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Entry version 171 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

14-3-3 protein gamma

Gene

YWHAG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-9614399 Regulation of localization of FOXO transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P61981

SIGNOR Signaling Network Open Resource

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SIGNORi
P61981

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein gamma
Alternative name(s):
Protein kinase C inhibitor protein 1
Short name:
KCIP-1
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YWHAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12852 YWHAG

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605356 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P61981

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 56 (EIEE56)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE56 is an autosomal dominant condition.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08022415E → A in EIEE56; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554618767EnsemblClinVar.1
Natural variantiVAR_080226129D → E in EIEE56. 1 PublicationCorresponds to variant dbSNP:rs1554616630EnsemblClinVar.1
Natural variantiVAR_080227132R → C in EIEE56. 1 PublicationCorresponds to variant dbSNP:rs1554616628EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

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DisGeNETi
7532

MalaCards human disease database

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MalaCardsi
YWHAG
MIMi617665 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000170027

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
442835 Undetermined early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37441

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1293296

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
YWHAG

Domain mapping of disease mutations (DMDM)

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DMDMi
48428721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003679071 – 24714-3-3 protein gammaAdd BLAST247
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources4 Publications
ChainiPRO_00000586062 – 24714-3-3 protein gamma, N-terminally processedAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial1 Publication1
Modified residuei2N-acetylvaline; in 14-3-3 protein gamma, N-terminally processed; partialCombined sources3 Publications1
Modified residuei2N-acetylvaline; partialCombined sources3 Publications1
Modified residuei71PhosphoserineCombined sources1
Modified residuei133PhosphotyrosineBy similarity1
Modified residuei145Phosphothreonine1 Publication1
Modified residuei215PhosphoserineBy similarity1
Modified residuei234PhosphothreonineCombined sources1
Modified residuei235PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by various PKC isozymes.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-450
CPTAC-451

Encyclopedia of Proteome Dynamics

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EPDi
P61981

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P61981

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P61981

MaxQB - The MaxQuant DataBase

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MaxQBi
P61981

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P61981

PeptideAtlas

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PeptideAtlasi
P61981

PRoteomics IDEntifications database

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PRIDEi
P61981

ProteomicsDB human proteome resource

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ProteomicsDBi
57355

Consortium for Top Down Proteomics

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TopDownProteomicsi
P61981

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00220642

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P61981

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P61981

SwissPalm database of S-palmitoylation events

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SwissPalmi
P61981

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, skeletal muscle, and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000170027 Expressed in 210 organ(s), highest expression level in lateral nuclear group of thalamus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61981 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB013274
CAB018389
HPA026918

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with SAMSN1 (By similarity).

Interacts with RAF1, SSH1 and CRTC2/TORC2.

Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.

Interacts with GAB2.

Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53.

Interacts with PKA-phosphorylated AANAT and SIRT2.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).

Interacts with SLITRK1 (PubMed:19640509).

Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).

By similarity13 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei57Interaction with phosphoserine on interacting protein1
Sitei132Interaction with phosphoserine on interacting protein1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113364, 355 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P61981

Database of interacting proteins

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DIPi
DIP-33406N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P61981

Protein interaction database and analysis system

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IntActi
P61981, 482 interactors

Molecular INTeraction database

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MINTi
P61981

STRING: functional protein association networks

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STRINGi
9606.ENSP00000306330

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P61981

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61981

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P61981

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0841 Eukaryota
COG5040 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00970000193388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000240379

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61981

KEGG Orthology (KO)

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KOi
K16198

Identification of Orthologs from Complete Genome Data

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OMAi
IKNCGET

Database of Orthologous Groups

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OrthoDBi
1176818at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P61981

TreeFam database of animal gene trees

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TreeFami
TF102003

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.190.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain

The PANTHER Classification System

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PANTHERi
PTHR18860 PTHR18860, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00244 14-3-3, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000868 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00305 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00101 14_3_3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48445 SSF48445, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P61981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV
110 120 130 140 150
LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS
160 170 180 190 200
EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Length:247
Mass (Da):28,303
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0D16C6DE1F4455D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4R → P in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti19R → G in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti78Missing in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti89I → V in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti104L → V in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti109I → Y in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti119 – 122SKVF → RKDL in AAD48408 (PubMed:10433554).Curated4
Sequence conflicti144 – 145AT → GD in AAD48408 (PubMed:10433554).Curated2
Sequence conflicti157 – 158AH → R in AAD48408 (PubMed:10433554).Curated2
Sequence conflicti200 – 202AFD → EFE in AAD48408 (PubMed:10433554).Curated3
Sequence conflicti214D → E in AAD48408 (PubMed:10433554).Curated1
Sequence conflicti240D → DH in AAD48408 (PubMed:10433554).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08022415E → A in EIEE56; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554618767EnsemblClinVar.1
Natural variantiVAR_08022550K → Q Found in an individual with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554616652EnsemblClinVar.1
Natural variantiVAR_080226129D → E in EIEE56. 1 PublicationCorresponds to variant dbSNP:rs1554616630EnsemblClinVar.1
Natural variantiVAR_080227132R → C in EIEE56. 1 PublicationCorresponds to variant dbSNP:rs1554616628EnsemblClinVar.1
Natural variantiVAR_080228133Y → S Probable disease-associated mutation found in an individual with neurodevelopmental disorder. 1 PublicationCorresponds to variant dbSNP:rs1554616627EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF142498 mRNA Translation: AAD48408.1
AB024334 mRNA Translation: BAA85184.1
CR541904 mRNA Translation: CAG46702.1
CR541925 mRNA Translation: CAG46723.1
AC006388 Genomic DNA No translation available.
BC020963 mRNA Translation: AAH20963.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5584.1

