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Entry version 148 (13 Nov 2019)
Sequence version 1 (07 Jun 2004)
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Protein

Malate dehydrogenase

Gene

mdh

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei34NADUniRule annotation2 Publications1
Binding sitei81SubstrateUniRule annotation2 Publications1
Binding sitei87SubstrateUniRule annotation2 Publications1
Binding sitei94NADUniRule annotation2 Publications1
Binding sitei119SubstrateUniRule annotation2 Publications1
Binding sitei153SubstrateUniRule annotation2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei177Proton acceptorUniRule annotation1 Publication1
Binding sitei227NADUniRule annotation2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi7 – 13NADUniRule annotation2 Publications7
Nucleotide bindingi117 – 119NADUniRule annotation2 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:MALATE-DEHASE-MONOMER
ECOL316407:JW3205-MONOMER
MetaCyc:MALATE-DEHASE-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.37 2026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malate dehydrogenase1 PublicationUniRule annotation (EC:1.1.1.37UniRule annotation2 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdh1 PublicationUniRule annotation
Ordered Locus Names:b3236, JW3205
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi153R → C: Loss of interaction with substrate. 1 Publication1

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09131 Cupric Chloride
DB00336 Nitrofural

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001133011 – 312Malate dehydrogenaseAdd BLAST312

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P61889

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P61889

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61889

PRoteomics IDEntifications database

More...
PRIDEi
P61889

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P61889

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260779, 27 interactors
852165, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-35924N

Protein interaction database and analysis system

More...
IntActi
P61889, 10 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3236

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P61889

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P61889

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotationCurated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C80 Bacteria
COG0039 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P61889

KEGG Orthology (KO)

