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Entry version 187 (16 Oct 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-977225 Amyloid fiber formation
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P61769

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-2-microglobulin
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:B2MImported
ORF Names:CDABP0092, HDCMA22P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:914 B2M

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109700 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P61769

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, MHC I, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 43 (IMD43)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by marked reduction in serum concentrations of immunoglobulins and albumin, and hypoproteinemia due to hypercatabolism. Patients may suffer from recurrent respiratory tract infections and severe skin disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03066011A → P in IMD43; lower levels of B2M, MHC class I and FCGRT proteins. 1 PublicationCorresponds to variant dbSNP:rs104894481EnsemblClinVar.1
Amyloidosis 8 (AMYL8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Apart from the presence of causative mutations, beta-2-microglobulin may adopt the fibrillar configuration of amyloid when its serum levels are persistently high. High beta(2)-microglobulin serum levels result in amyloidosis in patients on long-term hemodialysis (PubMed:7918443). In contrast to patients with dialysis-related amyloidosis, patients with hereditary amyloidosis have normal circulating concentrations of beta2-microglobulin (PubMed:22693999).2 Publications
Disease descriptionA form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07669196D → N in AMYL8; reduced stability; in contrast to the wild-type, the mutant aggregates into fibrils with classic amyloid-like properties under physiologic solvent conditions. 1 PublicationCorresponds to variant dbSNP:rs398122820EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi79D → P: Increases tendency towards amyloid formation. 1 Publication1
Mutagenesisi80W → G: Decreases tendency towards amyloid formation. 2 Publications1
Mutagenesisi80W → V: Increases tendency towards amyloid formation. 2 Publications1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
567

MalaCards human disease database

More...
MalaCardsi
B2M
MIMi105200 phenotype
241600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166710

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
34592 Immunodeficiency by defective expression of MHC class I
314652 Variant ABeta2M amyloidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25207

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P61769

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02740 3-Indolebutyric Acid
DB09130 Copper
DB04464 N-Formylmethionine
DB11130 Opium

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
B2M

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428791

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 205 PublicationsAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001877921 – 119Beta-2-microglobulinAdd BLAST99
ChainiPRO_000001878022 – 119Beta-2-microglobulin form pI 5.3Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22Pyrrolidone carboxylic acid; in form pI 5.31 Publication1
Glycosylationi39N-linked (Glc) (glycation) lysine; in vitro1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 100PROSITE-ProRule annotation8 Publications
Glycosylationi61N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi68N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi78N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi111N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi114N-linked (Glc) (glycation) lysine; in vitro1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1232

Encyclopedia of Proteome Dynamics

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EPDi
P61769

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P61769

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P61769

MaxQB - The MaxQuant DataBase

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MaxQBi
P61769

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P61769

PeptideAtlas

More...
PeptideAtlasi
P61769

PRoteomics IDEntifications database

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PRIDEi
P61769

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
12611
57333

Consortium for Top Down Proteomics

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TopDownProteomicsi
P61769

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P61769

USC-OGP 2-DE database

More...
OGPi
P61769

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P61769

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P61769

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P61769

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P61769

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166710 Expressed in 234 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P61769 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P61769 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002572
HPA006361

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected in patients with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553).

Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624).

Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715).

Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107044, 44 interactors

Database of interacting proteins

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DIPi
DIP-6055N

Protein interaction database and analysis system

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IntActi
P61769, 132 interactors

Molecular INTeraction database

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MINTi
P61769

STRING: functional protein association networks

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STRINGi
9606.ENSP00000452780

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P61769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P61769

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P61769

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 113Ig-like C1-typeAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J15A Eukaryota
ENOG410YTDG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00690000102227

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P61769

KEGG Orthology (KO)

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KOi
K08055

Identification of Orthologs from Complete Genome Data

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OMAi
HTEFTPT

Database of Orthologous Groups

More...
OrthoDBi
1556447at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P61769

TreeFam database of animal gene trees

More...
TreeFami
TF334167

Family and domain databases

Conserved Domains Database

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CDDi
cd05770 IgC_beta2m, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set

The PANTHER Classification System

More...
PANTHERi
PTHR19944:SF62 PTHR19944:SF62, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07654 C1-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P61769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF
60 70 80 90 100
HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC
110
RVNHVTLSQP KIVKWDRDM
Length:119
Mass (Da):13,715
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFD2DBEF07DCEF27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6I0F5H6I0_HUMAN
Beta-2-microglobulin
B2M
101Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLF3H0YLF3_HUMAN
Beta-2-microglobulin
B2M
71Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q16446Q16446_HUMAN
Beta 2-microglobulin protein
B2M beta 2-microglobulin, hCG_1786707
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNU0J3KNU0_HUMAN
Beta-2-microglobulin
B2M
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20A → G in AAA51811 (PubMed:3312414).Curated1
Sequence conflicti52P → Q in AAA51811 (PubMed:3312414).Curated1
Sequence conflicti119M → I in CAG33347 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03066011A → P in IMD43; lower levels of B2M, MHC class I and FCGRT proteins. 1 PublicationCorresponds to variant dbSNP:rs104894481EnsemblClinVar.1
Natural variantiVAR_07669196D → N in AMYL8; reduced stability; in contrast to the wild-type, the mutant aggregates into fibrils with classic amyloid-like properties under physiologic solvent conditions. 1 PublicationCorresponds to variant dbSNP:rs398122820EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17987, M17986 Genomic DNA Translation: AAA51811.1
AY187687 mRNA Translation: AAO20842.1
AB021288 mRNA Translation: BAA35182.1
DQ217933 Genomic DNA Translation: ABB01003.1
AF072097 mRNA Translation: AAD48083.1
AY007153 mRNA Translation: AAG02006.1
CR457066 mRNA Translation: CAG33347.1
AK315776 mRNA Translation: BAG38125.1
CH471082 Genomic DNA Translation: EAW77277.1
BC032589 mRNA Translation: AAH32589.1
BC064910 mRNA Translation: AAH64910.1
V00567 mRNA Translation: CAA23830.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10113.1

