UniProtKB - P61924 (COPZ1_MOUSE)
Protein
Coatomer subunit zeta-1
Gene
Copz1
Organism
Mus musculus (Mouse)
Status
Functioni
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).By similarity
GO - Biological processi
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: UniProtKB
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
- toxin transport Source: MGI
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Coatomer subunit zeta-1Alternative name(s): Zeta-1-coat protein Short name: Zeta-1 COP |
Gene namesi | Name:Copz1 Synonyms:Copz |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929063, Copz1 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cytoplasm By similarity
- COPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.By similarity
Golgi apparatus
- COPI vesicle coat Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193826 | 1 – 177 | Coatomer subunit zeta-1Add BLAST | 177 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P61924 |
jPOSTi | P61924 |
PaxDbi | P61924 |
PeptideAtlasi | P61924 |
PRIDEi | P61924 |
PTM databases
iPTMneti | P61924 |
PhosphoSitePlusi | P61924 |
SwissPalmi | P61924 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000060992, Expressed in adult mammalian kidney and 305 other tissues |
ExpressionAtlasi | P61924, baseline and differential |
Genevisiblei | P61924, MM |
Interactioni
Subunit structurei
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
By similarityProtein-protein interaction databases
BioGRIDi | 207987, 11 interactors |
CORUMi | P61924 |
IntActi | P61924, 2 interactors |
MINTi | P61924 |
STRINGi | 10090.ENSMUSP00000097738 |
Miscellaneous databases
RNActi | P61924, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the adaptor complexes small subunit family.Curated
Phylogenomic databases
eggNOGi | KOG3343, Eukaryota |
GeneTreei | ENSGT00390000004405 |
HOGENOMi | CLU_086803_2_0_1 |
InParanoidi | P61924 |
OMAi | YKHSLDL |
OrthoDBi | 1522668at2759 |
PhylomeDBi | P61924 |
TreeFami | TF300262 |
Family and domain databases
InterProi | View protein in InterPro IPR022775, AP_mu_sigma_su IPR000804, Clathrin_sm-chain_CS IPR039652, Coatomer_zeta IPR011012, Longin-like_dom_sf |
PANTHERi | PTHR11043, PTHR11043, 1 hit |
Pfami | View protein in Pfam PF01217, Clat_adaptor_s, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00989, CLAT_ADAPTOR_S, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P61924-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN
60 70 80 90 100
KTHRTDSEIA LLEGLTVVYK SSIDLYFYVI GSSYENELML MAVLNCLFDS
110 120 130 140 150
LSQMLRKNVE KRALLENMEG LFLAVDEIVD GGVILESDPQ QVVHRVALRG
160 170
EDVPLTEQTV SQVLQSAKEQ IKWSLLR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8R3M1 | Q8R3M1_MOUSE | Coatomer subunit zeta | Copz1 | 163 | Annotation score: | ||
A0A2R8VJV3 | A0A2R8VJV3_MOUSE | Coatomer subunit zeta | Copz1 | 84 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037370 mRNA Translation: BAA90303.1 AK003302 mRNA Translation: BAB22703.1 BC002246 mRNA No translation available. BC058524 mRNA Translation: AAH58524.1 BC085314 mRNA Translation: AAH85314.1 |
CCDSi | CCDS27901.1 |
RefSeqi | NP_062791.1, NM_019817.1 |
Genome annotation databases
Ensembli | ENSMUST00000100162; ENSMUSP00000097738; ENSMUSG00000060992 |
GeneIDi | 56447 |
KEGGi | mmu:56447 |
UCSCi | uc007xxv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037370 mRNA Translation: BAA90303.1 AK003302 mRNA Translation: BAB22703.1 BC002246 mRNA No translation available. BC058524 mRNA Translation: AAH58524.1 BC085314 mRNA Translation: AAH85314.1 |
CCDSi | CCDS27901.1 |
RefSeqi | NP_062791.1, NM_019817.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5A1U | electron microscopy | 13.00 | F | 1-177 | [»] | |
5A1V | electron microscopy | 21.00 | F/N/W | 1-177 | [»] | |
5A1W | electron microscopy | 18.00 | F | 1-177 | [»] | |
5A1X | electron microscopy | 23.00 | F/N | 1-177 | [»] | |
5A1Y | electron microscopy | 21.00 | F/N/W | 1-177 | [»] | |
5NZR | electron microscopy | 9.20 | L/Z | 1-177 | [»] | |
5NZS | electron microscopy | 10.10 | L/Z | 1-177 | [»] | |
5NZT | electron microscopy | 17.00 | L/Z | 1-177 | [»] | |
5NZU | electron microscopy | 15.00 | L/Z | 1-177 | [»] | |
5NZV | electron microscopy | 17.30 | L/S/U/Z | 1-177 | [»] | |
BMRBi | P61924 | |||||
SMRi | P61924 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 207987, 11 interactors |
CORUMi | P61924 |
IntActi | P61924, 2 interactors |
MINTi | P61924 |
STRINGi | 10090.ENSMUSP00000097738 |
PTM databases
iPTMneti | P61924 |
PhosphoSitePlusi | P61924 |
SwissPalmi | P61924 |
Proteomic databases
EPDi | P61924 |
jPOSTi | P61924 |
PaxDbi | P61924 |
PeptideAtlasi | P61924 |
PRIDEi | P61924 |
Protocols and materials databases
Antibodypediai | 27430, 206 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000100162; ENSMUSP00000097738; ENSMUSG00000060992 |
GeneIDi | 56447 |
KEGGi | mmu:56447 |
UCSCi | uc007xxv.1, mouse |
Organism-specific databases
CTDi | 22818 |
MGIi | MGI:1929063, Copz1 |
Phylogenomic databases
eggNOGi | KOG3343, Eukaryota |
GeneTreei | ENSGT00390000004405 |
HOGENOMi | CLU_086803_2_0_1 |
InParanoidi | P61924 |
OMAi | YKHSLDL |
OrthoDBi | 1522668at2759 |
PhylomeDBi | P61924 |
TreeFami | TF300262 |
Enzyme and pathway databases
Reactomei | R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 56447, 7 hits in 19 CRISPR screens |
ChiTaRSi | Copz1, mouse |
PROi | PR:P61924 |
RNActi | P61924, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060992, Expressed in adult mammalian kidney and 305 other tissues |
ExpressionAtlasi | P61924, baseline and differential |
Genevisiblei | P61924, MM |
Family and domain databases
InterProi | View protein in InterPro IPR022775, AP_mu_sigma_su IPR000804, Clathrin_sm-chain_CS IPR039652, Coatomer_zeta IPR011012, Longin-like_dom_sf |
PANTHERi | PTHR11043, PTHR11043, 1 hit |
Pfami | View protein in Pfam PF01217, Clat_adaptor_s, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00989, CLAT_ADAPTOR_S, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COPZ1_MOUSE | |
Accessioni | P61924Primary (citable) accession number: P61924 Secondary accession number(s): Q9Y3C3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families