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Protein

Prefoldin subunit 3

Gene

Vbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

  • tubulin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:Vbp1
Synonyms:Pfdn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1333804 Vbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001536532 – 196Prefoldin subunit 3Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei58N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61759
MaxQBiP61759
PaxDbiP61759
PRIDEiP61759

2D gel databases

REPRODUCTION-2DPAGEiIPI00121851
P61759

PTM databases

iPTMnetiP61759
PhosphoSitePlusiP61759

Expressioni

Gene expression databases

BgeeiENSMUSG00000031197 Expressed in 307 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_VBP1
ExpressionAtlasiP61759 baseline and differential
GenevisibleiP61759 MM

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204503, 10 interactors
IntActiP61759, 11 interactors
MINTiP61759
STRINGi10090.ENSMUSP00000033540

Structurei

3D structure databases

ProteinModelPortaliP61759
SMRiP61759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313 Eukaryota
ENOG410XRZ8 LUCA
GeneTreeiENSGT00390000018904
HOGENOMiHOG000184744
HOVERGENiHBG053576
InParanoidiP61759
OMAiQITVMEV
OrthoDBiEOG091G0P5N
PhylomeDBiP61759
TreeFamiTF313706

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR016655 PFD3
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PANTHERiPTHR12409 PTHR12409, 1 hit
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
PIRSFiPIRSF016396 Prefoldin_subunit_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P61759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAKDGCGL ETAAGNGRRL HLGIPEAVFV EDVDSFMKQP GNETADTVLK
60 70 80 90 100
KLDEQYQKYK FMELNLAQKK RRLKGQIPEI KQTLEILKYM QKKKESTNSM
110 120 130 140 150
ETRFLLADNL YCKASVPPTD KVCLWLGANV MLEYDIDEAQ ALLEKNLSTA
160 170 180 190
TKNLDSLEED LDFLRDQFTT TEVNMARVYN WDVKRRNKDD STKNKA
Length:196
Mass (Da):22,436
Last modified:August 30, 2005 - v2
Checksum:iE5B9179296418DDE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TIR6Q3TIR6_MOUSE
Prefoldin subunit 3
Vbp1
130Annotation score:

Sequence cautioni

The sequence AAC23908 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002282 mRNA Translation: BAB21986.1
AK008847 mRNA Translation: BAB25926.1
AK077923 mRNA Translation: BAC37066.1
AK151527 mRNA Translation: BAE30475.1
AK153069 mRNA Translation: BAE31695.1
AK159284 mRNA Translation: BAE34961.1
AK167064 mRNA Translation: BAE39225.1
AK169185 mRNA Translation: BAE40962.1
U96760 mRNA Translation: AAC23908.1 Different initiation.
CCDSiCCDS41032.1
RefSeqiNP_035822.2, NM_011692.2
UniGeneiMm.8294

Genome annotation databases

EnsembliENSMUST00000033540; ENSMUSP00000033540; ENSMUSG00000031197
GeneIDi22327
KEGGimmu:22327
UCSCiuc009tqd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002282 mRNA Translation: BAB21986.1
AK008847 mRNA Translation: BAB25926.1
AK077923 mRNA Translation: BAC37066.1
AK151527 mRNA Translation: BAE30475.1
AK153069 mRNA Translation: BAE31695.1
AK159284 mRNA Translation: BAE34961.1
AK167064 mRNA Translation: BAE39225.1
AK169185 mRNA Translation: BAE40962.1
U96760 mRNA Translation: AAC23908.1 Different initiation.
CCDSiCCDS41032.1
RefSeqiNP_035822.2, NM_011692.2
UniGeneiMm.8294

3D structure databases

ProteinModelPortaliP61759
SMRiP61759
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204503, 10 interactors
IntActiP61759, 11 interactors
MINTiP61759
STRINGi10090.ENSMUSP00000033540

PTM databases

iPTMnetiP61759
PhosphoSitePlusiP61759

2D gel databases

REPRODUCTION-2DPAGEiIPI00121851
P61759

Proteomic databases

EPDiP61759
MaxQBiP61759
PaxDbiP61759
PRIDEiP61759

Protocols and materials databases

DNASUi22327
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033540; ENSMUSP00000033540; ENSMUSG00000031197
GeneIDi22327
KEGGimmu:22327
UCSCiuc009tqd.1 mouse

Organism-specific databases

CTDi7411
MGIiMGI:1333804 Vbp1

Phylogenomic databases

eggNOGiKOG3313 Eukaryota
ENOG410XRZ8 LUCA
GeneTreeiENSGT00390000018904
HOGENOMiHOG000184744
HOVERGENiHBG053576
InParanoidiP61759
OMAiQITVMEV
OrthoDBiEOG091G0P5N
PhylomeDBiP61759
TreeFamiTF313706

Miscellaneous databases

ChiTaRSiVbp1 mouse
PROiPR:P61759
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031197 Expressed in 307 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_VBP1
ExpressionAtlasiP61759 baseline and differential
GenevisibleiP61759 MM

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR016655 PFD3
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PANTHERiPTHR12409 PTHR12409, 1 hit
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
PIRSFiPIRSF016396 Prefoldin_subunit_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD3_MOUSE
AccessioniPrimary (citable) accession number: P61759
Secondary accession number(s): O55228
, Q15765, Q3U6M9, Q9CPZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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