Protein sequence database of the Protein Information Resource

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PIRi
A90976 MGHUB2

NCBI Reference Sequences

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RefSeqi
NP_004039.1, NM_004048.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000559916; ENSP00000453350; ENSG00000166710
ENST00000561424; ENSP00000453191; ENSG00000166710
ENST00000617605; ENSP00000481426; ENSG00000273686
ENST00000631573; ENSP00000488548; ENSG00000273686
ENST00000631728; ENSP00000488321; ENSG00000273686
ENST00000648006; ENSP00000497910; ENSG00000166710

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
567

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:567

UCSC genome browser

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UCSCi
uc001zuc.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Beta-2-microglobulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17987, M17986 Genomic DNA Translation: AAA51811.1
AY187687 mRNA Translation: AAO20842.1
AB021288 mRNA Translation: BAA35182.1
DQ217933 Genomic DNA Translation: ABB01003.1
AF072097 mRNA Translation: AAD48083.1
AY007153 mRNA Translation: AAG02006.1
CR457066 mRNA Translation: CAG33347.1
AK315776 mRNA Translation: BAG38125.1
CH471082 Genomic DNA Translation: EAW77277.1
BC032589 mRNA Translation: AAH32589.1
BC064910 mRNA Translation: AAH64910.1
V00567 mRNA Translation: CAA23830.1
CCDSiCCDS10113.1
PIRiA90976 MGHUB2
RefSeqiNP_004039.1, NM_004048.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A1MX-ray2.30B21-119[»]
1A1NX-ray2.00B21-119[»]
1A1OX-ray2.30B21-119[»]
1A6ZX-ray2.60B/D21-119[»]
1A9BX-ray3.20B/E21-119[»]
1A9EX-ray2.50B21-119[»]
1AGBX-ray2.20B21-119[»]
1AGCX-ray2.10B21-119[»]
1AGDX-ray2.05B21-119[»]
1AGEX-ray2.30B21-119[»]
1AGFX-ray2.20B21-119[»]
1AKJX-ray2.65B21-119[»]
1AO7X-ray2.60B21-119[»]
1B0GX-ray2.50B/E21-119[»]
1B0RX-ray2.90B21-119[»]
1BD2X-ray2.50B21-119[»]
1C16X-ray3.10B/D/F/H21-119[»]
1CE6X-ray2.90B21-119[»]
1CG9X-ray2.70B21-119[»]
1DE4X-ray2.80B/E/H21-119[»]
1DUYX-ray2.15B/E21-119[»]
1DUZX-ray1.80B/E21-119[»]
1E27X-ray2.20B21-119[»]
1E28X-ray3.00B21-119[»]
1EEYX-ray2.25B/E21-119[»]
1EEZX-ray2.30B/E21-119[»]
1EFXX-ray3.00B21-119[»]
1EXUX-ray2.70B21-119[»]
1GZPX-ray2.80B21-119[»]
1GZQX-ray2.26B21-119[»]
1HHGX-ray2.60B/E21-119[»]
1HHHX-ray3.00B21-119[»]
1HHIX-ray2.50B/E21-119[»]
1HHJX-ray2.50B/E21-119[»]
1HHKX-ray2.50B/E21-119[»]
1HLAX-ray3.50M21-117[»]
1HSAX-ray2.10B/E21-119[»]
1HSBX-ray1.90B21-119[»]
1I1FX-ray2.80B/E21-119[»]
1I1YX-ray2.20B/E21-119[»]
1I4FX-ray1.40B21-119[»]
1I7RX-ray2.20B/E21-119[»]
1I7TX-ray2.80B/E21-119[»]
1I7UX-ray1.80B/E21-119[»]
1IM3X-ray2.20B/F/J/N21-119[»]
1IM9X-ray2.80B/F21-119[»]
1JF1X-ray1.85B21-119[»]
1JGDX-ray1.90B21-119[»]
1JGEX-ray2.10B21-119[»]
1JHTX-ray2.15B21-119[»]
1JNJNMR-A21-119[»]
1K5NX-ray1.09B21-119[»]
1KPRX-ray2.80B/D21-119[»]
1KTLX-ray3.10B/D21-119[»]
1LDSX-ray1.80A21-119[»]
1LP9X-ray2.00B/I21-119[»]
1M05X-ray1.90B/D21-119[»]
1M6OX-ray1.60B21-119[»]
1MHEX-ray2.85B/D21-119[»]
1MI5X-ray2.50B21-119[»]
1N2RX-ray1.70B21-119[»]
1OF2X-ray2.20B21-119[»]
1OGAX-ray1.40B21-119[»]
1OGTX-ray1.47B21-119[»]
1ONQX-ray2.15B/D21-119[»]
1P7QX-ray3.40B21-119[»]
1PY4X-ray2.90A/B/C/D21-119[»]
1Q94X-ray2.40B/E21-119[»]
1QEWX-ray2.20B21-119[»]
1QLFX-ray2.65B21-119[»]
1QQDX-ray2.70B21-118[»]
1QR1X-ray2.40B/E20-119[»]
1QRNX-ray2.80B21-119[»]
1QSEX-ray2.80B20-119[»]
1QSFX-ray2.80B20-119[»]
1QVOX-ray2.22B/E21-119[»]
1R3HX-ray2.50B/D/F/H21-119[»]
1S8DX-ray2.20B21-119[»]
