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Protein

LIM domain transcription factor LMO4

Gene

LMO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain transcription factor LMO4
Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name:
LMO-4
Gene namesi
Name:LMO4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143013.12
HGNCiHGNC:6644 LMO4
MIMi603129 gene
neXtProtiNX_P61968

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi8543
OpenTargetsiENSG00000143013
PharmGKBiPA30410

Polymorphism and mutation databases

BioMutaiLMO4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758201 – 165LIM domain transcription factor LMO4Add BLAST165

Proteomic databases

EPDiP61968
MaxQBiP61968
PaxDbiP61968
PeptideAtlasiP61968
PRIDEiP61968
ProteomicsDBi57350

PTM databases

iPTMnetiP61968
PhosphoSitePlusiP61968

Expressioni

Gene expression databases

BgeeiENSG00000143013 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_LMO4
GenevisibleiP61968 HS

Organism-specific databases

HPAiCAB022345
HPA045877
HPA061638

Interactioni

Subunit structurei

Interacts strongly with LDBS. Interacts with DEAF1; LMO4 blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114113, 60 interactors
CORUMiP61968
DIPiDIP-41414N
IntActiP61968, 126 interactors
MINTiP61968
STRINGi9606.ENSP00000359573

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61968
SMRiP61968
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61968

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini87 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP61968
OMAiICENDYS
OrthoDBiEOG091G0LKW
PhylomeDBiP61968
TreeFamiTF351071

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

P61968-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC
60 70 80 90 100
SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV
110 120 130 140 150
MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL
160
NSLQSNPLLP DQKVC
Length:165
Mass (Da):17,994
Last modified:June 7, 2004 - v1
Checksum:iC8AC295144AD7787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24576 mRNA Translation: AAB51073.1
CH471097 Genomic DNA Translation: EAW73168.1
CH471097 Genomic DNA Translation: EAW73169.1
BC003600 mRNA Translation: AAH03600.1
BC017673 mRNA Translation: AAH17673.1
BC065818 mRNA Translation: AAH65818.1
CCDSiCCDS713.1
RefSeqiNP_006760.1, NM_006769.3
XP_005271348.1, XM_005271291.3
UniGeneiHs.436792

Genome annotation databases

EnsembliENST00000370542; ENSP00000359573; ENSG00000143013
ENST00000370544; ENSP00000359575; ENSG00000143013
GeneIDi8543
KEGGihsa:8543
UCSCiuc001dmi.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24576 mRNA Translation: AAB51073.1
CH471097 Genomic DNA Translation: EAW73168.1
CH471097 Genomic DNA Translation: EAW73169.1
BC003600 mRNA Translation: AAH03600.1
BC017673 mRNA Translation: AAH17673.1
BC065818 mRNA Translation: AAH65818.1
CCDSiCCDS713.1
RefSeqiNP_006760.1, NM_006769.3
XP_005271348.1, XM_005271291.3
UniGeneiHs.436792

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4ZNMR-A16-82[»]
ProteinModelPortaliP61968
SMRiP61968
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114113, 60 interactors
CORUMiP61968
DIPiDIP-41414N
IntActiP61968, 126 interactors
MINTiP61968
STRINGi9606.ENSP00000359573

PTM databases

iPTMnetiP61968
PhosphoSitePlusiP61968

Polymorphism and mutation databases

BioMutaiLMO4

Proteomic databases

EPDiP61968
MaxQBiP61968
PaxDbiP61968
PeptideAtlasiP61968
PRIDEiP61968
ProteomicsDBi57350

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370542; ENSP00000359573; ENSG00000143013
ENST00000370544; ENSP00000359575; ENSG00000143013
GeneIDi8543
KEGGihsa:8543
UCSCiuc001dmi.4 human

Organism-specific databases

CTDi8543
DisGeNETi8543
EuPathDBiHostDB:ENSG00000143013.12
GeneCardsiLMO4
HGNCiHGNC:6644 LMO4
HPAiCAB022345
HPA045877
HPA061638
MIMi603129 gene
neXtProtiNX_P61968
OpenTargetsiENSG00000143013
PharmGKBiPA30410
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP61968
OMAiICENDYS
OrthoDBiEOG091G0LKW
PhylomeDBiP61968
TreeFamiTF351071

Miscellaneous databases

ChiTaRSiLMO4 human
EvolutionaryTraceiP61968
GeneWikiiLMO4
GenomeRNAii8543
PROiPR:P61968
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143013 Expressed in 236 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_LMO4
GenevisibleiP61968 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLMO4_HUMAN
AccessioniPrimary (citable) accession number: P61968
Secondary accession number(s): D3DT23, O00158, O88894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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