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UniProtKB - P61812 (TGFB2_HUMAN)

Entry version 181 (22 Apr 2020)
Sequence version 1 (01 Aug 1988)
Previous versions | rss
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Protein

Transforming growth factor beta-2 proprotein

Gene

TGFB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.By similarity
Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity).By similarity
Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).By similarity2 Publications

Caution

In contrast to other members of the family, does not contain a R-G-D cell attachment site motif that mediates binding to integrins and promotes release of Latency-associated peptide (LAP) chain from TGF-beta-2.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-3000178 ECM proteoglycans

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P61812

SIGNOR Signaling Network Open Resource

More...SIGNORi		P61812

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming growth factor beta-2 proprotein
Alternative name(s):
Cetermin
Glioblastoma-derived T-cell suppressor factor1 Publication
Short name:
G-TSF1 Publication
Cleaved into the following 2 chains:
Latency-associated peptide
Short name:
LAP
Transforming growth factor beta-2
Short name:
TGF-beta-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGFB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11768 TGFB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		190220 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P61812

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.1 Publication
Loeys-Dietz syndrome 4 (LDS4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068931100 – 104Missing in LDS4. 1 Publication5
Natural variantiVAR_080342102 – 414Missing in LDS4. 1 PublicationAdd BLAST313
Natural variantiVAR_080343229 – 414Missing in LDS4. 1 PublicationAdd BLAST186
Natural variantiVAR_068932299R → W in LDS4. 1 PublicationCorresponds to variant dbSNP:rs863223792Ensembl.1
Natural variantiVAR_068933302R → C in LDS4. 1 PublicationCorresponds to variant dbSNP:rs869312903Ensembl.1
Natural variantiVAR_068934338P → H in LDS4. 1 PublicationCorresponds to variant dbSNP:rs387907278Ensembl.1
Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.1 Publication

Keywords - Diseasei

Aortic aneurysm, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		7042

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TGFB2

MalaCards human disease database

More...MalaCardsi		TGFB2
MIMi614816 phenotype

Open Targets

More...OpenTargetsi		ENSG00000092969

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		91387 Familial thoracic aortic aneurysm and aortic dissection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36482

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P61812 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3217393

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TGFB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		48429157

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003378421 – 302Latency-associated peptide1 PublicationAdd BLAST282
ChainiPRO_0000033785303 – 414Transforming growth factor beta-21 PublicationAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi309 ↔ 3182 Publications
Disulfide bondi317 ↔ 3802 Publications
Disulfide bondi346 ↔ 4112 Publications
Disulfide bondi350 ↔ 4132 Publications
Disulfide bondi379Interchain2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Transforming growth factor beta-2 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P61812

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P61812

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P61812

MaxQB - The MaxQuant DataBase

More...MaxQBi		P61812

PeptideAtlas

More...PeptideAtlasi		P61812

PRoteomics IDEntifications database

More...PRIDEi		P61812

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57335
57336 [P61812-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1836

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P61812

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P61812

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000092969 Expressed in lung and 157 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P61812 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000092969 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity).

Interacts with ASPN (PubMed:17827158).

Interacts with MFAP5 (By similarity). Latency-associated peptide:

Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Latency-associated peptide:

Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (PubMed:19651619). Latency-associated peptide:

Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (PubMed:1631557, PubMed:1641027). Transforming growth factor beta-2:

Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112900, 10 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-605 TGF-beta-2 complex
CPX-834 TGF-beta-2-TGFR complex

Database of interacting proteins

More...DIPi		DIP-5936N

Protein interaction database and analysis system

More...IntActi		P61812, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355896

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P61812 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P61812

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P61812

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157390

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039840_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P61812

KEGG Orthology (KO)

More...KOi		K13376

Identification of Orthologs from Complete Genome Data

More...OMAi		NAIPPPF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P61812

TreeFam database of animal gene trees

More...TreeFami		TF318514

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR016319 TGF-beta
IPR015615 TGF-beta-rel
IPR003940 TGFb2
IPR017948 TGFb_CS

The PANTHER Classification System

More...PANTHERi		PTHR11848 PTHR11848, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001787 TGF-beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01423 TGFBETA
PR01425 TGFBETA2

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00204 TGFB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P61812-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHYCVLSAFL ILHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL 
        60         70         80         90        100
TSPPEDYPEP EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA 
       110        120        130        140        150
KEVYKIDMPP FFPSENAIPP TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR 
       160        170        180        190        200
VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS 
       210        220        230        240        250
FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF 
       260        270        280        290        300
AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK 
       310        320        330        340        350
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC 
       360        370        380        390        400
PYLWSSDTQH SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI 
       410 
EQLSNMIVKS CKCS
Length:414
Mass (Da):47,748
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D9D569E0F4A07D0
GO
Isoform B (identifier: P61812-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-116: N → TVCPVVTTPSGSVGSLCSRQSQVLCGYLD

