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Protein

ADP-ribosylation factor 4

Gene

Arf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 4
Gene namesi
Name:Arf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:99433 Arf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002073922 – 180ADP-ribosylation factor 4Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei147PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP61750
PaxDbiP61750
PeptideAtlasiP61750
PRIDEiP61750

PTM databases

iPTMnetiP61750
PhosphoSitePlusiP61750
SwissPalmiP61750

Expressioni

Gene expression databases

BgeeiENSMUSG00000021877 Expressed in 346 organ(s), highest expression level in vault of skull
CleanExiMM_ARF4
ExpressionAtlasiP61750 baseline and differential
GenevisibleiP61750 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cadps2Q8BYR52EBI-7569554,EBI-7569313

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198187, 6 interactors
IntActiP61750, 5 interactors
MINTiP61750
STRINGi10090.ENSMUSP00000022429

Structurei

3D structure databases

ProteinModelPortaliP61750
SMRiP61750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61750
KOiK07939
OMAiWHIESTC
OrthoDBiEOG091G0S7S
PhylomeDBiP61750
TreeFamiTF300808

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P61750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI
110 120 130 140 150
QEGAAVLQKM LLEDELQDAV LLLFANKQDL PNAMAISEMT DKLGLQSLRN
160 170 180
RTWYVQATCA TQGTGLYEGL DWLSNELSKR
Length:180
Mass (Da):20,397
Last modified:January 23, 2007 - v2
Checksum:i09112917D8CE15D6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q2C2E9Q2C2_MOUSE
ADP-ribosylation factor 4
Arf4
64Annotation score:
E9Q798E9Q798_MOUSE
ADP-ribosylation factor 4
Arf4
153Annotation score:
F6UFB9F6UFB9_MOUSE
ADP-ribosylation factor 4
Arf4
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → E in BAB29041 (PubMed:16141072).Curated1
Sequence conflicti176E → R in BAB29041 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87901 mRNA Translation: BAA13493.1
AK013892 mRNA Translation: BAB29041.1
AK081686 mRNA Translation: BAC38292.1
AK153011 mRNA Translation: BAE31650.1
AK168793 mRNA Translation: BAE40626.1
CCDSiCCDS26881.1
PIRiJC4948
RefSeqiNP_031505.1, NM_007479.3
UniGeneiMm.297768

Genome annotation databases

EnsembliENSMUST00000022429; ENSMUSP00000022429; ENSMUSG00000021877
ENSMUST00000230068; ENSMUSP00000155713; ENSMUSG00000115861
GeneIDi11843
KEGGimmu:11843
UCSCiuc007sta.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87901 mRNA Translation: BAA13493.1
AK013892 mRNA Translation: BAB29041.1
AK081686 mRNA Translation: BAC38292.1
AK153011 mRNA Translation: BAE31650.1
AK168793 mRNA Translation: BAE40626.1
CCDSiCCDS26881.1
PIRiJC4948
RefSeqiNP_031505.1, NM_007479.3
UniGeneiMm.297768

3D structure databases

ProteinModelPortaliP61750
SMRiP61750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198187, 6 interactors
IntActiP61750, 5 interactors
MINTiP61750
STRINGi10090.ENSMUSP00000022429

PTM databases

iPTMnetiP61750
PhosphoSitePlusiP61750
SwissPalmiP61750

Proteomic databases

EPDiP61750
PaxDbiP61750
PeptideAtlasiP61750
PRIDEiP61750

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022429; ENSMUSP00000022429; ENSMUSG00000021877
ENSMUST00000230068; ENSMUSP00000155713; ENSMUSG00000115861
GeneIDi11843
KEGGimmu:11843
UCSCiuc007sta.1 mouse

Organism-specific databases

CTDi378
MGIiMGI:99433 Arf4

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61750
KOiK07939
OMAiWHIESTC
OrthoDBiEOG091G0S7S
PhylomeDBiP61750
TreeFamiTF300808

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:P61750
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021877 Expressed in 346 organ(s), highest expression level in vault of skull
CleanExiMM_ARF4
ExpressionAtlasiP61750 baseline and differential
GenevisibleiP61750 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARF4_MOUSE
AccessioniPrimary (citable) accession number: P61750
Secondary accession number(s): P36403, Q3TGC2, Q9CXX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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