1S9WX-ray2.20B21-119[»]
1S9XX-ray2.50B21-119[»]
1S9YX-ray2.30B21-119[»]
1SYSX-ray2.40B21-119[»]
1SYVX-ray1.70B21-119[»]
1T1WX-ray2.20B21-119[»]
1T1XX-ray2.20B21-119[»]
1T1YX-ray2.00B21-119[»]
1T1ZX-ray1.90B21-119[»]
1T20X-ray2.20B21-119[»]
1T21X-ray2.19B21-119[»]
1T22X-ray2.20B21-119[»]
1TMCX-ray2.30B21-119[»]
1TVBX-ray1.80B/E21-119[»]
1TVHX-ray1.80B/E21-119[»]
1UQSX-ray3.10B21-119[»]
1UR7model-B21-119[»]
1UXSX-ray1.55B21-119[»]
1UXWX-ray1.71B21-119[»]
1VGKX-ray2.06B21-119[»]
1W0VX-ray2.27B21-119[»]
1W0WX-ray2.10B21-119[»]
1W72X-ray2.15B/E21-119[»]
1X7QX-ray1.45B21-119[»]
1XH3X-ray1.48B21-119[»]
1XR8X-ray2.30B21-119[»]
1XR9X-ray1.79B21-119[»]
1XZ0X-ray2.80B/D21-119[»]
1YDPX-ray1.90B21-119[»]
1YPZX-ray3.40B/D21-119[»]
1ZHKX-ray1.60B21-119[»]
1ZHLX-ray1.50B21-119[»]
1ZS8X-ray3.00B/D/F/H/J21-119[»]
1ZSDX-ray1.70B21-119[»]
1ZT4X-ray3.00B/D21-119[»]
1ZVSX-ray2.80B/E21-119[»]
2A83X-ray1.40B21-119[»]
2AK4X-ray2.50B/G/L/R21-119[»]
2AV1X-ray1.95B/E21-119[»]
2AV7X-ray2.05B/E21-119[»]
2AXFX-ray1.80B21-119[»]
2AXGX-ray2.00B21-119[»]
2BCKX-ray2.80B/E21-119[»]
2BNQX-ray1.70B21-119[»]
2BNRX-ray1.90B21-119[»]
2BSRX-ray2.30B21-119[»]
2BSSX-ray2.00B21-119[»]
2BSTX-ray2.10B21-119[»]
2BVOX-ray1.65B21-119[»]
2BVPX-ray1.35B21-119[»]
2BVQX-ray2.00B21-119[»]
2C7UX-ray2.38B/E21-119[»]
2CIIX-ray2.55B21-119[»]
2CIKX-ray1.75B21-119[»]
2CLRX-ray2.00B/E21-119[»]
2D31X-ray3.20B/E21-119[»]
2D4DX-ray2.10A21-119[»]
2D4FX-ray1.70A21-119[»]
2DYPX-ray2.50B21-119[»]
2E8DNMR-A/B/C/D40-61[»]
2ESVX-ray2.60B21-119[»]
2F53X-ray2.10B21-119[»]
2F54X-ray2.70B/G21-119[»]
2F74X-ray2.70B/E21-119[»]
2F8OX-ray1.70A/B21-119[»]
2FYYX-ray1.50B21-119[»]
2FZ3X-ray1.90B21-119[»]
2GITX-ray1.70B/E21-119[»]
2GJ6X-ray2.56B21-119[»]
2GT9X-ray1.75B/E21-119[»]
2GTWX-ray1.55B/E21-119[»]
2GTZX-ray1.70B/E21-119[»]
2GUOX-ray1.90B/E21-119[»]
2H26X-ray1.80B21-119[»]
2H6PX-ray1.90B21-119[»]
2HJKX-ray1.85B21-119[»]
2HJLX-ray1.50B21-119[»]
2HLAX-ray2.60B21-119[»]
2HN7X-ray1.60B21-119[»]
2J8UX-ray2.88B/I21-119[»]
2JCCX-ray2.50B/I21-119[»]
2NW3X-ray1.70B21-119[»]
2NX5X-ray2.70B/G/L/R21-119[»]
2P5EX-ray1.89B21-119[»]
2P5WX-ray2.20B21-119[»]
2PO6X-ray3.20B/F21-119[»]
2PYEX-ray2.30B21-119[»]
2RFXX-ray2.50B21-119[»]
2UWEX-ray2.40B/I21-119[»]
2V2WX-ray1.60B/E21-119[»]
2V2XX-ray1.60B/E21-119[»]
2VB5NMR-A21-119[»]
2VLJX-ray2.40B21-119[»]
2VLKX-ray2.50B21-119[»]
2VLLX-ray1.60B/E21-119[»]
2VLRX-ray2.30B/G21-119[»]
2X4NX-ray2.34B/E21-119[»]
2X4OX-ray2.30B/E21-119[»]
2X4PX-ray2.30B/E21-119[»]
2X4QX-ray1.90B/E21-119[»]
2X4RX-ray2.30B/E21-119[»]
2X4SX-ray2.55B/E21-119[»]
2X4TX-ray2.30B/E21-119[»]
2X4UX-ray2.10B/E21-119[»]
2X70X-ray2.00B/E21-119[»]
2X89X-ray2.16D/E/F/G27-119[»]
2XKSNMR-A21-119[»]
2XKUNMR-A27-119[»]
2XPGX-ray2.60B22-118[»]
2YPKX-ray1.95B21-119[»]
2YPLX-ray2.40B21-119[»]
2YXFX-ray1.13A21-119[»]
2Z9TX-ray1.80A21-119[»]
3AM8X-ray2.80C/D21-119[»]
3B3IX-ray1.86B21-119[»]
3B6SX-ray1.80B21-119[»]
3BGMX-ray1.60B21-119[»]
3BH8X-ray1.65B21-119[»]
3BH9X-ray1.70B21-119[»]
3BHBX-ray2.20B22-119[»]
3BO8X-ray1.80B21-119[»]
3BP4X-ray1.85B21-119[»]
3BP7X-ray1.80B21-119[»]
3BVNX-ray2.55B/E21-119[»]
3BW9X-ray1.75B21-119[»]
3BWAX-ray1.30B21-119[»]
3BXNX-ray1.86B21-119[»]
3BZEX-ray2.50B/D/F/H21-119[»]
3BZFX-ray2.50B/D23-119[»]
3C9NX-ray1.87B21-119[»]
3CDGX-ray3.40B/D21-119[»]
3CIIX-ray4.41B/E21-119[»]
3CIQX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L21-119[»]
3CZFX-ray1.20B21-119[»]
3D18X-ray1.74B21-119[»]
3D25X-ray1.30B22-119[»]
3D2UX-ray2.21B/F21-119[»]
3D39X-ray2.81B21-119[»]
3D3VX-ray2.80B21-119[»]
