UniProtKB - P61829 (ATP9_YEAST)
ATP synthase subunit 9, mitochondrial
OLI1
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 59 | Reversibly protonated during proton transportBy similarity | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- lipid binding Source: UniProtKB-KW
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- ATP synthesis coupled proton transport Source: SGD
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-SCE-163210, Formation of ATP by chemiosmotic coupling R-SCE-8949613, Cristae formation |
Protein family/group databases
TCDBi | 3.A.2.1.3, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit 9, mitochondrialAlternative name(s): Lipid-binding protein Oligomycin resistance protein 1 |
Gene namesi | Name:OLI1 Synonyms:ATP9, OLI3, PHO2 Ordered Locus Names:Q0130 |
Encoded oni | Mitochondrion |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000007274, OLI1 |
VEuPathDBi | FungiDB:Q0130 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane Curated; Multi-pass membrane protein Curated
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial inner membrane Source: ComplexPortal
- mitochondrial intermembrane space Source: Reactome
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: SGD
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting ATP synthase complex, coupling factor F(o) Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
CF(0), Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000112240 | 1 – 76 | ATP synthase subunit 9, mitochondrialAdd BLAST | 76 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-formylmethionine1 Publication | 1 |
Keywords - PTMi
FormylationProteomic databases
PaxDbi | P61829 |
PRIDEi | P61829 |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
Binary interactionsi
P61829
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-9016907,EBI-9016907 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 34780, 13 interactors |
ComplexPortali | CPX-3281, Mitochondrial proton-transporting ATP synthase complex |
DIPi | DIP-3041N |
IntActi | P61829, 2 interactors |
STRINGi | 4932.Q0130 |
Miscellaneous databases
RNActi | P61829, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P61829 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61829 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3025, Eukaryota |
GeneTreei | ENSGT00940000176138 |
HOGENOMi | CLU_148047_4_1_1 |
InParanoidi | P61829 |
OMAi | MDPQAAK |
Family and domain databases
Gene3Di | 1.20.20.10, 1 hit |
HAMAPi | MF_01396, ATP_synth_c_bact, 1 hit |
InterProi | View protein in InterPro IPR000454, ATP_synth_F0_csu IPR020537, ATP_synth_F0_csu_DDCD_BS IPR038662, ATP_synth_F0_csu_sf IPR002379, ATPase_proteolipid_c-like_dom IPR035921, F/V-ATP_Csub_sf |
PANTHERi | PTHR10031, PTHR10031, 1 hit |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 1 hit |
PRINTSi | PR00124, ATPASEC |
SUPFAMi | SSF81333, SSF81333, 1 hit |
PROSITEi | View protein in PROSITE PS00605, ATPASE_C, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MQLVLAAKYI GAGISTIGLL GAGIGIAIVF AALINGVSRN PSIKDTVFPM
60 70
AILGFALSEA TGLFCLMVSF LLLFGV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 46 | T → L in strain: DS400/A3 and KL14-4A. | 1 | |
Natural varianti | 53 | L → F in strain: DS400/A3, DS401 and oligomycin-resistant mutant. | 1 | |
Natural varianti | 57 | L → V in oligomycin-resistant mutant and cross-resistance to venturicidin. | 1 | |
Natural varianti | 65 | C → S in oligomycin-resistant mutant. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00007 Genomic DNA Translation: AAA32146.1 J01462 Genomic DNA Translation: AAA32169.1 V00707 Genomic DNA Translation: CAA24079.1 L36899 Genomic DNA Translation: AAA67535.1 X03968 Genomic DNA Translation: CAA27605.1 KP263414 Genomic DNA Translation: AIZ98894.1 |
