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Entry version 137 (08 May 2019)
Sequence version 1 (07 Jun 2004)
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Protein

Lysophosphatidic acid receptor 1

Gene

Lpar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for lysophosphatidic acid (LPA) (PubMed:11087877, PubMed:18066075). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins (PubMed:8922387, PubMed:9600933, PubMed:11040035, PubMed:18157949, PubMed:18066075, PubMed:23478264). Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11040035, PubMed:12215548). Signaling triggers an increase of cytoplasmic Ca2+ levels (PubMed:12215548). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:11040035, PubMed:12215548, PubMed:23478264). Signaling mediates activation of down-stream MAP kinases (PubMed:11040035). Contributes to the regulation of cell shape (PubMed:8922387, PubMed:9600933, PubMed:11040035, PubMed:11087877). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:9600933, PubMed:11040035, PubMed:12181339). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:9600933, PubMed:12215548). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (PubMed:23478264). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:11087877, PubMed:18066075, PubMed:23478264). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14 (PubMed:21821728). Promotes cell proliferation in response to lysophosphatidic acid (PubMed:9600933, PubMed:11087877, PubMed:12215548, PubMed:18157949, PubMed:17692995, PubMed:23478264). Required for normal skeleton development (PubMed:21569876). May play a role in osteoblast differentiation (PubMed:21569876). Required for normal brain development (PubMed:17656621, PubMed:18708146). Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus (PubMed:18708146). Plays a role in pain perception and in the initiation of neuropathic pain (PubMed:15195086, PubMed:19689455).15 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39Lysophosphatidic acidBy similarity1
Binding sitei210Lysophosphatidic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-419408 Lysosphingolipid and LPA receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophosphatidic acid receptor 1Curated
Short name:
LPA receptor 1Curated
Short name:
LPA-12 Publications
Alternative name(s):
Lysophosphatidic acid receptor Edg-21 Publication
Rec1.31 Publication
VZG-12 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lpar1
Synonyms:Edg2, Gpcr261 Publication, Lpa12 Publications, Vzg12 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:108429 Lpar1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 50ExtracellularBy similarityAdd BLAST50
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 75Helical; Name=1By similarityAdd BLAST25
Topological domaini76 – 83CytoplasmicBy similarity8
Transmembranei84 – 107Helical; Name=2By similarityAdd BLAST24
Topological domaini108 – 121ExtracellularBy similarityAdd BLAST14
Transmembranei122 – 144Helical; Name=3By similarityAdd BLAST23
Topological domaini145 – 163CytoplasmicBy similarityAdd BLAST19
Transmembranei164 – 184Helical; Name=4By similarityAdd BLAST21
Topological domaini185 – 204ExtracellularBy similarityAdd BLAST20
Transmembranei205 – 225Helical; Name=5By similarityAdd BLAST21
Topological domaini226 – 255CytoplasmicBy similarityAdd BLAST30
Transmembranei256 – 280Helical; Name=6By similarityAdd BLAST25
Topological domaini281 – 294ExtracellularBy similarityAdd BLAST14
Transmembranei295 – 315Helical; Name=7By similarityAdd BLAST21
Topological domaini316 – 364CytoplasmicBy similarityAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant embryos are detected at the expected Mendelian rate, but there is about 50% perinatal lethality. This is mostly due to suckling defects, possibly because the neonates cannot find a nipple. Surviving mice are smaller, and they have shorter snouts and more widely spaced eyes than wild-type. A small percentage of the embryos and neonates display frontal hematomas. Besides, a small percentage of the embryos display exencephaly (PubMed:11087877). These mice display also deformity of the rib cage with sterno-distal rib fusions, shorter, crooked sternebrae, delayed vertebral calcification and closure of the thoracic spine (PubMed:21569876). Their small size is due to growth defects of limbs and vertebrae (PubMed:21569876). Mutant mice display decreased bone mass, as well as defects in proliferation and osteoblastic differentiation of bone marrow mesenchymal stem cells (PubMed:21569876). A spontaneous variant (the Malaga variant) that appeared among the descendants of the original knockout mice shows almost complete perinatal viability, but the mice still present small size, shorter snouts, wider-spaced eyes and reduced brain volume (PubMed:17656621). Compared to wild-type, the Malaga variants display smaller olfactory bulbs, and generally a smaller brain with slightly decreased thickness of the brain cortex and subtle defects in cortex development (PubMed:17656621). The hippocampus appears normal at birth, but displays a reduced number of cell divisions in adult dentate gyrus, both under normal conditions and when mice are exposed to a stimulating environment that promotes neurogenesis (PubMed:18708146). Compared to wild-type, the newly formed hippocampus cells show reduced survival (PubMed:18708146). Newly formed granule cells display defects in their maturation (PubMed:18708146). Mutant mice present subtle myelination defects in the brain cortex (PubMed:25226845). Mutant mice display minor defects in somesthesis, olfaction, grasping and keeping their equilibrium, and show decreased sensitivity to pain caused by heat (PubMed:19689455). Mutant mice do not display allodynia and hyperalgesia after nerve injury and are protected against demyelination after nerve injury (PubMed:15195086). Mutant mice display increased Schwann cell apoptosis in sciatic nerve, but this still leaves the majority of Schwann cells intact and does not cause any visible effect on movement (PubMed:11087877). Mutant mice display decreased exploration in the open field and increased anxiety-like responses to novelty; they also show subtle deficits in spatial learning and memory (PubMed:19689455). Mutant mice show blunted responses to bacterial lipopolysaccharide (LPS) and show reduced acute inflammation in response to LPS (PubMed:21821728). Mutant mice show decreased migration of fibroblasts to sites of lung injury, decreased injury-induced vascular leak, and are protected against the development of lung fibrosis after bleomycin treatment (PubMed:18066075). Mutant mice have reduced levels of proliferating epithelial cells in their intestinal crypts, and the cells do not migrate normally from the bottom of the crypts up into the villi (PubMed:23478264). Mutant mice show impaired repair after wounding of the intestinal mucosa (PubMed:23478264).Mutant mice have less body weight, but increased brown and white adipose tissue (PubMed:20358347). Contrary to wild-type, mutant mice do not increase their food consumption on a high fat diet and do not gain weight on a high fat diet (PubMed:20358347). Mice deficient in both Lpar1 and Lpar2 have the same phenotype as mice lacking Lpar1, excepting a higher incidence of frontal hematomas and slightly higher perinatal lethality (PubMed:12215548).11 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3621025

