STXBP1

Functionⁱ

Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
phospholipase binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase binding Source: Ensembl
protein N-terminus binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
  Castello A., Fischer B., Eichelbaum K., Horos R., Beckmann B.M., Strein C., Davey N.E., Humphreys D.T., Preiss T., Steinmetz L.M., Krijgsveld J., Hentze M.W.
  Cell 149:1393-1406(2012) [PubMed] [Europe PMC] [Abstract]
SNARE binding Source: UniProtKB
syntaxin-1 binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.7
  "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18."
  Tian J.H., Das S., Sheng Z.H.
  J. Biol. Chem. 278:26265-26274(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: INTERACTION WITH STX1A.
- "Munc18/Syntaxin interaction kinetics control secretory vesicle dynamics."
  Rickman C., Duncan R.R.
  J Biol Chem 285:3965-3972(2010) [PubMed] [Europe PMC] [Abstract]
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "A role for Sec1/Munc18 proteins in platelet exocytosis."
  Schraw T.D., Lemons P.P., Dean W.L., Whiteheart S.W.
  Biochem J 374:207-217(2003) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

PathwayCommonsⁱ	P61764
Reactomeⁱ	R-HSA-181429, Serotonin Neurotransmitter Release Cycle [P61764-1] R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle [P61764-1] R-HSA-210500, Glutamate Neurotransmitter Release Cycle [P61764-1] R-HSA-212676, Dopamine Neurotransmitter Release Cycle [P61764-1] R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle [P61764-1] R-HSA-422356, Regulation of insulin secretion R-HSA-6794361, Neurexins and neuroligins R-HSA-888590, GABA synthesis, release, reuptake and degradation [P61764-1]
SIGNORⁱ	P61764

Protein family/group databases

TCDBⁱ	1.F.1.1.3, the synaptosomal vesicle fusion pore (svf-pore) family

TCDBⁱ

1.F.1.1.3, the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syntaxin-binding protein 1 Alternative name(s): MUNC18-1 N-Sec1 Protein unc-18 homolog 1 Short name: Unc18-1 Protein unc-18 homolog A Short name: Unc-18A p67
Gene namesⁱ	Name:STXBP1 Synonyms:UNC18A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11444, STXBP1
MIMⁱ	602926, gene
neXtProtⁱ	NX_P61764
VEuPathDBⁱ	HostDB:ENSG00000136854.17

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epileptic encephalopathy, early infantile, 4 (EIEE4)11 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Affected individuals have neonatal or infantile onset of seizures, profound mental retardation, and MRI evidence of brain hypomyelination.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078631	42	S → F in EIEE4. 1 Publication	1
Natural variantⁱVAR_046205	84	V → D in EIEE4; may alter protein structure. 1 PublicationCorresponds to variant dbSNP:rs121918320EnsemblClinVar.	1
Natural variantⁱVAR_078757	122 – 594	Missing in EIEE4. 1 PublicationAdd BLAST	473
Natural variantⁱVAR_046206	180	C → Y in EIEE4; reduced thermostability; decreased binding to STX1A. 1 PublicationCorresponds to variant dbSNP:rs121918318EnsemblClinVar.	1
Natural variantⁱVAR_073149	183	L → R in EIEE4. 1 Publication	1
Natural variantⁱVAR_078633	190	R → W in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053355Ensembl.	1
Natural variantⁱVAR_073150	251	A → T in EIEE4. 1 Publication	1
Natural variantⁱVAR_078758	281	L → P in EIEE4. 1 Publication	1
Natural variantⁱVAR_071814	283	E → K in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs587777310EnsemblClinVar.	1
Natural variantⁱVAR_071815	285	D → Y in EIEE4. 1 Publication	1
Natural variantⁱVAR_078759	292	R → H in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053361EnsemblClinVar.	1
Natural variantⁱVAR_078634	354	C → R in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs886041337EnsemblClinVar.	1
Natural variantⁱVAR_078218	406	R → C in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053367EnsemblClinVar.	1
Natural variantⁱVAR_073151	406	R → H in EIEE4. 2 PublicationsCorresponds to variant dbSNP:rs886041246EnsemblClinVar.	1
Natural variantⁱVAR_046207	443	M → R in EIEE4; may alter protein structure. 1 PublicationCorresponds to variant dbSNP:rs121918319EnsemblClinVar.	1
Natural variantⁱVAR_071816	445	H → P in EIEE4. 1 Publication	1
Natural variantⁱVAR_073153	480	P → L in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053368EnsemblClinVar.	1
Natural variantⁱVAR_046208	544	G → D in EIEE4; may alter protein structure. 1 PublicationCorresponds to variant dbSNP:rs121918317EnsemblClinVar.	1
Natural variantⁱVAR_073154	574	T → P in EIEE4. 1 Publication	1

