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UniProtKB - P61978 (HNRPK_HUMAN)

Entry version 196 (11 Dec 2019)
Sequence version 1 (07 Jun 2004)
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Protein

Heterogeneous nuclear ribonucleoprotein K

Gene

HNRNPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, Ribonucleoprotein, RNA-binding
Biological processHost-virus interaction, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

SIGNOR Signaling Network Open Resource

More...SIGNORi		P61978

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P61978 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein K
Short name:
hnRNP K
Alternative name(s):
Transformation up-regulated nuclear protein
Short name:
TUNP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPK
Synonyms:HNRPK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000165119.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:5044 HNRNPK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600712 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P61978

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Au-Kline syndrome (AUKS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by intellectual disability, facial dysmorphism, cardiac defects, and connective tissue and skeletal abnormalities. Dysmorphic features include long palpebral fissures, ptosis, a broad prominent nasal bridge, hypoplastic alae nasi, an open downturned mouth, ears with underdeveloped and thick helices, high palate, and a unique tongue with a prominent median crease. Hypotonia, hyporeflexia, and high pain tolerance are additional features.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi422K → R: Loss of sumoylation. Loss of TP53 transcriptional stimulation. 1 Publication1
Mutagenesisi424D → A: Loss of sumoylation. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		3190

MalaCards human disease database

More...MalaCardsi		HNRNPK
MIMi616580 phenotype

Open Targets

More...OpenTargetsi		ENSG00000165119

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		352665 Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
453504 Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391350

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P61978 Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11638 Artenimol
DB12695 Phenethyl Isothiocyanate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HNRNPK

Domain mapping of disease mutations (DMDM)

More...DMDMi		48429103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000500961 – 463Heterogeneous nuclear ribonucleoprotein KAdd BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei34N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphothreonineBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei75PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei198N6-acetyllysineBy similarity1
Modified residuei214PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei219N6-succinyllysine; alternateBy similarity1
Cross-linki219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei284PhosphoserineCombined sources1 Publication1
Modified residuei316Omega-N-methylarginineCombined sources1
Modified residuei377Omega-N-methylarginineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei380PhosphotyrosineCombined sources1
Modified residuei405N6-acetyllysine; alternateBy similarity1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei420PhosphoserineCombined sources1
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine.
Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions.3 Publications
Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination.2 Publications
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1028

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P61978

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P61978

MaxQB - The MaxQuant DataBase

More...MaxQBi		P61978

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P61978

PeptideAtlas

More...PeptideAtlasi		P61978

PRoteomics IDEntifications database

More...PRIDEi		P61978

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57352
57353 [P61978-2]
57354 [P61978-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P61978-1 [P61978-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P61978

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P61978

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P61978

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P61978

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By DNA damage, including ionizing radiations and phleomycin treatment or UV irradiation. This induction requires ATM kinase activity (ionizing radiations and phleomycin) or ATR activity (UV irradiation). Up-regulation is due to protein stabilization. Constitutive protein levels are controlled by MDM2-mediated ubiquitination and degradation via the proteasome pathway.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165119 Expressed in 239 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P61978 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P61978 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB004435
CAB016225
HPA007644
HPA044105

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RBM42 and ZIK1 (By similarity).

Interacts with BRDT (By similarity). Identified in the spliceosome C complex (PubMed:11991638).

Interacts with ANKRD28 (PubMed:16564677).

Interacts with ASFV p30 protein (PubMed:18775702).

Interacts with DDX1 (PubMed:12183465).

Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation (PubMed:16360036).

Interacts with p53/TP53 (PubMed:16360036).

Interacts with IVNS1ABP (PubMed:23825951).

By similarity7 Publications

(Microbial infection) Interacts with HCV core protein (PubMed:9651361).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109431, 403 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P61978

Database of interacting proteins

More...DIPi		DIP-31805N

Protein interaction database and analysis system

More...IntActi		P61978, 219 interactors

Molecular INTeraction database

More...MINTi		P61978

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365439

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P61978 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P61978

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P61978

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 104KH 1PROSITE-ProRule annotationAdd BLAST63
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati54 – 761-1Add BLAST23
Repeati59 – 623-14
Domaini144 – 209KH 2PROSITE-ProRule annotationAdd BLAST66
Repeati245 – 2502-16
Repeati257 – 2603-24
Repeati267 – 2703-34
Repeati295 – 2983-44
Repeati324 – 3292-26
Domaini387 – 451KH 3PROSITE-ProRule annotationAdd BLAST65
Repeati399 – 4211-2Add BLAST23
Repeati404 – 4073-54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 276Necessary for interaction with DDX11 PublicationAdd BLAST276
Regioni35 – 197Interaction with ASFV p30Add BLAST163
Regioni54 – 4212 X 22 AA approximate repeatsAdd BLAST368
Regioni59 – 4075 X 4 AA repeats of G-X-G-GAdd BLAST349
Regioni209 – 337Interaction with ZIK1By similarityAdd BLAST129
Regioni236 – 273RNA-binding RGG-boxAdd BLAST38
Regioni245 – 3292 X 6 AA approximate repeatsAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi289 – 294Poly-Pro6
Compositional biasi310 – 315Poly-Pro6