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694181 – 364Lysophosphatidic acid receptor 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 190By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 195By similarity
Disulfide bondi284 ↔ 287By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341PhosphoserineBy similarity1
Modified residuei351PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P61793

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P61793

PeptideAtlas

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PeptideAtlasi
P61793

PRoteomics IDEntifications database

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PRIDEi
P61793

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P61793

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P61793

SwissPalm database of S-palmitoylation events

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SwissPalmi
P61793

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lung (PubMed:21821728). Detected in oligodendrocytes in corpus callosum in brain cortex (at protein level) (PubMed:25226845). Expressed within the embryonic cerebral cortex, where it is enriched in the ventricular zone (PubMed:8922387). In the adult brain, also expressed in oligodendrocytes, as well as Schwann cells of the peripheral nervous system (PubMed:9013780, PubMed:25226845). Expressed in many other tissues, including lung, heart, intestine, spleen, thymus, and stomach. No expression in liver (PubMed:9013780). Detected in kidney and testis (PubMed:9013780, PubMed:12215548). Detected in embryonic fibroblasts (PubMed:12215548). Detected in adult lung fibroblasts and lung endothelial cells (PubMed:18066075). Detected in dorsal root ganglion and dorsal root (PubMed:15195086). Detected in astrocytes (PubMed:17692995). Detected in bone (PubMed:21569876).7 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by bacterial lipopolysaccharide (LPS) (at protein level). Up-regulated by bacterial lipopolysaccharide (LPS).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000038668 Expressed in 311 organ(s), highest expression level in hindlimb bud

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P61793 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P61793 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RALA and GRK2 (By similarity). Interacts with GNAQ and GNA13 (PubMed:23478264). Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (PubMed:21821728).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGEF12Q9NZN53EBI-7512335,EBI-821440From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
200018, 3 interactors

Database of interacting proteins

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DIPi
DIP-42214N

Protein interaction database and analysis system

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IntActi
P61793, 3 interactors

Molecular INTeraction database

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MINTi
P61793

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000052581

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61793

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 129Lysophosphatidic acid bindingBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233501

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61793

KEGG Orthology (KO)

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KOi
K04289

Identification of Orthologs from Complete Genome Data

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OMAi
EQCYYNE

Database of Orthologous Groups

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OrthoDBi
989859at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P61793

TreeFam database of animal gene trees

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TreeFami
TF330052

Family and domain databases

Conserved Domains Database

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CDDi
cd15344 7tmA_LPAR1_Edg2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P61793-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK
60 70 80 90 100
LVMGLGITVC VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
110 120 130 140 150
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV
160 170 180 190 200
FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIDHCSNMAP
210 220 230 240 250
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
260 270 280 290 300
DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
310 320 330 340 350
EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH
360
TILAGVHSND HSVV
Length:364
Mass (Da):41,119
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0FA6265AA6688B7
GO
Isoform 2 (identifier: P61793-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:346
Mass (Da):39,343
Checksum:i7634E3976257933D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AMI9A2AMI9_MOUSE
Lysophosphatidic acid receptor 1
Lpar1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AMJ0A2AMJ0_MOUSE
Lysophosphatidic acid receptor 1
Lpar1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AMJ1A2AMJ1_MOUSE
Lysophosphatidic acid receptor 1
Lpar1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119S → N in AAC34301 (PubMed:9721207).Curated1
Sequence conflicti119S → N in AAC34302 (PubMed:9721207).Curated1
Sequence conflicti181 – 183IPS → MPT in AAC34301 (PubMed:9721207).Curated3
Sequence conflicti181 – 183IPS → MPT in AAC34302 (PubMed:9721207).Curated3
Sequence conflicti225Y → S in AAC53035 (PubMed:9013780).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0019861 – 18Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70622 mRNA Translation: AAC52923.1
U48235 mRNA Translation: AAC53035.1
AF075456, AF075453, AF075455 Genomic DNA Translation: AAC34301.1
AF075456, AF075455 Genomic DNA Translation: AAC34302.1
AL807748 Genomic DNA No translation available.
BC025425 mRNA Translation: AAH25425.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS18212.1
CCDS71391.1 [P61793-2]

