RNASE1

Functionⁱ

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.1 Publication

Miscellaneous

Ribonuclease can destabilize or unwind the DNA helix by complexing with single-stranded DNA; this complex arises by an extended multisite cation-anion interaction between the lysine and arginine residues of the enzyme and the phosphate groups of the nucleotides.

Catalytic activityⁱ

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	33	Substrate	1
Binding siteⁱ	36	Substrate	1
Active siteⁱ	38	Proton acceptor	1
Binding siteⁱ	92	Substrate	1
Binding siteⁱ	111	Substrate	1
Active siteⁱ	145	Proton donor	1

GO - Molecular functionⁱ

nucleic acid binding Source: InterPro
ribonuclease A activity Source: UniProtKB-EC
ribonuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Endonuclease, Hydrolase, Nuclease

Molecular function

Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BRENDAⁱ	3.1.27.5 908
SABIO-RKⁱ	P61823

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribonuclease pancreatic (EC:3.1.27.5) Alternative name(s): RNase 1 RNase A
Gene namesⁱ	Name:RNASE1 Synonyms:RNS1
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 10

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	38	H → A: Loss of activity.		1
Mutagenesisⁱ	145	H → A: Loss of activity.		1

Chemistry databases

ChEMBLⁱ	CHEMBL6091

ChEMBLⁱ

CHEMBL6091

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	2 PublicationsAdd BLAST		26
ChainⁱPRO_0000030915	27 – 150	Ribonuclease pancreaticAdd BLAST		124

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	27	N-linked (Glc) (glycation) lysine; in vitro1 Publication	1
Glycosylationⁱ	33	N-linked (Glc) (glycation) lysine; in vitro1 Publication	1
Disulfide bondⁱ	52 ↔ 110	1 Publication
GlycosylationⁱCAR_000006	60	N-linked (GlcNAc...) asparagine; partial1 Publication	1
Glycosylationⁱ	63	N-linked (Glc) (glycation) lysine; in vitro1 Publication	1
Disulfide bondⁱ	66 ↔ 121	1 Publication
Glycosylationⁱ	67	N-linked (Glc) (glycation) lysine; in vitro1 Publication	1
Disulfide bondⁱ	84 ↔ 136	1 Publication
Disulfide bondⁱ	91 ↔ 98	1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycation, Glycoprotein

Proteomic databases

PaxDbⁱ	P61823
PeptideAtlas More...PeptideAtlasⁱ	P61823
PRIDEⁱ	P61823

PTM databases

CarbonylDBⁱ	P61823
GlyConnectⁱ	529
UniCarbKBⁱ	P61823

Miscellaneous databases

PMAP-CutDBⁱ	P61823

PMAP-CutDBⁱ

P61823

Expressionⁱ

Tissue specificityⁱ

Pancreas.

Gene expression databases

Bgeeⁱ	ENSBTAG00000008793 Expressed in 8 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSBTAG00000008793 Expressed in 8 organ(s), highest expression level in adult mammalian kidney

Interactionⁱ

Subunit structureⁱ

Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity). Monomer.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Fbxo2	Q80UW2	2	EBI-908364,EBI-2314714	From Mus musculus.
PDI1	P17967	2	EBI-908364,EBI-13012	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
RNH1	P13489	3	EBI-908364,EBI-1237106	From Homo sapiens.

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-36384N
IntActⁱ	P61823, 7 interactors
Molecular INTeraction database More...MINTⁱ	P61823
STRINGⁱ	9913.ENSBTAP00000011586

Chemistry databases

BindingDBⁱ

P61823

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	30 – 38	Combined sources	9
Beta strandⁱ	43 – 45	Combined sources	3
Helixⁱ	48 – 50	Combined sources	3
Helixⁱ	51 – 58	Combined sources	8
Turnⁱ	59 – 62	Combined sources	4
Beta strandⁱ	63 – 65	Combined sources	3
Beta strandⁱ	68 – 73	Combined sources	6
Helixⁱ	77 – 81	Combined sources	5
Helixⁱ	82 – 85	Combined sources	4
Beta strandⁱ	86 – 89	Combined sources	4
Beta strandⁱ	92 – 94	Combined sources	3
Beta strandⁱ	98 – 100	Combined sources	3
Beta strandⁱ	105 – 112	Combined sources	8
Beta strandⁱ	118 – 120	Combined sources	3
Beta strandⁱ	123 – 130	Combined sources	8
Beta strandⁱ	132 – 137	Combined sources	6
Turnⁱ	138 – 141	Combined sources	4
Beta strandⁱ	142 – 149	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P61823
SMRⁱ	P61823
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P61823

