UniProtKB - P61982 (1433G_MOUSE)
14-3-3 protein gamma
Ywhag
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB
- identical protein binding Source: MGI
- insulin-like growth factor receptor binding Source: UniProtKB
- protein domain specific binding Source: MGI
- protein kinase C binding Source: UniProtKB
- receptor tyrosine kinase binding Source: MGI
GO - Biological processi
- cellular response to insulin stimulus Source: MGI
- protein targeting Source: MGI
- regulation of neuron differentiation Source: UniProtKB
- regulation of synaptic plasticity Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-MMU-111447, Activation of BAD and translocation to mitochondria R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-380259, Loss of Nlp from mitotic centrosomes R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-MMU-380320, Recruitment of NuMA to mitotic centrosomes R-MMU-5620912, Anchoring of the basal body to the plasma membrane R-MMU-5625740, RHO GTPases activate PKNs R-MMU-5628897, TP53 Regulates Metabolic Genes R-MMU-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-MMU-8854518, AURKA Activation by TPX2 R-MMU-9614399, Regulation of localization of FOXO transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein gammaCleaved into the following chain: |
Gene namesi | Name:Ywhag |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108109, Ywhag |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: Reactome
Other locations
- myelin sheath Source: UniProtKB
- presynapse Source: MGI
- synapse Source: MGI
- vesicle Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058607 | 1 – 247 | 14-3-3 protein gammaAdd BLAST | 247 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000367908 | 2 – 247 | 14-3-3 protein gamma, N-terminally processedAdd BLAST | 246 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylvaline; in 14-3-3 protein gamma, N-terminally processedBy similarity | 1 | |
Modified residuei | 71 | PhosphoserineCombined sources | 1 | |
Modified residuei | 133 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 145 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 215 | PhosphoserineBy similarity | 1 | |
Modified residuei | 234 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 235 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3956 non-CPTAC-3957 |
EPDi | P61982 |
jPOSTi | P61982 |
MaxQBi | P61982 |
PaxDbi | P61982 |
PRIDEi | P61982 |
2D gel databases
REPRODUCTION-2DPAGEi | P61982 |
UCD-2DPAGEi | P61982 |
PTM databases
iPTMneti | P61982 |
PhosphoSitePlusi | P61982 |
SwissPalmi | P61982 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000051391, Expressed in primary motor cortex and 340 other tissues |
Genevisiblei | P61982, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53.
Interacts with RAF1, SSH1 and CRTC2/TORC2.
Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.
Interacts with GAB2.
Interacts with PKA-phosphorylated AANAT and SIRT2 (By similarity).
Interacts with SAMSN1.
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).
Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity).
Interacts with SLITRK1 (By similarity).
Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity).
Interacts with MARK2 and MARK3 (By similarity).
By similarity2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 57 | Interaction with phosphoserine on interacting proteinBy similarity | 1 | |
Sitei | 132 | Interaction with phosphoserine on interacting proteinBy similarity | 1 |
Binary interactionsi
Hide detailsGO - Molecular functioni
- actin binding Source: UniProtKB
- identical protein binding Source: MGI
- insulin-like growth factor receptor binding Source: UniProtKB
- protein domain specific binding Source: MGI
- protein kinase C binding Source: UniProtKB
- receptor tyrosine kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204620, 48 interactors |
IntActi | P61982, 32 interactors |
MINTi | P61982 |
STRINGi | 10090.ENSMUSP00000051223 |
Miscellaneous databases
RNActi | P61982, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01010000222256 |
InParanoidi | P61982 |
OMAi | IKNCGET |
OrthoDBi | 1176818at2759 |
PhylomeDBi | P61982 |
TreeFami | TF102003 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV
110 120 130 140 150
LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS
160 170 180 190 200
EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | S → F in AAC14345 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058799 mRNA Translation: AAC14345.1 CT010208 mRNA Translation: CAJ18416.1 AK088847 mRNA Translation: BAC40609.1 AK148618 mRNA Translation: BAE28625.1 Different initiation. AK153307 mRNA Translation: BAE31888.1 AK164356 mRNA Translation: BAE37756.1 BC008129 mRNA Translation: AAH08129.1 |
CCDSi | CCDS19748.1 |
RefSeqi | NP_061359.2, NM_018871.3 |
Genome annotation databases
Ensembli | ENSMUST00000055808; ENSMUSP00000051223; ENSMUSG00000051391 ENSMUST00000198270; ENSMUSP00000143631; ENSMUSG00000051391 |
GeneIDi | 22628 |
KEGGi | mmu:22628 |
UCSCi | uc008zzf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058799 mRNA Translation: AAC14345.1 CT010208 mRNA Translation: CAJ18416.1 AK088847 mRNA Translation: BAC40609.1 AK148618 mRNA Translation: BAE28625.1 Different initiation. AK153307 mRNA Translation: BAE31888.1 AK164356 mRNA Translation: BAE37756.1 BC008129 mRNA Translation: AAH08129.1 |
CCDSi | CCDS19748.1 |
RefSeqi | NP_061359.2, NM_018871.3 |
3D structure databases
SMRi | P61982 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204620, 48 interactors |
IntActi | P61982, 32 interactors |
MINTi | P61982 |
STRINGi | 10090.ENSMUSP00000051223 |
PTM databases
iPTMneti | P61982 |
PhosphoSitePlusi | P61982 |
SwissPalmi | P61982 |
2D gel databases
REPRODUCTION-2DPAGEi | P61982 |
UCD-2DPAGEi | P61982 |
Proteomic databases
CPTACi | non-CPTAC-3956 non-CPTAC-3957 |
EPDi | P61982 |
jPOSTi | P61982 |
MaxQBi | P61982 |
PaxDbi | P61982 |
PRIDEi | P61982 |
Protocols and materials databases
Antibodypediai | 4339, 543 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000055808; ENSMUSP00000051223; ENSMUSG00000051391 ENSMUST00000198270; ENSMUSP00000143631; ENSMUSG00000051391 |
GeneIDi | 22628 |
KEGGi | mmu:22628 |
UCSCi | uc008zzf.2, mouse |
Organism-specific databases
CTDi | 7532 |
MGIi | MGI:108109, Ywhag |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01010000222256 |
InParanoidi | P61982 |
OMAi | IKNCGET |
OrthoDBi | 1176818at2759 |
PhylomeDBi | P61982 |
TreeFami | TF102003 |
Enzyme and pathway databases
Reactomei | R-MMU-111447, Activation of BAD and translocation to mitochondria R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-380259, Loss of Nlp from mitotic centrosomes R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-MMU-380320, Recruitment of NuMA to mitotic centrosomes R-MMU-5620912, Anchoring of the basal body to the plasma membrane R-MMU-5625740, RHO GTPases activate PKNs R-MMU-5628897, TP53 Regulates Metabolic Genes R-MMU-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-MMU-8854518, AURKA Activation by TPX2 R-MMU-9614399, Regulation of localization of FOXO transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 22628, 4 hits in 17 CRISPR screens |
ChiTaRSi | Ywhag, mouse |
PROi | PR:P61982 |
RNActi | P61982, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051391, Expressed in primary motor cortex and 340 other tissues |
Genevisiblei | P61982, MM |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433G_MOUSE | |
Accessioni | P61982Primary (citable) accession number: P61982 Secondary accession number(s): O70457 Q9UN99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families