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Protein

Flavodoxin 1

Gene

fldA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.Curated1 Publication

Cofactori

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Transport
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciEcoCyc:FLAVODOXIN1-MONOMER
MetaCyc:FLAVODOXIN1-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Flavodoxin 1
Gene namesi
Name:fldA
Ordered Locus Names:b0684, JW0671
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10318 fldA

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc

Pathology & Biotechi

Chemistry databases

DrugBankiDB03247 Riboflavin Monophosphate

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001716222 – 176Flavodoxin 1Add BLAST175

Proteomic databases

EPDiP61949
PaxDbiP61949
PRIDEiP61949

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi4261909, 12 interactors
DIPiDIP-48242N
IntActiP61949, 29 interactors
STRINGi316385.ECDH10B_0749

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61949
SMRiP61949
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61949

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 165Flavodoxin-likePROSITE-ProRule annotationAdd BLAST162

Sequence similaritiesi

Belongs to the flavodoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105MHQ Bacteria
COG0716 LUCA
HOGENOMiHOG000030543
InParanoidiP61949
KOiK03839
OMAiASKGMAD
PhylomeDBiP61949

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR008254 Flavodoxin/NO_synth
IPR001226 Flavodoxin_CS
IPR010086 Flavodoxin_lc
IPR029039 Flavoprotein-like_sf
PfamiView protein in Pfam
PF00258 Flavodoxin_1, 1 hit
PIRSFiPIRSF038996 FldA, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
TIGRFAMsiTIGR01752 flav_long, 1 hit
PROSITEiView protein in PROSITE
PS00201 FLAVODOXIN, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61949-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAITGIFFGS DTGNTENIAK MIQKQLGKDV ADVHDIAKSS KEDLEAYDIL
60 70 80 90 100
LLGIPTWYYG EAQCDWDDFF PTLEEIDFNG KLVALFGCGD QEDYAEYFCD
110 120 130 140 150
ALGTIRDIIE PRGATIVGHW PTAGYHFEAS KGLADDDHFV GLAIDEDRQP
160 170
ELTAERVEKW VKQISEELHL DEILNA
Length:176
Mass (Da):19,737
Last modified:January 23, 2007 - v2
Checksum:i8878DA1A8EAA55BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59426 Genomic DNA Translation: AAA23789.1
U00096 Genomic DNA Translation: AAC73778.1
AP009048 Genomic DNA Translation: BAA35333.1
PIRiA37319
RefSeqiNP_415210.1, NC_000913.3
WP_001018618.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73778; AAC73778; b0684
BAA35333; BAA35333; BAA35333
GeneIDi945293
KEGGiecj:JW0671
eco:b0684
PATRICifig|1411691.4.peg.1592

Similar proteinsi

Entry informationi

Entry nameiFLAV_ECOLI
AccessioniPrimary (citable) accession number: P61949
Secondary accession number(s): P23243
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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