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UniProtKB - P61823 (RNAS1_BOVIN)

Entry version 155 (17 Jun 2020)
Sequence version 1 (07 Jun 2004)
Previous versions | rss
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Protein

Ribonuclease pancreatic

Gene

RNASE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.1 Publication

Miscellaneous

Ribonuclease can destabilize or unwind the DNA helix by complexing with single-stranded DNA; this complex arises by an extended multisite cation-anion interaction between the lysine and arginine residues of the enzyme and the phosphate groups of the nucleotides.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA). EC:4.6.1.18
  • An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA). EC:4.6.1.18

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33Substrate1
Binding sitei36Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei38Proton acceptor1
Binding sitei92Substrate1
Binding sitei111Substrate1
Active sitei145Proton donor1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Lyase, Nuclease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.27.5 908

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P61823

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease pancreatic (EC:4.6.1.18)
Alternative name(s):
RNase 1
RNase A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASE1
Synonyms:RNS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38H → A: Loss of activity. 1
Mutagenesisi145H → A: Loss of activity. 1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6091

DrugCentral

More...DrugCentrali		P61823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 262 PublicationsAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003091527 – 150Ribonuclease pancreaticAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi33N-linked (Glc) (glycation) lysine; in vitro1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi52 ↔ 1101 Publication
GlycosylationiCAR_00000660N-linked (GlcNAc...) asparagine; partial1 Publication1
Glycosylationi63N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi66 ↔ 1211 Publication
Glycosylationi67N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi84 ↔ 1361 Publication
Disulfide bondi91 ↔ 981 Publication

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P61823

PeptideAtlas

More...PeptideAtlasi		P61823

PRoteomics IDEntifications database

More...PRIDEi		P61823

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P61823

GlyConnect protein glycosylation platform

More...GlyConnecti		529

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P61823

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSBTAG00000008793 Expressed in adult mammalian kidney and 7 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P61823 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity). Monomer.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		159601, 1 interactor

Database of interacting proteins

More...DIPi		DIP-36384N

Protein interaction database and analysis system

More...IntActi		P61823, 7 interactors

Molecular INTeraction database

More...MINTi		P61823

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000011586

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P61823

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P61823

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P61823

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 71Substrate binding5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IYEN Eukaryota
ENOG41113F1 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_117006_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P61823

KEGG Orthology (KO)

More...KOi		K01168

Identification of Orthologs from Complete Genome Data

More...OMAi		CNQMMKS

Database of Orthologous Groups

More...OrthoDBi		1549558at2759

TreeFam database of animal gene trees

More...TreeFami		TF333393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain

The PANTHER Classification System

More...PANTHERi		PTHR11437 PTHR11437, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00074 RnaseA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00794 RIBONUCLEASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00092 RNAse_Pc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54076 SSF54076, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P61823-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKSLVLLS LLVLVLLLVR VQPSLGKETA AAKFERQHMD SSTSAASSSN 
        60         70         80         90        100
YCNQMMKSRN LTKDRCKPVN TFVHESLADV QAVCSQKNVA CKNGQTNCYQ 
       110        120        130        140        150
SYSTMSITDC RETGSSKYPN CAYKTTQANK HIIVACEGNP YVPVHFDASV
Length:150
Mass (Da):16,461
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74E5DC61E679187D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LPK8A0A3Q1LPK8_BOVIN
Ribonuclease pancreatic
RNASE1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X07283 Genomic DNA Translation: CAA30263.1
BC149529 mRNA Translation: AAI49530.1
BC149636 mRNA Translation: AAI49637.1
S80747 mRNA Translation: AAB35594.1
S81740 Genomic DNA Translation: AAB36134.1

Protein sequence database of the Protein Information Resource

More...PIRi		S00897 NRBO

NCBI Reference Sequences

More...RefSeqi		NP_001014408.2, NM_001014386.4
XP_005211519.1, XM_005211462.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSBTAT00000011586; ENSBTAP00000011586; ENSBTAG00000008793

Database of genes from NCBI RefSeq genomes

More...GeneIDi		282340

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:282340

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Worthington enzyme manual
Functional Glycomics Gateway - Glycan Binding

