Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DDB1- and CUL4-associated factor 7

Gene

Dcaf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 7
Alternative name(s):
WD repeat-containing protein 68
WD repeat-containing protein An11 homolog
Gene namesi
Name:Dcaf7
Synonyms:Han11, Wdr68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919083 Dcaf7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514261 – 342DDB1- and CUL4-associated factor 7Add BLAST342

Proteomic databases

EPDiP61963
MaxQBiP61963
PaxDbiP61963
PeptideAtlasiP61963
PRIDEiP61963

2D gel databases

REPRODUCTION-2DPAGEiP61963

PTM databases

iPTMnetiP61963
PhosphoSitePlusiP61963

Expressioni

Developmental stagei

Highly expressed in E10.5 embryo limb buds, in an overlapping pattern with PTCH1 and GLI1.1 Publication

Gene expression databases

BgeeiENSMUSG00000049354 Expressed in 246 organ(s), highest expression level in bone marrow
CleanExiMM_WDR68
GenevisibleiP61963 MM

Interactioni

Subunit structurei

Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703 (By similarity).By similarity

Protein-protein interaction databases

BioGridi214962, 5 interactors
IntActiP61963, 4 interactors
MINTiP61963
STRINGi10090.ENSMUSP00000058168

Structurei

3D structure databases

ProteinModelPortaliP61963
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 108WD 1Add BLAST43
Repeati118 – 160WD 2Add BLAST43
Repeati172 – 214WD 3Add BLAST43
Repeati264 – 304WD 4Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat DCAF7 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0290 Eukaryota
ENOG410XQ78 LUCA
GeneTreeiENSGT00390000006939
HOGENOMiHOG000260968
HOVERGENiHBG050497
InParanoidiP61963
KOiK11805
OMAiTCTVWNI
OrthoDBiEOG091G08UU
PhylomeDBiP61963
TreeFamiTF106135

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P61963-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV
60 70 80 90 100
GLDEESSEFI CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV
110 120 130 140 150
GETETRLECL LNNNKNSDFC APLTSFDWNE VDPYLLGTSS IDTTCTIWGL
160 170 180 190 200
ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI AFSRAGGGRD MFASVGADGS
210 220 230 240 250
VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM AMDGMEVVIL
260 270 280 290 300
DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP
310 320 330 340
RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV
Length:342
Mass (Da):38,926
Last modified:June 7, 2004 - v1
Checksum:i794CC69A45D0CC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005902 mRNA Translation: BAB24308.1
AK047435 mRNA Translation: BAC33058.1
AK165674 mRNA Translation: BAE38331.1
BC048722 mRNA Translation: AAH48722.1
CCDSiCCDS25546.1
RefSeqiNP_082222.1, NM_027946.3
UniGeneiMm.307455

Genome annotation databases

EnsembliENSMUST00000058438; ENSMUSP00000058168; ENSMUSG00000049354
GeneIDi71833
KEGGimmu:71833
UCSCiuc007lxy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005902 mRNA Translation: BAB24308.1
AK047435 mRNA Translation: BAC33058.1
AK165674 mRNA Translation: BAE38331.1
BC048722 mRNA Translation: AAH48722.1
CCDSiCCDS25546.1
RefSeqiNP_082222.1, NM_027946.3
UniGeneiMm.307455

3D structure databases

ProteinModelPortaliP61963
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214962, 5 interactors
IntActiP61963, 4 interactors
MINTiP61963
STRINGi10090.ENSMUSP00000058168

PTM databases

iPTMnetiP61963
PhosphoSitePlusiP61963

2D gel databases

REPRODUCTION-2DPAGEiP61963

Proteomic databases

EPDiP61963
MaxQBiP61963
PaxDbiP61963
PeptideAtlasiP61963
PRIDEiP61963

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058438; ENSMUSP00000058168; ENSMUSG00000049354
GeneIDi71833
KEGGimmu:71833
UCSCiuc007lxy.1 mouse

Organism-specific databases

CTDi10238
MGIiMGI:1919083 Dcaf7

Phylogenomic databases

eggNOGiKOG0290 Eukaryota
ENOG410XQ78 LUCA
GeneTreeiENSGT00390000006939
HOGENOMiHOG000260968
HOVERGENiHBG050497
InParanoidiP61963
KOiK11805
OMAiTCTVWNI
OrthoDBiEOG091G08UU
PhylomeDBiP61963
TreeFamiTF106135

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSiDcaf7 mouse
PROiPR:P61963
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049354 Expressed in 246 organ(s), highest expression level in bone marrow
CleanExiMM_WDR68
GenevisibleiP61963 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCAF7_MOUSE
AccessioniPrimary (citable) accession number: P61963
Secondary accession number(s): O15491, Q3TMV9, Q9DAE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again