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	67 – 71	Substrate binding		5

Sequence similaritiesⁱ

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IYEN Eukaryota ENOG41113F1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140967
HOGENOMⁱ	HOG000276883
HOVERGENⁱ	HBG008396
InParanoidⁱ	P61823
KEGG Orthology (KO) More...KOⁱ	K01168
OMAⁱ	HHVRVAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15X3
TreeFamⁱ	TF333393

Family and domain databases

Gene3Dⁱ	3.10.130.10, 1 hit
InterProⁱ	View protein in InterPro IPR001427 RNaseA IPR036816 RNaseA-like_dom_sf IPR023411 RNaseA_AS IPR023412 RNaseA_domain
PANTHERⁱ	PTHR11437 PTHR11437, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00074 RnaseA, 1 hit
PRINTSⁱ	PR00794 RIBONUCLEASE
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000535 RNaseA, 1 hit
SMARTⁱ	View protein in SMART SM00092 RNAse_Pc, 1 hit
SUPFAMⁱ	SSF54076 SSF54076, 1 hit
PROSITEⁱ	View protein in PROSITE PS00127 RNASE_PANCREATIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P61823-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MALKSLVLLS LLVLVLLLVR VQPSLGKETA AAKFERQHMD SSTSAASSSN 
        60         70         80         90        100
YCNQMMKSRN LTKDRCKPVN TFVHESLADV QAVCSQKNVA CKNGQTNCYQ 
       110        120        130        140        150
SYSTMSITDC RETGSSKYPN CAYKTTQANK HIIVACEGNP YVPVHFDASV

Length:150

Mass (Da):16,461

Last modified:June 7, 2004 - v1

Checksum:ⁱ74E5DC61E679187D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07283 Genomic DNA Translation: CAA30263.1 BC149529 mRNA Translation: AAI49530.1 BC149636 mRNA Translation: AAI49637.1 S80747 mRNA Translation: AAB35594.1 S81740 Genomic DNA Translation: AAB36134.1
PIRⁱ	S00897 NRBO
NCBI Reference Sequences More...RefSeqⁱ	NP_001014408.2, NM_001014386.4 XP_005211519.1, XM_005211462.2
UniGeneⁱ	Bt.4630

Genome annotation databases

Ensemblⁱ	ENSBTAT00000011586; ENSBTAP00000011586; ENSBTAG00000008793
GeneIDⁱ	282340
KEGGⁱ	bta:282340

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P61823	Ribonuclease A C2		BOVIN		215	UniRef100_P61823
UPI0000110AED		BOVIN		128
UPI0000112D2D		BOVIN		118
UPI0000112D39		BOVIN		112
UPI0000112D34		BOVIN		113

Protein	Similar proteins		Species	Score	Length	Source
P61823	Ribonuclease A C2		BOVIN		215	UniRef90_P61823
UPI0000110AED		BOVIN		128
UPI0000112D2D		BOVIN		118
UPI0000112D39		BOVIN		112
UPI0000112D34		BOVIN		113

Protein	Similar proteins		Species	Score	Length	Source
P61823	Ribonuclease pancreatic B		CAVPO		128	UniRef50_P61823
Ribonuclease A C2		BOVIN		215
Uncharacterized protein		CANLF		156
Pancreatic ribonuclease (Fragment)		CANRF		140
Pancreatic ribonuclease (Fragment)		CANLU		140
+14

Cross-referencesⁱ

Web resourcesⁱ

Worthington enzyme manual

Functional Glycomics Gateway - Glycan Binding

RNase A

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07283 Genomic DNA Translation: CAA30263.1 BC149529 mRNA Translation: AAI49530.1 BC149636 mRNA Translation: AAI49637.1 S80747 mRNA Translation: AAB35594.1 S81740 Genomic DNA Translation: AAB36134.1
PIRⁱ	S00897 NRBO
RefSeqⁱ	NP_001014408.2, NM_001014386.4 XP_005211519.1, XM_005211462.2
UniGeneⁱ	Bt.4630

