UniProtKB - P61812 (TGFB2_HUMAN)
Transforming growth factor beta-2 proprotein
TGFB2
Functioni
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
By similarityRequired to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity).
Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity).
By similarityTransforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368).
Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity).
At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity).
Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
By similarity2 PublicationsCaution
GO - Molecular functioni
- amyloid-beta binding Source: UniProtKB
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- transforming growth factor beta receptor binding Source: UniProtKB
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: BHF-UCL
GO - Biological processi
- activation of protein kinase activity Source: BHF-UCL
- ascending aorta morphogenesis Source: BHF-UCL
- atrial septum morphogenesis Source: BHF-UCL
- atrial septum primum morphogenesis Source: BHF-UCL
- atrioventricular valve morphogenesis Source: BHF-UCL
- BMP signaling pathway Source: GO_Central
- cardiac epithelial to mesenchymal transition Source: BHF-UCL
- cardiac muscle cell proliferation Source: UniProtKB
- cardiac right ventricle morphogenesis Source: BHF-UCL
- cardioblast differentiation Source: UniProtKB
- cell-cell junction organization Source: BHF-UCL
- cell death Source: UniProtKB
- cell migration Source: BHF-UCL
- cell morphogenesis Source: UniProtKB
- collagen fibril organization Source: BHF-UCL
- cranial skeletal system development Source: BHF-UCL
- dopamine biosynthetic process Source: UniProtKB
- embryo development ending in birth or egg hatching Source: UniProtKB
- embryonic digestive tract development Source: DFLAT
- embryonic limb morphogenesis Source: BHF-UCL
- endocardial cushion fusion Source: BHF-UCL
- endocardial cushion morphogenesis Source: BHF-UCL
- epithelial to mesenchymal transition Source: BHF-UCL
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- eye development Source: UniProtKB
- generation of neurons Source: UniProtKB
- glial cell migration Source: BHF-UCL
- hair follicle development Source: UniProtKB
- hair follicle morphogenesis Source: UniProtKB
- heart development Source: UniProtKB
- heart morphogenesis Source: BHF-UCL
- heart valve morphogenesis Source: BHF-UCL
- hemopoiesis Source: UniProtKB
- inner ear development Source: BHF-UCL
- kidney development Source: BHF-UCL
- male gonad development Source: BHF-UCL
- membranous septum morphogenesis Source: BHF-UCL
- negative regulation of alkaline phosphatase activity Source: BHF-UCL
- negative regulation of angiogenesis Source: BHF-UCL
- negative regulation of cell growth Source: BHF-UCL
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: BHF-UCL
- negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of macrophage cytokine production Source: DFLAT
- negative regulation of Ras protein signal transduction Source: BHF-UCL
- neural retina development Source: BHF-UCL
- neural tube closure Source: BHF-UCL
- neuron development Source: UniProtKB
- neutrophil chemotaxis Source: UniProtKB
- odontogenesis Source: BHF-UCL
- outflow tract septum morphogenesis Source: BHF-UCL
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- pharyngeal arch artery morphogenesis Source: BHF-UCL
- positive regulation of cardioblast differentiation Source: UniProtKB
- positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of epithelial cell migration Source: BHF-UCL
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- positive regulation of heart contraction Source: UniProtKB
- positive regulation of immune response Source: UniProtKB
- positive regulation of integrin biosynthetic process Source: BHF-UCL
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of Notch signaling pathway Source: BHF-UCL
- positive regulation of ossification Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: ComplexPortal
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of protein secretion Source: BHF-UCL
- positive regulation of stress-activated MAPK cascade Source: BHF-UCL
- positive regulation of timing of catagen Source: UniProtKB
- protein phosphorylation Source: BHF-UCL
- pulmonary valve morphogenesis Source: BHF-UCL
- regulation of apoptotic process involved in outflow tract morphogenesis Source: BHF-UCL