3DBXX-ray2.00B21-119[»]
3DHJX-ray2.00A21-119[»]
3DHMX-ray1.80A21-119[»]
3DTXX-ray2.10B21-119[»]
3DX6X-ray1.70B21-119[»]
3DX7X-ray1.60B21-119[»]
3DX8X-ray2.10B21-119[»]
3DXAX-ray3.50B/G/L21-119[»]
3EKCX-ray1.80A21-119[»]
3FFCX-ray2.80B/G21-119[»]
3FQNX-ray1.65B22-119[»]
3FQRX-ray1.70B22-119[»]
3FQTX-ray1.80B22-119[»]
3FQUX-ray1.80B22-119[»]
3FQWX-ray1.93B22-119[»]
3FQXX-ray1.70B22-119[»]
3FT2X-ray1.80B21-119[»]
3FT3X-ray1.95B21-119[»]
3FT4X-ray1.90B21-119[»]
3GIVX-ray2.00B/E21-119[»]
3GJFX-ray1.90B/E21-119[»]
3GSNX-ray2.80L21-119[»]
3GSOX-ray1.60B21-119[»]
3GSQX-ray2.12B21-119[»]
3GSRX-ray1.95B21-119[»]
3GSUX-ray1.80B21-119[»]
3GSVX-ray1.90B21-119[»]
3GSWX-ray1.81B21-119[»]
3GSXX-ray2.10B21-119[»]
3H7BX-ray1.88B/E21-119[»]
3H9HX-ray2.00B/E21-119[»]
3H9SX-ray2.70B21-119[»]
3HAEX-ray2.90B/E/K/Q21-119[»]
3HCVX-ray1.95B21-119[»]
3HG1X-ray3.00B21-119[»]
3HLAX-ray2.60B21-119[»]
3HPJX-ray2.00B/E21-119[»]
3HUJX-ray2.50B/D21-119[»]
3I6GX-ray2.20B/E21-119[»]
3I6KX-ray2.80B/F21-119[»]
3I6LX-ray2.40E21-119[»]
3IB4X-ray1.25A21-119[»]
3IXAX-ray2.10B/E21-119[»]
3JTSX-ray2.80B/E/H1-119[»]
3KLAX-ray1.65B/E21-119[»]
3KPLX-ray1.96B21-119[»]
3KPMX-ray1.60B21-119[»]
3KPNX-ray2.00B21-119[»]
3KPOX-ray2.30B21-119[»]
3KPPX-ray1.90B21-119[»]
3KPQX-ray1.84B21-119[»]
3KPRX-ray2.60B/G21-119[»]
3KPSX-ray2.70B21-119[»]
3KWWX-ray2.18B21-119[»]
3KXFX-ray3.10B/F/J/L21-119[»]
3KYNX-ray2.40B21-119[»]
3KYOX-ray1.70B/D21-119[»]
3L3DX-ray1.80B21-119[»]
3L3GX-ray2.10B21-119[»]
3L3IX-ray1.70B21-119[»]
3L3JX-ray2.40B21-119[»]
3L3KX-ray2.60B21-119[»]
3LKNX-ray2.00B21-119[»]
3LKOX-ray1.80B21-119[»]
3LKPX-ray1.80B21-119[»]
3LKQX-ray1.80B21-119[»]
3LKRX-ray2.00B21-119[»]
3LKSX-ray1.90B21-119[»]
3LN4X-ray1.30B21-119[»]
3LN5X-ray1.90B21-119[»]
3LOWX-ray2.30A/B21-119[»]
3LOZX-ray1.80A/B/C/D74-79[»]
3LV3X-ray1.94B21-119[»]
3M17X-ray2.60B/D/F/H21-119[»]
3M1BX-ray3.10B/D/F/H21-119[»]
3MGOX-ray2.30B/E/H/K21-119[»]
3MGTX-ray2.20B/E/H/K21-119[»]
3MR9X-ray1.93B21-119[»]
3MRBX-ray1.40B21-119[»]
3MRCX-ray1.80B21-119[»]
3MRDX-ray1.70B21-119[»]
3MREX-ray1.10B21-119[»]
3MRFX-ray2.30B21-119[»]
3MRGX-ray1.30B21-119[»]
3MRHX-ray2.40B21-119[»]
3MRIX-ray2.10B21-119[»]
3MRJX-ray1.87B21-119[»]
3MRKX-ray1.40B21-119[»]
3MRLX-ray2.41B21-119[»]
3MRMX-ray1.90B21-119[»]
3MRNX-ray2.30B21-119[»]
3MROX-ray2.35B21-119[»]
3MRPX-ray2.10B21-119[»]
3MRQX-ray2.20B21-119[»]
3MRRX-ray1.60B21-119[»]
3MV7X-ray2.00B21-119[»]
3MV8X-ray2.10B21-119[»]
3MV9X-ray2.70B21-119[»]
3MYJX-ray1.89B/E21-119[»]
3MYZX-ray1.60A/B21-119[»]
3MZTX-ray2.70A/B/C/D/E/F21-119[»]
3NA4X-ray1.90A21-119[»]
3NFNX-ray2.39B21-119[»]
3O3AX-ray1.80B/E21-119[»]
3O3BX-ray1.90B/E21-119[»]
3O3DX-ray1.70B/E21-119[»]
3O3EX-ray1.85B/E21-119[»]
3O4LX-ray2.54B21-119[»]
3OV6X-ray2.50A21-119[»]
3OX8X-ray2.16B/E21-119[»]
3OXRX-ray1.70B21-119[»]
3OXSX-ray1.75B21-119[»]
3PWJX-ray1.70B/E21-119[»]
3PWLX-ray1.65B/E21-119[»]
3PWNX-ray1.60B/E21-119[»]
3PWPX-ray2.69B21-119[»]
3QDAX-ray1.57A21-119[»]
3QDGX-ray2.69B21-119[»]
3QDJX-ray2.30B21-119[»]
3QDMX-ray2.80B21-119[»]
3QEQX-ray2.59B21-119[»]
3QFDX-ray1.68B/E21-119[»]
3QFJX-ray2.29B21-119[»]
3QZWX-ray2.80B/E21-119[»]
3REWX-ray1.90B/E21-119[»]
3RL1X-ray2.00B21-119[»]
3RL2X-ray2.39B21-119[»]
3RWJX-ray2.70B21-119[»]
3S6CX-ray2.90A21-119[»]
3SDXX-ray3.12B/D21-119[»]
3SJVX-ray3.10B/G/L/Q21-119[»]
3SKMX-ray1.80B21-119[»]
3SKOX-ray1.60B21-119[»]
3SPVX-ray1.30B21-119[»]
3T8XX-ray1.90B/D21-119[»]
3TIDX-ray1.65B21-119[»]
3TIEX-ray2.25B/E21-119[»]
3TLRX-ray2.45A/B/C/D21-119[»]
3TM6X-ray2.70A/B/C/D/E/F/G/H21-119[»]
