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Protein

60S ribosomal protein L37

Gene

RPL37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi37ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L37
Alternative name(s):
G1.16
Large ribosomal subunit protein eL371 Publication
Gene namesi
Name:RPL37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145592.13
HGNCiHGNC:10347 RPL37
MIMi604181 gene
neXtProtiNX_P61927

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6167
OpenTargetsiENSG00000145592
PharmGKBiPA34736

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin
DB04602 PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE
DB04805 Virginiamycin S1

Polymorphism and mutation databases

BioMutaiRPL37
DMDMi48429090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397051 – 9760S ribosomal protein L37Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP61927
MaxQBiP61927
PaxDbiP61927
PeptideAtlasiP61927
PRIDEiP61927
ProteomicsDBi57340
TopDownProteomicsiP61927

PTM databases

iPTMnetiP61927
PhosphoSitePlusiP61927

Expressioni

Gene expression databases

BgeeiENSG00000145592 Expressed in 246 organ(s), highest expression level in female gonad
CleanExiHS_RPL37
ExpressionAtlasiP61927 baseline and differential
GenevisibleiP61927 HS

Interactioni

Protein-protein interaction databases

BioGridi112086, 102 interactors
CORUMiP61927
IntActiP61927, 13 interactors
STRINGi9606.ENSP00000274242

Structurei

3D structure databases

ProteinModelPortaliP61927
SMRiP61927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3475 Eukaryota
COG2126 LUCA
GeneTreeiENSGT00390000005254
HOGENOMiHOG000111076
HOVERGENiHBG004454
InParanoidiP61927
KOiK02922
OrthoDBiEOG091G10FG
PhylomeDBiP61927
TreeFamiTF300260

Family and domain databases

Gene3Di2.20.25.30, 1 hit
HAMAPiMF_00547 Ribosomal_L37e, 1 hit
InterProiView protein in InterPro
IPR011331 Ribosomal_L37ae/L37e
IPR001569 Ribosomal_L37e
IPR018267 Ribosomal_L37e_CS
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF01907 Ribosomal_L37e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005132 Ribosomal_L37e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01077 RIBOSOMAL_L37E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P61927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS
60 70 80 90
AKAKRRNTTG TGRMRHLKIV YRRFRHGFRE GTTPKPKRAA VAASSSS
Length:97
Mass (Da):11,078
Last modified:January 23, 2007 - v2
Checksum:iF565A11E983027C9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RG19D6RG19_HUMAN
Ribosomal protein L37
RPL37
82Annotation score:
D6R9X9D6R9X9_HUMAN
Ribosomal protein L37
RPL37
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65R → S in AAB47039 (PubMed:7588717).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D23661 mRNA Translation: BAA04888.1
L11567 mRNA Translation: AAA62148.1
S79979 mRNA Translation: AAB47039.2
AB061834 Genomic DNA Translation: BAB79472.1
CR456890 mRNA Translation: CAG33171.1
AK311827 mRNA Translation: BAG34769.1
BC079477 mRNA Translation: AAH79477.1
BC084576 mRNA Translation: AAH84576.1
AB007184 Genomic DNA Translation: BAA25843.1
AB007183 Genomic DNA Translation: BAA25842.1
CCDSiCCDS3934.1
PIRiS47646
RefSeqiNP_000988.1, NM_000997.4
UniGeneiHs.447582
Hs.558601
Hs.731513

Genome annotation databases

EnsembliENST00000274242; ENSP00000274242; ENSG00000145592
GeneIDi6167
KEGGihsa:6167
UCSCiuc021xxr.2 human

Similar proteinsi

Entry informationi

Entry nameiRL37_HUMAN
AccessioniPrimary (citable) accession number: P61927
Secondary accession number(s): B2R4H2
, P02403, Q6IBB4, Q99883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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