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Protein

LIM domain transcription factor LMO4

Gene

Lmo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional factor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain transcription factor LMO4
Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name:
LMO-4
Gene namesi
Name:Lmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109360 Lmo4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758211 – 165LIM domain transcription factor LMO4Add BLAST165

Proteomic databases

PaxDbiP61969
PeptideAtlasiP61969
PRIDEiP61969

PTM databases

iPTMnetiP61969
PhosphoSitePlusiP61969

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues.

Gene expression databases

BgeeiENSMUSG00000028266 Expressed in 337 organ(s), highest expression level in primary motor cortex
CleanExiMM_LMO4
ExpressionAtlasiP61969 baseline and differential
GenevisibleiP61969 MM

Interactioni

Subunit structurei

Interacts strongly with LDBS. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity. Interacts with DEAF1; LMO4 blocks export from nucleus.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201180, 4 interactors
STRINGi10090.ENSMUSP00000113513

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61969
SMRiP61969
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61969

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini87 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP61969
OMAiTELRTCV
OrthoDBiEOG091G0LKW
PhylomeDBiP61969
TreeFamiTF351071

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC
60 70 80 90 100
SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV
110 120 130 140 150
MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL
160
NSLQSNPLLP DQKVC
Length:165
Mass (Da):17,994
Last modified:June 7, 2004 - v1
Checksum:iC8AC295144AD7787
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDX9A0A0G2JDX9_MOUSE
LIM domain transcription factor LMO...
Lmo4
132Annotation score:
A0A0G2JF61A0A0G2JF61_MOUSE
LIM domain transcription factor LMO...
Lmo4
85Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074600 mRNA Translation: AAC62958.1
AF102817 mRNA Translation: AAC98510.1
AF096996 mRNA Translation: AAC83789.1
BC003488 mRNA Translation: AAH03488.1
BC004661 mRNA No translation available.
BC010278 mRNA Translation: AAH10278.3
CCDSiCCDS51085.1
RefSeqiNP_001155241.1, NM_001161769.1
NP_001155242.1, NM_001161770.1
NP_034853.1, NM_010723.3
UniGeneiMm.29187

Genome annotation databases

EnsembliENSMUST00000120539; ENSMUSP00000113840; ENSMUSG00000028266
ENSMUST00000121112; ENSMUSP00000113865; ENSMUSG00000028266
ENSMUST00000121796; ENSMUSP00000113513; ENSMUSG00000028266
GeneIDi16911
KEGGimmu:16911
UCSCiuc008rpl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074600 mRNA Translation: AAC62958.1
AF102817 mRNA Translation: AAC98510.1
AF096996 mRNA Translation: AAC83789.1
BC003488 mRNA Translation: AAH03488.1
BC004661 mRNA No translation available.
BC010278 mRNA Translation: AAH10278.3
CCDSiCCDS51085.1
RefSeqiNP_001155241.1, NM_001161769.1
NP_001155242.1, NM_001161770.1
NP_034853.1, NM_010723.3
UniGeneiMm.29187

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M3VNMR-A16-86[»]
1RUTX-ray1.30X16-152[»]
2DFYX-ray1.65C/X18-161[»]
2MBVNMR-A77-147[»]
ProteinModelPortaliP61969
SMRiP61969
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201180, 4 interactors
STRINGi10090.ENSMUSP00000113513

PTM databases

iPTMnetiP61969
PhosphoSitePlusiP61969

Proteomic databases

PaxDbiP61969
PeptideAtlasiP61969
PRIDEiP61969

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120539; ENSMUSP00000113840; ENSMUSG00000028266
ENSMUST00000121112; ENSMUSP00000113865; ENSMUSG00000028266
ENSMUST00000121796; ENSMUSP00000113513; ENSMUSG00000028266
GeneIDi16911
KEGGimmu:16911
UCSCiuc008rpl.2 mouse

Organism-specific databases

CTDi8543
MGIiMGI:109360 Lmo4

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP61969
OMAiTELRTCV
OrthoDBiEOG091G0LKW
PhylomeDBiP61969
TreeFamiTF351071

Miscellaneous databases

ChiTaRSiLmo4 mouse
EvolutionaryTraceiP61969
PROiPR:P61969
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028266 Expressed in 337 organ(s), highest expression level in primary motor cortex
CleanExiMM_LMO4
ExpressionAtlasiP61969 baseline and differential
GenevisibleiP61969 MM

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLMO4_MOUSE
AccessioniPrimary (citable) accession number: P61969
Secondary accession number(s): O00158, O88894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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