3TO2X-ray2.60B21-119[»]
3TZVX-ray3.06D21-119[»]
3U0PX-ray2.80B/D/F21-119[»]
3UPRX-ray2.00B/D21-119[»]
3UTQX-ray1.67B21-119[»]
3UTSX-ray2.71B/G21-119[»]
3UTTX-ray2.60B/G21-119[»]
3V5DX-ray2.00B/E21-119[»]
3V5HX-ray1.63B/E21-119[»]
3V5KX-ray2.31B/E21-119[»]
3VCLX-ray1.70B21-119[»]
3VFMX-ray1.90B21-119[»]
3VFNX-ray1.50B21-119[»]
3VFOX-ray1.70B21-119[»]
3VFPX-ray1.85B21-119[»]
3VFRX-ray1.85B21-119[»]
3VFSX-ray1.85B21-119[»]
3VFTX-ray1.95B21-119[»]
3VFUX-ray1.65B21-119[»]
3VFVX-ray1.55B21-119[»]
3VFWX-ray2.30B21-119[»]
3VH8X-ray1.80B/E21-119[»]
3VRIX-ray1.60B21-119[»]
3VRJX-ray1.90B21-119[»]
3VWJX-ray3.09B21-119[»]
3VWKX-ray2.94B21-119[»]
3VXMX-ray2.50B21-119[»]
3VXNX-ray1.95B21-119[»]
3VXOX-ray2.61B/E21-119[»]
3VXPX-ray2.50B/E21-119[»]
3VXRX-ray2.40B21-119[»]
3VXSX-ray1.80B21-119[»]
3VXUX-ray2.70B/G21-119[»]
3W0WX-ray2.60B21-119[»]
3W39X-ray3.10B/E21-119[»]
3WL9X-ray1.66B21-119[»]
3WLBX-ray2.00B21-119[»]
3WUWX-ray2.00B22-119[»]
3X11X-ray2.15B21-119[»]
3X12X-ray1.80B21-119[»]
3X13X-ray1.80B21-119[»]
3X14X-ray2.00B21-119[»]
4E0KX-ray0.97A/B/C/D78-83[»]
4E0LX-ray1.70A/B/C/D82-89[»]
4E5XX-ray1.95B/E21-119[»]
4EN3X-ray2.57D21-119[»]
4EUPX-ray2.88B/E21-119[»]
4F7MX-ray2.40B/E21-119[»]
4F7PX-ray1.90B21-119[»]
4F7TX-ray1.70B/E21-119[»]
4FTVX-ray2.74B21-119[»]
4FXLX-ray1.40A21-119[»]
4G8GX-ray2.40B21-119[»]
4G8IX-ray1.60B21-119[»]
4G9DX-ray1.60B21-119[»]
4G9FX-ray1.90B21-119[»]
4GKNX-ray2.75B/E21-119[»]
4GKSX-ray2.35B/E21-119[»]
4GUPX-ray3.20B/D21-119[»]
4HKJX-ray3.00B/F/J/N21-119[»]
4HWZX-ray2.40B21-119[»]
4HX1X-ray1.80B21-119[»]
4I48X-ray2.80B21-119[»]
4I4WX-ray1.77B21-119[»]
4JFDX-ray2.46B21-119[»]
4JFEX-ray2.70B21-119[»]
4JFFX-ray2.43B21-119[»]
4JFOX-ray2.11B/E21-119[»]
4JFPX-ray1.91B/E21-119[»]
4JFQX-ray1.90B/E21-119[»]
4JQVX-ray1.50C21-119[»]
4JQXX-ray1.90C21-119[»]
4JRXX-ray2.30B21-119[»]
4JRYX-ray2.80B21-119[»]
4K71X-ray2.40C/F21-119[»]
4K7FX-ray2.00B/E21-119[»]
4KDTX-ray2.60C/D21-119[»]
4L29X-ray3.09B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3CX-ray2.64B/D/F/H/J/L/N/P/R/T/V/X/Z/b21-119[»]
4L3EX-ray2.56B21-119[»]
4L4TX-ray2.00B/F21-119[»]
4L4VX-ray1.90B/F21-119[»]
4LCWX-ray2.40B/F21-119[»]
4LCYX-ray1.60B/H21-119[»]
4LHUX-ray2.87B21-119[»]
4LNRX-ray2.00B21-119[»]
4M8VX-ray1.95A/B21-119[»]
4MJ5X-ray2.40B21-119[»]
4MJ6X-ray2.57B21-119[»]
4MJIX-ray2.99B/G21-119[»]
4MNQX-ray2.74B21-119[»]
4N0FX-ray3.02B/F/I/L21-119[»]
4N0UX-ray3.80B21-119[»]
4N8VX-ray2.50B/E21-119[»]
4NNXX-ray2.10B21-119[»]
4NNYX-ray1.90B21-119[»]
4NO0X-ray2.70B21-119[»]
4NO2X-ray2.00B21-119[»]
4NO3X-ray1.70B21-119[»]
4NO5X-ray2.10B22-119[»]
4NQCX-ray2.50B/F21-119[»]
4NQDX-ray2.20B/F21-119[»]
4NQEX-ray2.10B/F21-119[»]
4NQVX-ray2.39B/D/F/H/J/L21-119[»]
4NQXX-ray2.00B/D/F/H/J/L21-119[»]
4NT6X-ray1.84B21-118[»]
4O2CX-ray1.80B21-119[»]
4O2EX-ray1.98B/E21-119[»]
4O2FX-ray1.90B/E21-119[»]
4ONOX-ray2.70A21-119[»]
4PJ5X-ray2.00B/F21-119[»]
4PJ7X-ray2.50B/D21-119[»]
4PJ8X-ray3.30B21-119[»]
4PJ9X-ray2.00B21-119[»]
4PJAX-ray2.68B/D21-119[»]
4PJBX-ray2.85B/D21-119[»]
4PJCX-ray2.50B/D21-119[»]
4PJDX-ray2.78B/D21-119[»]
4PJEX-ray1.95B/D21-119[»]
4PJFX-ray2.45B/D21-119[»]
4PJGX-ray2.40B/D21-119[»]
4PJHX-ray2.00B/D21-119[»]
4PJIX-ray2.50B/D21-119[»]
4PJXX-ray2.25B/D21-119[»]
4PR5X-ray1.80B21-119[»]
4PRAX-ray1.85B21-119[»]
4PRBX-ray1.75B21-119[»]
4PRDX-ray1.75B21-119[»]
4PREX-ray1.65B21-119[»]
4PRHX-ray2.50B23-119[»]
4PRIX-ray2.40B21-119[»]
4PRNX-ray1.65B21-119[»]
4PRPX-ray2.50B21-119[»]
4QOKX-ray3.00B21-119[»]
4QRPX-ray2.90B/G21-119[»]
4QRQX-ray1.70B21-119[»]
