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Protein

LIM domain transcription factor LMO4

Gene

Lmo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional factor.

GO - Molecular functioni

  • enhancer sequence-specific DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcription factor binding Source: MGI

GO - Biological processi

  • negative regulation of protein complex assembly Source: MGI
  • neural tube closure Source: UniProtKB
  • positive regulation of kinase activity Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell activation Source: MGI
  • regulation of cell fate specification Source: MGI
  • regulation of cell migration Source: UniProtKB
  • spinal cord association neuron differentiation Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • thymus development Source: MGI
  • transcription by RNA polymerase II Source: MGI
  • ventral spinal cord interneuron differentiation Source: MGI
  • ventricular septum development Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain transcription factor LMO4
Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name:
LMO-4
Gene namesi
Name:Lmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109360 Lmo4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758211 – 165LIM domain transcription factor LMO4Add BLAST165

Proteomic databases

PaxDbiP61969
PeptideAtlasiP61969
PRIDEiP61969

PTM databases

iPTMnetiP61969
PhosphoSitePlusiP61969

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues.

Gene expression databases

BgeeiENSMUSG00000028266
CleanExiMM_LMO4
ExpressionAtlasiP61969 baseline and differential
GenevisibleiP61969 MM

Interactioni

Subunit structurei

Interacts strongly with LDBS. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity. Interacts with DEAF1; LMO4 blocks export from nucleus.5 Publications

GO - Molecular functioni

  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi201180, 4 interactors
STRINGi10090.ENSMUSP00000113513

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 26Combined sources3
Beta strandi33 – 38Combined sources6
Beta strandi41 – 43Combined sources3
Helixi45 – 47Combined sources3
Turni51 – 53Combined sources3
Helixi57 – 60Combined sources4
Beta strandi62 – 67Combined sources6
Beta strandi70 – 72Combined sources3
Helixi74 – 81Combined sources8
Turni88 – 90Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi106 – 109Combined sources4
Helixi110 – 112Combined sources3
Turni116 – 118Combined sources3
Beta strandi127 – 131Combined sources5
Beta strandi134 – 137Combined sources4
Helixi138 – 140Combined sources3
Turni143 – 145Combined sources3

3D structure databases

ProteinModelPortaliP61969
SMRiP61969
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61969

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini87 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP61969
OMAiICENDYS
OrthoDBiEOG091G0LKW
PhylomeDBiP61969
TreeFamiTF351071

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

P61969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC
60 70 80 90 100
SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV
110 120 130 140 150
MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL
160
NSLQSNPLLP DQKVC
Length:165
Mass (Da):17,994
Last modified:June 7, 2004 - v1
Checksum:iC8AC295144AD7787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074600 mRNA Translation: AAC62958.1
AF102817 mRNA Translation: AAC98510.1
AF096996 mRNA Translation: AAC83789.1
BC003488 mRNA Translation: AAH03488.1
BC004661 mRNA No translation available.
BC010278 mRNA Translation: AAH10278.3
CCDSiCCDS51085.1
RefSeqiNP_001155241.1, NM_001161769.1
NP_001155242.1, NM_001161770.1
NP_034853.1, NM_010723.3
UniGeneiMm.29187

Genome annotation databases

EnsembliENSMUST00000120539; ENSMUSP00000113840; ENSMUSG00000028266
ENSMUST00000121112; ENSMUSP00000113865; ENSMUSG00000028266
ENSMUST00000121796; ENSMUSP00000113513; ENSMUSG00000028266
GeneIDi16911
KEGGimmu:16911
UCSCiuc008rpl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLMO4_MOUSE
AccessioniPrimary (citable) accession number: P61969
Secondary accession number(s): O00158, O88894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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