More...
KOi
K00024

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P61889

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.110.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01516 Malate_dehydrog_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11540:SF22 PTHR11540:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000102 Lac_mal_DH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01772 MDH_euk_gproteo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00068 MDH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P61889-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVAVLGAAG GIGQALALLL KTQLPSGSEL SLYDIAPVTP GVAVDLSHIP
60 70 80 90 100
TAVKIKGFSG EDATPALEGA DVVLISAGVA RKPGMDRSDL FNVNAGIVKN
110 120 130 140 150
LVQQVAKTCP KACIGIITNP VNTTVAIAAE VLKKAGVYDK NKLFGVTTLD
160 170 180 190 200
IIRSNTFVAE LKGKQPGEVE VPVIGGHSGV TILPLLSQVP GVSFTEQEVA
210 220 230 240 250
DLTKRIQNAG TEVVEAKAGG GSATLSMGQA AARFGLSLVR ALQGEQGVVE
260 270 280 290 300
CAYVEGDGQY ARFFSQPLLL GKNGVEERKS IGTLSAFEQN ALEGMLDTLK
310
KDIALGEEFV NK
Length:312
Mass (Da):32,337
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17741A3B5AD068BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37P → S (PubMed:2993232).Curated1
Sequence conflicti70A → R (PubMed:3322223).Curated1
Sequence conflicti80A → R (PubMed:3299262).Curated1
Sequence conflicti80A → R (PubMed:3322223).Curated1
Sequence conflicti116I → N (PubMed:3322223).Curated1
Sequence conflicti144F → L (PubMed:3299262).Curated1
Sequence conflicti305 – 312LGEEFVNK → WAKSSLISN (PubMed:3322223).Curated8
Sequence conflicti307E → Q (PubMed:3299262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti71D → N in strain: EC47, EC49, EC50 and RT272. 1
Natural varianti106A → S in strain: ECOR 27 and RT082. 1
Natural varianti209A → P in strain: MB001D. 1
Natural varianti218A → R in strain: A8190, E2666-74, E830587, E851819, E3406, EC10, EC14, EC32, EC35, EC38, EC40, EC44, EC46, EC47, EC49, EC50, EC52, EC58, E64 and EC70. 1
Natural varianti232A → T in strain: ECO R37. 1
Natural varianti249V → I in strain: RT083. 1
Natural varianti289Q → K in strain: EC35, EC38, EC40, EC44, EC46, EC47 and RT272. 1
Natural varianti290N → S in strain: E2666-74, ECOR 27, ECOR 45, RL012A, RT104 and RT174. 1
Natural varianti291A → S in strain: EC35. 1
Natural varianti294G → A in strain: ECOR 45. 1
Natural varianti297D → N in strain: E830587. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00129 Genomic DNA Translation: CAA68326.1
M24777 Unassigned DNA Translation: AAA16107.1
U18997 Genomic DNA Translation: AAA58038.1
U00096 Genomic DNA Translation: AAC76268.1
AP009048 Genomic DNA Translation: BAE77279.1
M10417 Genomic DNA Translation: AAA24147.1
U04742 Genomic DNA Translation: AAC43730.1
U04743 Genomic DNA Translation: AAC43731.1
U04744 Genomic DNA Translation: AAC43732.1
U04745 Genomic DNA Translation: AAC43733.1
U04746 Genomic DNA Translation: AAC43734.1
U04747 Genomic DNA Translation: AAC43735.1
U04748 Genomic DNA Translation: AAC43736.1
U04749 Genomic DNA Translation: AAC43737.1
U04750 Genomic DNA Translation: AAC43738.1
U04751 Genomic DNA Translation: AAC43739.1
U04752 Genomic DNA Translation: AAC43740.1
U04753 Genomic DNA Translation: AAC43741.1
U04754 Genomic DNA Translation: AAC43742.1
U04755 Genomic DNA Translation: AAC43743.1
U04756 Genomic DNA Translation: AAC43744.1
U04757 Genomic DNA Translation: AAC43745.1
U04758 Genomic DNA Translation: AAC43746.1
U04759 Genomic DNA Translation: AAC43747.1
U04760 Genomic DNA Translation: AAC43748.1
U04770 Genomic DNA Translation: AAC43758.1
AF004170 Genomic DNA Translation: AAB87003.1
AF004171 Genomic DNA Translation: AAB87004.1
AF004172 Genomic DNA Translation: AAB87005.1
AF004173 Genomic DNA Translation: AAB87006.1
AF004174 Genomic DNA Translation: AAB87007.1
AF004175 Genomic DNA Translation: AAB87008.1
AF004176 Genomic DNA Translation: AAB87009.1
AF004177 Genomic DNA Translation: AAB87010.1
AF004179 Genomic DNA Translation: AAB87012.1
AF004180 Genomic DNA Translation: AAB87013.1
AF004182 Genomic DNA Translation: AAB87015.1
AF004183 Genomic DNA Translation: AAB87016.1
AF004184 Genomic DNA Translation: AAB87017.1
AF004186 Genomic DNA Translation: AAB87019.1
AF004187 Genomic DNA Translation: AAB87020.1
AF004188 Genomic DNA Translation: AAB87021.1
AF004190 Genomic DNA Translation: AAB87023.1
AF004191 Genomic DNA Translation: AAB87024.1
AF004195 Genomic DNA Translation: AAB87028.1
AF004196 Genomic DNA Translation: AAB87029.1
AF004199 Genomic DNA Translation: AAB87032.1
AF004200 Genomic DNA Translation: AAB87033.1
AF004201 Genomic DNA Translation: AAB87034.1
AF004202 Genomic DNA Translation: AAB87035.1
AF004203 Genomic DNA Translation: AAB87036.1
AF004204 Genomic DNA Translation: AAB87037.1
AF004205 Genomic DNA Translation: AAB87038.1
AF004206 Genomic DNA Translation: AAB87039.1
AF004207 Genomic DNA Translation: AAB87040.1
AF004208 Genomic DNA Translation: AAB87041.1
AF004209 Genomic DNA Translation: AAB87042.1
AF091758 Genomic DNA Translation: AAF97988.1
AF091759 Genomic DNA Translation: AAF97989.1
AF091760 Genomic DNA Translation: AAF97990.1
AF091761 Genomic DNA Translation: AAF97991.1
AF091762 Genomic DNA Translation: AAF97992.1
AF091763 Genomic DNA Translation: AAF97993.1
AF091764 Genomic DNA Translation: AAF97994.1
AF091765 Genomic DNA Translation: AAF97995.1
AF091766 Genomic DNA Translation: AAF97996.1
AF091767 Genomic DNA Translation: AAF97997.1
AF091768 Genomic DNA Translation: AAF97998.1
AF091769 Genomic DNA Translation: AAF97999.1
AF091770 Genomic DNA Translation: AAF98000.1
AF091771 Genomic DNA Translation: AAF98001.1
AF091772 Genomic DNA Translation: AAF98002.1
AF091773 Genomic DNA Translation: AAF98003.1
AF091774 Genomic DNA Translation: AAF98004.1
AF091775 Genomic DNA Translation: AAF98005.1
AF091776 Genomic DNA Translation: AAF98006.1
AF091777 Genomic DNA Translation: AAF98007.1
AF091778 Genomic DNA Translation: AAF98008.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F65115 DEECM