4QRRX-ray3.00B21-119[»]
4QRSX-ray1.40B22-119[»]
4QRTX-ray1.40B21-119[»]
4QRUX-ray1.60B21-119[»]
4R9HX-ray1.90A/B/C/D21-119[»]
4RA3X-ray2.80A/B/C/D21-119[»]
4RAHX-ray1.40A21-119[»]
4RMQX-ray1.46A21-119[»]
4RMRX-ray1.53A21-119[»]
4RMSX-ray1.70A21-119[»]
4RMTX-ray1.24A21-117[»]
4RMUX-ray1.40A21-119[»]
4RMVX-ray1.46A21-119[»]
4RMWX-ray1.40A21-119[»]
4U1HX-ray1.59B21-119[»]
4U1IX-ray1.92B21-119[»]
4U1JX-ray1.38B21-119[»]
4U1KX-ray2.09B/E21-119[»]
4U1LX-ray2.06B/E21-119[»]
4U1MX-ray1.18B21-119[»]
4U1NX-ray1.77B21-119[»]
4U1SX-ray1.76B21-119[»]
4U6XX-ray1.68B21-119[»]
4U6YX-ray1.47B21-119[»]
4UQ2X-ray2.43B/D21-119[»]
4UQ3X-ray2.10B/D21-119[»]
4WC8X-ray1.91A/B/C/D/E/F/G/H/I/J/K/L83-89[»]
4WDIX-ray2.31B/E21-119[»]
4WJ5X-ray1.65B/E21-119[»]
4WO4X-ray2.50B21-119[»]
4WU5X-ray2.40B/E21-119[»]
4WU7X-ray2.30B/E21-119[»]
4WUUX-ray3.05B21-119[»]
4WW2X-ray2.48F21-119[»]
4WWKX-ray3.10D1-119[»]
4X0SX-ray2.03A83-89[»]
4X6CX-ray2.80B/D21-119[»]
4X6DX-ray2.98B/D21-119[»]
4X6EX-ray2.10B21-119[»]
4X6FX-ray1.91B21-119[»]
4XXCX-ray1.43C21-119[»]
4Z76X-ray1.88B/E21-119[»]
4Z77X-ray1.85B/E21-119[»]
4Z78X-ray2.30B/E/H21-119[»]
5B38X-ray2.30B21-119[»]
5B39X-ray2.50B21-119[»]
5BJTX-ray3.20B/D/F/H21-119[»]
5BRZX-ray2.62B21-119[»]
5BS0X-ray2.40B21-119[»]
5BXFX-ray2.85B/D1-119[»]
5C07X-ray2.11B/G21-119[»]
5C08X-ray2.33B/G21-119[»]
5C09X-ray2.48B/G21-119[»]
5C0AX-ray2.46B/G21-119[»]
5C0BX-ray2.03B/G21-119[»]
5C0CX-ray1.97B/G21-119[»]
5C0DX-ray1.68B21-119[»]
5C0EX-ray1.49B21-119[»]
5C0FX-ray1.46B21-119[»]
5C0GX-ray1.37B21-119[»]
5C0IX-ray1.53B21-119[»]
5C0JX-ray1.64B21-119[»]
5C9JX-ray2.40B21-118[»]
5CFHX-ray1.49A21-119[»]
5CKAX-ray1.70A21-119[»]
5CKGX-ray1.75A/B21-119[»]
5CS7X-ray2.10A21-119[»]
5CSBX-ray1.72A21-119[»]
5CSGX-ray1.50A21-119[»]
5D2LX-ray3.51B/D/H/N21-119[»]
5D2NX-ray2.10B/L21-119[»]
5D5MX-ray2.20B/D21-119[»]
5D7IX-ray2.00B/D21-119[»]
5D7JX-ray1.97D/F21-119[»]
5D7LX-ray3.40B/F21-119[»]
5D9SX-ray1.87B21-119[»]
5DDHX-ray1.50B21-119[»]
5DEFX-ray1.60B21-119[»]
5DEGX-ray1.83B21-119[»]
5E00X-ray1.70B21-119[»]
5E6IX-ray4.00D/J/N/U21-119[»]
5E9DX-ray2.51B/G21-119[»]
5ENWX-ray1.85B21-119[»]
5EO0X-ray1.70B21-119[»]
5EO1X-ray1.85B21-119[»]
5EOTX-ray2.10B21-119[»]
5EU3X-ray1.97B21-119[»]
5EU4X-ray2.12B/E21-119[»]
5EU5X-ray1.54B21-119[»]
5EU6X-ray2.02B21-119[»]
5EUOX-ray2.10B/D21-119[»]
5F1IX-ray2.90B/E/H/K/N/Q/T/W21-119[»]
5F7DX-ray2.30B21-119[»]
5F9JX-ray2.51B21-118[»]
5FA3X-ray1.86B21-119[»]
5FA4X-ray2.40B21-119[»]
5FDWX-ray2.70B21-119[»]
5GR7X-ray2.40B21-119[»]
5GRDX-ray1.80B21-119[»]
5GRGX-ray1.94B21-119[»]
5GSBX-ray1.80B21-119[»]
5GSDX-ray2.30B21-119[»]
5GSRX-ray2.20B/D20-119[»]
5GSVX-ray2.00B21-119[»]
5GSXX-ray2.50B/E21-119[»]
5HGAX-ray2.20B/E21-119[»]
5HGBX-ray2.40B/E/H/K21-119[»]
5HGDX-ray2.07B/E21-119[»]
5HGHX-ray2.39B21-119[»]
5HHMX-ray2.50B/G21-119[»]
5HHNX-ray2.03B21-119[»]
5HHOX-ray2.95B21-119[»]
5HHPX-ray1.90B21-119[»]
5HHQX-ray2.10B21-119[»]
5HYJX-ray3.06B/G21-119[»]
5IB1X-ray1.91B21-119[»]
5IB2X-ray1.44B21-119[»]
5IB3X-ray1.91B21-119[»]
5IB4X-ray1.95B21-119[»]
5IB5X-ray2.49B/E21-119[»]
5IEHX-ray1.50B21-119[»]
5IEKX-ray1.80B21-119[»]
5IM7X-ray2.50B/D21-119[»]
5INCX-ray2.88B/D21-119[»]
5INDX-ray2.13B/D21-119[»]
5IROX-ray2.64C/G/K/O/S/W21-119[»]
5ISZX-ray2.06B22-119[»]
5IUEX-ray2.62B/F/H/J19-119[»]
5J1AX-ray1.86B1-119[»]
5JHDX-ray2.46B/G21-119[»]
5JZIX-ray2.50B/G21-119[»]
5KNMX-ray3.30B21-119[»]
5L2JX-ray1.65B21-118[»]
5L2KX-ray3.20B21-118[»]
5MENX-ray2.81B21-119[»]
5MEOX-ray1.77B21-119[»]
5MEPX-ray2.71B/E21-119[»]
5MEQX-ray2.27B21-119[»]