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A2W	X-ray	2.10	A/B	27-150	[»]
	1A5P	X-ray	1.60	A	27-150	[»]
	1A5Q	X-ray	2.30	A	27-150	[»]
	1AFK	X-ray	1.70	A/B	27-150	[»]
	1AFL	X-ray	1.70	A/B	27-150	[»]
	1AFU	X-ray	2.00	A/B	27-150	[»]
	1AQP	X-ray	2.00	A	27-150	[»]
	1B6V	X-ray	2.00	A/B	27-150	[»]
	1BEL	X-ray	1.60	A	27-150	[»]
	1BZQ	X-ray	2.80	A/B/C/D	27-150	[»]
	1C0B	X-ray	1.90	A	23-150	[»]
	1C0C	X-ray	2.00	A	23-150	[»]
	1C8W	X-ray	1.80	A	27-150	[»]
	1C9V	X-ray	1.70	A	27-150	[»]
	1C9X	X-ray	1.80	A	27-150	[»]
	1CJQ	X-ray	3.00	A	27-41	[»]
				B	50-150	[»]
	1CJR	X-ray	2.30	A	27-41	[»]
				B	50-150	[»]
	1D5D	X-ray	2.25	A	27-41	[»]
				B	50-150	[»]
	1D5E	X-ray	2.25	A	27-41	[»]
				B	50-150	[»]
	1D5H	X-ray	2.25	A	27-41	[»]
				B	50-150	[»]
	1DFJ	X-ray	2.50	E	27-150	[»]
	1DY5	X-ray	0.87	A/B	27-150	[»]
	1EIC	X-ray	1.40	A	27-150	[»]
	1EID	X-ray	1.40	A	27-150	[»]
	1EIE	X-ray	1.40	A	27-150	[»]
	1EOS	X-ray	2.00	A/B	27-150	[»]
	1EOW	X-ray	2.00	A	27-150	[»]
	1F0V	X-ray	1.70	A/B/C/D	27-150	[»]
	1FEV	X-ray	2.25	A	27-41	[»]
				B	50-150	[»]
	1FS3	X-ray	1.40	A	27-150	[»]
	1GV7	X-ray	2.10	A	84-99	[»]
	1IZP	X-ray	1.50	A	27-150	[»]
	1IZQ	X-ray	1.80	A	27-150	[»]
	1IZR	X-ray	1.50	A	27-150	[»]
	1J7Z	X-ray	2.25	A	27-41	[»]
				B	47-150	[»]
	1J80	X-ray	2.10	A	27-41	[»]
				B	47-150	[»]
	1J81	X-ray	2.20	A	27-41	[»]
				B	47-150	[»]
	1J82	X-ray	2.30	A	27-41	[»]
				B	47-150	[»]
	1JN4	X-ray	1.80	A/B	27-150	[»]
	1JS0	X-ray	2.20	A/B/C	27-150	[»]
	1JVT	X-ray	2.05	A/B	27-150	[»]
	1JVU	X-ray	1.78	A/B	27-150	[»]
	1JVV	X-ray	2.20	A/B	27-150	[»]
	1KF2	X-ray	1.10	A	27-150	[»]
	1KF3	X-ray	1.05	A	27-150	[»]
	1KF4	X-ray	1.10	A	27-150	[»]
	1KF5	X-ray	1.15	A	27-150	[»]
	1KF7	X-ray	1.15	A	27-150	[»]
	1KF8	X-ray	1.15	A	27-150	[»]
	1KH8	X-ray	2.00	A	27-150	[»]
	1LSQ	X-ray	1.90	A/B	27-150	[»]
	1O0F	X-ray	1.50	A/B	27-150	[»]
	1O0H	X-ray	1.20	A/B	27-150	[»]
1O0M	X-ray	1.50	A/B	27-150	[»]
1O0N	X-ray	1.50	A/B	27-150	[»]
1O0O	X-ray	1.20	A/B	27-150	[»]
1QHC	X-ray	1.70	A/B	27-150	[»]
1RAR	X-ray	1.90	A	28-150	[»]
1RAS	X-ray	1.70	A	28-150	[»]
1RAT	X-ray	1.50	A	27-150	[»]
1RBB	X-ray	2.50	A/B	27-150	[»]
1RBC	X-ray	2.00	A	47-150	[»]
			S	27-41	[»]
1RBD	X-ray	1.70	A	47-150	[»]
			S	27-41	[»]
1RBE	X-ray	1.75	A	47-150	[»]
			S	27-41	[»]
1RBF	X-ray	1.80	A	47-150	[»]
			S	27-41	[»]
1RBG	X-ray	1.80	A	47-150	[»]
			S	27-41	[»]
1RBH	X-ray	1.70	A	47-150	[»]