Keywords - Diseaseⁱ

Disease variant, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6812
GeneReviewsⁱ	STXBP1
MalaCards human disease database More...MalaCardsⁱ	STXBP1
MIMⁱ	612164, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000136854
Orphanetⁱ	495818, 9q33.3q34.11 microdeletion syndrome 3095, Atypical Rett syndrome 178469, Autosomal dominant non-syndromic intellectual disability 33069, Dravet syndrome 1934, Early infantile epileptic encephalopathy 442835, Undetermined early-onset epileptic encephalopathy 3451, West syndrome
PharmGKBⁱ	PA36241

Miscellaneous databases

Pharosⁱ	P61764, Tbio

Pharosⁱ

P61764, Tbio

Genetic variation databases

BioMutaⁱ	STXBP1
DMDMⁱ	50403646

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206277	1 – 594	Syntaxin-binding protein 1Add BLAST		594

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	476	PhosphoserineBy similarity	1
Modified residueⁱ	509	PhosphoserineBy similarity	1
Modified residueⁱ	511	PhosphoserineBy similarity	1
Modified residueⁱ	516	PhosphoserineBy similarity	1
Modified residueⁱ	593	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P61764
jPOSTⁱ	P61764
MassIVEⁱ	P61764
PaxDbⁱ	P61764
PeptideAtlas More...PeptideAtlasⁱ	P61764
PRIDEⁱ	P61764
ProteomicsDBⁱ	57331 57332 [P61764-2]

PTM databases

iPTMnetⁱ	P61764
MetOSiteⁱ	P61764
PhosphoSitePlusⁱ	P61764

Expressionⁱ

Tissue specificityⁱ

Brain and spinal cord. Highly enriched in axons.

Gene expression databases

Bgeeⁱ	ENSG00000136854, Expressed in primary visual cortex and 236 other tissues
ExpressionAtlasⁱ	P61764, baseline and differential
Genevisibleⁱ	P61764, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000136854, Tissue enriched (brain)

HPAⁱ

ENSG00000136854, Tissue enriched (brain)

Interactionⁱ

Subunit structureⁱ

Interacts with SYTL4 (By similarity).

Interacts with STX1A (PubMed:12730201).

Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation (PubMed:27597756).

Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity).

Interacts with CABP5 (By similarity).

By similarity2 Publications

Binary interactionsⁱ

Hide details

P61764

With	#Exp.	IntAct
APP [P05067]	7	EBI-960169,EBI-77613
C19orf57 [Q0VDD7]	3	EBI-960169,EBI-741210
CENPP [Q6IPU0]	3	EBI-960169,EBI-10250303
DRD4 [P21917]	3	EBI-960169,EBI-8592297
HSPA8 [P11142]	2	EBI-960169,EBI-351896
HTT [P42858]	7	EBI-960169,EBI-466029
KLF11 [O14901]	3	EBI-960169,EBI-948266
MAPK1 [P28482]	3	EBI-960169,EBI-959949
MEOX2 [P50222]	3	EBI-960169,EBI-748397
NCOR1 [O75376]	3	EBI-960169,EBI-347233
PSEN1 [P49768]	2	EBI-960169,EBI-297277
SPICE1 [Q8N0Z3]	3	EBI-960169,EBI-2361917
STX11 [O75558]	6	EBI-960169,EBI-714135
STX19 [Q8N4C7]	9	EBI-960169,EBI-8484990
STX5 [Q13190]	6	EBI-960169,EBI-714206
SYTL4 [Q96C24]	3	EBI-960169,EBI-747142
TRIM38 [O00635]	9	EBI-960169,EBI-2130415