NCBI Reference Sequences

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RefSeqi
NP_001277415.1, NM_001290486.1 [P61793-2]
NP_034466.2, NM_010336.2 [P61793-1]
NP_766577.1, NM_172989.1 [P61793-1]
XP_011248230.1, XM_011249928.2 [P61793-1]
XP_011248231.1, XM_011249929.2 [P61793-1]
XP_011248232.1, XM_011249930.2 [P61793-1]
XP_011248233.1, XM_011249931.2 [P61793-1]
XP_011248234.1, XM_011249932.2 [P61793-1]
XP_011248235.1, XM_011249933.2 [P61793-1]
XP_011248236.1, XM_011249934.2 [P61793-1]
XP_011248237.1, XM_011249935.2 [P61793-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000055018; ENSMUSP00000052581; ENSMUSG00000038668 [P61793-1]
ENSMUST00000107570; ENSMUSP00000103196; ENSMUSG00000038668 [P61793-2]
ENSMUST00000107571; ENSMUSP00000103197; ENSMUSG00000038668 [P61793-1]
ENSMUST00000107574; ENSMUSP00000103200; ENSMUSG00000038668 [P61793-1]
ENSMUST00000107575; ENSMUSP00000103201; ENSMUSG00000038668 [P61793-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
14745

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:14745

UCSC genome browser

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UCSCi
uc008szb.3 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70622 mRNA Translation: AAC52923.1
U48235 mRNA Translation: AAC53035.1
AF075456, AF075453, AF075455 Genomic DNA Translation: AAC34301.1
AF075456, AF075455 Genomic DNA Translation: AAC34302.1
AL807748 Genomic DNA No translation available.
BC025425 mRNA Translation: AAH25425.1
CCDSiCCDS18212.1
CCDS71391.1 [P61793-2]
RefSeqiNP_001277415.1, NM_001290486.1 [P61793-2]
NP_034466.2, NM_010336.2 [P61793-1]
NP_766577.1, NM_172989.1 [P61793-1]
XP_011248230.1, XM_011249928.2 [P61793-1]
XP_011248231.1, XM_011249929.2 [P61793-1]
XP_011248232.1, XM_011249930.2 [P61793-1]
XP_011248233.1, XM_011249931.2 [P61793-1]
XP_011248234.1, XM_011249932.2 [P61793-1]
XP_011248235.1, XM_011249933.2 [P61793-1]
XP_011248236.1, XM_011249934.2 [P61793-1]
XP_011248237.1, XM_011249935.2 [P61793-1]

3D structure databases

SMRiP61793
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200018, 3 interactors
DIPiDIP-42214N
IntActiP61793, 3 interactors
MINTiP61793
STRINGi10090.ENSMUSP00000052581

Chemistry databases

ChEMBLiCHEMBL3621025
GuidetoPHARMACOLOGYi272

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP61793
PhosphoSitePlusiP61793
SwissPalmiP61793

Proteomic databases

jPOSTiP61793
PaxDbiP61793
PeptideAtlasiP61793
PRIDEiP61793

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055018; ENSMUSP00000052581; ENSMUSG00000038668 [P61793-1]
ENSMUST00000107570; ENSMUSP00000103196; ENSMUSG00000038668 [P61793-2]
ENSMUST00000107571; ENSMUSP00000103197; ENSMUSG00000038668 [P61793-1]
ENSMUST00000107574; ENSMUSP00000103200; ENSMUSG00000038668 [P61793-1]
ENSMUST00000107575; ENSMUSP00000103201; ENSMUSG00000038668 [P61793-1]
GeneIDi14745
KEGGimmu:14745
UCSCiuc008szb.3 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1902
MGIiMGI:108429 Lpar1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00950000182615
HOGENOMiHOG000233501
InParanoidiP61793
KOiK04289
OMAiEQCYYNE
OrthoDBi989859at2759
PhylomeDBiP61793
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-419408 Lysosphingolipid and LPA receptors

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P61793

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038668 Expressed in 311 organ(s), highest expression level in hindlimb bud
ExpressionAtlasiP61793 baseline and differential
GenevisibleiP61793 MM

Family and domain databases

CDDicd15344 7tmA_LPAR1_Edg2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPAR1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61793
Secondary accession number(s): A2AMJ2
, O88584, P56487, P70420, Q61130
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 8, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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