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Entry version 186 (07 Oct 2020)
Sequence version 1 (07 Jun 2004)
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Protein

WD repeat-containing protein 5

Gene

WDR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).By similarity9 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei107Important for interaction with histone H31
Sitei133Important for interaction with histone H31
Sitei263Important for interaction with histone H31
Sitei322Important for interaction with histone H31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GO_Central
  • methylated histone binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P61964

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-3214847, HATs acetylate histones
R-HSA-3214858, RMTs methylate histone arginines
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8951664, Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P61964

SIGNOR Signaling Network Open Resource

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SIGNORi
P61964

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 5
Alternative name(s):
BMP2-induced 3-kb gene protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR5
Synonyms:BIG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196363.9

Human Gene Nomenclature Database

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HGNCi
HGNC:12757, WDR5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609012, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P61964

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47A → E: Strongly reduced affinity for histone H3. 1 Publication1
Mutagenesisi91S → F: Strongly reduced affinity for histone H3. 1 Publication1
Mutagenesisi107D → A: Strongly reduced affinity for histone H3. Significant decrease in interaction with KMT2A. 3 Publications1
Mutagenesisi107D → N: Strongly reduced affinity for histone H3. 1 Publication1
Mutagenesisi133F → A: Strongly reduced affinity for histone H3. Significant decrease in interaction with KMT2A. 2 Publications1
Mutagenesisi133F → D: Strongly reduced affinity for histone H3. 1 Publication1
Mutagenesisi133F → L: Strongly reduced affinity for histone H3. 1 Publication1
Mutagenesisi149F → A: Significant decrease in interaction with KMT2A. 1 Publication1
Mutagenesisi225N → A: Loss of interaction with RBBP5 and reduced ability to stimulate KMT2A methyltransferase activity in association with RBBP5 and ASH2L. 1 Publication1
Mutagenesisi240L → K: Loss of interaction with RBBP5 and reduced ability to stimulate KMT2A methyltransferase activity in association with RBBP5 and ASH2L. 1 Publication1
Mutagenesisi263F → A: Strongly reduced affinity for histone H3. Significant decrease in interaction with KMT2A. 2 Publications1
Mutagenesisi263F → W: Strongly reduced affinity for histone H3. 1 Publication1
Mutagenesisi289Q → A: Reduced interaction with RBBP5 and reduced ability to stimulate KMT2A methyltransferase activity in association with RBBP5 and ASH2L. 1 Publication1
Mutagenesisi321L → A: Abolishes histone H3 binding. 1 Publication1
Mutagenesisi322E → A: Strongly reduced affinity for histone H3. No effect on interaction with KMT2A. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
11091

Open Targets

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OpenTargetsi
ENSG00000196363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37361

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P61964, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1075317

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2831

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
WDR5

Domain mapping of disease mutations (DMDM)

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DMDMi
48429182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513502 – 334WD repeat-containing protein 5Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei112N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P61964

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P61964

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P61964

MaxQB - The MaxQuant DataBase

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MaxQBi
P61964

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P61964

PeptideAtlas

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PeptideAtlasi
P61964

PRoteomics IDEntifications database

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PRIDEi
P61964

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57347

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P61964

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P61964

SwissPalm database of S-palmitoylation events

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SwissPalmi
P61964

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196363, Expressed in testis and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P61964, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61964, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000196363, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3 (By similarity).

Interacts with HCFC1 (PubMed:12670868).

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755).

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (PubMed:15199122, PubMed:15960975, PubMed:17021013, PubMed:17500065). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (PubMed:14992727, PubMed:18378692).

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852).

Interacts with KMT2A/MLL1 (via WIN motif) and RBBP5; the interaction is direct (PubMed:19556245, PubMed:21220120, PubMed:22665483, PubMed:22266653, PubMed:18840606, PubMed:18829459).

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT2A, MBIP and KAT14 (PubMed:19103755).

Interacts with histone H3 (PubMed:16946699, PubMed:16600877, PubMed:16829960, PubMed:16829959).

Interacts with SETD1A (via WIN motif) (PubMed:17998332, PubMed:22665483, PubMed:22266653).

Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (PubMed:19131338).

Interacts with ZNF335 (PubMed:19131338, PubMed:23178126). Components of this complex may associate with components of the ZNF335-CCAR2-EMSY nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (PubMed:19131338).

Interacts with PER1 (By similarity).

Interacts with KMT2B (via WIN motif), KMT2C (via WIN motif), KMT2D (via WIN motif) and SETD1B (via WIN motif) (PubMed:22665483, PubMed:22266653, PubMed:18840606).