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	112681, 89 interactors
IntActⁱ	P61764, 73 interactors
Molecular INTeraction database More...MINTⁱ	P61764
STRINGⁱ	9606.ENSP00000362399

Miscellaneous databases

RNActⁱ	P61764, protein

RNActⁱ

P61764, protein

Structureⁱ

3D structure databases

SMRⁱ	P61764
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1300, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155127
HOGENOMⁱ	CLU_009210_2_0_1
InParanoidⁱ	P61764
OMAⁱ	FYPRESH
Database of Orthologous Groups More...OrthoDBⁱ	725424at2759
PhylomeDBⁱ	P61764
TreeFamⁱ	TF313242

Family and domain databases

Gene3Dⁱ	3.40.50.1910, 1 hit 3.40.50.2060, 1 hit 3.90.830.10, 1 hit
InterProⁱ	View protein in InterPro IPR043154, Sec-1-like_dom1 IPR027482, Sec-1-like_dom2 IPR043127, Sec-1-like_dom3a IPR001619, Sec1-like IPR036045, Sec1-like_sf
PANTHERⁱ	PTHR11679, PTHR11679, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00995, Sec1, 1 hit
PIRSFⁱ	PIRSF005715, VPS45_Sec1, 1 hit
SUPFAMⁱ	SSF56815, SSF56815, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P61764-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI 
        60         70         80         90        100
MTEGITIVED INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR 
       110        120        130        140        150
AAHVFFTDSC PDALFNELVK SRAAKVIKTL TEINIAFLPY ESQVYSLDSA 
       160        170        180        190        200
DSFQSFYSPH KAQMKNPILE RLAEQIATLC ATLKEYPAVR YRGEYKDNAL 
       210        220        230        240        250
LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS SPVLHELTFQ 
       260        270        280        290        300
AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS 
       310        320        330        340        350
QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL 
       360        370        380        390        400
AEDCMKHYQG TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS 
       410        420        430        440        450
TYDKIRIILL YIFLKNGITE ENLNKLIQHA QIPPEDSEII TNMAHLGVPI 
       460        470        480        490        500
VTDSTLRRRS KPERKERISE QTYQLSRWTP IIKDIMEDTI EDKLDTKHYP 
       510        520        530        540        550
YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF ILGGVSLNEM 
       560        570        580        590 
RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS

Length:594

Mass (Da):67,569

Last modified:June 7, 2004 - v1

Checksum:ⁱ2DD0715F875CE0F3

GO

Isoform 2 (identifier: P61764-2) [UniParc] [UniParc]FASTA Add to basket

Also known as: BE, HUNC18b

The sequence of this isoform differs from the canonical sequence as follows:
576-594: QKLLDTLKKLNKTDEEISS → TKFLMDLRHPDFRESSRVSFEDQAPTME

« Hide

        10         20         30         40         50
MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI 
        60         70         80         90        100
MTEGITIVED INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR 
       110        120        130        140        150
AAHVFFTDSC PDALFNELVK SRAAKVIKTL TEINIAFLPY ESQVYSLDSA 
       160        170        180        190        200
DSFQSFYSPH KAQMKNPILE RLAEQIATLC ATLKEYPAVR YRGEYKDNAL 
       210        220        230        240        250
LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS SPVLHELTFQ 
       260        270        280        290        300
AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS 
       310        320        330        340        350
QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL 
       360        370        380        390        400
AEDCMKHYQG TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS 
       410        420        430        440        450
TYDKIRIILL YIFLKNGITE ENLNKLIQHA QIPPEDSEII TNMAHLGVPI 
       460        470        480        490        500
VTDSTLRRRS KPERKERISE QTYQLSRWTP IIKDIMEDTI EDKLDTKHYP 
       510        520        530        540        550
YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF ILGGVSLNEM 
       560        570        580        590        600
RCAYEVTQAN GKWEVLIGST HILTPTKFLM DLRHPDFRES SRVSFEDQAP 

