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Protein

Ubiquitin-fold modifier 1

Gene

Ufm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (PubMed:21494687). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (By similarity). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (PubMed:21494687).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-fold modifier 1
Gene namesi
Name:Ufm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915140 Ufm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000421261 – 83Ubiquitin-fold modifier 1Add BLAST83
PropeptideiPRO_000004212784 – 85Removed in mature formBy similarity2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)By similarity
Cross-linki83Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP61961
MaxQBiP61961
PaxDbiP61961
PeptideAtlasiP61961
PRIDEiP61961
TopDownProteomicsiP61961

PTM databases

iPTMnetiP61961
PhosphoSitePlusiP61961

Expressioni

Tissue specificityi

Widely expressed with higher expression in secretory tissues (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000027746 Expressed in 258 organ(s), highest expression level in colon
CleanExiMM_UFM1
ExpressionAtlasiP61961 baseline and differential
GenevisibleiP61961 MM

Interactioni

Subunit structurei

Interacts with UBA5.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000118478

Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61961
SMRiP61961
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61961

Family & Domainsi

Sequence similaritiesi

Belongs to the UFM1 family.Curated

Phylogenomic databases

eggNOGiKOG3483 Eukaryota
ENOG4111TVI LUCA
GeneTreeiENSGT00390000010391
HOGENOMiHOG000185753
HOVERGENiHBG094129
InParanoidiP61961
KOiK12162
OMAiPWQTSAI
OrthoDBiEOG091G0DO7
PhylomeDBiP61961
TreeFamiTF312934

Family and domain databases

CDDicd01766 Ufm1, 1 hit
InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR005375 UFM1
PANTHERiPTHR15825 PTHR15825, 1 hit
PfamiView protein in Pfam
PF03671 Ufm1, 1 hit
PIRSFiPIRSF038027 Ubiquitin-like_Ufm1, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61961-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII
60 70 80
TNDGIGINPA QTAGNVFLKH GSELRIIPRD RVGSC
Length:85
Mass (Da):9,118
Last modified:June 7, 2004 - v1
Checksum:iEDB2412E5E5836D8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YW97D3YW97_MOUSE
Ubiquitin-fold modifier 1
Ufm1
82Annotation score:
H7BWZ1H7BWZ1_MOUSE
Ubiquitin-fold modifier 1
Ufm1
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007788 mRNA Translation: BAB25255.1
AK008280 mRNA Translation: BAB25572.1
AK089948 mRNA Translation: BAC41011.1
AK148146 mRNA Translation: BAE28374.1
AK166332 mRNA Translation: BAE38712.1
AK167301 mRNA Translation: BAE39406.1
AK167321 mRNA Translation: BAE39423.1
BC061065 mRNA Translation: AAH61065.1
CCDSiCCDS38430.1
RefSeqiNP_080711.1, NM_026435.5
UniGeneiMm.23067

Genome annotation databases

EnsembliENSMUST00000146598; ENSMUSP00000118478; ENSMUSG00000027746
GeneIDi67890
KEGGimmu:67890
UCSCiuc008pfa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007788 mRNA Translation: BAB25255.1
AK008280 mRNA Translation: BAB25572.1
AK089948 mRNA Translation: BAC41011.1
AK148146 mRNA Translation: BAE28374.1
AK166332 mRNA Translation: BAE38712.1
AK167301 mRNA Translation: BAE39406.1
AK167321 mRNA Translation: BAE39423.1
BC061065 mRNA Translation: AAH61065.1
CCDSiCCDS38430.1
RefSeqiNP_080711.1, NM_026435.5
UniGeneiMm.23067

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0GNMR-A1-85[»]
ProteinModelPortaliP61961
SMRiP61961
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000118478

PTM databases

iPTMnetiP61961
PhosphoSitePlusiP61961

Proteomic databases

EPDiP61961
MaxQBiP61961
PaxDbiP61961
PeptideAtlasiP61961
PRIDEiP61961
TopDownProteomicsiP61961

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146598; ENSMUSP00000118478; ENSMUSG00000027746
GeneIDi67890
KEGGimmu:67890
UCSCiuc008pfa.2 mouse

Organism-specific databases

CTDi51569
MGIiMGI:1915140 Ufm1

Phylogenomic databases

eggNOGiKOG3483 Eukaryota
ENOG4111TVI LUCA
GeneTreeiENSGT00390000010391
HOGENOMiHOG000185753
HOVERGENiHBG094129
InParanoidiP61961
KOiK12162
OMAiPWQTSAI
OrthoDBiEOG091G0DO7
PhylomeDBiP61961
TreeFamiTF312934

Miscellaneous databases

EvolutionaryTraceiP61961
PROiPR:P61961
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027746 Expressed in 258 organ(s), highest expression level in colon
CleanExiMM_UFM1
ExpressionAtlasiP61961 baseline and differential
GenevisibleiP61961 MM

Family and domain databases

CDDicd01766 Ufm1, 1 hit
InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR005375 UFM1
PANTHERiPTHR15825 PTHR15825, 1 hit
PfamiView protein in Pfam
PF03671 Ufm1, 1 hit
PIRSFiPIRSF038027 Ubiquitin-like_Ufm1, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUFM1_MOUSE
AccessioniPrimary (citable) accession number: P61961
Secondary accession number(s): Q14346
, Q3TLT0, Q542A7, Q9CPX2, Q9NZF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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