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Protein

Coatomer subunit zeta-1

Gene

Copz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.By similarity

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
  • toxin transport Source: MGI

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit zeta-1
Alternative name(s):
Zeta-1-coat protein
Short name:
Zeta-1 COP
Gene namesi
Name:Copz1
Synonyms:Copz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1929063 Copz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938261 – 177Coatomer subunit zeta-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61924
PaxDbiP61924
PeptideAtlasiP61924
PRIDEiP61924

PTM databases

iPTMnetiP61924
PhosphoSitePlusiP61924

Expressioni

Gene expression databases

BgeeiENSMUSG00000060992 Expressed in 290 organ(s), highest expression level in colon
CleanExiMM_COPZ1
ExpressionAtlasiP61924 baseline and differential
GenevisibleiP61924 MM

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi207987, 1 interactor
CORUMiP61924
IntActiP61924, 1 interactor
MINTiP61924
STRINGi10090.ENSMUSP00000097738

Structurei

3D structure databases

ProteinModelPortaliP61924
SMRiP61924
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3343 Eukaryota
COG5541 LUCA
GeneTreeiENSGT00390000004405
HOGENOMiHOG000214428
HOVERGENiHBG051077
InParanoidiP61924
KOiK20472
OMAiVYKHSLD
OrthoDBiEOG091G0TM0
PhylomeDBiP61924
TreeFamiTF300262

Family and domain databases

InterProiView protein in InterPro
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR039652 Coatomer_zeta
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11043 PTHR11043, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P61924-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN
60 70 80 90 100
KTHRTDSEIA LLEGLTVVYK SSIDLYFYVI GSSYENELML MAVLNCLFDS
110 120 130 140 150
LSQMLRKNVE KRALLENMEG LFLAVDEIVD GGVILESDPQ QVVHRVALRG
160 170
EDVPLTEQTV SQVLQSAKEQ IKWSLLR
Length:177
Mass (Da):20,198
Last modified:June 7, 2004 - v1
Checksum:i355530D032D3A049
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R3M1Q8R3M1_MOUSE
Coatomer subunit zeta-1
Copz1
163Annotation score:
A0A2R8VJV3A0A2R8VJV3_MOUSE
Coatomer subunit zeta-1
Copz1
84Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037370 mRNA Translation: BAA90303.1
AK003302 mRNA Translation: BAB22703.1
BC002246 mRNA No translation available.
BC058524 mRNA Translation: AAH58524.1
BC085314 mRNA Translation: AAH85314.1
CCDSiCCDS27901.1
RefSeqiNP_062791.1, NM_019817.1
UniGeneiMm.29473

Genome annotation databases

EnsembliENSMUST00000100162; ENSMUSP00000097738; ENSMUSG00000060992
GeneIDi56447
KEGGimmu:56447
UCSCiuc007xxv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037370 mRNA Translation: BAA90303.1
AK003302 mRNA Translation: BAB22703.1
BC002246 mRNA No translation available.
BC058524 mRNA Translation: AAH58524.1
BC085314 mRNA Translation: AAH85314.1
CCDSiCCDS27901.1
RefSeqiNP_062791.1, NM_019817.1
UniGeneiMm.29473

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A1Uelectron microscopy13.00F1-177[»]
5A1Velectron microscopy21.00F/N/W1-177[»]
5A1Welectron microscopy18.00F1-177[»]
5A1Xelectron microscopy23.00F/N1-177[»]
5A1Yelectron microscopy21.00F/N/W1-177[»]
5NZRelectron microscopy9.20L/Z1-177[»]
5NZSelectron microscopy10.10L/Z1-177[»]
5NZTelectron microscopy17.00L/Z1-177[»]
5NZUelectron microscopy15.00L/Z1-177[»]
5NZVelectron microscopy17.30L/S/U/Z1-177[»]
ProteinModelPortaliP61924
SMRiP61924
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207987, 1 interactor
CORUMiP61924
IntActiP61924, 1 interactor
MINTiP61924
STRINGi10090.ENSMUSP00000097738

PTM databases

iPTMnetiP61924
PhosphoSitePlusiP61924

Proteomic databases

EPDiP61924
PaxDbiP61924
PeptideAtlasiP61924
PRIDEiP61924

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100162; ENSMUSP00000097738; ENSMUSG00000060992
GeneIDi56447
KEGGimmu:56447
UCSCiuc007xxv.1 mouse

Organism-specific databases

CTDi22818
MGIiMGI:1929063 Copz1

Phylogenomic databases

eggNOGiKOG3343 Eukaryota
COG5541 LUCA
GeneTreeiENSGT00390000004405
HOGENOMiHOG000214428
HOVERGENiHBG051077
InParanoidiP61924
KOiK20472
OMAiVYKHSLD
OrthoDBiEOG091G0TM0
PhylomeDBiP61924
TreeFamiTF300262

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiCopz1 mouse
PROiPR:P61924
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060992 Expressed in 290 organ(s), highest expression level in colon
CleanExiMM_COPZ1
ExpressionAtlasiP61924 baseline and differential
GenevisibleiP61924 MM

Family and domain databases

InterProiView protein in InterPro
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR039652 Coatomer_zeta
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11043 PTHR11043, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPZ1_MOUSE
AccessioniPrimary (citable) accession number: P61924
Secondary accession number(s): Q9Y3C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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