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Protein

Lysophosphatidic acid receptor 1

Gene

Lpar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca2+ levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39Lysophosphatidic acidBy similarity1
Binding sitei210Lysophosphatidic acidBy similarity1

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • lysophosphatidic acid binding Source: Ensembl
  • lysophosphatidic acid receptor activity Source: UniProtKB
  • PDZ domain binding Source: Ensembl
  • phospholipid binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events
R-RNO-418594 G alpha (i) signalling events
R-RNO-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 1
Short name:
LPA receptor 1
Short name:
LPA-1
Alternative name(s):
Lysophosphatidic acid receptor Edg-2
Gene namesi
Name:Lpar1
Synonyms:Edg21 Publication, Gpcr91, Lpa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620563 Lpar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularBy similarityAdd BLAST50
Transmembranei51 – 75Helical; Name=1By similarityAdd BLAST25
Topological domaini76 – 83CytoplasmicBy similarity8
Transmembranei84 – 107Helical; Name=2By similarityAdd BLAST24
Topological domaini108 – 121ExtracellularBy similarityAdd BLAST14
Transmembranei122 – 144Helical; Name=3By similarityAdd BLAST23
Topological domaini145 – 163CytoplasmicBy similarityAdd BLAST19
Transmembranei164 – 184Helical; Name=4By similarityAdd BLAST21
Topological domaini185 – 204ExtracellularBy similarityAdd BLAST20
Transmembranei205 – 225Helical; Name=5By similarityAdd BLAST21
Topological domaini226 – 255CytoplasmicBy similarityAdd BLAST30
Transmembranei256 – 280Helical; Name=6By similarityAdd BLAST25
Topological domaini281 – 294ExtracellularBy similarityAdd BLAST14
Transmembranei295 – 315Helical; Name=7By similarityAdd BLAST21
Topological domaini316 – 364CytoplasmicBy similarityAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4595

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694191 – 364Lysophosphatidic acid receptor 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 190By similarity
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 195By similarity
Disulfide bondi284 ↔ 287By similarity
Modified residuei341PhosphoserineBy similarity1
Modified residuei351PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP61794

PTM databases

PhosphoSitePlusiP61794

Expressioni

Tissue specificityi

Detected in brain corpus callosum, medulla oblongata, cerebellum and sciatic nerve. Detected in heart.1 Publication

Gene expression databases

BgeeiENSRNOG00000013656 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiP61794 RN

Interactioni

Subunit structurei

Interacts with RALA and GRK2 (By similarity). Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043652

Chemistry databases

BindingDBiP61794

Structurei

3D structure databases

ProteinModelPortaliP61794
SMRiP61794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 129Lysophosphatidic acid bindingBy similarity6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiP61794
KOiK04289
OMAiCCQRQEN
OrthoDBiEOG091G0DD4
PhylomeDBiP61794
TreeFamiTF330052

Family and domain databases

CDDicd15344 7tmA_LPAR1_Edg2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P61794-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK
60 70 80 90 100
LVMGLGITVC VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
110 120 130 140 150
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV
160 170 180 190 200
FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIDHCSNMAP
210 220 230 240 250
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
260 270 280 290 300
DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
310 320 330 340 350
EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH
360
TILAGVHSND HSVV
Length:364
Mass (Da):41,119
Last modified:June 7, 2004 - v1
Checksum:iB0FA6265AA6688B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014418 mRNA Translation: AAB86381.1
AF090347 mRNA Translation: AAG24469.1
BC089227 mRNA Translation: AAH89227.1
RefSeqiNP_446388.1, NM_053936.3
XP_006238257.1, XM_006238195.3
XP_006238259.1, XM_006238197.3
XP_006238262.1, XM_006238200.3
XP_006238263.1, XM_006238201.3
XP_017448614.1, XM_017593125.1
XP_017448615.1, XM_017593126.1
XP_017448616.1, XM_017593127.1
XP_017448617.1, XM_017593128.1
UniGeneiRn.11200

Genome annotation databases

EnsembliENSRNOT00000044348; ENSRNOP00000043652; ENSRNOG00000013656
GeneIDi116744
KEGGirno:116744
UCSCiRGD:620563 rat

Similar proteinsi

Entry informationi

Entry nameiLPAR1_RAT
AccessioniPrimary (citable) accession number: P61794
Secondary accession number(s): O88584
, P56487, P70420, Q5FWS2, Q61130
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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