UniProtKB - P61774 (HBD_HYLLA)
Protein
Hemoglobin subunit delta
Gene
HBD
Organism
Hylobates lar (Common gibbon) (White-handed gibbon)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 93 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit deltaAlternative name(s): Delta-globin Hemoglobin delta chain |
Gene namesi | Name:HBD |
Organismi | Hylobates lar (Common gibbon) (White-handed gibbon) |
Taxonomic identifieri | 9580 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hylobatidae › Hylobates |
Subcellular locationi
Cytosol
- hemoglobin complex Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000053168 | 2 – 147 | Hemoglobin subunit deltaAdd BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | P61774 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two delta chains and two alpha chains.
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P61774-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVHLTPEEKT AVNALWGKVN VDAVGGEALG RLLVVYPWTQ RFFESFGDLS
60 70 80 90 100
SPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFSQLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVCVLARNFG KEFTPQVQAA YQKVVAGVAN ALAHKYH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 7 | E → G Or in position 7, in a common allele. | 1 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
3D structure databases
SMRi | P61774 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P61774 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HBD_HYLLA | |
Accessioni | P61774Primary (citable) accession number: P61774 Secondary accession number(s): P02043 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 18, 2019 | |
This is version 63 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families