			S	27-41	[»]
1RBI	X-ray	1.80	A	47-150	[»]
			S	27-41	[»]
1RBJ	X-ray	2.70	A	27-150	[»]
1RBN	X-ray	2.10	A	27-150	[»]
1RBW	X-ray	1.69	A	27-150	[»]
1RBX	X-ray	1.69	A	27-150	[»]
1RCA	X-ray	1.90	A	27-150	[»]
1RCN	X-ray	2.32	E	27-150	[»]
1RHA	X-ray	1.80	A	27-150	[»]
1RHB	X-ray	1.50	A	27-150	[»]
1RNC	X-ray	1.50	A	27-150	[»]
1RND	X-ray	1.50	A	27-150	[»]
1RNM	X-ray	2.00	E	27-150	[»]
1RNN	X-ray	1.80	E	27-150	[»]
1RNO	X-ray	1.90	A	27-150	[»]
1RNQ	X-ray	2.00	A	27-150	[»]
1RNU	X-ray	1.60	A	27-150	[»]
1RNV	X-ray	1.60	A	27-150	[»]
1RNW	X-ray	1.80	A	27-150	[»]
1RNX	X-ray	1.90	A	27-150	[»]
1RNY	X-ray	2.00	A	27-150	[»]
1RNZ	X-ray	1.90	A	27-150	[»]
1ROB	X-ray	1.60	A	27-150	[»]
1RPF	X-ray	2.20	A	27-150	[»]
1RPG	X-ray	1.40	A	27-150	[»]
1RPH	X-ray	2.20	A	27-150	[»]
1RSM	X-ray	2.00	A	27-150	[»]
1RTA	X-ray	2.50	E	27-150	[»]
1RTB	X-ray	2.50	A	27-150	[»]
1RUV	X-ray	1.25	A	27-150	[»]
1SRN	X-ray	1.80	A	27-144	[»]
			B	137-150	[»]
1SSA	X-ray	2.00	A	27-144	[»]
			B	137-150	[»]
1SSB	X-ray	2.00	A	27-144	[»]
			B	137-150	[»]
1SSC	X-ray	2.00	A	27-138	[»]
			B	140-150	[»]
1U1B	X-ray	2.00	A/B	27-150	[»]
1UN5	X-ray	2.60	A	64-74	[»]
1W4O	X-ray	1.60	A/B	27-150	[»]
1W4P	X-ray	1.69	A/B	27-150	[»]
1W4Q	X-ray	1.68	A/B	27-150	[»]
1WBU	X-ray	1.90	A/B	27-150	[»]
1XPS	X-ray	1.80	A/B	27-150	[»]
1XPT	X-ray	1.90	A/B	27-150	[»]
1YMN	X-ray	1.45	A	27-150	[»]
1YMR	X-ray	1.50	A	27-150	[»]
1YMW	X-ray	1.50	A	27-150	[»]
1Z3L	X-ray	1.80	E	47-150	[»]
			S	27-41	[»]
1Z3M	X-ray	2.00	E	47-150	[»]
			S	27-41	[»]
1Z3P	X-ray	2.00	E	47-150	[»]
			S	27-41	[»]
1Z6D	X-ray	1.54	A/B	27-150	[»]
1Z6S	X-ray	1.50	A/B	27-150	[»]
2AAS	NMR	-	A	27-150	[»]
2APQ	X-ray	1.80	A	27-150	[»]
2APU	model	-	0/1/2/3/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z	27-150	[»]
2BLP	X-ray	1.40	A	27-150	[»]
2BLZ	X-ray	1.40	A	27-150	[»]
2E33	X-ray	2.70	B	27-150	[»]
2E3W	X-ray	1.05	A	27-150	[»]
2G4W	X-ray	1.84	A/B	27-150	[»]
2G4X	X-ray	1.95	A	27-150	[»]
2G8Q	X-ray	1.50	A/B	27-150	[»]
2G8R	X-ray	1.70	A/B	27-150	[»]
2NUI	X-ray	1.10	A	27-150	[»]
2OP2	X-ray	1.60	A	27-150	[»]
2OQF	X-ray	2.30	A/B/C/D	27-150	[»]
2P42	X-ray	1.80	A/C	27-150	[»]
2P43	X-ray	1.65	A	27-150	[»]
2P44	X-ray	1.80	A	27-150	[»]
2P45	X-ray	1.10	A	27-150	[»]
2P46	X-ray	2.50	A/C	27-150	[»]
2P47	X-ray	2.50	A	27-150	[»]
2P48	X-ray	2.30	A	27-150	[»]
2P49	X-ray	1.38	A	27-150	[»]
2P4A	X-ray	1.90	A/C	27-150	[»]
2QCA	X-ray	1.33	A	27-150	[»]
