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Protein

AP-1 complex subunit sigma-1A

Gene

Ap1s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • response to virus Source: Ensembl
  • retrograde transport, endosome to Golgi Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit sigma-1A
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1A
Adaptor-related protein complex 1 subunit sigma-1A
Clathrin assembly protein complex 1 sigma-1A small chain
Clathrin coat assembly protein AP19
Golgi adaptor HA1/AP1 adaptin sigma-1A subunit
HA1 19 kDa subunit
Sigma 1a subunit of AP-1 clathrin
Sigma-adaptin 1A
Sigma1A-adaptin
Gene namesi
Name:Ap1s1
Synonyms:Ap19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1098244 Ap1s1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937981 – 158AP-1 complex subunit sigma-1AAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61967
MaxQBiP61967
PaxDbiP61967
PeptideAtlasiP61967
PRIDEiP61967

PTM databases

iPTMnetiP61967
PhosphoSitePlusiP61967

Expressioni

Tissue specificityi

Detected in brain and embryonic stem cells.

Gene expression databases

BgeeiENSMUSG00000004849 Expressed in 286 organ(s), highest expression level in striatum
CleanExiMM_AP1S1
ExpressionAtlasiP61967 baseline and differential
GenevisibleiP61967 MM

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

Protein-protein interaction databases

BioGridi198127, 1 interactor
CORUMiP61967
IntActiP61967, 4 interactors
STRINGi10090.ENSMUSP00000106709

Structurei

3D structure databases

ProteinModelPortaliP61967
SMRiP61967
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61967

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0934 Eukaryota
COG5030 LUCA
GeneTreeiENSGT00530000062839
HOGENOMiHOG000185227
HOVERGENiHBG050517
InParanoidiP61967
KOiK12394
OMAiYRVVYKR
PhylomeDBiP61967
TreeFamiTF312921

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P61967-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL
60 70 80 90 100
EWRDLKVVYK RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE
110 120 130 140 150
LDIIFNFEKA YFILDEFLMG GDVQDTSKKS VLKAIEQADL LQEEDESPRS

VLEEMGLA
Length:158
Mass (Da):18,733
Last modified:June 7, 2004 - v1
Checksum:iE461937790406D8B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXN0D3YXN0_MOUSE
AP complex subunit sigma
Ap1s1
189Annotation score:
D3Z0D6D3Z0D6_MOUSE
AP complex subunit sigma
Ap1s1
150Annotation score:
D3Z268D3Z268_MOUSE
AP-1 complex subunit sigma-1A
Ap1s1
77Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62418 mRNA Translation: AAA37243.1
AK002225 mRNA Translation: BAB21947.1
BC052692 mRNA Translation: AAH52692.1
CCDSiCCDS39330.1
PIRiA40535
RefSeqiNP_031483.1, NM_007457.2
UniGeneiMm.833

Genome annotation databases

EnsembliENSMUST00000111080; ENSMUSP00000106709; ENSMUSG00000004849
GeneIDi11769
KEGGimmu:11769
UCSCiuc009abm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62418 mRNA Translation: AAA37243.1
AK002225 mRNA Translation: BAB21947.1
BC052692 mRNA Translation: AAH52692.1
CCDSiCCDS39330.1
PIRiA40535
RefSeqiNP_031483.1, NM_007457.2
UniGeneiMm.833

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W63X-ray4.00Q/S/T/U/W/X1-158[»]
ProteinModelPortaliP61967
SMRiP61967
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198127, 1 interactor
CORUMiP61967
IntActiP61967, 4 interactors
STRINGi10090.ENSMUSP00000106709

PTM databases

iPTMnetiP61967
PhosphoSitePlusiP61967

Proteomic databases

EPDiP61967
MaxQBiP61967
PaxDbiP61967
PeptideAtlasiP61967
PRIDEiP61967

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111080; ENSMUSP00000106709; ENSMUSG00000004849
GeneIDi11769
KEGGimmu:11769
UCSCiuc009abm.1 mouse

Organism-specific databases

CTDi1174
MGIiMGI:1098244 Ap1s1

Phylogenomic databases

eggNOGiKOG0934 Eukaryota
COG5030 LUCA
GeneTreeiENSGT00530000062839
HOGENOMiHOG000185227
HOVERGENiHBG050517
InParanoidiP61967
KOiK12394
OMAiYRVVYKR
PhylomeDBiP61967
TreeFamiTF312921

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

EvolutionaryTraceiP61967
PROiPR:P61967
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004849 Expressed in 286 organ(s), highest expression level in striatum
CleanExiMM_AP1S1
ExpressionAtlasiP61967 baseline and differential
GenevisibleiP61967 MM

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1S1_MOUSE
AccessioniPrimary (citable) accession number: P61967
Secondary accession number(s): P82267
, Q00382, Q9BTN4, Q9UDW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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