UniProtKB - P61978 (HNRPK_HUMAN)
Heterogeneous nuclear ribonucleoprotein K
HNRNPK
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- mRNA binding Source: GO_Central
- protein domain specific binding Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: Reactome
- negative regulation of apoptotic process Source: MGI
- negative regulation of mRNA splicing, via spliceosome Source: Ensembl
- positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
- positive regulation of receptor-mediated endocytosis Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of gene expression Source: GO_Central
- regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- regulation of low-density lipoprotein particle clearance Source: BHF-UCL
- regulation of mRNA splicing, via spliceosome Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- RNA metabolic process Source: Reactome
- RNA processing Source: ProtInc
- signal transduction Source: ProtInc
- viral life cycle Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding, Repressor, Ribonucleoprotein, RNA-binding |
Biological process | Host-virus interaction, mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P61978 |
Reactomei | R-HSA-4570464, SUMOylation of RNA binding proteins R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA R-HSA-9610379, HCMV Late Events |
SIGNORi | P61978 |
Protein family/group databases
MoonDBi | P61978, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein KShort name: hnRNP K Alternative name(s): Transformation up-regulated nuclear protein Short name: TUNP |
Gene namesi | Name:HNRNPK Synonyms:HNRPK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5044, HNRNPK |
MIMi | 600712, gene |
neXtProti | NX_P61978 |
VEuPathDBi | HostDB:ENSG00000165119.18 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- nucleoplasm 4 Publications
Other locations
- podosome 1 Publication
Note: Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702).
Cytoskeleton
- podosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cell projection Source: UniProtKB-KW
- chromatin Source: BHF-UCL
- cytoplasm Source: GO_Central
- cytoplasmic stress granule Source: ARUK-UCL
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Nucleus, SpliceosomePathology & Biotechi
Involvement in diseasei
Au-Kline syndrome (AUKS)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 422 | K → R: Loss of sumoylation. Loss of TP53 transcriptional stimulation. 1 Publication | 1 | |
Mutagenesisi | 424 | D → A: Loss of sumoylation. 1 Publication | 1 |
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 3190 |
GeneReviewsi | HNRNPK |
MalaCardsi | HNRNPK |
MIMi | 616580, phenotype |
OpenTargetsi | ENSG00000165119 |
Orphaneti | 352665, Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion 453504, Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation |
PharmGKBi | PA162391350 |
Miscellaneous databases
Pharosi | P61978, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | HNRNPK |
DMDMi | 48429103 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050096 | 1 – 463 | Heterogeneous nuclear ribonucleoprotein KAdd BLAST | 463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 34 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 34 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 34 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 36 | PhosphoserineCombined sources | 1 | |
Modified residuei | 39 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 60 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Cross-linki | 163 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 163 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 198 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 214 | PhosphoserineCombined sources | 1 | |
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Modified residuei | 219 | N6-succinyllysine; alternateBy similarity | 1 | |
Cross-linki | 219 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 284 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 316 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 377 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 379 | PhosphoserineCombined sources | 1 | |
Modified residuei | 380 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 405 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 405 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 420 | PhosphoserineCombined sources | 1 | |
Cross-linki | 422 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 422 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 422 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1028 |
jPOSTi | P61978 |
MassIVEi | P61978 |
MaxQBi | P61978 |
PaxDbi | P61978 |
PeptideAtlasi | P61978 |
PRIDEi | P61978 |
ProteomicsDBi | 57352 57353 [P61978-2] 57354 [P61978-3] |
TopDownProteomicsi | P61978-1 [P61978-1] |
2D gel databases
SWISS-2DPAGEi | P61978 |
PTM databases
iPTMneti | P61978 |
MetOSitei | P61978 |
PhosphoSitePlusi | P61978 |
SwissPalmi | P61978 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000165119, Expressed in female gonad and 248 other tissues |
ExpressionAtlasi | P61978, baseline and differential |
Genevisiblei | P61978, HS |
Organism-specific databases
HPAi | ENSG00000165119, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RBM42 and ZIK1 (By similarity).
