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Protein

14-3-3 protein gamma

Gene

Ywhag

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-111447 Activation of BAD and translocation to mitochondria
R-RNO-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-5625740 RHO GTPases activate PKNs
R-RNO-5628897 TP53 Regulates Metabolic Genes
R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-RNO-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein gamma
Cleaved into the following chain:
Gene namesi
Name:Ywhag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi62002 Ywhag

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586091 – 24714-3-3 protein gammaAdd BLAST247
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003679102 – 24714-3-3 protein gamma, N-terminally processedAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylvaline; in 14-3-3 protein gamma, N-terminally processedBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei133PhosphotyrosineCombined sources1
Modified residuei145PhosphothreonineBy similarity1
Modified residuei215PhosphoserineCombined sources1
Modified residuei234PhosphothreonineBy similarity1
Modified residuei235PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by various PKC isozymes.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61983
PRIDEiP61983

PTM databases

iPTMnetiP61983
PhosphoSitePlusiP61983
SwissPalmiP61983

Expressioni

Tissue specificityi

Localized in neurons, and axonally transported to the nerve terminals. May be also present, at lower levels, in various other tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000001436 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP61983 RN

Interactioni

Subunit structurei

Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2, SAMSN1 and SIRT2 (By similarity). Interacts with PKA-phosphorylated AANAT. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interaction with phosphoserine on interacting proteinBy similarity1
Sitei132Interaction with phosphoserine on interacting proteinBy similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0076EBI-359821,EBI-5323863From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248553, 4 interactors
IntActiP61983, 4 interactors
MINTiP61983
STRINGi10116.ENSRNOP00000001954

Structurei

3D structure databases

ProteinModelPortaliP61983
SMRiP61983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00760000119116
HOGENOMiHOG000240379
HOVERGENiHBG050423
InParanoidiP61983
KOiK16198
OMAiIKNCGET
PhylomeDBiP61983
TreeFamiTF102003

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV
110 120 130 140 150
LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS
160 170 180 190 200
EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Length:247
Mass (Da):28,303
Last modified:January 23, 2007 - v2
Checksum:iB0D16C6DE1F4455D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17447 mRNA Translation: BAA04261.1
S55305 mRNA Translation: AAA13844.1
BC127496 mRNA Translation: AAI27497.1
PIRiB49023
RefSeqiNP_062249.1, NM_019376.2
XP_006249246.2, XM_006249184.3
UniGeneiRn.29936

Genome annotation databases

EnsembliENSRNOT00000001954; ENSRNOP00000001954; ENSRNOG00000001436
ENSRNOT00000084730; ENSRNOP00000069671; ENSRNOG00000001436
GeneIDi56010
KEGGirno:56010
UCSCiRGD:62002 rat

Similar proteinsi

Entry informationi

Entry namei1433G_RAT
AccessioniPrimary (citable) accession number: P61983
Secondary accession number(s): A0JPM0
, O70457, P35214, Q9UDP2, Q9UN99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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