Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

GNG11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:GNG11
Synonyms:GNGT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127920.5
HGNCiHGNC:4403 GNG11
MIMi604390 gene
neXtProtiNX_P61952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2791
OpenTargetsiENSG00000127920
PharmGKBiPA28782

Polymorphism and mutation databases

BioMutaiGNG11
DMDMi48428913

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126591 – 70Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11Add BLAST70
PropeptideiPRO_000001266071 – 73Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70Cysteine methyl esterSequence analysis1
Lipidationi70S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP61952
PaxDbiP61952
PeptideAtlasiP61952
PRIDEiP61952
ProteomicsDBi57341
TopDownProteomicsiP61952

PTM databases

iPTMnetiP61952
PhosphoSitePlusiP61952

Expressioni

Tissue specificityi

Abundantly expressed in all tissues tested except for brain.

Gene expression databases

BgeeiENSG00000127920 Expressed in 232 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_GNG11
ExpressionAtlasiP61952 baseline and differential
GenevisibleiP61952 HS

Organism-specific databases

HPAiHPA045255

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

Protein-protein interaction databases

BioGridi109053, 11 interactors
IntActiP61952, 5 interactors
STRINGi9606.ENSP00000248564

Structurei

3D structure databases

ProteinModelPortaliP61952
SMRiP61952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiP61952
KOiK04546
OMAiMPAINIE
OrthoDBiEOG091G17J0
PhylomeDBiP61952
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31384 mRNA Translation: AAC50206.1
AF493878 mRNA Translation: AAM12592.1
AC002076 Genomic DNA Translation: AAS02020.1
BC009709 mRNA Translation: AAH09709.1
CCDSiCCDS5634.1
PIRiI39159
RefSeqiNP_004117.1, NM_004126.3
UniGeneiHs.83381

Genome annotation databases

EnsembliENST00000248564; ENSP00000248564; ENSG00000127920
GeneIDi2791
KEGGihsa:2791

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31384 mRNA Translation: AAC50206.1
AF493878 mRNA Translation: AAM12592.1
AC002076 Genomic DNA Translation: AAS02020.1
BC009709 mRNA Translation: AAH09709.1
CCDSiCCDS5634.1
PIRiI39159
RefSeqiNP_004117.1, NM_004126.3
UniGeneiHs.83381

3D structure databases

ProteinModelPortaliP61952
SMRiP61952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109053, 11 interactors
IntActiP61952, 5 interactors
STRINGi9606.ENSP00000248564

PTM databases

iPTMnetiP61952
PhosphoSitePlusiP61952

Polymorphism and mutation databases

BioMutaiGNG11
DMDMi48428913

Proteomic databases

EPDiP61952
PaxDbiP61952
PeptideAtlasiP61952
PRIDEiP61952
ProteomicsDBi57341
TopDownProteomicsiP61952

Protocols and materials databases

DNASUi2791
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248564; ENSP00000248564; ENSG00000127920
GeneIDi2791
KEGGihsa:2791

Organism-specific databases

CTDi2791
DisGeNETi2791
EuPathDBiHostDB:ENSG00000127920.5
GeneCardsiGNG11
HGNCiHGNC:4403 GNG11
HPAiHPA045255
MIMi604390 gene
neXtProtiNX_P61952
OpenTargetsiENSG00000127920
PharmGKBiPA28782
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiP61952
KOiK04546
OMAiMPAINIE
OrthoDBiEOG091G17J0
PhylomeDBiP61952
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

GeneWikiiGNG11
GenomeRNAii2791
PROiPR:P61952
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127920 Expressed in 232 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_GNG11
ExpressionAtlasiP61952 baseline and differential
GenevisibleiP61952 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG11_HUMAN
AccessioniPrimary (citable) accession number: P61952
Secondary accession number(s): P50152
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again