Interacts with BRDT (By similarity). Identified in the spliceosome C complex (PubMed:11991638).
Interacts with ANKRD28 (PubMed:16564677).
Interacts with ASFV p30 protein (PubMed:18775702).
Interacts with DDX1 (PubMed:12183465).
Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation (PubMed:16360036).
Interacts with p53/TP53 (PubMed:16360036).
Interacts with IVNS1ABP (PubMed:23825951).
Interacts with PPIA/CYPA (PubMed:25678563).
By similarity8 Publications(Microbial infection) Interacts with HCV core protein (PubMed:9651361).
1 PublicationBinary interactionsi
P61978
HNRNPK - isoform 1 [P61978-1]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-431928,EBI-431928 |
HNRNPK - isoform 2 [P61978-2]
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109431, 522 interactors |
CORUMi | P61978 |
DIPi | DIP-31805N |
IntActi | P61978, 241 interactors |
MINTi | P61978 |
STRINGi | 9606.ENSP00000365439 |
Miscellaneous databases
RNActi | P61978, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P61978 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61978 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 104 | KH 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Repeati | 54 – 76 | 1-1Add BLAST | 23 | |
Repeati | 59 – 62 | 3-1 | 4 | |
Domaini | 144 – 209 | KH 2PROSITE-ProRule annotationAdd BLAST | 66 | |
Repeati | 245 – 250 | 2-1 | 6 | |
Repeati | 257 – 260 | 3-2 | 4 | |
Repeati | 267 – 270 | 3-3 | 4 | |
Repeati | 295 – 298 | 3-4 | 4 | |
Repeati | 324 – 329 | 2-2 | 6 | |
Domaini | 387 – 451 | KH 3PROSITE-ProRule annotationAdd BLAST | 65 | |
Repeati | 399 – 421 | 1-2Add BLAST | 23 | |
Repeati | 404 – 407 | 3-5 | 4 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 276 | Necessary for interaction with DDX11 PublicationAdd BLAST | 276 | |
Regioni | 35 – 197 | Interaction with ASFV p30Add BLAST | 163 | |
Regioni | 54 – 421 | 2 X 22 AA approximate repeatsAdd BLAST | 368 | |
Regioni | 59 – 407 | 5 X 4 AA repeats of G-X-G-GAdd BLAST | 349 | |
Regioni | 209 – 337 | Interaction with ZIK1By similarityAdd BLAST | 129 | |
Regioni | 236 – 273 | RNA-binding RGG-boxAdd BLAST | 38 | |
Regioni | 245 – 329 | 2 X 6 AA approximate repeatsAdd BLAST | 85 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 289 – 294 | Poly-Pro | 6 | |
Compositional biasi | 310 – 315 | Poly-Pro | 6 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2192, Eukaryota |
GeneTreei | ENSGT00940000153434 |
InParanoidi | P61978 |
OMAi | DCTGPER |
OrthoDBi | 394765at2759 |
PhylomeDBi | P61978 |
TreeFami | TF316335 |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR033090, hnRNP_K IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR012987, ROK_N |
PANTHERi | PTHR10288:SF262, PTHR10288:SF262, 1 hit |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits PF08067, ROKNT, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ
60 70 80 90 100
SKNAGAVIGK GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI
110 120 130 140 150
LKKIIPTLEE GLQLPSPTAT SQLPLESDAV ECLNYQHYKG SDFDCELRLL
160 170 180 190 200
IHQSLAGGII GVKGAKIKEL RENTQTTIKL FQECCPHSTD RVVLIGGKPD
210 220 230 240 250
RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT MMFDDRRGRP
260 270 280 290 300
VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY DDMSPRRGPP PPPPGRGGRG
310 320 330 340 350
GSRARNLPLP PPPPPRGGDL MAYDRRGRPG DRYDGMVGFS ADETWDSAID
360 370 380 390 400