2RAT	X-ray	1.50	A	27-150	[»]
2RLN	X-ray	1.85	E	42-150	[»]
			S	27-41	[»]
2RNS	X-ray	1.60	A	27-150	[»]
2W5G	X-ray	1.70	A/B	27-150	[»]
2W5I	X-ray	2.40	A/B	27-150	[»]
2W5K	X-ray	1.70	A/B	27-150	[»]
2W5L	X-ray	1.70	A/B	27-150	[»]
2W5M	X-ray	1.80	A/B	27-150	[»]
2XOG	X-ray	1.72	A/B	27-150	[»]
2XOI	X-ray	1.72	A/B	27-150	[»]
3A1R	neutron diffraction	1.70	A	27-150	[»]
3D6O	X-ray	1.58	A/B	27-150	[»]
3D6P	X-ray	1.60	A/B	27-150	[»]
3D6Q	X-ray	1.60	A/B	27-150	[»]
3D7B	X-ray	1.60	A/B	27-150	[»]
3D8Y	X-ray	1.72	A/B	27-150	[»]
3D8Z	X-ray	1.98	A/B	27-150	[»]
3DH5	X-ray	1.60	A	27-150	[»]
3DH6	X-ray	1.60	A	27-150	[»]
3DI7	X-ray	1.60	A	27-150	[»]
3DI8	X-ray	1.60	A	27-150	[»]
3DI9	X-ray	2.00	A	27-150	[»]
3DIB	X-ray	1.40	A	27-150	[»]
3DIC	X-ray	1.60	A	27-150	[»]
3DXG	X-ray	1.39	A/B	27-150	[»]
3DXH	X-ray	1.40	A/B	27-150	[»]
3EUX	X-ray	1.65	A/B	27-150	[»]
3EUY	X-ray	1.95	A/B	27-150	[»]
3EUZ	X-ray	1.84	A/B	27-150	[»]
3EV0	X-ray	1.76	A/B	27-150	[»]
3EV1	X-ray	2.00	A/B	27-150	[»]
3EV2	X-ray	2.02	A/B	27-150	[»]
3EV3	X-ray	1.68	A/B	27-150	[»]
3EV4	X-ray	1.93	A/B	27-150	[»]
3EV5	X-ray	1.68	A/B	27-150	[»]
3EV6	X-ray	1.76	A/B	27-150	[»]
3FKZ	X-ray	1.99	A/B	27-150	[»]
3FL0	X-ray	1.94	A/B	27-150	[»]
3FL1	X-ray	1.90	A/B	27-150	[»]
3FL3	X-ray	1.60	A/B	27-150	[»]
3I67	X-ray	1.30	A	27-150	[»]
3I6F	X-ray	1.30	A	27-150	[»]
3I6H	X-ray	1.30	A	27-150	[»]
3I6J	X-ray	1.30	A	27-150	[»]
3I7W	X-ray	2.35	A	27-150	[»]
3I7X	X-ray	2.60	A	27-150	[»]
3I7Y	X-ray	2.40	A	27-150	[»]
3JW1	X-ray	1.60	A/B	27-150	[»]
3LXO	X-ray	1.55	A	27-150	[»]
3MWQ	X-ray	1.68	A	26-150	[»]
3MWR	X-ray	1.85	A	27-150	[»]
3MX8	X-ray	2.10	A	26-150	[»]
3MZQ	X-ray	1.50	A	23-150	[»]
3MZR	X-ray	1.50	A	23-150	[»]
3OQY	X-ray	1.49	A/B	47-150	[»]
			a/b	27-41	[»]
3OQZ	X-ray	2.50	A/B	47-150	[»]
			a/b	27-41	[»]
3OR0	X-ray	2.30	A/B	47-150	[»]
			a/b	27-41	[»]
3QL1	X-ray	1.29	A	27-150	[»]
3QL2	X-ray	1.49	A/B	27-150	[»]
3QSK	X-ray	1.75	A	27-150	[»]
3RAT	X-ray	1.50	A	27-150	[»]
3RH1	X-ray	2.10	A	27-150	[»]
3RID	X-ray	2.18	A/B/C/D	27-150	[»]
3RN3	X-ray	1.45	A	27-150	[»]
3RSD	X-ray	1.60	A	27-150	[»]
3RSK	X-ray	2.00	A	27-150	[»]
3RSP	X-ray	1.70	A	27-150	[»]
3SRN	X-ray	2.00	A	27-139	[»]
			B	140-146	[»]
4AO1	X-ray	1.58	A	27-150	[»]
4G8V	X-ray	1.70	A/B	27-150	[»]
4G8Y	X-ray	1.80	A/B	27-150	[»]
4G90	X-ray	1.90	A/B	27-150	[»]
4J5Z	X-ray	1.80	A	27-150	[»]
4J60	X-ray	1.69	A	27-150	[»]