- regulation of cell population proliferation Source: BHF-UCL
- regulation of timing of catagen Source: UniProtKB
- regulation of transforming growth factor beta2 production Source: BHF-UCL
- response to hypoxia Source: BHF-UCL
- response to progesterone Source: BHF-UCL
- response to wounding Source: BHF-UCL
- response to xenobiotic stimulus Source: UniProtKB
- salivary gland morphogenesis Source: BHF-UCL
- secondary palate development Source: BHF-UCL
- skeletal system development Source: BHF-UCL
- SMAD protein signal transduction Source: BHF-UCL
- somatic stem cell division Source: UniProtKB
- substantia propria of cornea development Source: BHF-UCL
- transforming growth factor beta receptor signaling pathway Source: BHF-UCL
- uterine wall breakdown Source: BHF-UCL
- uterus development Source: BHF-UCL
- ventricular septum morphogenesis Source: BHF-UCL
- ventricular trabecula myocardium morphogenesis Source: BHF-UCL
- wound healing Source: UniProtKB
Keywordsi
Molecular function | Growth factor, Mitogen |
Enzyme and pathway databases
PathwayCommonsi | P61812 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-2129379, Molecules associated with elastic fibres R-HSA-3000178, ECM proteoglycans |
SignaLinki | P61812 |
SIGNORi | P61812 |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-2 proproteinAlternative name(s): Cetermin Glioblastoma-derived T-cell suppressor factor1 Publication Short name: G-TSF1 Publication Cleaved into the following 2 chains: |
Gene namesi | Name:TGFB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11768, TGFB2 |
MIMi | 190220, gene |
neXtProti | NX_P61812 |
VEuPathDBi | HostDB:ENSG00000092969 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: AgBase
Other locations
- axon Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- neuronal cell body Source: UniProtKB
- platelet alpha granule lumen Source: Reactome
- transforming growth factor beta complex Source: ComplexPortal
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Loeys-Dietz syndrome 4 (LDS4)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068931 | 100 – 104 | Missing in LDS4. 1 Publication | 5 | |
Natural variantiVAR_080342 | 102 – 414 | Missing in LDS4. 1 PublicationAdd BLAST | 313 | |
Natural variantiVAR_080343 | 229 – 414 | Missing in LDS4. 1 PublicationAdd BLAST | 186 | |
Natural variantiVAR_068932 | 299 | R → W in LDS4. 1 PublicationCorresponds to variant dbSNP:rs863223792EnsemblClinVar. | 1 | |
Natural variantiVAR_068933 | 302 | R → C in LDS4. 1 PublicationCorresponds to variant dbSNP:rs869312903EnsemblClinVar. | 1 | |
Natural variantiVAR_068934 | 338 | P → H in LDS4. 1 PublicationCorresponds to variant dbSNP:rs387907278EnsemblClinVar. | 1 |
Keywords - Diseasei
Aortic aneurysm, Disease variantOrganism-specific databases
DisGeNETi | 7042 |
GeneReviewsi | TGFB2 |
MalaCardsi | TGFB2 |
MIMi | 614816, phenotype |
OpenTargetsi | ENSG00000092969 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection |
PharmGKBi | PA36482 |
Miscellaneous databases
Pharosi | P61812, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3217393 |
Genetic variation databases
BioMutai | TGFB2 |
DMDMi | 48429157 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000033784 | 21 – 302 | Latency-associated peptide1 PublicationAdd BLAST | 282 | |
ChainiPRO_0000033785 | 303 – 414 | Transforming growth factor beta-21 PublicationAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 309 ↔ 318 | 2 Publications | ||
Disulfide bondi | 317 ↔ 380 | 2 Publications | ||
Disulfide bondi | 346 ↔ 411 | 2 Publications | ||
Disulfide bondi | 350 ↔ 413 | 2 Publications | ||
Disulfide bondi | 379 | Interchain2 Publications |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
EPDi | P61812 |
jPOSTi | P61812 |
MassIVEi | P61812 |
MaxQBi | P61812 |
PeptideAtlasi | P61812 |
PRIDEi | P61812 |
ProteomicsDBi | 57335 57336 [P61812-2] |
PTM databases
GlyConnecti | 1836, 1 N-Linked glycan (1 site) |
GlyGeni | P61812, 3 sites, 1 N-linked glycan (1 site) |
iPTMneti | P61812 |
PhosphoSitePlusi | P61812 |
Expressioni
Gene expression databases
Bgeei | ENSG00000092969, Expressed in calcaneal tendon and 175 other tissues |
Genevisiblei | P61812, HS |
Organism-specific databases
HPAi | ENSG00000092969, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity).
Interacts with ASPN (PubMed:17827158).