RNase A

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07283 Genomic DNA Translation: CAA30263.1
BC149529 mRNA Translation: AAI49530.1
BC149636 mRNA Translation: AAI49637.1
S80747 mRNA Translation: AAB35594.1
S81740 Genomic DNA Translation: AAB36134.1
PIRiS00897 NRBO
RefSeqiNP_001014408.2, NM_001014386.4
XP_005211519.1, XM_005211462.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2WX-ray2.10A/B27-150[»]
1A5PX-ray1.60A27-150[»]
1A5QX-ray2.30A27-150[»]
1AFKX-ray1.70A/B27-150[»]
1AFLX-ray1.70A/B27-150[»]
1AFUX-ray2.00A/B27-150[»]
1AQPX-ray2.00A27-150[»]
1B6VX-ray2.00A/B27-150[»]
1BELX-ray1.60A27-150[»]
1BZQX-ray2.80A/B/C/D27-150[»]
1C0BX-ray1.90A23-150[»]
1C0CX-ray2.00A23-150[»]
1C8WX-ray1.80A27-150[»]
1C9VX-ray1.70A27-150[»]
1C9XX-ray1.80A27-150[»]
1CJQX-ray3.00A27-41[»]
B50-150[»]
1CJRX-ray2.30A27-41[»]
B50-150[»]
1D5DX-ray2.25A27-41[»]
B50-150[»]
1D5EX-ray2.25A27-41[»]
B50-150[»]
1D5HX-ray2.25A27-41[»]
B50-150[»]
1DFJX-ray2.50E27-150[»]
1DY5X-ray0.87A/B27-150[»]
1EICX-ray1.40A27-150[»]
1EIDX-ray1.40A27-150[»]
1EIEX-ray1.40A27-150[»]
1EOSX-ray2.00A/B27-150[»]
1EOWX-ray2.00A27-150[»]
1F0VX-ray1.70A/B/C/D27-150[»]
1FEVX-ray2.25A27-41[»]
B50-150[»]
1FS3X-ray1.40A27-150[»]
1GV7X-ray2.10A84-99[»]
1IZPX-ray1.50A27-150[»]
1IZQX-ray1.80A27-150[»]
1IZRX-ray1.50A27-150[»]
1J7ZX-ray2.25A27-41[»]
B47-150[»]
1J80X-ray2.10A27-41[»]
B47-150[»]
1J81X-ray2.20A27-41[»]
B47-150[»]
1J82X-ray2.30A27-41[»]
B47-150[»]
1JN4X-ray1.80A/B27-150[»]
1JS0X-ray2.20A/B/C27-150[»]
1JVTX-ray2.05A/B27-150[»]
1JVUX-ray1.78A/B27-150[»]
1JVVX-ray2.20A/B27-150[»]
1KF2X-ray1.10A27-150[»]
1KF3X-ray1.05A27-150[»]
1KF4X-ray1.10A27-150[»]
1KF5X-ray1.15A27-150[»]
1KF7X-ray1.15A27-150[»]
1KF8X-ray1.15A27-150[»]
1KH8X-ray2.00A27-150[»]
1LSQX-ray1.90A/B27-150[»]
1O0FX-ray1.50A/B27-150[»]
1O0HX-ray1.20A/B27-150[»]
1O0MX-ray1.50A/B27-150[»]
1O0NX-ray1.50A/B27-150[»]
1O0OX-ray1.20A/B27-150[»]
1QHCX-ray1.70A/B27-150[»]
1RARX-ray1.90A28-150[»]
1RASX-ray1.70A28-150[»]
1RATX-ray1.50A27-150[»]
1RBBX-ray2.50A/B27-150[»]
1RBCX-ray2.00A47-150[»]
S27-41[»]
1RBDX-ray1.70A47-150[»]
S27-41[»]
1RBEX-ray1.75A47-150[»]
S27-41[»]
1RBFX-ray1.80A47-150[»]
S27-41[»]
1RBGX-ray1.80A47-150[»]
S27-41[»]
1RBHX-ray1.70A47-150[»]
S27-41[»]
1RBIX-ray1.80A47-150[»]
S27-41[»]
1RBJX-ray2.70A27-150[»]
1RBNX-ray2.10A27-150[»]
1RBWX-ray1.69A27-150[»]
1RBXX-ray1.69A27-150[»]
1RCAX-ray1.90A27-150[»]
1RCNX-ray2.32E27-150[»]
1RHAX-ray1.80A27-150[»]
1RHBX-ray1.50A27-150[»]
1RNCX-ray1.50A27-150[»]
1RNDX-ray1.50A27-150[»]
1RNMX-ray2.00E27-150[»]
1RNNX-ray1.80E27-150[»]
1RNOX-ray1.90A27-150[»]
1RNQX-ray2.00A27-150[»]
1RNUX-ray1.60A27-150[»]
1RNVX-ray1.60A27-150[»]
1RNWX-ray1.80A27-150[»]
1RNXX-ray1.90A27-150[»]
1RNYX-ray2.00A27-150[»]
1RNZX-ray1.90A27-150[»]
1ROBX-ray1.60A27-150[»]