5MERX-ray1.88B/E21-119[»]
5N1YX-ray1.39B21-119[»]
5N6BX-ray1.71B/E21-119[»]
5NHTX-ray3.20L21-119[»]
5NMEX-ray2.94B/G21-119[»]
5NMFX-ray2.89B/G21-119[»]
5NMGX-ray2.75B/G21-119[»]
5NMHX-ray1.55B21-119[»]
5NMKX-ray1.66B21-119[»]
5NQ1X-ray2.14B/E21-119[»]
5NQ3X-ray1.57B/E21-119[»]
5NQKX-ray3.25L21-119[»]
5OPIX-ray3.30B21-119[»]
5SWQX-ray2.00B21-119[»]
5T6WX-ray1.90B21-119[»]
5T6XX-ray1.69B21-119[»]
5T6YX-ray1.76B21-119[»]
5T6ZX-ray2.00B21-119[»]
5T70X-ray2.10B21-119[»]
5TEZX-ray1.70B20-119[»]
5TRZX-ray2.25B/D21-119[»]
5TS1X-ray2.30B/D/F/H21-119[»]
5TXSX-ray1.70B21-119[»]
5U16X-ray2.00B/D21-119[»]
5U17X-ray2.15F/H21-119[»]
5U1RX-ray2.70F/H21-119[»]
5U2VX-ray2.20B/D21-119[»]
5U6QX-ray1.90F/H21-119[»]
5U72X-ray2.50F/H21-119[»]
5U98X-ray2.00B/E21-119[»]
5V5LX-ray2.00B/D21-119[»]
5V5MX-ray2.88B/D21-119[»]
5VGDX-ray2.32B21-119[»]
5VGEX-ray2.60B21-119[»]
5VUDX-ray2.00B21-119[»]
5VUEX-ray1.80B21-119[»]
5VUFX-ray1.90B21-119[»]
5VVPX-ray2.00B21-119[»]
5VWDX-ray1.80B21-119[»]
5VWFX-ray1.80B21-119[»]
5VWHX-ray1.65B21-119[»]
5VWJX-ray2.00B21-119[»]
5VZ5X-ray2.59B21-119[»]
5W1VX-ray3.31B/G/L/Q21-119[»]
5W1WX-ray3.10B/G/L/Q21-119[»]
5W67X-ray2.30B21-119[»]
5W69X-ray2.80B/D/F/H21-119[»]
5W6AX-ray1.74B/D21-119[»]
5WERX-ray3.41B/E/H/K21-119[»]
5WHKX-ray2.50B1-119[»]
5WJLX-ray3.15B/E/H21-119[»]
5WJNX-ray2.85B/E/H21-119[»]
5WKEX-ray1.69B21-119[»]
5WKFX-ray2.95B/G21-119[»]
5WKGX-ray2.06B21-119[»]
5WKHX-ray3.20B/G21-119[»]
5WKIX-ray2.75B21-119[»]
5WL1X-ray1.38B21-119[»]
5WMNX-ray1.82B/D21-119[»]
5WMOX-ray1.62B21-119[»]
5WMPX-ray1.60B21-119[»]
5WMQX-ray1.40B21-119[»]
5WMRX-ray1.58B21-119[»]
5WSHX-ray2.00B21-119[»]
5WWIX-ray3.19B20-119[»]
5WWJX-ray2.29B/D21-119[»]
5WWUX-ray2.79B21-119[»]
5WXCX-ray2.29B/D20-119[»]
5WXDX-ray3.29B20-119[»]
5XOSX-ray1.70B21-119[»]
5XOTX-ray2.79B21-119[»]
5XOVX-ray2.68B/E21-119[»]
5YXNX-ray2.03D20-119[»]
5YXUX-ray2.70D/H20-119[»]
6AEEX-ray3.30B/E21-119[»]
6AM5X-ray2.39B21-119[»]
6AMTX-ray2.50B/E21-119[»]
6AMUX-ray2.15B21-119[»]
6APNX-ray2.22A/B16-119[»]
6AT5X-ray1.50B1-119[»]
6AT9X-ray2.95B21-119[»]
6AVFX-ray2.03M21-119[»]
6AVGX-ray2.60A/H13-119[»]
6BJ2X-ray3.35B21-119[»]
6BJ3X-ray1.90B21-119[»]
6BJ8X-ray1.75B21-119[»]
6BXPX-ray1.45B21-119[»]
6BXQX-ray1.58C21-119[»]
6C09X-ray2.95B21-119[»]
6C15X-ray3.21B21-119[»]
6C97X-ray2.00B/D21-119[»]
6C98X-ray1.85B/D21-119[»]
6C99X-ray2.00B/D21-119[»]
6CUGX-ray2.40B21-119[»]
6D29X-ray1.88B21-119[»]
6D2BX-ray2.04B21-119[»]
6D2RX-ray1.83B21-119[»]
6D2TX-ray1.90B21-119[»]
6D64X-ray1.70B21-119[»]
6D78X-ray2.35B21-119[»]
6DKPX-ray2.97B21-119[»]
6EI2X-ray1.61B21-119[»]
6ENYelectron microscopy5.80B21-119[»]
6EQAX-ray3.16B21-119[»]
6EQBX-ray2.81B21-119[»]
6EWAX-ray2.39B/F21-119[»]
6EWCX-ray3.20B/F21-119[»]
6EWOX-ray2.30B/F21-119[»]
6FGBX-ray2.90B21-119[»]
6G3JX-ray2.45B/E21-119[»]
6G3KX-ray2.90B/E21-119[»]
6GGMX-ray2.73B/D21-119[»]
6GH1X-ray2.10B/D/F/H21-119[»]
6GH4X-ray2.16B/D/F/H21-119[»]
6GHNX-ray2.54B/D21-119[»]
6GK3electron microscopy3.90A/B/C/D/E/F/G/H42-105[»]
6GL1X-ray2.62B/D/F/H21-119[»]
6ID4X-ray2.40B/F21-119[»]
6ILMelectron microscopy3.40F21-119[»]
6MT3X-ray1.21C21-119[»]
6MT4X-ray1.55B21-119[»]
6MT5X-ray1.55B21-119[»]
6MT6X-ray1.31C21-119[»]
6MTLX-ray1.35B21-119[»]
6MTMX-ray3.00B21-119[»]
6OPDX-ray1.79B21-119[»]
6PTBX-ray2.15B/E21-119[»]
6PTEX-ray1.90B/F/I/L21-119[»]
6Q3KX-ray1.50B21-119[»]
6Q3SX-ray2.50B21-119[»]
SMRiP61769
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107044, 44 interactors
DIPiDIP-6055N
IntActiP61769, 132 interactors
MINTiP61769
STRINGi9606.ENSP00000452780

