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Protein

Metallothionein-1

Gene

MtnA

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

GO - Molecular functioni

Keywordsi

LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Gene namesi
Name:MtnA
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013782 Dana\MtnA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973521 – 40Metallothionein-1Add BLAST40

Proteomic databases

PRIDEiP61873

Expressioni

Developmental stagei

Late embryogenesis, larva and adult.

Inductioni

Strongly induced by cadmium, copper and mercury.

Structurei

3D structure databases

SMRiP61873
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
OrthoDBiEOG091G1A2R

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA

Sequencei

Sequence statusi: Complete.

P61873-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK
Length:40
Mass (Da):3,852
Last modified:June 7, 2004 - v1
Checksum:i9182A53CCCAE634A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75822 Genomic DNA Translation: AAB32801.2

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75822 Genomic DNA Translation: AAB32801.2

3D structure databases

SMRiP61873
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP61873

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0013782 Dana\MtnA

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
OrthoDBiEOG091G1A2R

Miscellaneous databases

ChiTaRSiMtnA fly

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_DROAN
AccessioniPrimary (citable) accession number: P61873
Secondary accession number(s): P22254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 23, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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