Interacts with MFAP5 (By similarity). Latency-associated peptide:
Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (PubMed:19651619). Latency-associated peptide:
Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (PubMed:1631557, PubMed:1641027). Transforming growth factor beta-2:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarity4 PublicationsBinary interactionsi
P61812
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 7 | EBI-779581,EBI-77613 |
UNG - isoform 1 [P13051-2] | 3 | EBI-779581,EBI-25834258 |
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- transforming growth factor beta receptor binding Source: UniProtKB
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112900, 15 interactors |
ComplexPortali | CPX-605, TGF-beta-2 complex CPX-834, TGF-beta-2-TGFR complex |
DIPi | DIP-5936N |
IntActi | P61812, 5 interactors |
STRINGi | 9606.ENSP00000355896 |
Miscellaneous databases
RNActi | P61812, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P61812 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61812 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157390 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P61812 |
OMAi | YSGKTPH |
PhylomeDBi | P61812 |
TreeFami | TF318514 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHYCVLSAFL ILHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPP FFPSENAIPP TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR
160 170 180 190 200
VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS
210 220 230 240 250
FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF
260 270 280 290 300
AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK
310 320 330 340 350
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC
360 370 380 390 400
PYLWSSDTQH SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI
410
EQLSNMIVKS CKCS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | F → L in AAA61162 (PubMed:1764261).Curated | 1 | |
Sequence conflicti | 116 | Missing in AAA50405 (PubMed:2850146).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012708 | 91 | R → H2 PublicationsCorresponds to variant dbSNP:rs10482721EnsemblClinVar. | 1 | |
Natural variantiVAR_068931 | 100 – 104 | Missing in LDS4. 1 Publication | 5 | |
Natural variantiVAR_080342 | 102 – 414 | Missing in LDS4. 1 PublicationAdd BLAST | 313 | |
Natural variantiVAR_018923 | 207 | V → L1 PublicationCorresponds to variant dbSNP:rs10482810EnsemblClinVar. | 1 | |
Natural variantiVAR_080343 | 229 – 414 | Missing in LDS4. 1 PublicationAdd BLAST | 186 | |
Natural variantiVAR_068932 | 299 | R → W in LDS4. 1 PublicationCorresponds to variant dbSNP:rs863223792EnsemblClinVar. | 1 | |
Natural variantiVAR_068933 | 302 | R → C in LDS4. 1 PublicationCorresponds to variant dbSNP:rs869312903EnsemblClinVar. | 1 | |
Natural variantiVAR_072740 | 320 | R → C Probable disease-associated variant found in a family with non-syndromic aortic disease. 1 PublicationCorresponds to variant dbSNP:rs1553303352EnsemblClinVar. | 1 | |
Natural variantiVAR_068934 | 338 | P → H in LDS4. 1 PublicationCorresponds to variant dbSNP:rs387907278EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006417 | 116 | N → TVCPVVTTPSGSVGSLCSRQ SQVLCGYLD in isoform B. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00083 mRNA Translation: CAA68279.1 M19154 mRNA Translation: AAA50404.1 M19154 mRNA Translation: AAA50405.1 AY438979 Genomic DNA Translation: AAR05442.1 AK296504 mRNA Translation: BAG59137.1 CH471100 Genomic DNA Translation: EAW93326.1 BC096235 mRNA Translation: AAH96235.1 BC099635 mRNA Translation: AAH99635.1 M87843 Genomic DNA Translation: AAA61162.1 |
CCDSi | CCDS1521.1 CCDS44318.1 [P61812-2] |
PIRi | A29478, B31249 S06216, A31249 |
RefSeqi | NP_001129071.1, NM_001135599.3 [P61812-2] NP_003229.1, NM_003238.4 [P61812-1] |
Genome annotation databases
Ensembli | ENST00000366929; ENSP00000355896; ENSG00000092969 [P61812-2] ENST00000366930; ENSP00000355897; ENSG00000092969 |
