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Protein

DDB1- and CUL4-associated factor 7

Gene

DCAF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
SignaLinkiP61962
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 7
Alternative name(s):
WD repeat-containing protein 68
WD repeat-containing protein An11 homolog
Gene namesi
Name:DCAF7
Synonyms:HAN11, WDR68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136485.14
HGNCiHGNC:30915 DCAF7
MIMi605973 gene
neXtProtiNX_P61962

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10238
OpenTargetsiENSG00000136485
PharmGKBiPA165431770

Polymorphism and mutation databases

DMDMi48428729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514251 – 342DDB1- and CUL4-associated factor 7Add BLAST342

Proteomic databases

EPDiP61962
MaxQBiP61962
PaxDbiP61962
PeptideAtlasiP61962
PRIDEiP61962
ProteomicsDBi57346

PTM databases

iPTMnetiP61962
PhosphoSitePlusiP61962

Expressioni

Gene expression databases

BgeeiENSG00000136485 Expressed in 235 organ(s), highest expression level in cerebral cortex
CleanExiHS_WDR68
ExpressionAtlasiP61962 baseline and differential
GenevisibleiP61962 HS

Organism-specific databases

HPAiHPA022948
HPA022962

Interactioni

Subunit structurei

Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703. Interacts with human adenovirus 5 E1A protein (PubMed:23864635).5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115532, 137 interactors
DIPiDIP-40363N
IntActiP61962, 116 interactors
MINTiP61962
STRINGi9606.ENSP00000308344

Structurei

3D structure databases

ProteinModelPortaliP61962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 52WD 1Add BLAST47
Repeati60 – 100WD 2Add BLAST41
Repeati108 – 150WD 3Add BLAST43
Repeati165 – 206WD 4Add BLAST42
Repeati213 – 252WD 5Add BLAST40
Repeati257 – 296WD 6Add BLAST40
Repeati303 – 342WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat DCAF7 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0290 Eukaryota
ENOG410XQ78 LUCA
GeneTreeiENSGT00390000006939
HOGENOMiHOG000260968
HOVERGENiHBG050497
InParanoidiP61962
KOiK11805
OMAiTCTVWNI
OrthoDBiEOG091G08UU
PhylomeDBiP61962
TreeFamiTF106135

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P61962-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV
60 70 80 90 100
GLDEESSEFI CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV
110 120 130 140 150
GETETRLECL LNNNKNSDFC APLTSFDWNE VDPYLLGTSS IDTTCTIWGL
160 170 180 190 200
ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI AFSRAGGGRD MFASVGADGS
210 220 230 240 250
VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM AMDGMEVVIL
260 270 280 290 300
DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP
310 320 330 340
RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV
Length:342
Mass (Da):38,926
Last modified:June 7, 2004 - v1
Checksum:i794CC69A45D0CC7C
GO
Isoform 2 (identifier: P61962-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-246: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):16,340
Checksum:iA41A8991ACFDC698
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWI6A0A087WWI6_HUMAN
DDB1- and CUL4-associated factor 7
DCAF7
206Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05401547 – 246Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94747 mRNA Translation: AAC18913.1
AK303212 mRNA Translation: BAG64301.1
AC113554 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94305.1
CH471109 Genomic DNA Translation: EAW94306.1
BC001264 mRNA Translation: AAH01264.1
CCDSiCCDS74127.1 [P61962-1]
RefSeqiNP_005819.3, NM_005828.4 [P61962-1]
UniGeneiHs.410596

Genome annotation databases

EnsembliENST00000415273; ENSP00000403920; ENSG00000136485 [P61962-2]
ENST00000431926; ENSP00000402312; ENSG00000136485 [P61962-1]
ENST00000614556; ENSP00000483236; ENSG00000136485 [P61962-1]
GeneIDi10238
KEGGihsa:10238
UCSCiuc010wpn.5 human [P61962-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94747 mRNA Translation: AAC18913.1
AK303212 mRNA Translation: BAG64301.1
AC113554 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94305.1
CH471109 Genomic DNA Translation: EAW94306.1
BC001264 mRNA Translation: AAH01264.1
CCDSiCCDS74127.1 [P61962-1]
RefSeqiNP_005819.3, NM_005828.4 [P61962-1]
UniGeneiHs.410596

3D structure databases

ProteinModelPortaliP61962
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115532, 137 interactors
DIPiDIP-40363N
IntActiP61962, 116 interactors
MINTiP61962
STRINGi9606.ENSP00000308344

PTM databases

iPTMnetiP61962
PhosphoSitePlusiP61962

Polymorphism and mutation databases

DMDMi48428729

Proteomic databases

EPDiP61962
MaxQBiP61962
PaxDbiP61962
PeptideAtlasiP61962
PRIDEiP61962
ProteomicsDBi57346

Protocols and materials databases

DNASUi10238
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415273; ENSP00000403920; ENSG00000136485 [P61962-2]
ENST00000431926; ENSP00000402312; ENSG00000136485 [P61962-1]
ENST00000614556; ENSP00000483236; ENSG00000136485 [P61962-1]
GeneIDi10238
KEGGihsa:10238
UCSCiuc010wpn.5 human [P61962-1]

Organism-specific databases

CTDi10238
DisGeNETi10238
EuPathDBiHostDB:ENSG00000136485.14
GeneCardsiDCAF7
HGNCiHGNC:30915 DCAF7
HPAiHPA022948
HPA022962
MIMi605973 gene
neXtProtiNX_P61962
OpenTargetsiENSG00000136485
PharmGKBiPA165431770
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0290 Eukaryota
ENOG410XQ78 LUCA
GeneTreeiENSGT00390000006939
HOGENOMiHOG000260968
HOVERGENiHBG050497
InParanoidiP61962
KOiK11805
OMAiTCTVWNI
OrthoDBiEOG091G08UU
PhylomeDBiP61962
TreeFamiTF106135

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
SignaLinkiP61962

Miscellaneous databases

ChiTaRSiDCAF7 human
GeneWikiiWDR68
GenomeRNAii10238
PROiPR:P61962
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136485 Expressed in 235 organ(s), highest expression level in cerebral cortex
CleanExiHS_WDR68
ExpressionAtlasiP61962 baseline and differential
GenevisibleiP61962 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCAF7_HUMAN
AccessioniPrimary (citable) accession number: P61962
Secondary accession number(s): B4E039
, D3DU14, O15491, Q9DAE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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