PIRi | A23024, LWBYA |
RefSeqi | NP_009319.1, NC_001224.1 YP_009144710.1, NC_027264.1 |
Genome annotation databases
EnsemblFungii | Q0130_mRNA; Q0130; Q0130 |
GeneIDi | 24573116 854584 |
KEGGi | sce:Q0130 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00007 Genomic DNA Translation: AAA32146.1 J01462 Genomic DNA Translation: AAA32169.1 V00707 Genomic DNA Translation: CAA24079.1 L36899 Genomic DNA Translation: AAA67535.1 X03968 Genomic DNA Translation: CAA27605.1 KP263414 Genomic DNA Translation: AIZ98894.1 |
PIRi | A23024, LWBYA |
RefSeqi | NP_009319.1, NC_001224.1 YP_009144710.1, NC_027264.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WPD | X-ray | 3.43 | J/K/L/M/N/O/P/Q/R/S | 1-76 | [»] | |
2XOK | X-ray | 3.01 | K/L/M/N/O/P/Q/R/S/T | 1-76 | [»] | |
3U2F | X-ray | 2.00 | K/L/M/N/O | 1-76 | [»] | |
3U2Y | X-ray | 2.50 | K/L/M/N/O | 1-76 | [»] | |
3U32 | X-ray | 2.00 | K/L/M/N/O | 1-76 | [»] | |
3UD0 | X-ray | 2.00 | K/L/M/N/O | 1-76 | [»] | |
3ZRY | X-ray | 6.50 | J/K/L/M/N/O/P/Q/R/S | 1-76 | [»] | |
4B2Q | electron microscopy | 37.00 | J/K/L/M/N/O/P/Q/R/S/j/k/l/m/n/o/p/q/r/s | 1-76 | [»] | |
4F4S | X-ray | 1.90 | A/B/C/D/E/K/L/M/N/O | 1-76 | [»] | |
5BPS | X-ray | 2.10 | A/B/C/D/E/K/L/M/N/O | 1-76 | [»] | |
5BQ6 | X-ray | 2.30 | A/B/C/D/E/K/L/M/N/O | 1-76 | [»] | |
5BQA | X-ray | 2.10 | A/B/C/D/E/K/L/M/N/O | 1-76 | [»] | |
5BQJ | X-ray | 2.10 | A/B/C/D/E/K/L/M/N/O | 1-76 | [»] | |
6B2Z | electron microscopy | 3.60 | 0/1/2/3/4/5/6/7/8/9/B/C/D/E/F/G/H/I/J/K | 1-76 | [»] | |
6B8H | electron microscopy | 3.60 | 0/1/2/3/4/5/6/7/8/9/J/L/M/N/P/Q/R/S/T/U | 1-76 | [»] | |
6CP3 | electron microscopy | 3.80 | K/L/M/N/O/P/Q/R/S/T | 1-76 | [»] | |
6CP5 | electron microscopy | 4.20 | K/L/M/N/O/P/Q/R/S/T | 1-76 | [»] | |
6CP6 | electron microscopy | 3.60 | K/L/M/N/O/P/Q/R/S/T | 1-76 | [»] | |
6CP7 | electron microscopy | 4.10 | K/L/M/N/O/P/Q/R/S/T | 1-76 | [»] | |
6WTD | electron microscopy | 4.20 | K/L/M/N/O/P/Q/R/S/T | 1-76 | [»] | |
SMRi | P61829 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34780, 13 interactors |
ComplexPortali | CPX-3281, Mitochondrial proton-transporting ATP synthase complex |
DIPi | DIP-3041N |
IntActi | P61829, 2 interactors |
STRINGi | 4932.Q0130 |
Protein family/group databases
TCDBi | 3.A.2.1.3, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Proteomic databases
PaxDbi | P61829 |
PRIDEi | P61829 |
Genome annotation databases
EnsemblFungii | Q0130_mRNA; Q0130; Q0130 |
GeneIDi | 24573116 854584 |
KEGGi | sce:Q0130 |
Organism-specific databases
SGDi | S000007274, OLI1 |
VEuPathDBi | FungiDB:Q0130 |
Phylogenomic databases
eggNOGi | KOG3025, Eukaryota |
GeneTreei | ENSGT00940000176138 |
HOGENOMi | CLU_148047_4_1_1 |
InParanoidi | P61829 |
OMAi | MDPQAAK |
Enzyme and pathway databases
Reactomei | R-SCE-163210, Formation of ATP by chemiosmotic coupling R-SCE-8949613, Cristae formation |
Miscellaneous databases
EvolutionaryTracei | P61829 |
PROi | PR:P61829 |
RNActi | P61829, protein |
Family and domain databases
Gene3Di | 1.20.20.10, 1 hit |
HAMAPi | MF_01396, ATP_synth_c_bact, 1 hit |
InterProi | View protein in InterPro IPR000454, ATP_synth_F0_csu IPR020537, ATP_synth_F0_csu_DDCD_BS IPR038662, ATP_synth_F0_csu_sf IPR002379, ATPase_proteolipid_c-like_dom IPR035921, F/V-ATP_Csub_sf |
PANTHERi | PTHR10031, PTHR10031, 1 hit |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 1 hit |
PRINTSi | PR00124, ATPASEC |
SUPFAMi | SSF81333, SSF81333, 1 hit |
PROSITEi | View protein in PROSITE PS00605, ATPASE_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATP9_YEAST | |
Accessioni | P61829Primary (citable) accession number: P61829 Secondary accession number(s): A0A0A7P075, P00841, Q37750 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families