TME

Show »

Length:603

Mass (Da):68,736

Checksum:ⁱ73D8337768259493

GO

Computationally mapped potential isoform sequencesⁱ

There are 15 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0D9SG72	A0A0D9SG72_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	580	Annotation score:
	A0A1B0GVQ5	A0A1B0GVQ5_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	577	Annotation score:
	A0A1B0GTP9	A0A1B0GTP9_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	589	Annotation score:
	A0A1B0GWF2	A0A1B0GWF2_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	574	Annotation score:
	A0A2R8Y5D4	A0A2R8Y5D4_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	580	Annotation score:
	A0A1B0GW76	A0A1B0GW76_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	360	Annotation score:
	A0A096LP33	A0A096LP33_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	75	Annotation score:
	A0A096LP52	A0A096LP52_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	119	Annotation score:
	A0A0D9SEP9	A0A0D9SEP9_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	100	Annotation score:
	A0A0D9SEH5	A0A0D9SEH5_HUMAN	Syntaxin-binding protein 1 Syntaxin-binding protein 1	STXBP1	102	Annotation score:
There are more potential isoformsShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078631	42	S → F in EIEE4. 1 Publication	1
Natural variantⁱVAR_078632	80	S → P Probable disease-associated variant found in a patient with epileptic encephalopathy. 1 Publication	1
Natural variantⁱVAR_046205	84	V → D in EIEE4; may alter protein structure. 1 PublicationCorresponds to variant dbSNP:rs121918320EnsemblClinVar.	1
Natural variantⁱVAR_073148	84	V → I No effect on subcellular location. 1 PublicationCorresponds to variant dbSNP:rs34830702EnsemblClinVar.	1
Natural variantⁱVAR_078757	122 – 594	Missing in EIEE4. 1 PublicationAdd BLAST	473
Natural variantⁱVAR_046206	180	C → Y in EIEE4; reduced thermostability; decreased binding to STX1A. 1 PublicationCorresponds to variant dbSNP:rs121918318EnsemblClinVar.	1
Natural variantⁱVAR_073149	183	L → R in EIEE4. 1 Publication	1
Natural variantⁱVAR_078633	190	R → W in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053355Ensembl.	1
Natural variantⁱVAR_073150	251	A → T in EIEE4. 1 Publication	1
Natural variantⁱVAR_078758	281	L → P in EIEE4. 1 Publication	1
Natural variantⁱVAR_071814	283	E → K in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs587777310EnsemblClinVar.	1
Natural variantⁱVAR_071815	285	D → Y in EIEE4. 1 Publication	1
Natural variantⁱVAR_078759	292	R → H in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053361EnsemblClinVar.	1
Natural variantⁱVAR_078634	354	C → R in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs886041337EnsemblClinVar.	1
Natural variantⁱVAR_078218	406	R → C in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053367EnsemblClinVar.	1
Natural variantⁱVAR_073151	406	R → H in EIEE4. 2 PublicationsCorresponds to variant dbSNP:rs886041246EnsemblClinVar.	1
Natural variantⁱVAR_073152	431	Q → L Variant of uncertain significance; expressed at low levels compared with wild-type; no effect on subcellular location. 1 Publication	1
Natural variantⁱVAR_046207	443	M → R in EIEE4; may alter protein structure. 1 PublicationCorresponds to variant dbSNP:rs121918319EnsemblClinVar.	1
Natural variantⁱVAR_071816	445	H → P in EIEE4. 1 Publication	1
Natural variantⁱVAR_073153	480	P → L in EIEE4. 1 PublicationCorresponds to variant dbSNP:rs796053368EnsemblClinVar.	1
Natural variantⁱVAR_078635	544	G → C Found in a patient with Lennox-Gastaut syndrome; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_046208	544	G → D in EIEE4; may alter protein structure. 1 PublicationCorresponds to variant dbSNP:rs121918317EnsemblClinVar.	1
Natural variantⁱVAR_078636	570	T → A Probable disease-associated variant found in a patient with epileptic encephalopathy. 1 Publication	1
Natural variantⁱVAR_073154	574	T → P in EIEE4. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006713	576 – 594	QKLLD…EEISS → TKFLMDLRHPDFRESSRVSF EDQAPTME in isoform 2. 1 PublicationAdd BLAST		19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63851 mRNA Translation: BAA19483.1 AF004562 mRNA Translation: AAC39688.1 AF004563 mRNA Translation: AAC39689.1 Y12723 mRNA Translation: CAA73255.1 AL162426 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87679.1 CH471090 Genomic DNA Translation: EAW87681.1 BC015749 mRNA Translation: AAH15749.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35146.1 CCDS6874.1 [P61764-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001027392.1, NM_001032221.3 [P61764-1] NP_003156.1, NM_003165.3 [P61764-2]

