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Protein

Alpha-2,8-sialyltransferase 8F

Gene

ST8SIA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,36-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei214SubstrateBy similarity1
Active sitei370Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: Reactome
  • sialyltransferase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-4085001 Sialic acid metabolism
R-HSA-975577 N-Glycan antennae elongation
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2,8-sialyltransferase 8F (EC:2.4.99.-)
Alternative name(s):
Sialyltransferase 8F
Short name:
SIAT8-F
Sialyltransferase St8Sia VI
Short name:
ST8SiaVI
Gene namesi
Name:ST8SIA6
Synonyms:SIAT8F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148488.15
HGNCiHGNC:23317 ST8SIA6
MIMi610139 gene
neXtProtiNX_P61647

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini25 – 398LumenalSequence analysisAdd BLAST374

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148488
PharmGKBiPA134909138

Polymorphism and mutation databases

BioMutaiST8SIA6
DMDMi48428578

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492991 – 398Alpha-2,8-sialyltransferase 8FAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 335By similarity
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 395By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP61647
PeptideAtlasiP61647
PRIDEiP61647
ProteomicsDBi57329

PTM databases

iPTMnetiP61647
PhosphoSitePlusiP61647

Expressioni

Gene expression databases

BgeeiENSG00000148488 Expressed in 85 organ(s), highest expression level in heart
CleanExiHS_ST8SIA6
ExpressionAtlasiP61647 baseline and differential

Organism-specific databases

HPAiHPA011635
HPA072708

Interactioni

Protein-protein interaction databases

BioGridi130764, 1 interactor
STRINGi9606.ENSP00000366827

Structurei

3D structure databases

ProteinModelPortaliP61647
SMRiP61647
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 238Substrate bindingBy similarity3
Regioni322 – 324Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074407
HOGENOMiHOG000090201
HOVERGENiHBG106106
InParanoidiP61647
KOiK06615
OMAiQLHMKGI
OrthoDBiEOG091G0CER
PhylomeDBiP61647
TreeFamiTF323961

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P61647-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGGALLAL LASLLLLLLL RLLWCPADAP GRARILVEES REATHGTPAA
60 70 80 90 100
LRTLRSPATA VPRATNSTYL NEKSLQLTEK CKNLQYGIES FSNKTKGYSE
110 120 130 140 150
NDYLQIITDI QSCPWKRQAE EYANFRAKLA SCCDAVQNFV VSQNNTPVGT
160 170 180 190 200
NMSYEVESKK EIPIKKNIFH MFPVSQPFVD YPYNQCAVVG NGGILNKSLC
210 220 230 240 250
GTEIDKSDFV FRCNLPPTTG DVSKDVGSKT NLVTINPSII TLKYGNLKEK
260 270 280 290 300
KALFLEDIAT YGDAFFLLPA FSFRANTGTS FKVYYTLEES KARQKVLFFH
310 320 330 340 350
PKYLKDLALF WRTKGVTAYR LSTGLMITSV AVELCKNVKL YGFWPFSKTV
360 370 380 390
EDIPVSHHYY DNKLPKHGFH QMPKEYSQIL QLHMKGILKL QFSKCEVA
Length:398
Mass (Da):44,836
Last modified:June 7, 2004 - v1
Checksum:i48F58B82E4B69A26
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y405H0Y405_HUMAN
Alpha-2,8-sialyltransferase 8F
ST8SIA6
128Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621583 mRNA Translation: CAF21722.1
EF445032 Genomic DNA Translation: ACA06074.1
EF445032 Genomic DNA Translation: ACA06075.1
AL158164 Genomic DNA No translation available.
AL160289 Genomic DNA No translation available.
BC137102 mRNA Translation: AAI37103.1
BC137103 mRNA Translation: AAI37104.1
CCDSiCCDS31158.1
RefSeqiNP_001004470.1, NM_001004470.2
UniGeneiHs.677766

Genome annotation databases

EnsembliENST00000377602; ENSP00000366827; ENSG00000148488
GeneIDi338596
KEGGihsa:338596
UCSCiuc001ipd.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST8Sia VI

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621583 mRNA Translation: CAF21722.1
EF445032 Genomic DNA Translation: ACA06074.1
EF445032 Genomic DNA Translation: ACA06075.1
AL158164 Genomic DNA No translation available.
AL160289 Genomic DNA No translation available.
BC137102 mRNA Translation: AAI37103.1
BC137103 mRNA Translation: AAI37104.1
CCDSiCCDS31158.1
RefSeqiNP_001004470.1, NM_001004470.2
UniGeneiHs.677766

3D structure databases

ProteinModelPortaliP61647
SMRiP61647
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130764, 1 interactor
STRINGi9606.ENSP00000366827

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

PTM databases

iPTMnetiP61647
PhosphoSitePlusiP61647

Polymorphism and mutation databases

BioMutaiST8SIA6
DMDMi48428578

Proteomic databases

PaxDbiP61647
PeptideAtlasiP61647
PRIDEiP61647
ProteomicsDBi57329

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377602; ENSP00000366827; ENSG00000148488
GeneIDi338596
KEGGihsa:338596
UCSCiuc001ipd.4 human

Organism-specific databases

CTDi338596
EuPathDBiHostDB:ENSG00000148488.15
GeneCardsiST8SIA6
HGNCiHGNC:23317 ST8SIA6
HPAiHPA011635
HPA072708
MIMi610139 gene
neXtProtiNX_P61647
OpenTargetsiENSG00000148488
PharmGKBiPA134909138
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074407
HOGENOMiHOG000090201
HOVERGENiHBG106106
InParanoidiP61647
KOiK06615
OMAiQLHMKGI
OrthoDBiEOG091G0CER
PhylomeDBiP61647
TreeFamiTF323961

Enzyme and pathway databases

UniPathwayi
UPA00378

ReactomeiR-HSA-4085001 Sialic acid metabolism
R-HSA-975577 N-Glycan antennae elongation

Miscellaneous databases

ChiTaRSiST8SIA6 human
GenomeRNAii338596
PROiPR:P61647
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148488 Expressed in 85 organ(s), highest expression level in heart
CleanExiHS_ST8SIA6
ExpressionAtlasiP61647 baseline and differential

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIA8F_HUMAN
AccessioniPrimary (citable) accession number: P61647
Secondary accession number(s): B0YJ97, B9EH72, Q5VZH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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