By similarity25 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P61964
With#Exp.IntAct
AKAP8 [O43823]3EBI-540834,EBI-1237481
ANAPC2 [Q9UJX6]3EBI-540834,EBI-396211
ATN1 [P54259]3EBI-540834,EBI-945980
BBC3 [Q96PG8]3EBI-540834,EBI-17289784
C1orf104 [A2RRG2]3EBI-540834,EBI-10173042
CHD8 [Q9HCK8]3EBI-540834,EBI-1169146
FAM199X [Q6PEV8]4EBI-540834,EBI-4280426
H3C12 [P68431]11EBI-540834,EBI-79722
HCFC1 [P51610]5EBI-540834,EBI-396176
HSF2 [Q03933]7EBI-540834,EBI-2556750
KANSL1 [Q7Z3B3]11EBI-540834,EBI-740244
KANSL2 [Q9H9L4]3EBI-540834,EBI-2560840
KAT6A [Q92794]4EBI-540834,EBI-948013
KMT2A [Q03164]13EBI-540834,EBI-591370
MLL cleavage product C180 (PRO_0000390950)2EBI-540834,EBI-2638616
KMT2B [Q9UMN6]6EBI-540834,EBI-765774
KMT2C [Q8NEZ4]4EBI-540834,EBI-1042997
MARF1 [Q9Y4F3]6EBI-540834,EBI-5235902
MAVS - isoform 1 [Q7Z434-1]3EBI-540834,EBI-15577799
MBIP [Q9NS73]5EBI-540834,EBI-741953
MBIP - isoform 4 [Q9NS73-5]4EBI-540834,EBI-10182361
MDM4 [O15151]3EBI-540834,EBI-398437
MEOX2 [Q6FHY5]3EBI-540834,EBI-16439278
NCOA6 [Q14686]8EBI-540834,EBI-78670
NR2E3 [Q9Y5X4]5EBI-540834,EBI-7216962
PAXIP1 [Q6ZW49]9EBI-540834,EBI-743225
PDE9A - isoform PDE9A2 [O76083-2]3EBI-540834,EBI-11524542
RBBP5 [Q15291]14EBI-540834,EBI-592823
SRRM4 [A7MD48]3EBI-540834,EBI-3867173
SSX2IP [Q9Y2D8]3EBI-540834,EBI-2212028
TERF2IP [Q9NYB0]2EBI-540834,EBI-750109
TRAF3 [Q13114]2EBI-540834,EBI-357631
TRAF6 [Q9Y4K3]2EBI-540834,EBI-359276
WWP2 [O00308]3EBI-540834,EBI-743923
ZBTB48 [P10074]3EBI-540834,EBI-744864
ZXDC [Q2QGD7]5EBI-540834,EBI-1538838
Q9H8913EBI-540834,EBI-10218875
Arntl [Q9WTL8] from Mus musculus.2EBI-540834,EBI-644534

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116272, 238 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1004, PCAF-containing ATAC complex
CPX-809, NSL histone acetyltransferase complex
CPX-997, GCN5-containing ATAC complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P61964

Database of interacting proteins

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DIPi
DIP-29223N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P61964

Protein interaction database and analysis system

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IntActi
P61964, 169 interactors

Molecular INTeraction database

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MINTi
P61964

STRING: functional protein association networks

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STRINGi
9606.ENSP00000351446

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P61964

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P61964, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

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SASBDBi
P61964

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61964

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P61964

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 82WD 1Add BLAST40
Repeati85 – 126WD 2Add BLAST42
Repeati128 – 168WD 3Add BLAST41
Repeati169 – 208WD 4Add BLAST40
Repeati212 – 253WD 5Add BLAST42
Repeati256 – 296WD 6Add BLAST41
Repeati299 – 333WD 7Add BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0266, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154143

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000288_57_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61964

KEGG Orthology (KO)

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KOi
K14963

Identification of Orthologs from Complete Genome Data

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OMAi
CTTCHPT

Database of Orthologous Groups

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OrthoDBi
957291at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P61964

TreeFam database of animal gene trees

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TreeFami
TF314125

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00377

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020472, G-protein_beta_WD-40_rep
IPR037866, Swd3/WDR5
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR22847:SF516, PTHR22847:SF516, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400, WD40, 7 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00320, GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 4 hits
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61964-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS
60 70 80 90 100
VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN
110 120 130 140 150
LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD
160 170 180 190 200
ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT
210 220 230 240 250
ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK
260 270 280 290 300
TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH
310 320 330
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC
Length:334
Mass (Da):36,588
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF30914A2250286
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ59V9GZ59_HUMAN
WD repeat-containing protein 5
WDR5
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYQ5V9GYQ5_HUMAN
WD repeat-containing protein 5
WDR5
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB66159 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081531208T → M De novo variant found in a patient with childhood apraxia of speech; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ011376 mRNA Translation: CAB66159.1 Different initiation.
AK000552 mRNA Translation: BAA91248.1
BC001635 mRNA Translation: AAH01635.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6981.1