NCBI Reference Sequences

More...
RefSeqi
NP_417703.1, NC_000913.3
WP_001295272.1, NZ_STEB01000012.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76268; AAC76268; b3236
BAE77279; BAE77279; BAE77279

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3205
eco:b3236

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3492

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00129 Genomic DNA Translation: CAA68326.1
M24777 Unassigned DNA Translation: AAA16107.1
U18997 Genomic DNA Translation: AAA58038.1
U00096 Genomic DNA Translation: AAC76268.1
AP009048 Genomic DNA Translation: BAE77279.1
M10417 Genomic DNA Translation: AAA24147.1
U04742 Genomic DNA Translation: AAC43730.1
U04743 Genomic DNA Translation: AAC43731.1
U04744 Genomic DNA Translation: AAC43732.1
U04745 Genomic DNA Translation: AAC43733.1
U04746 Genomic DNA Translation: AAC43734.1
U04747 Genomic DNA Translation: AAC43735.1
U04748 Genomic DNA Translation: AAC43736.1
U04749 Genomic DNA Translation: AAC43737.1
U04750 Genomic DNA Translation: AAC43738.1
U04751 Genomic DNA Translation: AAC43739.1
U04752 Genomic DNA Translation: AAC43740.1
U04753 Genomic DNA Translation: AAC43741.1
U04754 Genomic DNA Translation: AAC43742.1
U04755 Genomic DNA Translation: AAC43743.1
U04756 Genomic DNA Translation: AAC43744.1
U04757 Genomic DNA Translation: AAC43745.1
U04758 Genomic DNA Translation: AAC43746.1
U04759 Genomic DNA Translation: AAC43747.1
U04760 Genomic DNA Translation: AAC43748.1
U04770 Genomic DNA Translation: AAC43758.1
AF004170 Genomic DNA Translation: AAB87003.1
AF004171 Genomic DNA Translation: AAB87004.1
AF004172 Genomic DNA Translation: AAB87005.1
AF004173 Genomic DNA Translation: AAB87006.1
AF004174 Genomic DNA Translation: AAB87007.1
AF004175 Genomic DNA Translation: AAB87008.1
AF004176 Genomic DNA Translation: AAB87009.1
AF004177 Genomic DNA Translation: AAB87010.1
AF004179 Genomic DNA Translation: AAB87012.1
AF004180 Genomic DNA Translation: AAB87013.1
AF004182 Genomic DNA Translation: AAB87015.1
AF004183 Genomic DNA Translation: AAB87016.1
AF004184 Genomic DNA Translation: AAB87017.1
AF004186 Genomic DNA Translation: AAB87019.1
AF004187 Genomic DNA Translation: AAB87020.1
AF004188 Genomic DNA Translation: AAB87021.1
AF004190 Genomic DNA Translation: AAB87023.1
AF004191 Genomic DNA Translation: AAB87024.1
AF004195 Genomic DNA Translation: AAB87028.1
AF004196 Genomic DNA Translation: AAB87029.1
AF004199 Genomic DNA Translation: AAB87032.1
AF004200 Genomic DNA Translation: AAB87033.1
AF004201 Genomic DNA Translation: AAB87034.1
AF004202 Genomic DNA Translation: AAB87035.1
AF004203 Genomic DNA Translation: AAB87036.1
AF004204 Genomic DNA Translation: AAB87037.1
AF004205 Genomic DNA Translation: AAB87038.1
AF004206 Genomic DNA Translation: AAB87039.1
AF004207 Genomic DNA Translation: AAB87040.1
AF004208 Genomic DNA Translation: AAB87041.1
AF004209 Genomic DNA Translation: AAB87042.1
AF091758 Genomic DNA Translation: AAF97988.1
AF091759 Genomic DNA Translation: AAF97989.1
AF091760 Genomic DNA Translation: AAF97990.1
AF091761 Genomic DNA Translation: AAF97991.1
AF091762 Genomic DNA Translation: AAF97992.1
AF091763 Genomic DNA Translation: AAF97993.1
AF091764 Genomic DNA Translation: AAF97994.1
AF091765 Genomic DNA Translation: AAF97995.1
AF091766 Genomic DNA Translation: AAF97996.1
AF091767 Genomic DNA Translation: AAF97997.1
AF091768 Genomic DNA Translation: AAF97998.1
AF091769 Genomic DNA Translation: AAF97999.1
AF091770 Genomic DNA Translation: AAF98000.1
AF091771 Genomic DNA Translation: AAF98001.1
AF091772 Genomic DNA Translation: AAF98002.1
AF091773 Genomic DNA Translation: AAF98003.1
AF091774 Genomic DNA Translation: AAF98004.1
AF091775 Genomic DNA Translation: AAF98005.1
AF091776 Genomic DNA Translation: AAF98006.1
AF091777 Genomic DNA Translation: AAF98007.1
AF091778 Genomic DNA Translation: AAF98008.1
PIRiF65115 DEECM
RefSeqiNP_417703.1, NC_000913.3
WP_001295272.1, NZ_STEB01000012.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMEmodel-A1-312[»]
1EMDX-ray1.90A1-312[»]
1IB6X-ray2.10A/B/C/D1-312[»]
1IE3X-ray2.50A/B/C/D1-312[»]
2CMDX-ray1.87A1-312[»]
2PWZX-ray2.20A/C/E/G1-312[»]
3HHPX-ray1.45A/B/C/D1-312[»]
5KKAX-ray1.75A/B1-312[»]
5Z3WX-ray2.29A/B/C/D1-311[»]
SMRiP61889
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260779, 27 interactors
852165, 2 interactors
DIPiDIP-35924N
IntActiP61889, 10 interactors
STRINGi511145.b3236