GeneIDi | 7042 |
KEGGi | hsa:7042 |
MANE-Selecti | ENST00000366930.9; ENSP00000355897.4; NM_003238.6; NP_003229.1 |
UCSCi | uc001hlm.4, human |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia TGF beta-2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00083 mRNA Translation: CAA68279.1 M19154 mRNA Translation: AAA50404.1 M19154 mRNA Translation: AAA50405.1 AY438979 Genomic DNA Translation: AAR05442.1 AK296504 mRNA Translation: BAG59137.1 CH471100 Genomic DNA Translation: EAW93326.1 BC096235 mRNA Translation: AAH96235.1 BC099635 mRNA Translation: AAH99635.1 M87843 Genomic DNA Translation: AAA61162.1 |
CCDSi | CCDS1521.1 CCDS44318.1 [P61812-2] |
PIRi | A29478, B31249 S06216, A31249 |
RefSeqi | NP_001129071.1, NM_001135599.3 [P61812-2] NP_003229.1, NM_003238.4 [P61812-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TFG | X-ray | 1.95 | A | 303-414 | [»] | |
2TGI | X-ray | 1.80 | A | 303-414 | [»] | |
4KXZ | X-ray | 2.83 | A/B/D/E | 303-414 | [»] | |
5TX4 | X-ray | 1.88 | B | 303-414 | [»] | |
5TY4 | electron microscopy | 2.90 | B | 317-413 | [»] | |
6I9J | X-ray | 2.00 | A | 303-414 | [»] | |
6XM2 | X-ray | 1.91 | I/J/K/L | 303-414 | [»] | |
7RCO | X-ray | 2.90 | A/B | 303-414 | [»] | |
SMRi | P61812 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112900, 15 interactors |
ComplexPortali | CPX-605, TGF-beta-2 complex CPX-834, TGF-beta-2-TGFR complex |
DIPi | DIP-5936N |
IntActi | P61812, 5 interactors |
STRINGi | 9606.ENSP00000355896 |
Chemistry databases
ChEMBLi | CHEMBL3217393 |
PTM databases
GlyConnecti | 1836, 1 N-Linked glycan (1 site) |
GlyGeni | P61812, 3 sites, 1 N-linked glycan (1 site) |
iPTMneti | P61812 |
PhosphoSitePlusi | P61812 |
Genetic variation databases
BioMutai | TGFB2 |
DMDMi | 48429157 |
Proteomic databases
EPDi | P61812 |
jPOSTi | P61812 |
MassIVEi | P61812 |
MaxQBi | P61812 |
PeptideAtlasi | P61812 |
PRIDEi | P61812 |
ProteomicsDBi | 57335 57336 [P61812-2] |
Protocols and materials databases
ABCDi | P61812, 7 sequenced antibodies |
Antibodypediai | 20732, 618 antibodies from 37 providers |
DNASUi | 7042 |
Genome annotation databases
Ensembli | ENST00000366929; ENSP00000355896; ENSG00000092969 [P61812-2] ENST00000366930; ENSP00000355897; ENSG00000092969 |
GeneIDi | 7042 |
KEGGi | hsa:7042 |
MANE-Selecti | ENST00000366930.9; ENSP00000355897.4; NM_003238.6; NP_003229.1 |
UCSCi | uc001hlm.4, human |
Organism-specific databases
CTDi | 7042 |
DisGeNETi | 7042 |
GeneCardsi | TGFB2 |
GeneReviewsi | TGFB2 |
HGNCi | HGNC:11768, TGFB2 |
HPAi | ENSG00000092969, Tissue enhanced (brain) |
MalaCardsi | TGFB2 |
MIMi | 190220, gene 614816, phenotype |
neXtProti | NX_P61812 |
OpenTargetsi | ENSG00000092969 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection |
PharmGKBi | PA36482 |
VEuPathDBi | HostDB:ENSG00000092969 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157390 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P61812 |
OMAi | YSGKTPH |
PhylomeDBi | P61812 |
TreeFami | TF318514 |
Enzyme and pathway databases
PathwayCommonsi | P61812 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-2129379, Molecules associated with elastic fibres R-HSA-3000178, ECM proteoglycans |
SignaLinki | P61812 |
SIGNORi | P61812 |
Miscellaneous databases
BioGRID-ORCSi | 7042, 7 hits in 1047 CRISPR screens |
ChiTaRSi | TGFB2, human |
EvolutionaryTracei | P61812 |
GeneWikii | TGF_beta_2 |
GenomeRNAii | 7042 |
Pharosi | P61812, Tbio |
PROi | PR:P61812 |
RNActi | P61812, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000092969, Expressed in calcaneal tendon and 175 other tissues |
Genevisiblei | P61812, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB2_HUMAN | |
Accessioni | P61812Primary (citable) accession number: P61812 Secondary accession number(s): B4DKC5 Q4VAV9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families