1RPFX-ray2.20A27-150[»]
1RPGX-ray1.40A27-150[»]
1RPHX-ray2.20A27-150[»]
1RSMX-ray2.00A27-150[»]
1RTAX-ray2.50E27-150[»]
1RTBX-ray2.50A27-150[»]
1RUVX-ray1.25A27-150[»]
1SRNX-ray1.80A27-144[»]
B137-150[»]
1SSAX-ray2.00A27-144[»]
B137-150[»]
1SSBX-ray2.00A27-144[»]
B137-150[»]
1SSCX-ray2.00A27-138[»]
B140-150[»]
1U1BX-ray2.00A/B27-150[»]
1UN5X-ray2.60A64-74[»]
1W4OX-ray1.60A/B27-150[»]
1W4PX-ray1.69A/B27-150[»]
1W4QX-ray1.68A/B27-150[»]
1WBUX-ray1.90A/B27-150[»]
1XPSX-ray1.80A/B27-150[»]
1XPTX-ray1.90A/B27-150[»]
1YMNX-ray1.45A27-150[»]
1YMRX-ray1.50A27-150[»]
1YMWX-ray1.50A27-150[»]
1Z3LX-ray1.80E47-150[»]
S27-41[»]
1Z3MX-ray2.00E47-150[»]
S27-41[»]
1Z3PX-ray2.00E47-150[»]
S27-41[»]
1Z6DX-ray1.54A/B27-150[»]
1Z6SX-ray1.50A/B27-150[»]
2AASNMR-A27-150[»]
2APQX-ray1.80A27-150[»]
2APUmodel-0/1/2/3/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z27-150[»]
2BLPX-ray1.40A27-150[»]
2BLZX-ray1.40A27-150[»]
2E33X-ray2.70B27-150[»]
2E3WX-ray1.05A27-150[»]
2G4WX-ray1.84A/B27-150[»]
2G4XX-ray1.95A27-150[»]
2G8QX-ray1.50A/B27-150[»]
2G8RX-ray1.70A/B27-150[»]
2NUIX-ray1.10A27-150[»]
2OP2X-ray1.60A27-150[»]
2OQFX-ray2.30A/B/C/D27-150[»]
2P42X-ray1.80A/C27-150[»]
2P43X-ray1.65A27-150[»]
2P44X-ray1.80A27-150[»]
2P45X-ray1.10A27-150[»]
2P46X-ray2.50A/C27-150[»]
2P47X-ray2.50A27-150[»]
2P48X-ray2.30A27-150[»]
2P49X-ray1.38A27-150[»]
2P4AX-ray1.90A/C27-150[»]
2QCAX-ray1.33A27-150[»]
2RATX-ray1.50A27-150[»]
2RLNX-ray1.85E42-150[»]
S27-41[»]
2RNSX-ray1.60A27-150[»]
2W5GX-ray1.70A/B27-150[»]
2W5IX-ray2.40A/B27-150[»]
2W5KX-ray1.70A/B27-150[»]
2W5LX-ray1.70A/B27-150[»]
2W5MX-ray1.80A/B27-150[»]
2XOGX-ray1.72A/B27-150[»]
2XOIX-ray1.72A/B27-150[»]
3A1Rneutron diffraction1.70A27-150[»]
3D6OX-ray1.58A/B27-150[»]
3D6PX-ray1.60A/B27-150[»]
3D6QX-ray1.60A/B27-150[»]
3D7BX-ray1.60A/B27-150[»]
3D8YX-ray1.72A/B27-150[»]
3D8ZX-ray1.98A/B27-150[»]
3DH5X-ray1.60A27-150[»]
3DH6X-ray1.60A27-150[»]
3DI7X-ray1.60A27-150[»]
3DI8X-ray1.60A27-150[»]
3DI9X-ray2.00A27-150[»]
3DIBX-ray1.40A27-150[»]
3DICX-ray1.60A27-150[»]
3DXGX-ray1.39A/B27-150[»]
3DXHX-ray1.40A/B27-150[»]
3EUXX-ray1.65A/B27-150[»]
3EUYX-ray1.95A/B27-150[»]
3EUZX-ray1.84A/B27-150[»]
3EV0X-ray1.76A/B27-150[»]
3EV1X-ray2.00A/B27-150[»]
3EV2X-ray2.02A/B27-150[»]
3EV3X-ray1.68A/B27-150[»]
3EV4X-ray1.93A/B27-150[»]
3EV5X-ray1.68A/B27-150[»]
3EV6X-ray1.76A/B27-150[»]
3FKZX-ray1.99A/B27-150[»]
3FL0X-ray1.94A/B27-150[»]
3FL1X-ray1.90A/B27-150[»]
3FL3X-ray1.60A/B27-150[»]
3I67X-ray1.30A27-150[»]
3I6FX-ray1.30A27-150[»]
3I6HX-ray1.30A27-150[»]
3I6JX-ray1.30A27-150[»]
3I7WX-ray2.35A27-150[»]
3I7XX-ray2.60A27-150[»]
3I7YX-ray2.40A27-150[»]
3JW1X-ray1.60A/B27-150[»]
3LXOX-ray1.55A27-150[»]
3MWQX-ray1.68A26-150[»]
3MWRX-ray1.85A27-150[»]
3MX8X-ray2.10A26-150[»]
3MZQX-ray1.50A23-150[»]
