
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 7 | Zinc | 1 | |
Metal bindingi | 10 | Zinc | 1 | |
Metal bindingi | 26 | Zinc | 1 | |
Metal bindingi | 29 | Zinc | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 2 – 34 | TFIIB-typeUniRule annotationAdd BLAST | 33 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB-UniRule
- TBP-class protein binding Source: InterPro
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- transcription preinitiation complex assembly Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor IIBUniRule annotationShort name: TFIIBUniRule annotation |
Gene namesi | Name:tfbUniRule annotation |
Organismi | Pyrococcus woesei |
Taxonomic identifieri | 2262 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119332 | 1 – 300 | Transcription initiation factor IIBAdd BLAST | 300 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P61999 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61999 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 114 – 197 | 1Add BLAST | 84 | |
Repeati | 210 – 291 | 2Add BLAST | 82 |
Sequence similaritiesi
Belongs to the TFIIB family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 2 – 34 | TFIIB-typeUniRule annotationAdd BLAST | 33 |
Keywords - Domaini
Repeat, Zinc-fingerFamily and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
HAMAPi | MF_00383, TF2B_arch, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR000812, TFIIB IPR023484, TFIIB_arc IPR023486, TFIIB_CS IPR013150, TFIIB_cyclin IPR013137, Znf_TFIIB |
PANTHERi | PTHR11618, PTHR11618, 1 hit |
Pfami | View protein in Pfam PF08271, TF_Zn_Ribbon, 1 hit PF00382, TFIIB, 2 hits |
PRINTSi | PR00685, TIFACTORIIB |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00782, TFIIB, 2 hits PS51134, ZF_TFIIB, 1 hit |
i Sequence
Sequence statusi: Complete.
P61999-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKQKVCPAC ESAELIYDPE RGEIVCAKCG YVIEENIIDM GPEWRAFDAS
60 70 80 90 100
QRERRSRTGA PESILLHDKG LSTEIGIDRS LSGLMREKMY RLRKWQSRLR
110 120 130 140 150
VSDAAERNLA FALSELDRIT AQLKLPRHVE EEAARLYREA VRKGLIRGRS
160 170 180 190 200
IESVMAACVY AACRLLKVPR TLDEIADIAR VDKKEIGRSY RFIARNLNLT
210 220 230 240 250
PKKLFVKPTD YVNKFADELG LSEKVRRRAI EILDEAYKRG LTSGKSPAGL
260 270 280 290 300
VAAALYIASL LEGEKRTQRE VAEVARVTEV TVRNRYKELV EKLKIKVPIA
Sequence cautioni
The sequence CAA50006 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70668 Genomic DNA Translation: CAA50006.1 Different initiation. X59857 Genomic DNA No translation available. |
PIRi | S34116 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70668 Genomic DNA Translation: CAA50006.1 Different initiation. X59857 Genomic DNA No translation available. |
PIRi | S34116 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AIS | X-ray | 2.10 | B | 101-300 | [»] | |
1D3U | X-ray | 2.40 | B | 100-300 | [»] | |
SMRi | P61999 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61999 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
HAMAPi | MF_00383, TF2B_arch, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR000812, TFIIB IPR023484, TFIIB_arc IPR023486, TFIIB_CS IPR013150, TFIIB_cyclin IPR013137, Znf_TFIIB |
PANTHERi | PTHR11618, PTHR11618, 1 hit |
Pfami | View protein in Pfam PF08271, TF_Zn_Ribbon, 1 hit PF00382, TFIIB, 2 hits |
PRINTSi | PR00685, TIFACTORIIB |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00782, TFIIB, 2 hits PS51134, ZF_TFIIB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TF2B_PYRWO | |
Accessioni | P61999Primary (citable) accession number: P61999 Secondary accession number(s): P29095, Q51731 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 7, 2004 | |
Last modified: | December 11, 2019 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families