TWSPSEWQMA YEPQGGSGYD YSYAGGRGSY GDLGGPIITT QVTIPKDLAG
410 420 430 440 450
SIIGKGGQRI KQIRHESGAS IKIDEPLEGS EDRIITITGT QDQIQNAQYL
460
LQNSVKQYSG KFF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T6W2 | Q5T6W2_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPK | 379 | Annotation score: | ||
S4R457 | S4R457_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPK | 77 | Annotation score: | ||
S4R359 | S4R359_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPK | 100 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | A → D in CAA51267 (PubMed:8107114).Curated | 1 |
Mass spectrometryi
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021669 | 111 – 134 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_002822 | 459 – 463 | SGKFF → ADVEGF in isoform 2 and isoform 3. 2 Publications | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S74678 mRNA Translation: AAB20770.1 X72727 mRNA Translation: CAA51267.1 CR456771 mRNA Translation: CAG33052.1 AB209562 mRNA Translation: BAD92799.1 Different initiation. AK291336 mRNA Translation: BAF84025.1 AB451263 mRNA Translation: BAG70077.1 AB451390 mRNA Translation: BAG70204.1 AL354733 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62675.1 CH471089 Genomic DNA Translation: EAW62677.1 BC000355 mRNA Translation: AAH00355.1 BC014980 mRNA Translation: AAH14980.1 |
CCDSi | CCDS6667.1 CCDS6668.1 [P61978-2] |
PIRi | S43363 |
RefSeqi | NP_001305115.1, NM_001318186.1 NP_001305116.1, NM_001318187.1 [P61978-3] NP_001305117.1, NM_001318188.1 [P61978-1] NP_002131.2, NM_002140.4 [P61978-2] NP_112552.1, NM_031262.3 [P61978-1] NP_112553.1, NM_031263.3 [P61978-2] XP_005252017.1, XM_005251960.2 [P61978-2] XP_005252020.1, XM_005251963.3 [P61978-3] XP_005252022.1, XM_005251965.2 [P61978-3] XP_016870157.1, XM_017014668.1 [P61978-1] |
Genome annotation databases
Ensembli | ENST00000351839; ENSP00000317788; ENSG00000165119 [P61978-1] ENST00000360384; ENSP00000353552; ENSG00000165119 [P61978-1] ENST00000376263; ENSP00000365439; ENSG00000165119 [P61978-2] ENST00000376281; ENSP00000365458; ENSG00000165119 [P61978-2] |
GeneIDi | 3190 |
KEGGi | hsa:3190 |
UCSCi | uc004anf.5, human uc004ang.5, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S74678 mRNA Translation: AAB20770.1 X72727 mRNA Translation: CAA51267.1 CR456771 mRNA Translation: CAG33052.1 AB209562 mRNA Translation: BAD92799.1 Different initiation. AK291336 mRNA Translation: BAF84025.1 AB451263 mRNA Translation: BAG70077.1 AB451390 mRNA Translation: BAG70204.1 AL354733 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62675.1 CH471089 Genomic DNA Translation: EAW62677.1 BC000355 mRNA Translation: AAH00355.1 BC014980 mRNA Translation: AAH14980.1 |
CCDSi | CCDS6667.1 CCDS6668.1 [P61978-2] |
PIRi | S43363 |
RefSeqi | NP_001305115.1, NM_001318186.1 NP_001305116.1, NM_001318187.1 [P61978-3] NP_001305117.1, NM_001318188.1 [P61978-1] NP_002131.2, NM_002140.4 [P61978-2] NP_112552.1, NM_031262.3 [P61978-1] NP_112553.1, NM_031263.3 [P61978-2] XP_005252017.1, XM_005251960.2 [P61978-2] XP_005252020.1, XM_005251963.3 [P61978-3] XP_005252022.1, XM_005251965.2 [P61978-3] XP_016870157.1, XM_017014668.1 [P61978-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J5K | NMR | - | A | 379-463 | [»] | |
1KHM | NMR | - | A | 379-463 | [»] | |
1ZZI | X-ray | 1.80 | A/B | 385-463 | [»] | |