3MZRX-ray1.50A23-150[»]
3OQYX-ray1.49A/B47-150[»]
a/b27-41[»]
3OQZX-ray2.50A/B47-150[»]
a/b27-41[»]
3OR0X-ray2.30A/B47-150[»]
a/b27-41[»]
3QL1X-ray1.29A27-150[»]
3QL2X-ray1.49A/B27-150[»]
3QSKX-ray1.75A27-150[»]
3RATX-ray1.50A27-150[»]
3RH1X-ray2.10A27-150[»]
3RIDX-ray2.18A/B/C/D27-150[»]
3RN3X-ray1.45A27-150[»]
3RSDX-ray1.60A27-150[»]
3RSKX-ray2.00A27-150[»]
3RSPX-ray1.70A27-150[»]
3SRNX-ray2.00A27-139[»]
B140-146[»]
4AO1X-ray1.58A27-150[»]
4G8VX-ray1.70A/B27-150[»]
4G8YX-ray1.80A/B27-150[»]
4G90X-ray1.90A/B27-150[»]
4J5ZX-ray1.80A27-150[»]
4J60X-ray1.69A27-150[»]
4J61X-ray1.69A27-150[»]
4J62X-ray2.04A27-150[»]
4J63X-ray2.04A27-150[»]
4J64X-ray1.78A27-150[»]
4J65X-ray1.96A27-150[»]
4J66X-ray2.04A27-150[»]
4J67X-ray1.86A27-150[»]
4J68X-ray1.78A27-150[»]
4J69X-ray1.89A27-150[»]
4J6AX-ray2.04A27-150[»]
4K7LX-ray1.38A27-41[»]
B47-150[»]
4K7MX-ray1.80A27-150[»]
4L55X-ray1.65A/B27-150[»]
4MXFX-ray2.25A/B27-150[»]
4O36X-ray1.22A27-41[»]
B47-150[»]
4O37X-ray1.40A27-41[»]
B47-150[»]
4OKFX-ray1.54A27-41[»]
B47-150[»]
4OOHX-ray1.89A27-150[»]
4OT4X-ray1.85A/B27-150[»]
4PEQX-ray2.21A/C27-150[»]
4POUX-ray1.75A27-150[»]
4QH3X-ray2.00A/B27-150[»]
4RATX-ray1.50A27-150[»]
4RSDX-ray1.60A27-150[»]
4RSKX-ray2.10A27-150[»]
4RTEX-ray1.95A27-150[»]
4S0QX-ray2.09A/B27-150[»]
4S18X-ray2.27A/B27-150[»]
4SRNX-ray2.00A27-139[»]
B140-150[»]
4WYNX-ray1.80A/B27-150[»]
4WYPX-ray1.50A/B27-150[»]
4WYZX-ray1.45A/B27-150[»]
4YGWX-ray2.18B48-150[»]
b27-41[»]
4ZZ4neutron diffraction1.80A27-150[»]
5D6UX-ray1.52A27-150[»]
5D97neutron diffraction1.80A27-150[»]
5E5EX-ray1.98A/B27-150[»]
5E5FX-ray1.68A/B27-150[»]
5ET4X-ray2.10A/B/C/D27-150[»]
5JLGX-ray1.79A/B27-150[»]
5JMGX-ray1.85A/B27-150[»]
5JMLX-ray2.29A/B27-150[»]
5NA9X-ray2.07A27-150[»]
5NJ7X-ray2.15A/B27-150[»]
5OBCX-ray2.07A/B27-150[»]
5OBDX-ray1.98A/B27-150[»]
5OBEX-ray1.82A/B27-150[»]
5OGHX-ray1.16A27-150[»]
5OLDX-ray1.78A/B27-150[»]
5RATX-ray1.50A27-150[»]
5RSAX-ray2.00A27-150[»]
6ETKX-ray0.85A27-150[»]
6ETLX-ray0.85A27-150[»]
6ETMX-ray0.92A27-150[»]
6ETNX-ray0.92A27-150[»]
6ETOX-ray1.02A27-150[»]
6ETPX-ray1.02A27-150[»]
6ETQX-ray1.08A27-150[»]
6ETRX-ray1.17A27-150[»]
6F60X-ray1.14A/B27-150[»]
6GOKX-ray2.65A/B27-150[»]
6PVUX-ray1.49A/B27-150[»]
6PVVX-ray1.65A/B27-150[»]
6PVWX-ray1.60A/B27-150[»]
6PVXX-ray1.55A/B27-150[»]
6QE9X-ray2.03A/B27-150[»]
6RATX-ray1.50A27-150[»]
6RSAX-ray2.00A27-150[»]
6XVXX-ray1.40AAA/BBB27-150[»]
6XW0X-ray1.80AAA/BBB27-150[»]
7RATX-ray1.50A27-150[»]
7RSAX-ray1.26A27-150[»]
8RATX-ray1.50A27-150[»]
8RSAX-ray1.80A/B27-150[»]
9RATX-ray1.50A27-150[»]
9RSAX-ray1.80A/B27-150[»]
SMRiP61823
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi159601, 1 interactor
DIPiDIP-36384N
IntActiP61823, 7 interactors
MINTiP61823
STRINGi9913.ENSBTAP00000011586

