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Protein

Prefoldin subunit 3

Gene

VBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
HIBBJ46
von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:VBP1
Synonyms:PFDN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000155959.10
HGNCiHGNC:12662 VBP1
MIMi300133 gene
neXtProtiNX_P61758

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7411
PharmGKBiPA37285

Polymorphism and mutation databases

BioMutaiVBP1
DMDMi125987848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001536522 – 197Prefoldin subunit 3Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei59N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61758
MaxQBiP61758
PaxDbiP61758
PeptideAtlasiP61758
PRIDEiP61758
ProteomicsDBi57330
TopDownProteomicsiP61758

2D gel databases

OGPiP61758

PTM databases

iPTMnetiP61758
PhosphoSitePlusiP61758

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000155959
CleanExiHS_VBP1
ExpressionAtlasiP61758 baseline and differential
GenevisibleiP61758 HS

Organism-specific databases

HPAiCAB006260
HPA023230

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113254, 76 interactors
CORUMiP61758
DIPiDIP-46479N
IntActiP61758, 50 interactors
MINTiP61758
STRINGi9606.ENSP00000286428

Structurei

3D structure databases

ProteinModelPortaliP61758
SMRiP61758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313 Eukaryota
ENOG410XRZ8 LUCA
HOVERGENiHBG053576
InParanoidiP61758
OrthoDBiEOG091G0P5N
PhylomeDBiP61758
TreeFamiTF313706

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR016655 PFD3
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PANTHERiPTHR12409 PTHR12409, 1 hit
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
PIRSFiPIRSF016396 Prefoldin_subunit_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL
60 70 80 90 100
KKLDEQYQKY KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS
110 120 130 140 150
METRFLLADN LYCKASVPPT DKMCLWLGAN VMLEYDIDEA QALLEKNLST
160 170 180 190
ATKNLDSLEE DLDFLRDQFT TTEVNMARVY NWDVKRRNKD DSTKNKA
Length:197
Mass (Da):22,658
Last modified:February 6, 2007 - v3
Checksum:i973BBDE2B3903E39
GO

Sequence cautioni

The sequence AAC23907 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023371123M → V6 PublicationsCorresponds to variant dbSNP:rs572013Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96759 mRNA Translation: AAC23907.1 Different initiation.
Y17394 mRNA Translation: CAA76761.1
AK313420 mRNA Translation: BAG36212.1
BT019604 mRNA Translation: AAV38411.1
AL356738 Genomic DNA Translation: CAI41469.1
BC046094 mRNA Translation: AAH46094.1
U56833 mRNA Translation: AAC50617.1
RefSeqiNP_001290472.1, NM_001303543.1
NP_001290474.1, NM_001303545.1
NP_003363.1, NM_003372.6
UniGeneiHs.436803

Genome annotation databases

EnsembliENST00000286428; ENSP00000286428; ENSG00000155959
GeneIDi7411
KEGGihsa:7411
UCSCiuc004fnc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPFD3_HUMAN
AccessioniPrimary (citable) accession number: P61758
Secondary accession number(s): B2R8L5
, O55228, Q15765, Q5JT81, Q86X96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 6, 2007
Last modified: July 18, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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