NCBI Reference Sequences

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RefSeqi
NP_060058.1, NM_017588.2
NP_438172.1, NM_052821.3
XP_005272220.1, XM_005272163.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358625; ENSP00000351446; ENSG00000196363

Database of genes from NCBI RefSeq genomes

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GeneIDi
11091

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11091

UCSC genome browser

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UCSCi
uc004cey.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011376 mRNA Translation: CAB66159.1 Different initiation.
AK000552 mRNA Translation: BAA91248.1
BC001635 mRNA Translation: AAH01635.1
CCDSiCCDS6981.1
RefSeqiNP_060058.1, NM_017588.2
NP_438172.1, NM_052821.3
XP_005272220.1, XM_005272163.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CNXX-ray2.10A20-334[»]
2CO0X-ray2.25A/C20-334[»]
2G99X-ray1.90A/B27-334[»]
2G9AX-ray2.70A29-334[»]
2GNQX-ray1.80A1-334[»]
2H13X-ray1.58A22-334[»]
2H14X-ray1.48A22-334[»]
2H68X-ray1.79A/B23-334[»]
2H6KX-ray1.89A/B23-334[»]
2H6NX-ray1.50A/B23-334[»]
2H6QX-ray1.87A/B23-334[»]
2H9LX-ray1.75A24-334[»]
2H9MX-ray1.90A/C24-334[»]
2H9NX-ray2.00A/C24-334[»]
2H9PX-ray1.91A24-334[»]
2O9KX-ray1.90A/C24-334[»]
3EG6X-ray1.72A23-334[»]
3EMHX-ray1.37A25-334[»]
3MXXX-ray2.05A31-334[»]
3N0DX-ray2.30A31-334[»]
3N0EX-ray2.50A31-334[»]
3P4FX-ray2.35A22-334[»]
3PSLX-ray1.70A/B21-334[»]
3SMRX-ray1.82A/B/C/D24-334[»]
3UR4X-ray1.80A/B24-334[»]
3UVKX-ray1.40A21-334[»]
3UVLX-ray2.20A21-334[»]
3UVMX-ray1.57A21-334[»]
3UVNX-ray1.79A/C21-334[»]
3UVOX-ray2.20A21-334[»]
4A7JX-ray1.90A21-334[»]
4CY1X-ray1.50A/B23-334[»]
4CY2X-ray2.00A23-334[»]
4ERQX-ray1.91A/B/C23-334[»]
4ERYX-ray1.30A23-334[»]
4ERZX-ray1.75A/B/C23-334[»]
4ES0X-ray1.82A23-334[»]
4ESGX-ray1.70A/B23-334[»]
4EWRX-ray1.50A23-334[»]
4GM3X-ray3.39A/B/C/D/E/F/G/H22-334[»]
4GM8X-ray2.60A/B/C/D22-334[»]
4GM9X-ray2.10A/B22-334[»]
4GMBX-ray2.78A22-334[»]
4IA9X-ray1.66A24-334[»]
4O45X-ray1.87A24-334[»]
4QL1X-ray1.50A/B24-334[»]
4Y7RX-ray1.90A22-334[»]
5EALX-ray1.80A/B24-334[»]
5EAMX-ray1.80A/B24-334[»]
5EAPX-ray1.73A24-334[»]
5EARX-ray1.80A/B24-334[»]
5M23X-ray1.97A22-334[»]
5M25X-ray2.43A22-334[»]
5SXMX-ray2.00A/B23-334[»]
5VFCX-ray1.64A24-334[»]
6BYNX-ray2.69W31-334[»]
6D9XX-ray1.83A22-334[»]
6DAIX-ray1.63A22-334[»]
6DAKX-ray1.60A22-334[»]
6DARX-ray1.88A22-334[»]
6DASX-ray1.80A/B22-334[»]
6DY7X-ray1.90A31-334[»]
6DYAX-ray2.56A30-334[»]
6E1YX-ray1.22A/B22-334[»]
6E1ZX-ray1.10A/B22-334[»]
6E22X-ray1.60A/B22-334[»]
6E23X-ray1.66A/B22-334[»]
6IAMX-ray1.51A29-334[»]
6KIUelectron microscopy3.20R1-334[»]
6KIVelectron microscopy4.00R1-334[»]
6KIWelectron microscopy4.00R1-334[»]
6KIXelectron microscopy4.10R1-334[»]
6KIZelectron microscopy4.50R1-334[»]
6OFZX-ray1.85A22-334[»]
6OI0X-ray1.92A22-334[»]
6OI1X-ray1.68A22-334[»]
6OI2X-ray1.68A22-334[»]
6OI3X-ray1.66A22-334[»]
6PG3X-ray2.04A/B22-334[»]
6PG4X-ray1.60A32-334[»]
6PG5X-ray1.99A32-334[»]
6PG6X-ray1.68A/B22-334[»]
6PG7X-ray2.45A32-334[»]
6PG8X-ray1.67A/B/C/D22-334[»]
6PG9X-ray1.75A/B22-334[»]
6PGAX-ray2.45A32-334[»]
6PGBX-ray1.73A32-334[»]
6PGCX-ray1.81A32-334[»]
6PGDX-ray1.50A32-334[»]
6PGEX-ray1.76A32-334[»]
6PGFX-ray1.54A32-334[»]
6PWVelectron microscopy6.20B22-334[»]
6PWWelectron microscopy4.40B22-334[»]
6U5MX-ray1.80A/B31-334[»]
6U5YX-ray1.53A/B31-334[»]
6U6WX-ray1.20A/B24-334[»]
6U80X-ray1.55A/B24-334[»]
6U8BX-ray1.26A/B24-334[»]
6U8LX-ray1.57A/B31-334[»]
6U8OX-ray1.60A31-334[»]
6UCSX-ray1.85A/B22-334[»]
6UFXX-ray2.02A32-334[»]
6UHYX-ray1.26A/B31-334[»]
6UHZX-ray1.26A/B31-334[»]
6UIFX-ray1.60A/B31-334[»]
6UIKX-ray1.60A/B31-334[»]
6UJ4X-ray1.53A/B31-334[»]
6UJHX-ray1.49A/B22-334[»]
6UJJX-ray1.73A22-334[»]
6UJLX-ray1.60A22-334[»]
6UOZX-ray1.53A/B31-334[»]
SASBDBiP61964
SMRiP61964
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116272, 238 interactors
ComplexPortaliCPX-1004, PCAF-containing ATAC complex
CPX-809, NSL histone acetyltransferase complex
CPX-997, GCN5-containing ATAC complex
CORUMiP61964
DIPiDIP-29223N
ELMiP61964
IntActiP61964, 169 interactors
MINTiP61964
STRINGi9606.ENSP00000351446