Chemistry databases

BindingDBiP61823
ChEMBLiCHEMBL6091
DrugCentraliP61823

PTM databases

CarbonylDBiP61823
GlyConnecti529
UniCarbKBiP61823

Proteomic databases

PaxDbiP61823
PeptideAtlasiP61823
PRIDEiP61823

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P61823 4 sequenced antibodies

Genome annotation databases

EnsembliENSBTAT00000011586; ENSBTAP00000011586; ENSBTAG00000008793
GeneIDi282340
KEGGibta:282340

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6035

Phylogenomic databases

eggNOGiENOG410IYEN Eukaryota
ENOG41113F1 LUCA
GeneTreeiENSGT00940000160869
HOGENOMiCLU_117006_0_0_1
InParanoidiP61823
KOiK01168
OMAiCNQMMKS
OrthoDBi1549558at2759
TreeFamiTF333393

Enzyme and pathway databases

BRENDAi3.1.27.5 908
SABIO-RKiP61823

Miscellaneous databases

EvolutionaryTraceiP61823

Protein Ontology

More...PROi		PR:P61823

Gene expression databases

BgeeiENSBTAG00000008793 Expressed in adult mammalian kidney and 7 other tissues
ExpressionAtlasiP61823 baseline

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain
PANTHERiPTHR11437 PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074 RnaseA, 1 hit
PRINTSiPR00794 RIBONUCLEASE
SMARTiView protein in SMART
SM00092 RNAse_Pc, 1 hit
SUPFAMiSSF54076 SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNAS1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61823
Secondary accession number(s): A6QPW8, P00656, Q9TSF2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 7, 2004
Last modified: June 17, 2020
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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