Genome annotation databases

Ensemblⁱ	ENST00000373299; ENSP00000362396; ENSG00000136854 [P61764-1] ENST00000373302; ENSP00000362399; ENSG00000136854 [P61764-2]
GeneIDⁱ	6812
KEGGⁱ	hsa:6812
UCSC genome browser More...UCSCⁱ	uc004brk.2, human uc004brl.3, human

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P61764	Syntaxin-binding protein 1		BOVIN		594	UniRef100_P61764
Syntaxin-binding protein 1		MOUSE		594
Syntaxin-binding protein 1		PONAB		594
Syntaxin-binding protein 1	)	RAT		594
Syntaxin-binding protein 1 isoform X2		PIG		594
+26
P61764-2	Syntaxin-binding protein 1 isoform a		PIG		603	UniRef100_A0A480WBE9
Uncharacterized protein		MACNE		603
Uncharacterized protein		BOBOX		603
Syntaxin binding protein 1		MACMU		603
Uncharacterized protein		RHIRO		603
+17

Protein	Similar proteins		Species	Score	Length	Source
P61764	Syntaxin-binding protein 1		BOVIN		594	UniRef90_P61764
Syntaxin-binding protein 1		MOUSE		594
Syntaxin-binding protein 1		PONAB		594
Syntaxin-binding protein 1	)	RAT		594
Syntaxin-binding protein 1		CHICK		594
+334

Protein	Similar proteins		Species	Score	Length	Source
P61764	Syntaxin-binding protein 1		BOVIN		594	UniRef50_P61764
Syntaxin-binding protein 1		MOUSE		594
Syntaxin-binding protein 1		PONAB		594
Syntaxin-binding protein 1	)	RAT		594
Syntaxin-binding protein 1		CHICK		594
+335

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63851 mRNA Translation: BAA19483.1 AF004562 mRNA Translation: AAC39688.1 AF004563 mRNA Translation: AAC39689.1 Y12723 mRNA Translation: CAA73255.1 AL162426 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87679.1 CH471090 Genomic DNA Translation: EAW87681.1 BC015749 mRNA Translation: AAH15749.1
CCDSⁱ	CCDS35146.1 CCDS6874.1 [P61764-2]
RefSeqⁱ	NP_001027392.1, NM_001032221.3 [P61764-1] NP_003156.1, NM_003165.3 [P61764-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6L03	X-ray	2.08	F	141-149	[»]
SMRⁱ	P61764
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	112681, 89 interactors
IntActⁱ	P61764, 73 interactors
MINTⁱ	P61764
STRINGⁱ	9606.ENSP00000362399

Protein family/group databases

TCDBⁱ	1.F.1.1.3, the synaptosomal vesicle fusion pore (svf-pore) family

TCDBⁱ

1.F.1.1.3, the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetⁱ	P61764
MetOSiteⁱ	P61764
PhosphoSitePlusⁱ	P61764

Genetic variation databases

BioMutaⁱ	STXBP1
DMDMⁱ	50403646

Proteomic databases

EPDⁱ	P61764
jPOSTⁱ	P61764
MassIVEⁱ	P61764
PaxDbⁱ	P61764
PeptideAtlasⁱ	P61764
PRIDEⁱ	P61764
ProteomicsDBⁱ	57331 57332 [P61764-2]

