Wdr5

Functionⁱ

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	107	Important for interaction with histone H3By similarity	1
Siteⁱ	133	Important for interaction with histone H3By similarity	1
Siteⁱ	263	Important for interaction with histone H3By similarity	1
Siteⁱ	322	Important for interaction with histone H3By similarity	1

GO - Molecular functionⁱ

histone acetyltransferase activity (H4-K16 specific) Source: Ensembl
histone acetyltransferase activity (H4-K5 specific) Source: Ensembl
histone acetyltransferase activity (H4-K8 specific) Source: Ensembl
histone methyltransferase activity (H3-K4 specific) Source: Ensembl
methylated histone binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H3 acetylation Source: MGI
histone H3-K4 methylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 24051374
histone H4-K16 acetylation Source: UniProtKB
histone H4-K5 acetylation Source: UniProtKB
histone H4-K8 acetylation Source: UniProtKB
neuron projection development Source: MGI
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
Source: MGI
Inferred from genetic interactionⁱ
- 24051374
skeletal system development
Source: MGI
Inferred from direct assayⁱ
- 11551928

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214841 PKMTs methylate histone lysines R-MMU-3214847 HATs acetylate histones R-MMU-3214858 RMTs methylate histone arginines R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3214847 HATs acetylate histones
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8951664 Neddylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 5 Alternative name(s): BMP2-induced 3-kb gene protein WD repeat-containing protein BIG-3
Gene namesⁱ	Name:Wdr5 Synonyms:Big, Big3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2155884 Wdr5

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000051351	2 – 334	WD repeat-containing protein 5Add BLAST		333

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Cross-linkⁱ	7	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	46	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	112	N6-acetyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P61965
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P61965
PaxDbⁱ	P61965
PeptideAtlas More...PeptideAtlasⁱ	P61965
PRIDEⁱ	P61965

PTM databases

iPTMnetⁱ	P61965
PhosphoSitePlusⁱ	P61965

Expressionⁱ

Tissue specificityⁱ

Expressed in liver (at protein level). Detected in brain, testis and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000026917 Expressed in 279 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_WDR5
ExpressionAtlasⁱ	P61965 baseline and differential
Genevisibleⁱ	P61965 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component ofthe ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and KAT14. Interacts with histone H3. Interacts with SETD1A. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Pou5f1	P20263	7	EBI-1247084,EBI-1606219

With

Entry

#Exp.

IntAct

Notes

Pou5f1

P20263

7

EBI-1247084,EBI-1606219

GO - Molecular functionⁱ

methylated histone binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	228326, 50 interactors
ComplexPortalⁱ	CPX-1025 GCN5-containing ATAC complex CPX-1029 PCAF-containing ATAC complex CPX-875 NSL histone acetyltransferase complex
CORUMⁱ	P61965
Database of interacting proteins More...DIPⁱ	DIP-38618N
ELMⁱ	P61965
IntActⁱ	P61965, 47 interactors
Molecular INTeraction database More...MINTⁱ	P61965
STRINGⁱ	10090.ENSMUSP00000109585