4J61	X-ray	1.69	A	27-150	[»]
4J62	X-ray	2.04	A	27-150	[»]
4J63	X-ray	2.04	A	27-150	[»]
4J64	X-ray	1.78	A	27-150	[»]
4J65	X-ray	1.96	A	27-150	[»]
4J66	X-ray	2.04	A	27-150	[»]
4J67	X-ray	1.86	A	27-150	[»]
4J68	X-ray	1.78	A	27-150	[»]
4J69	X-ray	1.89	A	27-150	[»]
4J6A	X-ray	2.04	A	27-150	[»]
4K7L	X-ray	1.38	A	27-41	[»]
			B	47-150	[»]
4K7M	X-ray	1.80	A	27-150	[»]
4L55	X-ray	1.65	A/B	27-150	[»]
4MXF	X-ray	2.25	A/B	27-150	[»]
4O36	X-ray	1.22	A	27-41	[»]
			B	47-150	[»]
4O37	X-ray	1.40	A	27-41	[»]
			B	47-150	[»]
4OKF	X-ray	1.54	A	27-41	[»]
			B	47-150	[»]
4OOH	X-ray	1.89	A	27-150	[»]
4OT4	X-ray	1.85	A/B	27-150	[»]
4PEQ	X-ray	2.21	A/C	27-150	[»]
4POU	X-ray	1.75	A	27-150	[»]
4QH3	X-ray	2.00	A/B	27-150	[»]
4RAT	X-ray	1.50	A	27-150	[»]
4RSD	X-ray	1.60	A	27-150	[»]
4RSK	X-ray	2.10	A	27-150	[»]
4RTE	X-ray	1.95	A	27-150	[»]
4S0Q	X-ray	2.09	A/B	27-150	[»]
4S18	X-ray	2.27	A/B	27-150	[»]
4SRN	X-ray	2.00	A	27-139	[»]
			B	140-150	[»]
4WYN	X-ray	1.80	A/B	27-150	[»]
4WYP	X-ray	1.50	A/B	27-150	[»]
4WYZ	X-ray	1.45	A/B	27-150	[»]
4YGW	X-ray	2.18	B	48-150	[»]
			b	27-41	[»]
4ZZ4	neutron diffraction	1.80	A	27-150	[»]
5D6U	X-ray	1.52	A	27-150	[»]
5D97	neutron diffraction	1.80	A	27-150	[»]
5E5E	X-ray	1.98	A/B	27-150	[»]
5E5F	X-ray	1.68	A/B	27-150	[»]
5ET4	X-ray	2.10	A/B/C/D	27-150	[»]
5JLG	X-ray	1.79	A/B	27-150	[»]
5JMG	X-ray	1.85	A/B	27-150	[»]
5JML	X-ray	2.29	A/B	27-150	[»]
5NA9	X-ray	2.07	A	27-150	[»]
5NJ7	X-ray	2.15	A/B	27-150	[»]
5OBC	X-ray	2.07	A/B	27-150	[»]
5OBD	X-ray	1.98	A/B	27-150	[»]
5OBE	X-ray	1.82	A/B	27-150	[»]
5OGH	X-ray	1.16	A	27-150	[»]
5OLD	X-ray	1.78	A/B	27-150	[»]
5RAT	X-ray	1.50	A	27-150	[»]
5RSA	X-ray	2.00	A	27-150	[»]
6ETK	X-ray	0.85	A	27-150	[»]
6ETL	X-ray	0.85	A	27-150	[»]
6ETM	X-ray	0.92	A	27-150	[»]
6ETN	X-ray	0.92	A	27-150	[»]
6ETO	X-ray	1.02	A	27-150	[»]
6ETP	X-ray	1.02	A	27-150	[»]
6ETQ	X-ray	1.08	A	27-150	[»]
6ETR	X-ray	1.17	A	27-150	[»]
6F60	X-ray	1.14	A/B	27-150	[»]
6GOK	X-ray	2.65	A/B	27-150	[»]
6RAT	X-ray	1.50	A	27-150	[»]
6RSA	X-ray	2.00	A	27-150	[»]
7RAT	X-ray	1.50	A	27-150	[»]
7RSA	X-ray	1.26	A	27-150	[»]
8RAT	X-ray	1.50	A	27-150	[»]
8RSA	X-ray	1.80	A/B	27-150	[»]
9RAT	X-ray	1.50	A	27-150	[»]
9RSA	X-ray	1.80	A/B	27-150	[»]
ProteinModelPortalⁱ	P61823
SMRⁱ	P61823
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-36384N
IntActⁱ	P61823, 7 interactors
MINTⁱ	P61823
STRINGⁱ	9913.ENSBTAP00000011586