Chemistry databases

BindingDBiP61769
DrugBankiDB02740 3-Indolebutyric Acid
DB09130 Copper
DB04464 N-Formylmethionine
DB11130 Opium

PTM databases

iPTMnetiP61769
PhosphoSitePlusiP61769
SwissPalmiP61769

Polymorphism and mutation databases

BioMutaiB2M
DMDMi48428791

2D gel databases

DOSAC-COBS-2DPAGEiP61769
OGPiP61769
SWISS-2DPAGEiP61769

Proteomic databases

CPTACiCPTAC-1232
EPDiP61769
jPOSTiP61769
MassIVEiP61769
MaxQBiP61769
PaxDbiP61769
PeptideAtlasiP61769
PRIDEiP61769
ProteomicsDBi12611
57333
TopDownProteomicsiP61769

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P61769

The DNASU plasmid repository

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DNASUi
567

Genome annotation databases

EnsembliENST00000559916; ENSP00000453350; ENSG00000166710
ENST00000561424; ENSP00000453191; ENSG00000166710
ENST00000617605; ENSP00000481426; ENSG00000273686
ENST00000631573; ENSP00000488548; ENSG00000273686
ENST00000631728; ENSP00000488321; ENSG00000273686
ENST00000648006; ENSP00000497910; ENSG00000166710
GeneIDi567
KEGGihsa:567
UCSCiuc001zuc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
567
DisGeNETi567

GeneCards: human genes, protein and diseases

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GeneCardsi
B2M
HGNCiHGNC:914 B2M
HPAiCAB002572
HPA006361
MalaCardsiB2M
MIMi105200 phenotype
109700 gene
241600 phenotype
neXtProtiNX_P61769
OpenTargetsiENSG00000166710
Orphaneti34592 Immunodeficiency by defective expression of MHC class I
314652 Variant ABeta2M amyloidosis
PharmGKBiPA25207

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J15A Eukaryota
ENOG410YTDG LUCA
GeneTreeiENSGT00690000102227
InParanoidiP61769
KOiK08055
OMAiHTEFTPT
OrthoDBi1556447at2759
PhylomeDBiP61769
TreeFamiTF334167

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-977225 Amyloid fiber formation
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP61769

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
B2M human
EvolutionaryTraceiP61769

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Beta-2_microglobulin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
567
PharosiP61769

Protein Ontology

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PROi
PR:P61769

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166710 Expressed in 234 organ(s), highest expression level in leukocyte
ExpressionAtlasiP61769 baseline and differential
GenevisibleiP61769 HS

Family and domain databases

CDDicd05770 IgC_beta2m, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2MG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P61769
Secondary accession number(s): P01884
, Q540F8, Q6IAT8, Q9UCK0, Q9UD48, Q9UDF4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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