Show »
Length:442
Mass (Da):50,573
Checksum:i5D7A3C2ED51753D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32F → L in AAA61162 (PubMed:1764261).Curated1
Sequence conflicti116Missing in AAA50405 (PubMed:2850146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01270891R → H2 PublicationsCorresponds to variant dbSNP:rs10482721EnsemblClinVar.1
Natural variantiVAR_068931100 – 104Missing in LDS4. 1 Publication5
Natural variantiVAR_080342102 – 414Missing in LDS4. 1 PublicationAdd BLAST313
Natural variantiVAR_018923207V → L1 PublicationCorresponds to variant dbSNP:rs10482810Ensembl.1
Natural variantiVAR_080343229 – 414Missing in LDS4. 1 PublicationAdd BLAST186
Natural variantiVAR_068932299R → W in LDS4. 1 PublicationCorresponds to variant dbSNP:rs863223792Ensembl.1
Natural variantiVAR_068933302R → C in LDS4. 1 PublicationCorresponds to variant dbSNP:rs869312903Ensembl.1
Natural variantiVAR_072740320R → C Probable disease-associated mutation found in a family with non-syndromic aortic disease. 1 PublicationCorresponds to variant dbSNP:rs1553303352Ensembl.1
Natural variantiVAR_068934338P → H in LDS4. 1 PublicationCorresponds to variant dbSNP:rs387907278Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006417116N → TVCPVVTTPSGSVGSLCSRQ SQVLCGYLD in isoform B. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00083 mRNA Translation: CAA68279.1
M19154 mRNA Translation: AAA50404.1
M19154 mRNA Translation: AAA50405.1
AY438979 Genomic DNA Translation: AAR05442.1
AK296504 mRNA Translation: BAG59137.1
CH471100 Genomic DNA Translation: EAW93326.1
BC096235 mRNA Translation: AAH96235.1
BC099635 mRNA Translation: AAH99635.1
M87843 Genomic DNA Translation: AAA61162.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1521.1
CCDS44318.1 [P61812-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A29478 B31249
S06216 A31249

NCBI Reference Sequences

More...RefSeqi		NP_001129071.1, NM_001135599.3 [P61812-2]
NP_003229.1, NM_003238.4 [P61812-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366929; ENSP00000355896; ENSG00000092969 [P61812-2]
ENST00000366930; ENSP00000355897; ENSG00000092969 [P61812-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7042

UCSC genome browser

More...UCSCi		uc001hlm.4 human

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

TGF beta-2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00083 mRNA Translation: CAA68279.1
M19154 mRNA Translation: AAA50404.1
M19154 mRNA Translation: AAA50405.1
AY438979 Genomic DNA Translation: AAR05442.1
AK296504 mRNA Translation: BAG59137.1
CH471100 Genomic DNA Translation: EAW93326.1
BC096235 mRNA Translation: AAH96235.1
BC099635 mRNA Translation: AAH99635.1
M87843 Genomic DNA Translation: AAA61162.1
CCDSiCCDS1521.1
CCDS44318.1 [P61812-2]
PIRiA29478 B31249
S06216 A31249
RefSeqiNP_001129071.1, NM_001135599.3 [P61812-2]
NP_003229.1, NM_003238.4 [P61812-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TFGX-ray1.95A303-414[»]
2TGIX-ray1.80A303-414[»]
4KXZX-ray2.83A/B/D/E303-414[»]
5TX4X-ray1.88B303-414[»]
5TY4electron microscopy2.90B317-413[»]
6I9JX-ray2.00A303-414[»]
SMRiP61812
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112900, 10 interactors
ComplexPortaliCPX-605 TGF-beta-2 complex
CPX-834 TGF-beta-2-TGFR complex
DIPiDIP-5936N
IntActiP61812, 2 interactors
STRINGi9606.ENSP00000355896

Chemistry databases

ChEMBLiCHEMBL3217393

PTM databases

GlyConnecti1836
iPTMnetiP61812
PhosphoSitePlusiP61812

Polymorphism and mutation databases

BioMutaiTGFB2
DMDMi48429157

Proteomic databases

EPDiP61812
jPOSTiP61812
MassIVEiP61812
MaxQBiP61812
PeptideAtlasiP61812
PRIDEiP61812
ProteomicsDBi57335
57336 [P61812-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P61812

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20732 555 antibodies

Genome annotation databases

EnsembliENST00000366929; ENSP00000355896; ENSG00000092969 [P61812-2]
ENST00000366930; ENSP00000355897; ENSG00000092969 [P61812-1]
GeneIDi7042
KEGGihsa:7042
UCSCiuc001hlm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7042
DisGeNETi7042

GeneCards: human genes, protein and diseases

More...GeneCardsi		TGFB2
GeneReviewsiTGFB2
HGNCiHGNC:11768 TGFB2
HPAiENSG00000092969 Low tissue specificity
MalaCardsiTGFB2
MIMi190220 gene
614816 phenotype
neXtProtiNX_P61812
OpenTargetsiENSG00000092969
Orphaneti91387 Familial thoracic aortic aneurysm and aortic dissection
PharmGKBiPA36482

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000157390
HOGENOMiCLU_039840_0_0_1
InParanoidiP61812
KOiK13376
OMAiNAIPPPF
PhylomeDBiP61812
TreeFamiTF318514

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-3000178 ECM proteoglycans
SignaLinkiP61812
SIGNORiP61812

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TGFB2 human
EvolutionaryTraceiP61812

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TGF_beta_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7042
PharosiP61812 Tbio

Protein Ontology

More...PROi		PR:P61812
RNActiP61812 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000092969 Expressed in lung and 157 other tissues
GenevisibleiP61812 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR016319 TGF-beta
IPR015615 TGF-beta-rel
IPR003940 TGFb2
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF001787 TGF-beta, 1 hit
PRINTSiPR01423 TGFBETA
PR01425 TGFBETA2
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGFB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61812
Secondary accession number(s): B4DKC5
, P08112, Q15579, Q15581, Q4VAV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 22, 2020
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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