Protocols and materials databases

Antibodypediaⁱ	2191, 484 antibodies
The DNASU plasmid repository More...DNASUⁱ	6812

Genome annotation databases

Ensemblⁱ	ENST00000373299; ENSP00000362396; ENSG00000136854 [P61764-1] ENST00000373302; ENSP00000362399; ENSG00000136854 [P61764-2]
GeneIDⁱ	6812
KEGGⁱ	hsa:6812
UCSCⁱ	uc004brk.2, human uc004brl.3, human

Organism-specific databases

CTDⁱ	6812
DisGeNETⁱ	6812
GeneCardsⁱ	STXBP1
GeneReviewsⁱ	STXBP1
HGNCⁱ	HGNC:11444, STXBP1
HPAⁱ	ENSG00000136854, Tissue enriched (brain)
MalaCardsⁱ	STXBP1
MIMⁱ	602926, gene 612164, phenotype
neXtProtⁱ	NX_P61764
OpenTargetsⁱ	ENSG00000136854
Orphanetⁱ	495818, 9q33.3q34.11 microdeletion syndrome 3095, Atypical Rett syndrome 178469, Autosomal dominant non-syndromic intellectual disability 33069, Dravet syndrome 1934, Early infantile epileptic encephalopathy 442835, Undetermined early-onset epileptic encephalopathy 3451, West syndrome
PharmGKBⁱ	PA36241
VEuPathDBⁱ	HostDB:ENSG00000136854.17
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1300, Eukaryota
GeneTreeⁱ	ENSGT00940000155127
HOGENOMⁱ	CLU_009210_2_0_1
InParanoidⁱ	P61764
OMAⁱ	FYPRESH
OrthoDBⁱ	725424at2759
PhylomeDBⁱ	P61764
TreeFamⁱ	TF313242

Enzyme and pathway databases

PathwayCommonsⁱ	P61764
Reactomeⁱ	R-HSA-181429, Serotonin Neurotransmitter Release Cycle [P61764-1] R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle [P61764-1] R-HSA-210500, Glutamate Neurotransmitter Release Cycle [P61764-1] R-HSA-212676, Dopamine Neurotransmitter Release Cycle [P61764-1] R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle [P61764-1] R-HSA-422356, Regulation of insulin secretion R-HSA-6794361, Neurexins and neuroligins R-HSA-888590, GABA synthesis, release, reuptake and degradation [P61764-1]
SIGNORⁱ	P61764

Miscellaneous databases

BioGRID-ORCSⁱ	6812, 41 hits in 874 CRISPR screens
ChiTaRSⁱ	STXBP1, human
GeneWikiⁱ	STXBP1
GenomeRNAiⁱ	6812
Pharosⁱ	P61764, Tbio
Protein Ontology More...PROⁱ	PR:P61764
RNActⁱ	P61764, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136854, Expressed in primary visual cortex and 236 other tissues
ExpressionAtlasⁱ	P61764, baseline and differential
Genevisibleⁱ	P61764, HS

Family and domain databases

Gene3Dⁱ	3.40.50.1910, 1 hit 3.40.50.2060, 1 hit 3.90.830.10, 1 hit
InterProⁱ	View protein in InterPro IPR043154, Sec-1-like_dom1 IPR027482, Sec-1-like_dom2 IPR043127, Sec-1-like_dom3a IPR001619, Sec1-like IPR036045, Sec1-like_sf
PANTHERⁱ	PTHR11679, PTHR11679, 1 hit
Pfamⁱ	View protein in Pfam PF00995, Sec1, 1 hit
PIRSFⁱ	PIRSF005715, VPS45_Sec1, 1 hit
SUPFAMⁱ	SSF56815, SSF56815, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STXB1_HUMAN
Accessionⁱ	P61764Primary (citable) accession number: P61764 Secondary accession number(s): B1AM97 , Q28208, Q62759, Q64320, Q68CM6, Q96TG8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	June 7, 2004
	Last modified:	February 10, 2021
	This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with genetic variants
List of human entries with genetic variants

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P61764 (STXB1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Syntaxin-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P61764

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