Chemistry databases

BindingDBiP61964
ChEMBLiCHEMBL1075317
GuidetoPHARMACOLOGYi2831

PTM databases

iPTMnetiP61964
PhosphoSitePlusiP61964
SwissPalmiP61964

Polymorphism and mutation databases

BioMutaiWDR5
DMDMi48429182

Proteomic databases

EPDiP61964
jPOSTiP61964
MassIVEiP61964
MaxQBiP61964
PaxDbiP61964
PeptideAtlasiP61964
PRIDEiP61964
ProteomicsDBi57347

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P61964, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31978, 396 antibodies

The DNASU plasmid repository

More...
DNASUi
11091

Genome annotation databases

EnsembliENST00000358625; ENSP00000351446; ENSG00000196363
GeneIDi11091
KEGGihsa:11091
UCSCiuc004cey.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11091
DisGeNETi11091
EuPathDBiHostDB:ENSG00000196363.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR5
HGNCiHGNC:12757, WDR5
HPAiENSG00000196363, Low tissue specificity
MIMi609012, gene
neXtProtiNX_P61964
OpenTargetsiENSG00000196363
PharmGKBiPA37361

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0266, Eukaryota
GeneTreeiENSGT00940000154143
HOGENOMiCLU_000288_57_1_1
InParanoidiP61964
KOiK14963
OMAiCTTCHPT
OrthoDBi957291at2759
PhylomeDBiP61964
TreeFamiTF314125

Enzyme and pathway databases

PathwayCommonsiP61964
ReactomeiR-HSA-3214841, PKMTs methylate histone lysines
R-HSA-3214847, HATs acetylate histones
R-HSA-3214858, RMTs methylate histone arginines
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8951664, Neddylation
SignaLinkiP61964
SIGNORiP61964

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11091, 666 hits in 886 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WDR5, human
EvolutionaryTraceiP61964

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WDR5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11091
PharosiP61964, Tchem

Protein Ontology

More...
PROi
PR:P61964
RNActiP61964, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196363, Expressed in testis and 207 other tissues
ExpressionAtlasiP61964, baseline and differential
GenevisibleiP61964, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
IDEALiIID00377
InterProiView protein in InterPro
IPR020472, G-protein_beta_WD-40_rep
IPR037866, Swd3/WDR5
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR22847:SF516, PTHR22847:SF516, 1 hit
PfamiView protein in Pfam
PF00400, WD40, 7 hits
PRINTSiPR00320, GPROTEINBRPT
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 4 hits
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61964
Secondary accession number(s): Q91VA5, Q9NWX7, Q9UGP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 7, 2020
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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