Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L12

Gene

rpl-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds directly to 26S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonProtiP61866

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L12
Gene namesi
Name:rpl-12
ORF Names:JC8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiJC8.3a ; CE17986 ; WBGene00004424 ; rpl-12
JC8.3c ; CE39743 ; WBGene00004424 ; rpl-12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044601 – 16560S ribosomal protein L12Add BLAST165

Proteomic databases

EPDiP61866
PaxDbiP61866
PRIDEiP61866

PTM databases

iPTMnetiP61866

Expressioni

Gene expression databases

BgeeiWBGene00004424

Interactioni

Protein-protein interaction databases

BioGridi43368, 2 interactors
DIPiDIP-26259N
IntActiP61866, 1 interactor
STRINGi6239.JC8.3a

Structurei

3D structure databases

ProteinModelPortaliP61866
SMRiP61866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0886 Eukaryota
COG0080 LUCA
GeneTreeiENSGT00390000006922
HOGENOMiHOG000082125
InParanoidiP61866
KOiK02870
OMAiIKHNGNL
OrthoDBiEOG091G0PW6
PhylomeDBiP61866

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020785 Ribosomal_L11_CS
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
PROSITEiView protein in PROSITE
PS00359 RIBOSOMAL_L11, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P61866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKFDPTEI KIVYLRCVGG EVGATSALAP KVGPLGLSPK KIGEDIAKAT
60 70 80 90 100
QDWKGLKVTC KLTIQNRVAK IDVVPSAASL IVKELKEPPR DRKKVKNVKH
110 120 130 140 150
NGDLTVDTII KIARIMRPRS MAKKLEGTVK EILGTAQSVG CTIDGQHPHD
160
IIESIANGEI EIPAQ
Note: No experimental confirmation available.
Length:165
Mass (Da):17,831
Last modified:June 7, 2004 - v1
Checksum:i0ECCD325C5347CBF
GO
Isoform c (identifier: P61866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Note: No experimental confirmation available.
Show »
Length:50
Mass (Da):5,371
Checksum:iFDE4B433520291A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207251 – 115Missing in isoform c. CuratedAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82274 Genomic DNA Translation: CAB05226.1
Z82274 Genomic DNA Translation: CAJ76933.1
PIRiT23150
RefSeqiNP_001040960.1, NM_001047495.4 [P61866-2]
NP_502542.1, NM_070141.6 [P61866-1]
UniGeneiCel.22878

Genome annotation databases

EnsemblMetazoaiJC8.3a; JC8.3a; WBGene00004424 [P61866-1]
GeneIDi178279
KEGGicel:CELE_JC8.3
UCSCiJC8.3a.2 c. elegans [P61866-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL12_CAEEL
AccessioniPrimary (citable) accession number: P61866
Secondary accession number(s): O62290, Q2EEM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health