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2192 Eukaryota
ENOG4111GSB LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153434

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P61978

KEGG Orthology (KO)

More...KOi		K12886

Identification of Orthologs from Complete Genome Data

More...OMAi		DCTGPER

Database of Orthologous Groups

More...OrthoDBi		394765at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P61978

TreeFam database of animal gene trees

More...TreeFami		TF316335

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033090 hnRNP_K
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012987 ROK_N

The PANTHER Classification System

More...PANTHERi		PTHR10288:SF262 PTHR10288:SF262, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00013 KH_1, 3 hits
PF08067 ROKNT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00322 KH, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54791 SSF54791, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P61978-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ 
        60         70         80         90        100
SKNAGAVIGK GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI 
       110        120        130        140        150
LKKIIPTLEE GLQLPSPTAT SQLPLESDAV ECLNYQHYKG SDFDCELRLL 
       160        170        180        190        200
IHQSLAGGII GVKGAKIKEL RENTQTTIKL FQECCPHSTD RVVLIGGKPD 
       210        220        230        240        250
RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT MMFDDRRGRP 
       260        270        280        290        300
VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY DDMSPRRGPP PPPPGRGGRG 
       310        320        330        340        350
GSRARNLPLP PPPPPRGGDL MAYDRRGRPG DRYDGMVGFS ADETWDSAID 
       360        370        380        390        400
TWSPSEWQMA YEPQGGSGYD YSYAGGRGSY GDLGGPIITT QVTIPKDLAG 
       410        420        430        440        450
SIIGKGGQRI KQIRHESGAS IKIDEPLEGS EDRIITITGT QDQIQNAQYL 
       460 
LQNSVKQYSG KFF
Length:463
Mass (Da):50,976
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F70EE169B2A064A
GO
Isoform 2 (identifier: P61978-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-463: SGKFF → ADVEGF

Show »
Length:464
Mass (Da):51,028
Checksum:i0B4EC22FE4534A06
GO
Isoform 3 (identifier: P61978-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-134: Missing.
     459-463: SGKFF → ADVEGF

Show »
Length:440
Mass (Da):48,562
Checksum:iC98A78A7462BF776
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T6W2Q5T6W2_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPK
379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R457S4R457_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPK
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R359S4R359_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPK
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92799 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32A → D in CAA51267 (PubMed:8107114).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 50976.25 Da. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021669111 – 134Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_002822459 – 463SGKFF → ADVEGF in isoform 2 and isoform 3. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S74678 mRNA Translation: AAB20770.1
X72727 mRNA Translation: CAA51267.1
CR456771 mRNA Translation: CAG33052.1
AB209562 mRNA Translation: BAD92799.1 Different initiation.
AK291336 mRNA Translation: BAF84025.1
AB451263 mRNA Translation: BAG70077.1
AB451390 mRNA Translation: BAG70204.1
AL354733 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62675.1
CH471089 Genomic DNA Translation: EAW62677.1
BC000355 mRNA Translation: AAH00355.1
BC014980 mRNA Translation: AAH14980.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6667.1
CCDS6668.1 [P61978-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S43363

NCBI Reference Sequences

More...RefSeqi		NP_001305115.1, NM_001318186.1
NP_001305116.1, NM_001318187.1 [P61978-3]
NP_001305117.1, NM_001318188.1 [P61978-1]
NP_002131.2, NM_002140.4 [P61978-2]
NP_112552.1, NM_031262.3 [P61978-1]
NP_112553.1, NM_031263.3 [P61978-2]
XP_005252017.1, XM_005251960.2 [P61978-2]
XP_005252020.1, XM_005251963.3 [P61978-3]
XP_005252022.1, XM_005251965.2 [P61978-3]
XP_016870157.1, XM_017014668.1 [P61978-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000351839; ENSP00000317788; ENSG00000165119 [P61978-1]
ENST00000360384; ENSP00000353552; ENSG00000165119 [P61978-1]
ENST00000376263; ENSP00000365439; ENSG00000165119 [P61978-2]
ENST00000376281; ENSP00000365458; ENSG00000165119 [P61978-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3190