Chemistry databases

BindingDBⁱ	P61823
ChEMBLⁱ	CHEMBL6091

PTM databases

CarbonylDBⁱ	P61823
GlyConnectⁱ	529
UniCarbKBⁱ	P61823

Proteomic databases

PaxDbⁱ	P61823
PeptideAtlasⁱ	P61823
PRIDEⁱ	P61823

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000011586; ENSBTAP00000011586; ENSBTAG00000008793
GeneIDⁱ	282340
KEGGⁱ	bta:282340

Organism-specific databases

CTDⁱ	6035

CTDⁱ

6035

Phylogenomic databases

eggNOGⁱ	ENOG410IYEN Eukaryota ENOG41113F1 LUCA
GeneTreeⁱ	ENSGT00900000140967
HOGENOMⁱ	HOG000276883
HOVERGENⁱ	HBG008396
InParanoidⁱ	P61823
KOⁱ	K01168
OMAⁱ	HHVRVAC
OrthoDBⁱ	EOG091G15X3
TreeFamⁱ	TF333393

Enzyme and pathway databases

BRENDAⁱ	3.1.27.5 908
SABIO-RKⁱ	P61823

Miscellaneous databases

EvolutionaryTraceⁱ	P61823
PMAP-CutDBⁱ	P61823
Protein Ontology More...PROⁱ	PR:P61823

Gene expression databases

Bgeeⁱ	ENSBTAG00000008793 Expressed in 8 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSBTAG00000008793 Expressed in 8 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Dⁱ	3.10.130.10, 1 hit
InterProⁱ	View protein in InterPro IPR001427 RNaseA IPR036816 RNaseA-like_dom_sf IPR023411 RNaseA_AS IPR023412 RNaseA_domain
PANTHERⁱ	PTHR11437 PTHR11437, 1 hit
Pfamⁱ	View protein in Pfam PF00074 RnaseA, 1 hit
PRINTSⁱ	PR00794 RIBONUCLEASE
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000535 RNaseA, 1 hit
SMARTⁱ	View protein in SMART SM00092 RNAse_Pc, 1 hit
SUPFAMⁱ	SSF54076 SSF54076, 1 hit
PROSITEⁱ	View protein in PROSITE PS00127 RNASE_PANCREATIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RNAS1_BOVIN
Accessionⁱ	P61823Primary (citable) accession number: P61823 Secondary accession number(s): A6QPW8, P00656, Q9TSF2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	June 7, 2004
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

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UniRef

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Supporting data

UniProtKB - P61823 (RNAS1_BOVIN)

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Ribonuclease pancreatic

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