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	36 – 41	Combined sources	6
Beta strandⁱ	48 – 53	Combined sources	6
Beta strandⁱ	57 – 64	Combined sources	8
Beta strandⁱ	69 – 73	Combined sources	5
Turnⁱ	74 – 76	Combined sources	3
Beta strandⁱ	79 – 83	Combined sources	5
Beta strandⁱ	90 – 95	Combined sources	6
Beta strandⁱ	99 – 106	Combined sources	8
Beta strandⁱ	109 – 115	Combined sources	7
Turnⁱ	116 – 119	Combined sources	4
Beta strandⁱ	120 – 126	Combined sources	7
Beta strandⁱ	132 – 137	Combined sources	6
Beta strandⁱ	142 – 148	Combined sources	7
Beta strandⁱ	153 – 157	Combined sources	5
Turnⁱ	158 – 160	Combined sources	3
Beta strandⁱ	163 – 167	Combined sources	5
Beta strandⁱ	174 – 179	Combined sources	6
Beta strandⁱ	183 – 190	Combined sources	8
Beta strandⁱ	195 – 199	Combined sources	5
Turnⁱ	200 – 203	Combined sources	4
Beta strandⁱ	204 – 209	Combined sources	6
Beta strandⁱ	217 – 222	Combined sources	6
Beta strandⁱ	226 – 233	Combined sources	8
Turnⁱ	234 – 236	Combined sources	3
Beta strandⁱ	237 – 242	Combined sources	6
Turnⁱ	243 – 246	Combined sources	4
Beta strandⁱ	247 – 252	Combined sources	6
Beta strandⁱ	258 – 260	Combined sources	3
Beta strandⁱ	264 – 267	Combined sources	4
Beta strandⁱ	269 – 271	Combined sources	3
Beta strandⁱ	273 – 276	Combined sources	4
Beta strandⁱ	283 – 287	Combined sources	5
Turnⁱ	288 – 290	Combined sources	3
Beta strandⁱ	293 – 297	Combined sources	5
Beta strandⁱ	304 – 309	Combined sources	6
Beta strandⁱ	311 – 320	Combined sources	10
Turnⁱ	322 – 324	Combined sources	3
Beta strandⁱ	327 – 331	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P61965
SMRⁱ	P61965
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P61965

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	43 – 82	WD 1Add BLAST	40
Repeatⁱ	85 – 126	WD 2Add BLAST	42
Repeatⁱ	128 – 168	WD 3Add BLAST	41
Repeatⁱ	169 – 208	WD 4Add BLAST	40
Repeatⁱ	212 – 253	WD 5Add BLAST	42
Repeatⁱ	256 – 296	WD 6Add BLAST	41
Repeatⁱ	299 – 333	WD 7Add BLAST	35

Sequence similaritiesⁱ

Belongs to the WD repeat WDR5/wds family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0266 Eukaryota ENOG410XP3K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000091642
HOVERGENⁱ	HBG055117
InParanoidⁱ	P61965
KEGG Orthology (KO) More...KOⁱ	K14963
OMAⁱ	DNPICSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CM2
PhylomeDBⁱ	P61965
TreeFamⁱ	TF314125

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf IPR037834 WDR5
PANTHERⁱ	PTHR22847:SF560 PTHR22847:SF560, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 4 hits PS50082 WD_REPEATS_2, 6 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P61965-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS 
        60         70         80         90        100
VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN 
       110        120        130        140        150
LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD 
       160        170        180        190        200
ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT 
       210        220        230        240        250
ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK 
       260        270        280        290        300
TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 
       310        320        330 
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC

Length:334

Mass (Da):36,588

Last modified:June 7, 2004 - v1

Checksum:ⁱ4BF30914A2250286

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F6Q3W0	F6Q3W0_MOUSE		WD repeat-containing protein 5 WD repeat-containing protein 5	Wdr5	281	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF416510 mRNA Translation: AAL27006.1 AK075937 mRNA Translation: BAC36067.1 BC008547 mRNA Translation: AAH08547.1 BC016103 mRNA Translation: AAH16103.1 BC025801 mRNA Translation: AAH25801.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15829.1
NCBI Reference Sequences More...RefSeqⁱ	NP_543124.1, NM_080848.2 XP_006497735.1, XM_006497672.3
UniGeneⁱ	Mm.28265

Genome annotation databases

Ensemblⁱ	ENSMUST00000113952; ENSMUSP00000109585; ENSMUSG00000026917
GeneIDⁱ	140858
KEGGⁱ	mmu:140858
UCSC genome browser More...UCSCⁱ	uc012bsw.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P61965	WD repeat-containing protein 5	)	HUMAN		334	UniRef100_P61964
WD repeat-containing protein 5	)	RAT		334
WD repeat domain 5 (Fragment)		MUSPF		333
WD repeat-containing protein 5		MACMU		334
WD repeat domain 5		PANTR		334
+33