UCSC genome browser

More...UCSCi		uc004anf.5 human
uc004ang.5 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74678 mRNA Translation: AAB20770.1
X72727 mRNA Translation: CAA51267.1
CR456771 mRNA Translation: CAG33052.1
AB209562 mRNA Translation: BAD92799.1 Different initiation.
AK291336 mRNA Translation: BAF84025.1
AB451263 mRNA Translation: BAG70077.1
AB451390 mRNA Translation: BAG70204.1
AL354733 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62675.1
CH471089 Genomic DNA Translation: EAW62677.1
BC000355 mRNA Translation: AAH00355.1
BC014980 mRNA Translation: AAH14980.1
CCDSiCCDS6667.1
CCDS6668.1 [P61978-2]
PIRiS43363
RefSeqiNP_001305115.1, NM_001318186.1
NP_001305116.1, NM_001318187.1 [P61978-3]
NP_001305117.1, NM_001318188.1 [P61978-1]
NP_002131.2, NM_002140.4 [P61978-2]
NP_112552.1, NM_031262.3 [P61978-1]
NP_112553.1, NM_031263.3 [P61978-2]
XP_005252017.1, XM_005251960.2 [P61978-2]
XP_005252020.1, XM_005251963.3 [P61978-3]
XP_005252022.1, XM_005251965.2 [P61978-3]
XP_016870157.1, XM_017014668.1 [P61978-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J5KNMR-A379-463[»]
1KHMNMR-A379-463[»]
1ZZIX-ray1.80A/B385-463[»]
1ZZJX-ray2.30A/B/C385-463[»]
1ZZKX-ray0.95A385-463[»]
SMRiP61978
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109431, 403 interactors
CORUMiP61978
DIPiDIP-31805N
IntActiP61978, 219 interactors
MINTiP61978
STRINGi9606.ENSP00000365439

Chemistry databases

DrugBankiDB11638 Artenimol
DB12695 Phenethyl Isothiocyanate

Protein family/group databases

MoonDBiP61978 Predicted

PTM databases

iPTMnetiP61978
PhosphoSitePlusiP61978
SwissPalmiP61978

Polymorphism and mutation databases

BioMutaiHNRNPK
DMDMi48429103

2D gel databases

SWISS-2DPAGEiP61978

Proteomic databases

CPTACiCPTAC-1028
jPOSTiP61978
MassIVEiP61978
MaxQBiP61978
PaxDbiP61978
PeptideAtlasiP61978
PRIDEiP61978
ProteomicsDBi57352
57353 [P61978-2]
57354 [P61978-3]
TopDownProteomicsiP61978-1 [P61978-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3190

Genome annotation databases

EnsembliENST00000351839; ENSP00000317788; ENSG00000165119 [P61978-1]
ENST00000360384; ENSP00000353552; ENSG00000165119 [P61978-1]
ENST00000376263; ENSP00000365439; ENSG00000165119 [P61978-2]
ENST00000376281; ENSP00000365458; ENSG00000165119 [P61978-2]
GeneIDi3190
KEGGihsa:3190
UCSCiuc004anf.5 human
uc004ang.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3190
DisGeNETi3190
EuPathDBiHostDB:ENSG00000165119.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		HNRNPK
HGNCiHGNC:5044 HNRNPK
HPAiCAB004435
CAB016225
HPA007644
HPA044105
MalaCardsiHNRNPK
MIMi600712 gene
616580 phenotype
neXtProtiNX_P61978
OpenTargetsiENSG00000165119
Orphaneti352665 Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
453504 Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation
PharmGKBiPA162391350

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2192 Eukaryota
ENOG4111GSB LUCA
GeneTreeiENSGT00940000153434
InParanoidiP61978
KOiK12886
OMAiDCTGPER
OrthoDBi394765at2759
PhylomeDBiP61978
TreeFamiTF316335

Enzyme and pathway databases

ReactomeiR-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP61978

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HNRNPK human
EvolutionaryTraceiP61978

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HNRPK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3190
PharosiP61978 Tbio

Protein Ontology

More...PROi		PR:P61978
RNActiP61978 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165119 Expressed in 239 organ(s), highest expression level in female gonad
ExpressionAtlasiP61978 baseline and differential
GenevisibleiP61978 HS

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR033090 hnRNP_K
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012987 ROK_N
PANTHERiPTHR10288:SF262 PTHR10288:SF262, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
PF08067 ROKNT, 1 hit
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61978
Secondary accession number(s): Q07244
, Q15671, Q59F98, Q5T6W4, Q60577, Q6IBN1, Q922Y7, Q96J62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: December 11, 2019
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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