Chemistry databases

DrugBankiDB09131 Cupric Chloride
DB00336 Nitrofural

2D gel databases

SWISS-2DPAGEiP61889

Proteomic databases

EPDiP61889
jPOSTiP61889
PaxDbiP61889
PRIDEiP61889

Genome annotation databases

EnsemblBacteriaiAAC76268; AAC76268; b3236
BAE77279; BAE77279; BAE77279
GeneIDi947854
KEGGiecj:JW3205
eco:b3236
PATRICifig|1411691.4.peg.3492

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

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EchoBASEi
EB0571

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
InParanoidiP61889
KOiK00024
PhylomeDBiP61889

Enzyme and pathway databases

BioCyciEcoCyc:MALATE-DEHASE-MONOMER
ECOL316407:JW3205-MONOMER
MetaCyc:MALATE-DEHASE-MONOMER
BRENDAi1.1.1.37 2026

Miscellaneous databases

EvolutionaryTraceiP61889

Protein Ontology

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PROi
PR:P61889

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01516 Malate_dehydrog_1, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDH_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61889
Secondary accession number(s): O30401
, O30402, O30403, P06994, Q2M8X7, Q59343, Q59344, Q59345, Q59346, Q59347, Q59348, Q60133, Q60150, Q933J3, Q93R02, Q9FDQ3, Q9FDQ4, Q9FDQ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 7, 2004
Last modified: November 13, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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