Protein	Similar proteins		Species	Score	Length	Source
P61965	WD repeat-containing protein 5	)	HUMAN		334	UniRef90_P61964
WD repeat-containing protein 5	)	RAT		334
WD repeat domain 5 (Fragment)		MUSPF		333
WD repeat-containing protein 5		MACMU		334
WD repeat domain 5		PANTR		334
+45

Protein	Similar proteins		Species	Score	Length	Source
P61965	WD repeat-containing protein 5	)	HUMAN		334	UniRef50_P61964
WD repeat-containing protein 5	)	RAT		334
WD repeat domain 5 (Fragment)		MUSPF		333
WD repeat-containing protein 5		MACMU		334
WD repeat domain 5		PANTR		334
+80

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF416510 mRNA Translation: AAL27006.1 AK075937 mRNA Translation: BAC36067.1 BC008547 mRNA Translation: AAH08547.1 BC016103 mRNA Translation: AAH16103.1 BC025801 mRNA Translation: AAH25801.1
CCDSⁱ	CCDS15829.1
RefSeqⁱ	NP_543124.1, NM_080848.2 XP_006497735.1, XM_006497672.3
UniGeneⁱ	Mm.28265

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2XL2	X-ray	2.40	A/B	1-334	[»]
	2XL3	X-ray	2.70	A/B	1-334	[»]
ProteinModelPortalⁱ	P61965
SMRⁱ	P61965
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	228326, 50 interactors
ComplexPortalⁱ	CPX-1025 GCN5-containing ATAC complex CPX-1029 PCAF-containing ATAC complex CPX-875 NSL histone acetyltransferase complex
CORUMⁱ	P61965
DIPⁱ	DIP-38618N
ELMⁱ	P61965
IntActⁱ	P61965, 47 interactors
MINTⁱ	P61965
STRINGⁱ	10090.ENSMUSP00000109585

PTM databases

iPTMnetⁱ	P61965
PhosphoSitePlusⁱ	P61965

Proteomic databases

EPDⁱ	P61965
MaxQBⁱ	P61965
PaxDbⁱ	P61965
PeptideAtlasⁱ	P61965
PRIDEⁱ	P61965

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000113952; ENSMUSP00000109585; ENSMUSG00000026917
GeneIDⁱ	140858
KEGGⁱ	mmu:140858
UCSCⁱ	uc012bsw.2 mouse

Organism-specific databases

CTDⁱ	11091
MGIⁱ	MGI:2155884 Wdr5

Phylogenomic databases

eggNOGⁱ	KOG0266 Eukaryota ENOG410XP3K LUCA
GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000091642
HOVERGENⁱ	HBG055117
InParanoidⁱ	P61965
KOⁱ	K14963
OMAⁱ	DNPICSH
OrthoDBⁱ	EOG091G0CM2
PhylomeDBⁱ	P61965
TreeFamⁱ	TF314125

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214841 PKMTs methylate histone lysines R-MMU-3214847 HATs acetylate histones R-MMU-3214858 RMTs methylate histone arginines R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3214847 HATs acetylate histones
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8951664 Neddylation

Miscellaneous databases

EvolutionaryTraceⁱ	P61965
Protein Ontology More...PROⁱ	PR:P61965
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026917 Expressed in 279 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_WDR5
ExpressionAtlasⁱ	P61965 baseline and differential
Genevisibleⁱ	P61965 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf IPR037834 WDR5
PANTHERⁱ	PTHR22847:SF560 PTHR22847:SF560, 1 hit
Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 4 hits PS50082 WD_REPEATS_2, 6 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR5_MOUSE
Accessionⁱ	P61965Primary (citable) accession number: P61965 Secondary accession number(s): Q91VA5 , Q922C9, Q9NWX7, Q9UGP9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	June 7, 2004
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P61965 (WDR5_MOUSE)

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WD repeat-containing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