1ZZJ | X-ray | 2.30 | A/B/C | 385-463 | [»] | |
1ZZK | X-ray | 0.95 | A | 385-463 | [»] | |
SMRi | P61978 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109431, 522 interactors |
CORUMi | P61978 |
DIPi | DIP-31805N |
IntActi | P61978, 241 interactors |
MINTi | P61978 |
STRINGi | 9606.ENSP00000365439 |
Chemistry databases
DrugBanki | DB11638, Artenimol DB12695, Phenethyl Isothiocyanate |
Protein family/group databases
MoonDBi | P61978, Predicted |
PTM databases
iPTMneti | P61978 |
MetOSitei | P61978 |
PhosphoSitePlusi | P61978 |
SwissPalmi | P61978 |
Genetic variation databases
BioMutai | HNRNPK |
DMDMi | 48429103 |
2D gel databases
SWISS-2DPAGEi | P61978 |
Proteomic databases
CPTACi | CPTAC-1028 |
jPOSTi | P61978 |
MassIVEi | P61978 |
MaxQBi | P61978 |
PaxDbi | P61978 |
PeptideAtlasi | P61978 |
PRIDEi | P61978 |
ProteomicsDBi | 57352 57353 [P61978-2] 57354 [P61978-3] |
TopDownProteomicsi | P61978-1 [P61978-1] |
Protocols and materials databases
Antibodypediai | 2214, 590 antibodies |
DNASUi | 3190 |
Genome annotation databases
Ensembli | ENST00000351839; ENSP00000317788; ENSG00000165119 [P61978-1] ENST00000360384; ENSP00000353552; ENSG00000165119 [P61978-1] ENST00000376263; ENSP00000365439; ENSG00000165119 [P61978-2] ENST00000376281; ENSP00000365458; ENSG00000165119 [P61978-2] |
GeneIDi | 3190 |
KEGGi | hsa:3190 |
UCSCi | uc004anf.5, human uc004ang.5, human |
Organism-specific databases
CTDi | 3190 |
DisGeNETi | 3190 |
GeneCardsi | HNRNPK |
GeneReviewsi | HNRNPK |
HGNCi | HGNC:5044, HNRNPK |
HPAi | ENSG00000165119, Low tissue specificity |
MalaCardsi | HNRNPK |
MIMi | 600712, gene 616580, phenotype |
neXtProti | NX_P61978 |
OpenTargetsi | ENSG00000165119 |
Orphaneti | 352665, Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion 453504, Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation |
PharmGKBi | PA162391350 |
VEuPathDBi | HostDB:ENSG00000165119.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2192, Eukaryota |
GeneTreei | ENSGT00940000153434 |
InParanoidi | P61978 |
OMAi | DCTGPER |
OrthoDBi | 394765at2759 |
PhylomeDBi | P61978 |
TreeFami | TF316335 |
Enzyme and pathway databases
PathwayCommonsi | P61978 |
Reactomei | R-HSA-4570464, SUMOylation of RNA binding proteins R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA R-HSA-9610379, HCMV Late Events |
SIGNORi | P61978 |
Miscellaneous databases
BioGRID-ORCSi | 3190, 798 hits in 994 CRISPR screens |
ChiTaRSi | HNRNPK, human |
EvolutionaryTracei | P61978 |
GeneWikii | HNRPK |
GenomeRNAii | 3190 |
Pharosi | P61978, Tbio |
PROi | PR:P61978 |
RNActi | P61978, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165119, Expressed in female gonad and 248 other tissues |
ExpressionAtlasi | P61978, baseline and differential |
Genevisiblei | P61978, HS |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR033090, hnRNP_K IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR012987, ROK_N |
PANTHERi | PTHR10288:SF262, PTHR10288:SF262, 1 hit |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits PF08067, ROKNT, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HNRPK_HUMAN | |
Accessioni | P61978Primary (citable) accession number: P61978 Secondary accession number(s): Q07244 Q96J62 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 7, 2004 | |
Last modified: | April 7, 2021 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references