NCBI Reference Sequences

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RefSeqi
NP_036611.2, NM_012479.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307630; ENSP00000306330; ENSG00000170027

Database of genes from NCBI RefSeq genomes

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GeneIDi
7532

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7532

UCSC genome browser

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UCSCi
uc011kgj.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142498 mRNA Translation: AAD48408.1
AB024334 mRNA Translation: BAA85184.1
CR541904 mRNA Translation: CAG46702.1
CR541925 mRNA Translation: CAG46723.1
AC006388 Genomic DNA No translation available.
BC020963 mRNA Translation: AAH20963.1
CCDSiCCDS5584.1
RefSeqiNP_036611.2, NM_012479.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B05X-ray2.55A/B/C/D/E/F2-247[»]
3UZDX-ray1.86A1-247[»]
4E2EX-ray2.25A1-247[»]
4J6SX-ray3.08A/B/C/D1-247[»]
4O46X-ray2.90A/B/C/D/E/F1-247[»]
5D3EX-ray2.75A/B/E/F/I/J1-238[»]
6A5SX-ray2.10A/B/D/G1-247[»]
6BYJX-ray2.90A/B/C/D/E/F2-241[»]
6BYLX-ray3.35A/B/C/D/E/F2-241[»]
6BZDX-ray2.67A/B/C/D2-247[»]
6FELX-ray2.84A/B/C/D1-234[»]
6GKFX-ray2.60A/B/C/D/E/F/G/H1-234[»]
6GKGX-ray2.85A/B/C/D/E/F/G/H1-234[»]
SMRiP61981
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113364, 355 interactors
CORUMiP61981
DIPiDIP-33406N
ELMiP61981
IntActiP61981, 482 interactors
MINTiP61981
STRINGi9606.ENSP00000306330

Chemistry databases

BindingDBiP61981
ChEMBLiCHEMBL1293296

PTM databases

iPTMnetiP61981
PhosphoSitePlusiP61981
SwissPalmiP61981

Polymorphism and mutation databases

BioMutaiYWHAG
DMDMi48428721

2D gel databases

REPRODUCTION-2DPAGEiIPI00220642

Proteomic databases

CPTACiCPTAC-450
CPTAC-451
EPDiP61981
jPOSTiP61981
MassIVEiP61981
MaxQBiP61981
PaxDbiP61981
PeptideAtlasiP61981
PRIDEiP61981
ProteomicsDBi57355
TopDownProteomicsiP61981

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7532
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307630; ENSP00000306330; ENSG00000170027
GeneIDi7532
KEGGihsa:7532
UCSCiuc011kgj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7532
DisGeNETi7532

GeneCards: human genes, protein and diseases

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GeneCardsi
YWHAG
HGNCiHGNC:12852 YWHAG
HPAiCAB013274
CAB018389
HPA026918
MalaCardsiYWHAG
MIMi605356 gene
617665 phenotype
neXtProtiNX_P61981
OpenTargetsiENSG00000170027
Orphaneti442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA37441

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00970000193388
HOGENOMiHOG000240379
InParanoidiP61981
KOiK16198
OMAiIKNCGET
OrthoDBi1176818at2759
PhylomeDBiP61981
TreeFamiTF102003

Enzyme and pathway databases

ReactomeiR-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-9614399 Regulation of localization of FOXO transcription factors
SignaLinkiP61981
SIGNORiP61981

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
YWHAG human
EvolutionaryTraceiP61981

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
YWHAG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7532

Pharos

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Pharosi
P61981

Protein Ontology

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PROi
PR:P61981

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000170027 Expressed in 210 organ(s), highest expression level in lateral nuclear group of thalamus
GenevisibleiP61981 HS

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433G_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61981
Secondary accession number(s): O70457
, P35214, Q6FH52, Q9UDP2, Q9UN99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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