UniProtKB - P61963 (DCAF7_MOUSE)
Protein
DDB1- and CUL4-associated factor 7
Gene
Dcaf7
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Developmental protein |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: DDB1- and CUL4-associated factor 7Alternative name(s): WD repeat-containing protein 68 WD repeat-containing protein An11 homolog |
Gene namesi | Name:Dcaf7 Synonyms:Han11, Wdr68 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919083, Dcaf7 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear body Source: MGI
- nuclear matrix Source: UniProtKB
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051426 | 1 – 342 | DDB1- and CUL4-associated factor 7Add BLAST | 342 |
Proteomic databases
EPDi | P61963 |
MaxQBi | P61963 |
PaxDbi | P61963 |
PeptideAtlasi | P61963 |
PRIDEi | P61963 |
2D gel databases
REPRODUCTION-2DPAGEi | P61963 |
PTM databases
iPTMneti | P61963 |
PhosphoSitePlusi | P61963 |
SwissPalmi | P61963 |
Expressioni
Developmental stagei
Highly expressed in 10.5 dpc embryo limb buds, in an overlapping pattern with PTCH1 and GLI1.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000049354, Expressed in bone marrow and 263 other tissues |
Genevisiblei | P61963, MM |
Interactioni
Subunit structurei
Interacts with DYRK1A, DYRK1B and DIAPH1.
Interacts with DDB1.
Interacts with ZNF703 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 214962, 24 interactors |
IntActi | P61963, 4 interactors |
MINTi | P61963 |
STRINGi | 10090.ENSMUSP00000058168 |
Miscellaneous databases
RNActi | P61963, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 66 – 108 | WD 1Add BLAST | 43 | |
Repeati | 118 – 160 | WD 2Add BLAST | 43 | |
Repeati | 172 – 214 | WD 3Add BLAST | 43 | |
Repeati | 264 – 304 | WD 4Add BLAST | 41 |
Sequence similaritiesi
Belongs to the WD repeat DCAF7 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0290, Eukaryota |
GeneTreei | ENSGT00390000006939 |
HOGENOMi | CLU_013694_0_0_1 |
InParanoidi | P61963 |
OMAi | VWNIDTS |
OrthoDBi | 750776at2759 |
PhylomeDBi | P61963 |
TreeFami | TF106135 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
P61963-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV
60 70 80 90 100
GLDEESSEFI CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV
110 120 130 140 150
GETETRLECL LNNNKNSDFC APLTSFDWNE VDPYLLGTSS IDTTCTIWGL
160 170 180 190 200
ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI AFSRAGGGRD MFASVGADGS
210 220 230 240 250
VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM AMDGMEVVIL
260 270 280 290 300
DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP
310 320 330 340
RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005902 mRNA Translation: BAB24308.1 AK047435 mRNA Translation: BAC33058.1 AK165674 mRNA Translation: BAE38331.1 BC048722 mRNA Translation: AAH48722.1 |
CCDSi | CCDS25546.1 |
RefSeqi | NP_082222.1, NM_027946.3 |
Genome annotation databases
Ensembli | ENSMUST00000058438; ENSMUSP00000058168; ENSMUSG00000049354 |
GeneIDi | 71833 |
KEGGi | mmu:71833 |
UCSCi | uc007lxy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005902 mRNA Translation: BAB24308.1 AK047435 mRNA Translation: BAC33058.1 AK165674 mRNA Translation: BAE38331.1 BC048722 mRNA Translation: AAH48722.1 |
CCDSi | CCDS25546.1 |
RefSeqi | NP_082222.1, NM_027946.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 214962, 24 interactors |
IntActi | P61963, 4 interactors |
MINTi | P61963 |
STRINGi | 10090.ENSMUSP00000058168 |
PTM databases
iPTMneti | P61963 |
PhosphoSitePlusi | P61963 |
SwissPalmi | P61963 |
2D gel databases
REPRODUCTION-2DPAGEi | P61963 |
Proteomic databases
EPDi | P61963 |
MaxQBi | P61963 |
PaxDbi | P61963 |
PeptideAtlasi | P61963 |
PRIDEi | P61963 |
Protocols and materials databases
Antibodypediai | 9425, 178 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000058438; ENSMUSP00000058168; ENSMUSG00000049354 |
GeneIDi | 71833 |
KEGGi | mmu:71833 |
UCSCi | uc007lxy.1, mouse |
Organism-specific databases
CTDi | 10238 |
MGIi | MGI:1919083, Dcaf7 |
Phylogenomic databases
eggNOGi | KOG0290, Eukaryota |
GeneTreei | ENSGT00390000006939 |
HOGENOMi | CLU_013694_0_0_1 |
InParanoidi | P61963 |
OMAi | VWNIDTS |
OrthoDBi | 750776at2759 |
PhylomeDBi | P61963 |
TreeFami | TF106135 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 71833, 9 hits in 19 CRISPR screens |
ChiTaRSi | Dcaf7, mouse |
PROi | PR:P61963 |
RNActi | P61963, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049354, Expressed in bone marrow and 263 other tissues |
Genevisiblei | P61963, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCAF7_MOUSE | |
Accessioni | P61963Primary (citable) accession number: P61963 Secondary accession number(s): O15491, Q3TMV9, Q9DAE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families